LOCUS       NM_003516                533 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens H2A clustered histone 18 (H2AC18), mRNA.
ACCESSION   NM_003516
VERSION     NM_003516.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Leszczynska,K.B., Freitas-Huhtamaki,A., Jayaprakash,C.,
            Dzwigonska,M., Vitorino,F.N.L., Horth,C., Wojnicki,K.,
            Gielniewski,B., Szadkowska,P., Kaza,B., Nazarian,J.,
            Ciolkowski,M.K., Trubicka,J., Grajkowska,W., Garcia,B.A.,
            Majewski,J., Kaminska,B. and Mieczkowski,J.
  TITLE     H2A.Z histone variants facilitate HDACi-dependent removal of
            H3.3K27M mutant protein in pediatric high-grade glioma cells
  JOURNAL   Cell Rep 43 (2), 113707 (2024)
   PUBMED   38306270
  REMARK    GeneRIF: H2A.Z histone variants facilitate HDACi-dependent removal
            of H3.3K27M mutant protein in pediatric high-grade glioma cells.
REFERENCE   2  (bases 1 to 533)
  AUTHORS   Dijkwel,Y., Hart-Smith,G., Kurscheid,S. and Tremethick,D.J.
  TITLE     ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and
            Regulates Its Protein Stability in the Cytoplasm
  JOURNAL   Mol Cell Biol 44 (2), 72-85 (2024)
   PUBMED   38482865
  REMARK    GeneRIF: ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent
            Manner and Regulates Its Protein Stability in the Cytoplasm.
REFERENCE   3  (bases 1 to 533)
  AUTHORS   Qiu,L., Xu,W., Lu,X., Chen,F., Chen,Y., Tian,Y., Zhu,Q., Liu,X.,
            Wang,Y., Pei,X.H., Xu,X., Zhang,J. and Zhu,W.G.
  TITLE     The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable
            double-strand break repair
  JOURNAL   Nucleic Acids Res 51 (17), 9166-9182 (2023)
   PUBMED   37503842
  REMARK    GeneRIF: The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination
            to enable double-strand break repair.
REFERENCE   4  (bases 1 to 533)
  AUTHORS   Li,S., Wei,T. and Panchenko,A.R.
  TITLE     Histone variant H2A.Z modulates nucleosome dynamics to promote DNA
            accessibility
  JOURNAL   Nat Commun 14 (1), 769 (2023)
   PUBMED   36765119
  REMARK    GeneRIF: Histone variant H2A.Z modulates nucleosome dynamics to
            promote DNA accessibility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 533)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   6  (bases 1 to 533)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 533)
  AUTHORS   Kaiser,P., Mandl,S., Schweiger,M. and Schneider,R.
  TITLE     Characterization of functionally independent domains in the human
            ubiquitin conjugating enzyme UbcH2
  JOURNAL   FEBS Lett 377 (2), 193-196 (1995)
   PUBMED   8543049
REFERENCE   8  (bases 1 to 533)
  AUTHORS   Mannironi,C., Orr,A., Hatch,C., Pilch,D., Ivanova,V. and Bonner,W.
  TITLE     The relative expression of human histone H2A genes is similar in
            different types of proliferating cells
  JOURNAL   DNA Cell Biol 13 (2), 161-170 (1994)
   PUBMED   8179821
REFERENCE   9  (bases 1 to 533)
  AUTHORS   Allen,B.S., Stein,J.L., Stein,G.S. and Ostrer,H.
  TITLE     Single-copy flanking sequences in human histone gene clusters map
            to chromosomes 1 and 6
  JOURNAL   Genomics 10 (2), 486-488 (1991)
   PUBMED   2071153
REFERENCE   10 (bases 1 to 533)
  AUTHORS   Marashi,F., Prokopp,K., Stein,J. and Stein,G.
  TITLE     Evidence for a human histone gene cluster containing H2B and H2A
            pseudogenes
  JOURNAL   Proc Natl Acad Sci U S A 81 (7), 1936-1940 (1984)
   PUBMED   6326092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            On Dec 3, 2019 this sequence version replaced NM_003516.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in a
            histone cluster on chromosome 1. This gene is one of four histone
            genes in the cluster that are duplicated; this record represents
            the centromeric copy. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA436359.1, CB998207.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000369159.3/
                                             ENSP00000358155.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               AC239868.2         126788-127320       c
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..533
                     /gene="H2AC18"
                     /gene_synonym="H2A; H2a-615; H2A.2; H2A/O; H2A/q; H2AC19;
                     H2AFO; HIST2H2AA; HIST2H2AA3"
                     /note="H2A clustered histone 18"
                     /db_xref="GeneID:8337"
                     /db_xref="HGNC:HGNC:4736"
                     /db_xref="MIM:142720"
     exon            1..533
                     /gene="H2AC18"
                     /gene_synonym="H2A; H2a-615; H2A.2; H2A/O; H2A/q; H2AC19;
                     H2AFO; HIST2H2AA; HIST2H2AA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..445
                     /gene="H2AC18"
                     /gene_synonym="H2A; H2a-615; H2A.2; H2A/O; H2A/q; H2AC19;
                     H2AFO; HIST2H2AA; HIST2H2AA3"
                     /note="H2A histone family, member O; histone 2, H2aa3;
                     histone cluster 2, H2aa3; histone cluster 2 H2A family
                     member a3; H2A-clustered histone 19"
                     /codon_start=1
                     /product="histone H2A type 2-A"
                     /protein_id="NP_003507.1"
                     /db_xref="CCDS:CCDS934.1"
                     /db_xref="GeneID:8337"
                     /db_xref="HGNC:HGNC:4736"
                     /db_xref="MIM:142720"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 gactttcccg atcgccaggc aggagtttct ctcggtgact actatcgctg tcatgtctgg
       61 tcgtggcaag caaggaggca aggcccgcgc caaggccaag tcgcgctcgt cccgcgctgg
      121 ccttcagttc ccggtagggc gagtgcatcg cttgctgcgc aaaggcaact acgcggagcg
      181 agtgggggcc ggcgcgcccg tctacatggc tgcggtcctc gagtatctga ccgccgagat
      241 cctggagctg gcgggcaacg cggctcggga caacaagaag acgcgcatca tccctcgtca
      301 cctccagctg gccatccgca acgacgagga actgaacaag ctgctgggca aagtcaccat
      361 cgcccagggc ggcgtcttgc ctaacatcca ggccgtactg ctccctaaga agacggagag
      421 tcaccacaag gcaaagggca agtgaggctg acgtccggcc caagtgggcc cagcccggcc
      481 cgcgtctcga aggggcacct gtgaactcaa aaggctcttt tcagagccac cca
//
