LOCUS       NM_001017991             591 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens H2A.B variant histone 2 (H2AB2), mRNA.
ACCESSION   NM_001017991
VERSION     NM_001017991.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Zhou,M., Dai,L., Li,C., Shi,L., Huang,Y., Guo,Z., Wu,F., Zhu,P. and
            Zhou,Z.
  TITLE     Structural basis of nucleosome dynamics modulation by histone
            variants H2A.B and H2A.Z.2.2
  JOURNAL   EMBO J 40 (1), e105907 (2021)
   PUBMED   33073403
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 591)
  AUTHORS   Molaro,A., Young,J.M. and Malik,H.S.
  TITLE     Evolutionary origins and diversification of testis-specific short
            histone H2A variants in mammals
  JOURNAL   Genome Res 28 (4), 460-473 (2018)
   PUBMED   29549088
REFERENCE   5  (bases 1 to 591)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   6  (bases 1 to 591)
  AUTHORS   Tolstorukov,M.Y., Goldman,J.A., Gilbert,C., Ogryzko,V.,
            Kingston,R.E. and Park,P.J.
  TITLE     Histone variant H2A.Bbd is associated with active transcription and
            mRNA processing in human cells
  JOURNAL   Mol Cell 47 (4), 596-607 (2012)
   PUBMED   22795134
  REMARK    GeneRIF: Changes in exon inclusion rates and increased presence of
            intronic sequences in mRNA products upon H2A.Bbd depletion.
REFERENCE   7  (bases 1 to 591)
  AUTHORS   Okuwaki,M., Kato,K., Shimahara,H., Tate,S. and Nagata,K.
  TITLE     Assembly and disassembly of nucleosome core particles containing
            histone variants by human nucleosome assembly protein I
  JOURNAL   Mol Cell Biol 25 (23), 10639-10651 (2005)
   PUBMED   16287874
REFERENCE   8  (bases 1 to 591)
  AUTHORS   Bao,Y., Konesky,K., Park,Y.J., Rosu,S., Dyer,P.N., Rangasamy,D.,
            Tremethick,D.J., Laybourn,P.J. and Luger,K.
  TITLE     Nucleosomes containing the histone variant H2A.Bbd organize only
            118 base pairs of DNA
  JOURNAL   EMBO J 23 (16), 3314-3324 (2004)
   PUBMED   15257289
REFERENCE   9  (bases 1 to 591)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     A novel chromatin protein, distantly related to histone H2A, is
            largely excluded from the inactive X chromosome
  JOURNAL   J Cell Biol 152 (2), 375-384 (2001)
   PUBMED   11266453
REFERENCE   10 (bases 1 to 591)
  AUTHORS   Naylor,J.A., Buck,D., Green,P., Williamson,H., Bentley,D. and
            Giannelli,F.
  TITLE     Investigation of the factor VIII intron 22 repeated region (int22h)
            and the associated inversion junctions
  JOURNAL   Hum Mol Genet 4 (7), 1217-1224 (1995)
   PUBMED   8528212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234781.7.
            
            On Dec 3, 2019 this sequence version replaced NM_001017991.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. This gene is part of a
            region that is repeated three times on chromosome X, once in intron
            22 of the F8 gene and twice closer to the Xq telomere. This record
            represents the middle copy. [provided by RefSeq, Oct 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: HY015568.1, HY018408.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000354514.6/
                                               ENSP00000346509.5
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AC234781.7         54218-54808         c
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..591
                     /gene="H2AB2"
                     /gene_synonym="H2A.B.1; H2A.Bbd; H2AB3; H2AFB2"
                     /note="H2A.B variant histone 2"
                     /db_xref="GeneID:474381"
                     /db_xref="HGNC:HGNC:18298"
                     /db_xref="MIM:301038"
     exon            1..591
                     /gene="H2AB2"
                     /gene_synonym="H2A.B.1; H2A.Bbd; H2AB3; H2AFB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..426
                     /gene="H2AB2"
                     /gene_synonym="H2A.B.1; H2A.Bbd; H2AB3; H2AFB2"
                     /note="H2A Barr body deficient; H2A histone family member
                     B2"
                     /codon_start=1
                     /product="histone H2A-Bbd type 2/3"
                     /protein_id="NP_001017991.1"
                     /db_xref="CCDS:CCDS35461.1"
                     /db_xref="GeneID:474381"
                     /db_xref="HGNC:HGNC:18298"
                     /db_xref="MIM:301038"
                     /translation="MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHY
                     AQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLF
                     NTTTISQVAPGED"
ORIGIN      
        1 actggacgcg gtaactgtcc tcttgagagc catcttgcct agctgggcca agccgagata
       61 gcacactcaa cgcccagcat gccgaggagg aggagacgcc gagggtcctc cggtgctggc
      121 ggccgggggc ggacctgctc tcgcaccgtc cgagcggagc tttcgttttc agtgagccag
      181 gtggagcgca gtctacggga gggccactac gctcagcgcc tgagtcgcac ggcgccggtc
      241 tacctcgctg cggttattga gtacctgacg gccaaggtcc tggagctggc gggcaacgag
      301 gcccagaaca gcggagagcg gaacatcact cccctgctgc tggacatggt ggttcacaac
      361 gacaggctac tgagcaccct tttcaacacg accaccatct ctcaagtggc ccctggcgag
      421 gactagcttc tgacacccgg cccctgggac ctgacaggtc cactcgtcca cccacccggc
      481 cccaaatccc ccggcctgaa cccccggcct taaacaccct ccccccacaa cccaggcccc
      541 aaagtcttgg gccttcatta attctgtcaa taaaatgttt caaggaagcc a
//
