LOCUS       NM_003517                494 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2A clustered histone 20 (H2AC20), mRNA.
ACCESSION   NM_003517
VERSION     NM_003517.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Baranova,S.V., Dmitrienok,P.S., Buneva,V.N. and Nevinsky,G.A.
  TITLE     HIV-Infected Patients: Cross Site-Specific Hydrolysis of H2a and
            H2b Histones and Myelin Basic Protein with Antibodies against These
            Three Proteins
  JOURNAL   Biomolecules 10 (11), 1501 (2020)
   PUBMED   33143355
  REMARK    GeneRIF: HIV-Infected Patients: Cross Site-Specific Hydrolysis of
            H2a and H2b Histones and Myelin Basic Protein with Antibodies
            against These Three Proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 494)
  AUTHORS   Monteiro,F.L., Vitorino,R., Wang,J., Cardoso,H., Laranjeira,H.,
            Simoes,J., Caldas,M., Henrique,R., Amado,F., Williams,C.,
            Jeronimo,C. and Helguero,L.A.
  TITLE     The histone H2A isoform Hist2h2ac is a novel regulator of
            proliferation and epithelial-mesenchymal transition in mammary
            epithelial and in breast cancer cells
  JOURNAL   Cancer Lett 396, 42-52 (2017)
   PUBMED   28288875
REFERENCE   4  (bases 1 to 494)
  AUTHORS   Zhao,S., Bellone,S., Lopez,S., Thakral,D., Schwab,C., English,D.P.,
            Black,J., Cocco,E., Choi,J., Zammataro,L., Predolini,F.,
            Bonazzoli,E., Bi,M., Buza,N., Hui,P., Wong,S., Abu-Khalaf,M.,
            Ravaggi,A., Bignotti,E., Bandiera,E., Romani,C., Todeschini,P.,
            Tassi,R., Zanotti,L., Odicino,F., Pecorelli,S., Donzelli,C.,
            Ardighieri,L., Facchetti,F., Falchetti,M., Silasi,D.A., Ratner,E.,
            Azodi,M., Schwartz,P.E., Mane,S., Angioli,R., Terranova,C.,
            Quick,C.M., Edraki,B., Bilguvar,K., Lee,M., Choi,M., Stiegler,A.L.,
            Boggon,T.J., Schlessinger,J., Lifton,R.P. and Santin,A.D.
  TITLE     Mutational landscape of uterine and ovarian carcinosarcomas
            implicates histone genes in epithelial-mesenchymal transition
  JOURNAL   Proc Natl Acad Sci U S A 113 (43), 12238-12243 (2016)
   PUBMED   27791010
  REMARK    GeneRIF: we found an excess of mutations in genes encoding histone
            H2A and H2B, as well as significant amplification of the segment of
            chromosome 6p harboring the histone gene cluster containing these
            genes.We also found frequent deletions of the genes TP53 and MBD3
            (a member with CHD4 of the nucleosome remodeling deacetylase
            complex).
REFERENCE   5  (bases 1 to 494)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   6  (bases 1 to 494)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 494)
  AUTHORS   Kimura,A. and Horikoshi,M.
  TITLE     Tip60 acetylates six lysines of a specific class in core histones
            in vitro
  JOURNAL   Genes Cells 3 (12), 789-800 (1998)
   PUBMED   10096020
REFERENCE   8  (bases 1 to 494)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 494)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 494)
  AUTHORS   Collart,D., Romain,P.L., Huebner,K., Pockwinse,S., Pilapil,S.,
            Cannizzaro,L.A., Lian,J.B., Croce,C.M., Stein,J.L. and Stein,G.S.
  TITLE     A human histone H2B.1 variant gene, located on chromosome 1,
            utilizes alternative 3' end processing
  JOURNAL   J Cell Biochem 50 (4), 374-385 (1992)
   PUBMED   1469070
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            On Dec 3, 2019 this sequence version replaced NM_003517.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: CD710576.1, CT002125.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000331380.4/
                                             ENSP00000332194.3
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               AC239868.2         171488-171981
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..494
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /note="H2A clustered histone 20"
                     /db_xref="GeneID:8338"
                     /db_xref="HGNC:HGNC:4738"
                     /db_xref="MIM:602797"
     exon            1..494
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..447
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /note="H2A histone family, member Q; histone cluster 2 H2A
                     family member c; histone 2, H2ac; histone IIa; histone
                     H2A/q; histone H2A-GL101; histone cluster 2, H2ac"
                     /codon_start=1
                     /product="histone H2A type 2-C"
                     /protein_id="NP_003508.1"
                     /db_xref="CCDS:CCDS937.1"
                     /db_xref="GeneID:8338"
                     /db_xref="HGNC:HGNC:4738"
                     /db_xref="MIM:602797"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHKAKSK"
     regulatory      443..448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /note="hexamer: AATAAA"
     polyA_site      458
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /note="major polyA site"
     polyA_site      462
                     /gene="H2AC20"
                     /gene_synonym="H2A; H2A-GL101; H2A/q; H2AFQ; HIST2H2AC"
                     /note="major polyA site"
ORIGIN      
        1 aatcttattt tgttgcgagg ttctgagcgt tgtctgtgtt taaccttgat ttcagtcatg
       61 tctggtcgtg gcaaacaagg aggcaaggcc cgcgccaagg ccaagtcgcg ctcgtcccgc
      121 gctggcctcc agttcccggt agggcgagtg caccgcttgc tgcgcaaagg caactacgcg
      181 gagcgggtgg gggccggcgc gcccgtctac atggcggcgg tcctcgagta cctgaccgcc
      241 gagatcctgg agctggcggg caacgcggct cgggacaaca agaagacgcg catcatccct
      301 cgtcacctcc agctggccat ccgcaacgac gaggaactga acaagctgct gggcaaagtc
      361 accatcgccc agggcggcgt tttgcctaac atccaggccg ttctgttacc aaagaaaacc
      421 gaaagccaca aagccaaaag caaataaatg cagacaaaca aaccaagacc aaaggctctt
      481 tttagagcca ccca
//
