LOCUS       NM_021066                476 bp    mRNA    linear   PRI 21-OCT-2023
DEFINITION  Homo sapiens H2A clustered histone 14 (H2AC14), mRNA.
ACCESSION   NM_021066
VERSION     NM_021066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Seal RL, Denny P, Bruford EA, Gribkova AK, Landsman D, Marzluff WF,
            McAndrews M, Panchenko AR, Shaytan AK and Talbert PB.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Lusic M, Marcello A, Cereseto A and Giacca M.
  TITLE     Regulation of HIV-1 gene expression by histone acetylation and
            factor recruitment at the LTR promoter
  JOURNAL   EMBO J 22 (24), 6550-6561 (2003)
   PUBMED   14657027
REFERENCE   3  (bases 1 to 476)
  AUTHORS   Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   4  (bases 1 to 476)
  AUTHORS   Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M and
            Lamond AI.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   5  (bases 1 to 476)
  AUTHORS   Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R,
            Wade JD, Lambert P and Kashanchi F.
  TITLE     Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
  JOURNAL   Virology 289 (2), 312-326 (2001)
   PUBMED   11689053
REFERENCE   6  (bases 1 to 476)
  AUTHORS   Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert
            P, Li H, Lee CG and Kashanchi F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   7  (bases 1 to 476)
  AUTHORS   Albig W, Trappe R, Kardalinou E, Eick S and Doenecke D.
  TITLE     The human H2A and H2B histone gene complement
  JOURNAL   Biol Chem 380 (1), 7-18 (1999)
   PUBMED   10064132
REFERENCE   8  (bases 1 to 476)
  AUTHORS   El Kharroubi A, Piras G, Zensen R and Martin MA.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 476)
  AUTHORS   Albig W and Doenecke D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 476)
  AUTHORS   Diaz-Jullien C, Perez-Estevez A, Covelo G and Freire M.
  TITLE     Prothymosin alpha binds histones in vitro and shows activity in
            nucleosome assembly assay
  JOURNAL   Biochim Biophys Acta 1296 (2), 219-227 (1996)
   PUBMED   8814229
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049822.30.
            
            On Dec 3, 2019 this sequence version replaced NM_021066.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC133048.1, CF272102.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000333151.5/
                                             ENSP00000328484.4
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AL049822.30        2649-3124           c
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..476
                     /gene="H2AC14"
                     /gene_synonym="dJ160A22.4; H2A/E; H2AFE; HIST1H2AJ"
                     /note="H2A clustered histone 14"
                     /db_xref="GeneID:8331"
                     /db_xref="HGNC:HGNC:4727"
                     /db_xref="MIM:602791"
     exon            1..476
                     /gene="H2AC14"
                     /gene_synonym="dJ160A22.4; H2A/E; H2AFE; HIST1H2AJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..424
                     /gene="H2AC14"
                     /gene_synonym="dJ160A22.4; H2A/E; H2AFE; HIST1H2AJ"
                     /note="H2A histone family, member E; histone 1, H2aj;
                     histone cluster 1 H2A family member j"
                     /codon_start=1
                     /product="histone cluster 1, H2aj"
                     /protein_id="NP_066544.1"
                     /db_xref="CCDS:CCDS4628.1"
                     /db_xref="GeneID:8331"
                     /db_xref="HGNC:HGNC:4727"
                     /db_xref="MIM:602791"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKTK"
     regulatory      420..425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AC14"
                     /gene_synonym="dJ160A22.4; H2A/E; H2AFE; HIST1H2AJ"
                     /note="hexamer: AGTAAA"
     polyA_site      439
                     /gene="H2AC14"
                     /gene_synonym="dJ160A22.4; H2A/E; H2AFE; HIST1H2AJ"
                     /note="major polyA site"
ORIGIN      
        1 agtctttctt gaccgtaaag gtaatagacc ttttgccatg tctgggcgtg gtaagcaggg
       61 aggcaaagct cgcgccaagg ccaagacccg ctcttctcgg gccgggcttc agtttcccgt
      121 aggccgagtg catcgcctgc tccgcaaagg caactatgcg gagcgggtcg gtgctggagc
      181 gccggtgtac ctggcggcgg tgctggagta cctgaccgcc gagatcctgg agctggctgg
      241 caacgcggcc cgcgacaaca agaagactcg catcatcccg cgtcacctcc agctggccat
      301 ccgcaacgat gaggagctca acaagcttct gggcaaagtc accatcgcac agggtggcgt
      361 cctgcccaac atccaggccg tgctgctgcc aaagaaaact gagagccacc acaagactaa
      421 gtaaagaccg agttgaaaag cgcataaaaa caaaggctct tttcagagcc acttca
//
