LOCUS       NM_170745                500 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens H2A clustered histone 1 (H2AC1), mRNA.
ACCESSION   NM_170745
VERSION     NM_170745.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Shi,W.Y., Yang,X., Huang,B., Shen,W.H. and Liu,L.
  TITLE     NOK mediates glycolysis and nuclear PDC associated histone
            acetylation
  JOURNAL   Front Biosci (Landmark Ed) 22 (10), 1792-1804 (2017)
   PUBMED   28410146
  REMARK    GeneRIF: Findings show that serine-threonine-tyrosine kinase 1
            (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase
            complex (PDC) associated histone acetylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 500)
  AUTHORS   Bauden,M., Kristl,T., Andersson,R., Marko-Varga,G. and Ansari,D.
  TITLE     Characterization of histone-related chemical modifications in
            formalin-fixed paraffin-embedded and fresh-frozen human pancreatic
            cancer xenografts using LC-MS/MS
  JOURNAL   Lab Invest 97 (3), 279-288 (2017)
   PUBMED   27941757
  REMARK    GeneRIF: Data indicate that formalin-fixed, paraffin-embedded
            (FFPE) tissue processing may result in persistent chemical
            modifications of histones, which correspond in mass shift of
            important post-translational modifications (PTMs).
REFERENCE   4  (bases 1 to 500)
  AUTHORS   Huynh,L.M., Shinagawa,T. and Ishii,S.
  TITLE     Two Histone Variants TH2A and TH2B Enhance Human Induced
            Pluripotent Stem Cell Generation
  JOURNAL   Stem Cells Dev 25 (3), 251-258 (2016)
   PUBMED   26649967
REFERENCE   5  (bases 1 to 500)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 500)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 500)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   8  (bases 1 to 500)
  AUTHORS   Deng,L., Wang,D., de la Fuente,C., Wang,L., Li,H., Lee,C.G.,
            Donnelly,R., Wade,J.D., Lambert,P. and Kashanchi,F.
  TITLE     Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
  JOURNAL   Virology 289 (2), 312-326 (2001)
   PUBMED   11689053
REFERENCE   9  (bases 1 to 500)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   10 (bases 1 to 500)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512384.9.
            
            On Sep 22, 2004 this sequence version replaced NM_170745.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene contain a palindromic
            termination element. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC062211.1, BU567795.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000297012.5/
                                             ENSP00000297012.4
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AL512384.9         33213-33712         c
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..500
                     /gene="H2AC1"
                     /gene_synonym="bA317E16.2; H2AA; H2AFR; HIST1H2AA;
                     HISTH2AA; TH2A"
                     /note="H2A clustered histone 1"
                     /db_xref="GeneID:221613"
                     /db_xref="HGNC:HGNC:18729"
                     /db_xref="MIM:613499"
     exon            1..500
                     /gene="H2AC1"
                     /gene_synonym="bA317E16.2; H2AA; H2AFR; HIST1H2AA;
                     HISTH2AA; TH2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..431
                     /gene="H2AC1"
                     /gene_synonym="bA317E16.2; H2AA; H2AFR; HIST1H2AA;
                     HISTH2AA; TH2A"
                     /note="histone 1, H2aa; H2A histone family, member R;
                     histone H2A/r; histone cluster 1, H2aa; histone cluster 1
                     H2A family member a"
                     /codon_start=1
                     /product="histone H2A type 1-A"
                     /protein_id="NP_734466.1"
                     /db_xref="CCDS:CCDS4562.1"
                     /db_xref="GeneID:221613"
                     /db_xref="HGNC:HGNC:18729"
                     /db_xref="MIM:613499"
                     /translation="MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERI
                     GAGAPVYLAAVLEYLTAEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVT
                     IAQGGVLPNIQAVLLPKKTESHHHKAQSK"
ORIGIN      
        1 gtggttctcg tgttgctgca atttgatgcg aggagatgtc tggacgaggg aagcagggag
       61 gaaaagcacg cgccaagtct aagtctcgct cttctagagc gggtttgcag tttcccgtag
      121 gccggatcca tcgtctgctt cgtaagggaa actatgcaga gcggataggg gcaggcgcac
      181 cagtgtattt ggcggcagtg ttagagtatc tcacagcaga aatccttgag ctggcaggca
      241 atgcgtctcg cgataacaaa aaaactcgca ttattccccg ccacctgcag ctagcgatcc
      301 gcaatgatga ggaactcaat aagcttttgg gcggcgtgac cattgcccag ggcggagtcc
      361 tgcctaacat tcaggcagtg ctgctgccca agaagactga gagtcaccac cataaagccc
      421 aaagcaagta acttaaggtt gtcattggta aaaagacttc tgtgtcagaa aaaacaaaag
      481 gctcttttca gagccaccta
//
