LOCUS       NM_001040874             534 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens H2A clustered histone 19 (H2AC19), mRNA.
ACCESSION   NM_001040874
VERSION     NM_001040874.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 534)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 534)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 534)
  AUTHORS   Valencia,A.M., Collings,C.K., Dao,H.T., St Pierre,R., Cheng,Y.C.,
            Huang,J., Sun,Z.Y., Seo,H.S., Mashtalir,N., Comstock,D.E.,
            Bolonduro,O., Vangos,N.E., Yeoh,Z.C., Dornon,M.K., Hermawan,C.,
            Barrett,L., Dhe-Paganon,S., Woolf,C.J., Muir,T.W. and Kadoch,C.
  TITLE     Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch
            Interaction Site That Potentiates mSWI/SNF Complex Chromatin
            Remodeling
  JOURNAL   Cell 179 (6), 1342-1356 (2019)
   PUBMED   31759698
REFERENCE   4  (bases 1 to 534)
  AUTHORS   Sadakierska-Chudy,A., Kostrzewa,R.M. and Filip,M.
  TITLE     A comprehensive view of the epigenetic landscape part I: DNA
            methylation, passive and active DNA demethylation pathways and
            histone variants
  JOURNAL   Neurotox Res 27 (1), 84-97 (2015)
   PUBMED   25362550
  REMARK    Review article
REFERENCE   5  (bases 1 to 534)
  AUTHORS   Bonenfant,D., Coulot,M., Towbin,H., Schindler,P. and van Oostrum,J.
  TITLE     Characterization of histone H2A and H2B variants and their
            post-translational modifications by mass spectrometry
  JOURNAL   Mol Cell Proteomics 5 (3), 541-552 (2006)
   PUBMED   16319397
REFERENCE   6  (bases 1 to 534)
  AUTHORS   Boyne,M.T. 2nd, Pesavento,J.J., Mizzen,C.A. and Kelleher,N.L.
  TITLE     Precise characterization of human histones in the H2A gene family
            by top down mass spectrometry
  JOURNAL   J Proteome Res 5 (2), 248-253 (2006)
   PUBMED   16457589
REFERENCE   7  (bases 1 to 534)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   8  (bases 1 to 534)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   9  (bases 1 to 534)
  AUTHORS   Mannironi,C., Orr,A., Hatch,C., Pilch,D., Ivanova,V. and Bonner,W.
  TITLE     The relative expression of human histone H2A genes is similar in
            different types of proliferating cells
  JOURNAL   DNA Cell Biol 13 (2), 161-170 (1994)
   PUBMED   8179821
REFERENCE   10 (bases 1 to 534)
  AUTHORS   Allen,B.S., Stein,J.L., Stein,G.S. and Ostrer,H.
  TITLE     Single-copy flanking sequences in human histone gene clusters map
            to chromosomes 1 and 6
  JOURNAL   Genomics 10 (2), 486-488 (1991)
   PUBMED   2071153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in a
            histone cluster on chromosome 1. This gene is one of four histone
            genes in the cluster that are duplicated; this record represents
            the telomeric copy. [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly.  The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BQ959893.1, CR998733.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000607355.3/
                                             ENSP00000475814.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 15527963
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AC239868.2         135631-136164
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..534
                     /gene="H2AC19"
                     /gene_synonym="H2A/R; H2AC18; HIST2H2AA4"
                     /note="H2A clustered histone 19"
                     /db_xref="GeneID:723790"
                     /db_xref="HGNC:HGNC:29668"
     exon            1..534
                     /gene="H2AC19"
                     /gene_synonym="H2A/R; H2AC18; HIST2H2AA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..446
                     /gene="H2AC19"
                     /gene_synonym="H2A/R; H2AC18; HIST2H2AA4"
                     /note="histone 2, H2aa4; histone H2A/r; histone cluster 2,
                     H2aa4; histone cluster 2 H2A family member a4;
                     H2A-clustered histone 18"
                     /codon_start=1
                     /product="histone H2A type 2-A"
                     /protein_id="NP_001035807.1"
                     /db_xref="CCDS:CCDS30849.1"
                     /db_xref="GeneID:723790"
                     /db_xref="HGNC:HGNC:29668"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 cgactttccc gatcgccagg caggagtttc tctcggtgac tactatcgct gtcatgtctg
       61 gtcgtggcaa gcaaggaggc aaggcccgcg ccaaggccaa gtcgcgctcg tcccgcgctg
      121 gccttcagtt cccggtaggg cgagtgcatc gcttgctgcg caaaggcaac tacgcggagc
      181 gagtgggggc cggcgcgccc gtctacatgg ctgcggtcct cgagtatctg accgccgaga
      241 tcctggagct ggcgggcaac gcggctcggg acaacaagaa gacgcgcatc atccctcgtc
      301 acctccagct ggccatccgc aacgacgagg aactgaacaa gctgctgggc aaagtcacca
      361 tcgcccaggg cggcgtcttg cctaacatcc aggccgtact gctccctaag aagacggaga
      421 gtcaccacaa ggcaaagggc aagtgaggct gacgtccggc ccaagtgggc ccagcccggc
      481 ccgcgtctcg aaggggcacc tgtgaactca aaaggctctt ttcagagcca ccca
//
