LOCUS       NM_080720                591 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens H2A.B variant histone 3 (H2AB3), mRNA.
ACCESSION   NM_080720 XM_373381
VERSION     NM_080720.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Zhou,M., Dai,L., Li,C., Shi,L., Huang,Y., Guo,Z., Wu,F., Zhu,P. and
            Zhou,Z.
  TITLE     Structural basis of nucleosome dynamics modulation by histone
            variants H2A.B and H2A.Z.2.2
  JOURNAL   EMBO J 40 (1), e105907 (2021)
   PUBMED   33073403
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 591)
  AUTHORS   Molaro,A., Young,J.M. and Malik,H.S.
  TITLE     Evolutionary origins and diversification of testis-specific short
            histone H2A variants in mammals
  JOURNAL   Genome Res 28 (4), 460-473 (2018)
   PUBMED   29549088
REFERENCE   5  (bases 1 to 591)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   6  (bases 1 to 591)
  AUTHORS   Goshima,T., Shimada,M., Sharif,J., Matsuo,H., Misaki,T.,
            Johmura,Y., Murata,K., Koseki,H. and Nakanishi,M.
  TITLE     Mammal-specific H2A variant, H2ABbd, is involved in apoptotic
            induction via activation of NF-kappaB signaling pathway
  JOURNAL   J Biol Chem 289 (17), 11656-11666 (2014)
   PUBMED   24584930
  REMARK    GeneRIF: data suggest that H2ABbd may contribute to specific
            chromatin structures and promote NF-kappaB activation, which could
            in turn induce apoptosis in mammalian cells
REFERENCE   7  (bases 1 to 591)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 591)
  AUTHORS   Bao,Y., Konesky,K., Park,Y.J., Rosu,S., Dyer,P.N., Rangasamy,D.,
            Tremethick,D.J., Laybourn,P.J. and Luger,K.
  TITLE     Nucleosomes containing the histone variant H2A.Bbd organize only
            118 base pairs of DNA
  JOURNAL   EMBO J 23 (16), 3314-3324 (2004)
   PUBMED   15257289
REFERENCE   9  (bases 1 to 591)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     A novel chromatin protein, distantly related to histone H2A, is
            largely excluded from the inactive X chromosome
  JOURNAL   J Cell Biol 152 (2), 375-384 (2001)
   PUBMED   11266453
REFERENCE   10 (bases 1 to 591)
  AUTHORS   Naylor,J.A., Buck,D., Green,P., Williamson,H., Bentley,D. and
            Giannelli,F.
  TITLE     Investigation of the factor VIII intron 22 repeated region (int22h)
            and the associated inversion junctions
  JOURNAL   Hum Mol Genet 4 (7), 1217-1224 (1995)
   PUBMED   8528212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX571846.3.
            
            On Jan 8, 2020 this sequence version replaced NM_080720.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. This gene is part of a
            region that is repeated three times on chromosome X, once in intron
            22 of the F8 gene and twice closer to the Xq telomere. This record
            represents the most telomeric copy. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL602062.1, BU740141.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000615853.1/
                                               ENSP00000482564.1
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               BX571846.3         57503-58093         c
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..591
                     /gene="H2AB3"
                     /gene_synonym="H2A.B.1; H2AB2; H2ABBD; H2AFB; H2AFB3"
                     /note="H2A.B variant histone 3"
                     /db_xref="GeneID:83740"
                     /db_xref="HGNC:HGNC:14455"
                     /db_xref="MIM:300445"
     exon            1..591
                     /gene="H2AB3"
                     /gene_synonym="H2A.B.1; H2AB2; H2ABBD; H2AFB; H2AFB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..426
                     /gene="H2AB3"
                     /gene_synonym="H2A.B.1; H2AB2; H2ABBD; H2AFB; H2AFB3"
                     /note="histone variant H2A, Barr-body deficient; H2A.Bbd;
                     H2A Barr body-deficient; H2A histone family member B3"
                     /codon_start=1
                     /product="histone H2A-Bbd type 2/3"
                     /protein_id="NP_542451.1"
                     /db_xref="CCDS:CCDS35464.1"
                     /db_xref="GeneID:83740"
                     /db_xref="HGNC:HGNC:14455"
                     /db_xref="MIM:300445"
                     /translation="MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHY
                     AQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLF
                     NTTTISQVAPGED"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AB3"
                     /gene_synonym="H2A.B.1; H2AB2; H2ABBD; H2AFB; H2AFB3"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="H2AB3"
                     /gene_synonym="H2A.B.1; H2AB2; H2ABBD; H2AFB; H2AFB3"
                     /note="major polyA site"
ORIGIN      
        1 actggacgcg gtaactgtcc tcttgagagc catcttgcct agctgggcca agccgagata
       61 gcacactcaa cgcccagcat gccgaggagg aggagacgcc gagggtcctc cggtgctggc
      121 ggccgggggc ggacctgctc tcgcaccgtc cgagcggagc tttcgttttc agtgagccag
      181 gtggagcgca gtctacggga gggccactac gctcagcgcc tgagtcgcac ggcgccggtc
      241 tacctcgctg cggttattga gtacctgacg gccaaggtcc tggagctggc gggcaacgag
      301 gcccagaaca gcggagagcg gaacatcact cccctgctgc tggacatggt ggttcacaac
      361 gacaggctac tgagcaccct tttcaacacg accaccatct ctcaagtggc ccctggcgag
      421 gactagcttc tgacacccgg cccctgggac ctgacaggtc cactcgtcca cccacccggc
      481 cccaaatccc ccggcctgaa cccccggcct taaacaccct ccccccacaa cccaggcccc
      541 aaagtcttgg gccttcatta attctgtcaa taaaatgttt caaggaagcc a
//
