LOCUS       NM_021064                493 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens H2A clustered histone 11 (H2AC11), mRNA.
ACCESSION   NM_021064
VERSION     NM_021064.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Budziszewski,G.R., Zhao,Y., Spangler,C.J., Kedziora,K.M.,
            Williams,M.R., Azzam,D.N., Skrajna,A., Koyama,Y., Cesmat,A.P.,
            Simmons,H.C., Arteaga,E.C., Strauss,J.D., Kireev,D. and
            McGinty,R.K.
  TITLE     Multivalent DNA and nucleosome acidic patch interactions specify
            VRK1 mitotic localization and activity
  JOURNAL   Nucleic Acids Res 50 (8), 4355-4371 (2022)
   PUBMED   35390161
REFERENCE   3  (bases 1 to 493)
  AUTHORS   Lubula,M.Y., Eckenroth,B.E., Carlson,S., Poplawski,A., Chruszcz,M.
            and Glass,K.C.
  TITLE     Structural insights into recognition of acetylated histone ligands
            by the BRPF1 bromodomain
  JOURNAL   FEBS Lett 588 (21), 3844-3854 (2014)
   PUBMED   25281266
REFERENCE   4  (bases 1 to 493)
  AUTHORS   Kim,W., Chakraborty,G., Kim,S., Shin,J., Park,C.H., Jeong,M.W.,
            Bharatham,N., Yoon,H.S. and Kim,K.T.
  TITLE     Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase
            VRK1 during interphase
  JOURNAL   J Biol Chem 287 (8), 5278-5289 (2012)
   PUBMED   22194607
REFERENCE   5  (bases 1 to 493)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 493)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 493)
  AUTHORS   Albig,W., Trappe,R., Kardalinou,E., Eick,S. and Doenecke,D.
  TITLE     The human H2A and H2B histone gene complement
  JOURNAL   Biol Chem 380 (1), 7-18 (1999)
   PUBMED   10064132
REFERENCE   8  (bases 1 to 493)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 493)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 493)
  AUTHORS   Mannironi,C., Orr,A., Hatch,C., Pilch,D., Ivanova,V. and Bonner,W.
  TITLE     The relative expression of human histone H2A genes is similar in
            different types of proliferating cells
  JOURNAL   DNA Cell Biol 13 (2), 161-170 (1994)
   PUBMED   8179821
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021807.2.
            
            On Dec 3, 2019 this sequence version replaced NM_021064.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the histone microcluster on chromosome 6p21.33. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC067782.1, BU659312.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000359193.4/
                                             ENSP00000352119.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AL021807.2         56348-56840
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..493
                     /gene="H2AC11"
                     /gene_synonym="H2A.1b; H2A/p; H2AC13; H2AC15; H2AC16;
                     H2AC17; H2AFP; H2AG; HIST1H2AG; pH2A/f"
                     /note="H2A clustered histone 11"
                     /db_xref="GeneID:8969"
                     /db_xref="HGNC:HGNC:4737"
                     /db_xref="MIM:615012"
     exon            1..493
                     /gene="H2AC11"
                     /gene_synonym="H2A.1b; H2A/p; H2AC13; H2AC15; H2AC16;
                     H2AC17; H2AFP; H2AG; HIST1H2AG; pH2A/f"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..422
                     /gene="H2AC11"
                     /gene_synonym="H2A.1b; H2A/p; H2AC13; H2AC15; H2AC16;
                     H2AC17; H2AFP; H2AG; HIST1H2AG; pH2A/f"
                     /note="H2A histone family, member P; histone cluster 1 H2A
                     family member g; histone 1, H2ag; histone H2A/p; histone
                     cluster 1, H2ag; histone H2A/ptl"
                     /codon_start=1
                     /product="histone H2A type 1"
                     /protein_id="NP_066408.1"
                     /db_xref="CCDS:CCDS4619.1"
                     /db_xref="GeneID:8969"
                     /db_xref="HGNC:HGNC:4737"
                     /db_xref="MIM:615012"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      450..455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AC11"
                     /gene_synonym="H2A.1b; H2A/p; H2AC13; H2AC15; H2AC16;
                     H2AC17; H2AFP; H2AG; HIST1H2AG; pH2A/f"
                     /note="hexamer: AGTAAA"
     polyA_site      493
                     /gene="H2AC11"
                     /gene_synonym="H2A.1b; H2A/p; H2AC13; H2AC15; H2AC16;
                     H2AC17; H2AFP; H2AG; HIST1H2AG; pH2A/f"
                     /note="major polyA site"
ORIGIN      
        1 gtggttgctc gtagtgagtt gcgctcgcta tgtctggacg tggcaagcag ggaggcaaag
       61 cccgcgctaa ggccaagact cgctcttcta gggccggtct ccagttcccc gtgggccgag
      121 tgcaccgcct gctccgcaaa ggcaactatg ccgagcgggt cggggccggc gcgccggtgt
      181 atctggcagc ggtgctggag tacctgaccg ccgagatcct ggaactggcg ggcaacgcgg
      241 cccgcgacaa caagaagacc cgcatcatcc cgcgtcatct ccaactggcc atccgcaacg
      301 acgaggagct caacaagctg ctgggcaaag tcaccatcgc acagggcggt gtcctgccca
      361 acattcaggc cgtgctactg cccaaaaaga ctgagagcca ccacaaggcg aagggcaagt
      421 aactatctgt actagtttgt ggcagctcaa gtaaaatcga gtccaaacca acggctcttt
      481 tcagggccac cca
//
