LOCUS       NM_003514                487 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens H2A clustered histone 17 (H2AC17), mRNA.
ACCESSION   NM_003514
VERSION     NM_003514.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Budziszewski,G.R., Zhao,Y., Spangler,C.J., Kedziora,K.M.,
            Williams,M.R., Azzam,D.N., Skrajna,A., Koyama,Y., Cesmat,A.P.,
            Simmons,H.C., Arteaga,E.C., Strauss,J.D., Kireev,D. and
            McGinty,R.K.
  TITLE     Multivalent DNA and nucleosome acidic patch interactions specify
            VRK1 mitotic localization and activity
  JOURNAL   Nucleic Acids Res 50 (8), 4355-4371 (2022)
   PUBMED   35390161
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Lubula,M.Y., Eckenroth,B.E., Carlson,S., Poplawski,A., Chruszcz,M.
            and Glass,K.C.
  TITLE     Structural insights into recognition of acetylated histone ligands
            by the BRPF1 bromodomain
  JOURNAL   FEBS Lett 588 (21), 3844-3854 (2014)
   PUBMED   25281266
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Kim,W., Chakraborty,G., Kim,S., Shin,J., Park,C.H., Jeong,M.W.,
            Bharatham,N., Yoon,H.S. and Kim,K.T.
  TITLE     Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase
            VRK1 during interphase
  JOURNAL   J Biol Chem 287 (8), 5278-5289 (2012)
   PUBMED   22194607
REFERENCE   5  (bases 1 to 487)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Mannironi,C., Orr,A., Hatch,C., Pilch,D., Ivanova,V. and Bonner,W.
  TITLE     The relative expression of human histone H2A genes is similar in
            different types of proliferating cells
  JOURNAL   DNA Cell Biol 13 (2), 161-170 (1994)
   PUBMED   8179821
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Dobner,T., Wolf,I., Mai,B. and Lipp,M.
  TITLE     A novel divergently transcribed human histone H2A/H2B gene pair
  JOURNAL   DNA Seq 1 (6), 409-413 (1991)
   PUBMED   1768865
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Hayashi,T., Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H2A. Isolation and four variant sequences
  JOURNAL   J Biochem 88 (1), 27-34 (1980)
   PUBMED   7410338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98744.2.
            
            On Sep 21, 2001 this sequence version replaced NM_003514.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB108854.1, DB117250.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000359611.4/
                                             ENSP00000352627.3
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               Z98744.2           56440-56926         c
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..487
                     /gene="H2AC17"
                     /gene_synonym="dJ193B12.1; H2A.1; H2A/n; H2AC11; H2AC13;
                     H2AC15; H2AC16; H2AFN; HIST1H2AM"
                     /note="H2A clustered histone 17"
                     /db_xref="GeneID:8336"
                     /db_xref="HGNC:HGNC:4735"
                     /db_xref="MIM:602796"
     exon            1..487
                     /gene="H2AC17"
                     /gene_synonym="dJ193B12.1; H2A.1; H2A/n; H2AC11; H2AC13;
                     H2AC15; H2AC16; H2AFN; HIST1H2AM"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..429
                     /gene="H2AC17"
                     /gene_synonym="dJ193B12.1; H2A.1; H2A/n; H2AC11; H2AC13;
                     H2AC15; H2AC16; H2AFN; HIST1H2AM"
                     /note="H2A histone family, member N; histone 1, H2am;
                     histone cluster 1, H2am; histone H2A/ptl; histone cluster
                     1 H2A family member m"
                     /codon_start=1
                     /product="histone H2A type 1"
                     /protein_id="NP_003505.1"
                     /db_xref="CCDS:CCDS4639.1"
                     /db_xref="GeneID:8336"
                     /db_xref="HGNC:HGNC:4735"
                     /db_xref="MIM:602796"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 actcactttc tgacttaggc cacaggtcgt tttaccatgt ctggacgtgg caagcagggc
       61 ggcaaggctc gcgccaaggc caaaacccgc tcctctagag ctgggctcca atttcctgta
      121 ggacgagtgc accgcctgct ccgcaagggc aactacgctg agcgggtcgg ggccggcgcg
      181 ccggtttacc tggcggcggt gctggagtac ctaactgccg agatcctgga gctggcgggc
      241 aacgcagccc gcgacaacaa aaagacccgc atcatcccgc gccacttgca gctggccatc
      301 cgcaacgacg aggagctcaa caagctgctt ggtaaagtta ccatcgctca gggcggtgtt
      361 ctgcctaaca tccaggccgt actgctcccc aagaagactg agagccacca caaagctaag
      421 ggcaagtaag ggctgaactt taaaaatgta aacttacaag acaaaaggct cttttcagag
      481 ccaccca
//
