LOCUS       NM_003513                527 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H2A clustered histone 4 (H2AC4), mRNA.
ACCESSION   NM_003513
VERSION     NM_003513.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Chai,X., Wang,G., Hong,X., Feng,M., Wang,H., Liu,F., Yao,W., Zhu,D.
            and Li,Q.
  TITLE     Inhibition of HIST1H2AB suppresses the proliferation of lung
            adenocarcinoma
  JOURNAL   J Gene Med 25 (5), e3469 (2023)
   PUBMED   36511295
  REMARK    GeneRIF: Inhibition of HIST1H2AB suppresses the proliferation of
            lung adenocarcinoma.
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 527)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 527)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 527)
  AUTHORS   Kujirai,T. and Kurumizaka,H.
  TITLE     Transcription through the nucleosome
  JOURNAL   Curr Opin Struct Biol 61, 42-49 (2020)
   PUBMED   31790919
  REMARK    Review article
REFERENCE   6  (bases 1 to 527)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 527)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   8  (bases 1 to 527)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   9  (bases 1 to 527)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 527)
  AUTHORS   Zhong,R., Roeder,R.G. and Heintz,N.
  TITLE     The primary structure and expression of four cloned human histone
            genes
  JOURNAL   Nucleic Acids Res 11 (21), 7409-7425 (1983)
   PUBMED   6647026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003513.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC125140.1, CK130258.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000615868.2/
                                             ENSP00000483842.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               U91328.1           107441-107967
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..527
                     /gene="H2AC4"
                     /gene_synonym="H2A/m; H2AC8; H2AFM; HIST1H2AB"
                     /note="H2A clustered histone 4"
                     /db_xref="GeneID:8335"
                     /db_xref="HGNC:HGNC:4734"
                     /db_xref="MIM:602795"
     exon            1..527
                     /gene="H2AC4"
                     /gene_synonym="H2A/m; H2AC8; H2AFM; HIST1H2AB"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..443
                     /gene="H2AC4"
                     /gene_synonym="H2A/m; H2AC8; H2AFM; HIST1H2AB"
                     /note="H2A histone family, member M; histone 1, H2ab;
                     histone H2A/m; histone cluster 1, H2ab; histone cluster 1
                     H2A family member b"
                     /codon_start=1
                     /product="histone H2A type 1-B/E"
                     /protein_id="NP_003504.2"
                     /db_xref="CCDS:CCDS4574.1"
                     /db_xref="GeneID:8335"
                     /db_xref="HGNC:HGNC:4734"
                     /db_xref="MIM:602795"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 gtagtttcat tacattttct tgtggcgatt ttcccttatc agaagtagtt atgtctggtc
       61 gcggcaaaca aggcggtaaa gctcgcgcca aggctaagac tcggtcttct cgtgcaggtt
      121 tgcagtttcc tgtgggccga gtgcaccgcc tgctccgcaa aggcaactac tccgagcgcg
      181 tcggggctgg cgcgccggtg tatctcgcgg cggtgcttga gtacctgacc gccgagatcc
      241 tggagctggc gggcaatgcg gcccgcgaca acaagaagac ccgcatcatc ccgcgccacc
      301 tgcaattggc catccgcaat gacgaggagc ttaataaact cttggggcgt gtgaccatcg
      361 cgcagggtgg cgttttgcct aatattcagg cggtgctgct gcctaagaaa actgagagcc
      421 atcataaggc caagggaaag tgaagagtta acgcttcatg cactgctgtt tttctgtcag
      481 cagacaaaat cagcctaaca gcaaaggctc ttttcagagc cacctac
//
