LOCUS       NM_033445                510 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens H2A clustered histone 25 (H2AC25), mRNA.
ACCESSION   NM_033445
VERSION     NM_033445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Yang,L., Ruan,Y. and Xu,H.
  TITLE     HIST3H2A promotes the progression of prostate cancer through
            inhibiting cell necroptosis
  JOURNAL   BMC Cancer 24 (1), 544 (2024)
   PUBMED   38684944
  REMARK    GeneRIF: HIST3H2A promotes the progression of prostate cancer
            through inhibiting cell necroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 510)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 510)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 510)
  AUTHORS   Ye,X.Y., Xu,L., Lu,S. and Chen,Z.W.
  TITLE     MiR-516a-5p inhibits the proliferation of non-small cell lung
            cancer by targeting HIST3H2A
  JOURNAL   Int J Immunopathol Pharmacol 33, 2058738419841481 (2019)
   PUBMED   30966836
  REMARK    GeneRIF: Overexpression of HIST3H2A reversed the anti-proliferation
            effects induced by miR-516a-5p in non-small cell lung cancer cells.
REFERENCE   6  (bases 1 to 510)
  AUTHORS   Lusic,M., Marcello,A., Cereseto,A. and Giacca,M.
  TITLE     Regulation of HIV-1 gene expression by histone acetylation and
            factor recruitment at the LTR promoter
  JOURNAL   EMBO J 22 (24), 6550-6561 (2003)
   PUBMED   14657027
REFERENCE   7  (bases 1 to 510)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   8  (bases 1 to 510)
  AUTHORS   Deng,L., Wang,D., de la Fuente,C., Wang,L., Li,H., Lee,C.G.,
            Donnelly,R., Wade,J.D., Lambert,P. and Kashanchi,F.
  TITLE     Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
  JOURNAL   Virology 289 (2), 312-326 (2001)
   PUBMED   11689053
REFERENCE   9  (bases 1 to 510)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   10 (bases 1 to 510)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139288.15.
            
            On Dec 3, 2019 this sequence version replaced NM_033445.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene contain a palindromic
            termination element. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BM744182.1, DA092328.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000689584.1/
                                             ENSP00000508783.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               AL139288.15        100492-101001
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..510
                     /gene="H2AC25"
                     /gene_synonym="H2AW; HIST3H2A"
                     /note="H2A clustered histone 25"
                     /db_xref="GeneID:92815"
                     /db_xref="HGNC:HGNC:20507"
                     /db_xref="MIM:615015"
     exon            1..510
                     /gene="H2AC25"
                     /gene_synonym="H2AW; HIST3H2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..449
                     /gene="H2AC25"
                     /gene_synonym="H2AW; HIST3H2A"
                     /note="histone 3, H2a; histone cluster 3, H2a; histone
                     cluster 3 H2A; H2A.W histone"
                     /codon_start=1
                     /product="histone H2A type 3"
                     /protein_id="NP_254280.1"
                     /db_xref="CCDS:CCDS1573.1"
                     /db_xref="GeneID:92815"
                     /db_xref="HGNC:HGNC:20507"
                     /db_xref="MIM:615015"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      484..489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AC25"
                     /gene_synonym="H2AW; HIST3H2A"
                     /note="hexamer: CATAAA"
     polyA_site      510
                     /gene="H2AC25"
                     /gene_synonym="H2AW; HIST3H2A"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgtttt tagtctcgct tttcggttgc cgttgtcttt tttccttgac tcggaaatgt
       61 ccggtcgtgg taagcagggt ggcaaggcgc gcgccaaggc taagtcgcgc tcgtcgcgcg
      121 cggggctgca gttccccgtg ggccgcgtgc accggttgct ccgcaagggc aactattcgg
      181 agcgcgtggg cgccggcgcc ccggtctatc tggccgcggt gctcgagtac ttgactgccg
      241 agatcctgga gcttgccggc aacgcggcgc gcgacaacaa gaagacgcgc atcatcccgc
      301 gccacctgca gctggccatc cgcaacgacg aggagctcaa caagctgctg ggccgcgtga
      361 ccatcgcgca gggtggcgtc ctgcccaaca tccaggccgt actgctgccc aagaagacgg
      421 agagccacca caaggccaag ggcaagtgag gccgcccgcc gcccccgggg cccctttgat
      481 ggacataaag gctcttttca gagccaccta
//
