LOCUS       NM_080596                457 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2A clustered histone 12 (H2AC12), mRNA.
ACCESSION   NM_080596
VERSION     NM_080596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 457)
  AUTHORS   Kimura,H., Takizawa,N., Allemand,E., Hori,T., Iborra,F.J.,
            Nozaki,N., Muraki,M., Hagiwara,M., Krainer,A.R., Fukagawa,T. and
            Okawa,K.
  TITLE     A novel histone exchange factor, protein phosphatase 2Cgamma,
            mediates the exchange and dephosphorylation of H2A-H2B
  JOURNAL   J Cell Biol 175 (3), 389-400 (2006)
   PUBMED   17074886
  REMARK    GeneRIF: Protein phosphatase 2C gamma binds to/dephosphorylates H2A
            to affect chromatin function.
REFERENCE   4  (bases 1 to 457)
  AUTHORS   Bergink,S., Salomons,F.A., Hoogstraten,D., Groothuis,T.A., de
            Waard,H., Wu,J., Yuan,L., Citterio,E., Houtsmuller,A.B.,
            Neefjes,J., Hoeijmakers,J.H., Vermeulen,W. and Dantuma,N.P.
  TITLE     DNA damage triggers nucleotide excision repair-dependent
            monoubiquitylation of histone H2A
  JOURNAL   Genes Dev 20 (10), 1343-1352 (2006)
   PUBMED   16702407
REFERENCE   5  (bases 1 to 457)
  AUTHORS   Cao,R., Tsukada,Y. and Zhang,Y.
  TITLE     Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene
            silencing
  JOURNAL   Mol Cell 20 (6), 845-854 (2005)
   PUBMED   16359901
REFERENCE   6  (bases 1 to 457)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 457)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 457)
  AUTHORS   Ahn,J. and Gruen,J.R.
  TITLE     The genomic organization of the histone clusters on human 6p21.3
  JOURNAL   Mamm Genome 10 (7), 768-770 (1999)
   PUBMED   10384058
REFERENCE   9  (bases 1 to 457)
  AUTHORS   Albig,W., Trappe,R., Kardalinou,E., Eick,S. and Doenecke,D.
  TITLE     The human H2A and H2B histone gene complement
  JOURNAL   Biol Chem 380 (1), 7-18 (1999)
   PUBMED   10064132
REFERENCE   10 (bases 1 to 457)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021807.2.
            
            On Dec 3, 2019 this sequence version replaced NM_080596.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the histone microcluster on chromosome 6p21.33. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BX955192.1, AK312232.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000377459.3/
                                             ENSP00000366679.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               AL021807.2         70411-70867
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..457
                     /gene="H2AC12"
                     /gene_synonym="dJ86C11.1; H2A/S; H2AFALii; H2AH;
                     HIST1H2AH"
                     /note="H2A clustered histone 12"
                     /db_xref="GeneID:85235"
                     /db_xref="HGNC:HGNC:13671"
                     /db_xref="MIM:615013"
     exon            1..457
                     /gene="H2AC12"
                     /gene_synonym="dJ86C11.1; H2A/S; H2AFALii; H2AH;
                     HIST1H2AH"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..410
                     /gene="H2AC12"
                     /gene_synonym="dJ86C11.1; H2A/S; H2AFALii; H2AH;
                     HIST1H2AH"
                     /note="H2A histone family member; histone cluster 1 H2A
                     family member h; histone cluster 1, H2ah; histone H2A/s"
                     /codon_start=1
                     /product="histone H2A type 1-H"
                     /protein_id="NP_542163.1"
                     /db_xref="CCDS:CCDS4622.1"
                     /db_xref="GeneID:85235"
                     /db_xref="HGNC:HGNC:13671"
                     /db_xref="MIM:615013"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAK"
ORIGIN      
        1 actttcagta agttgtgacc agtatgtctg gacgtggcaa gcaaggcggt aaagctcgcg
       61 ccaaggccaa gacccgctct tctcgggctg ggcttcagtt ccccgtgggc cgagtgcacc
      121 gcctgctccg caagggtaat tatgccgagc gggttggagc cggcgcgcca gtgtacctgg
      181 ctgcggtgct ggagtacctg accgctgaga tcctggagct ggctggcaat gcggcccgcg
      241 acaacaagaa gacccgtatc atcccgcgtc acctccaact ggccatccgc aacgacgagg
      301 agctcaacaa gctgctgggc aaagtcacca tcgcgcaggg tggtgtcttg cccaatatcc
      361 aggccgtgct gctgcctaag aagactgaga gccaccataa ggccaaataa ggagcgaggt
      421 tgtgaaaact ggaaaacaaa ggctcttttc agagcca
//
