LOCUS       NM_153833               1212 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens H1.8 linker histone (H1-8), transcript variant 1,
            mRNA.
ACCESSION   NM_153833
VERSION     NM_153833.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Maze,I., Noh,K.M., Soshnev,A.A. and Allis,C.D.
  TITLE     Every amino acid matters: essential contributions of histone
            variants to mammalian development and disease
  JOURNAL   Nat Rev Genet 15 (4), 259-271 (2014)
   PUBMED   24614311
  REMARK    Review article
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Talbert,P.B., Ahmad,K., Almouzni,G., Ausio,J., Berger,F.,
            Bhalla,P.L., Bonner,W.M., Cande,W.Z., Chadwick,B.P., Chan,S.W.,
            Cross,G.A., Cui,L., Dimitrov,S.I., Doenecke,D., Eirin-Lopez,J.M.,
            Gorovsky,M.A., Hake,S.B., Hamkalo,B.A., Holec,S., Jacobsen,S.E.,
            Kamieniarz,K., Khochbin,S., Ladurner,A.G., Landsman,D.,
            Latham,J.A., Loppin,B., Malik,H.S., Marzluff,W.F., Pehrson,J.R.,
            Postberg,J., Schneider,R., Singh,M.B., Smith,M.M., Thompson,E.,
            Torres-Padilla,M.E., Tremethick,D.J., Turner,B.M., Waterborg,J.H.,
            Wollmann,H., Yelagandula,R., Zhu,B. and Henikoff,S.
  TITLE     A unified phylogeny-based nomenclature for histone variants
  JOURNAL   Epigenetics Chromatin 5, 7 (2012)
   PUBMED   22650316
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   Mizusawa,Y., Kuji,N., Tanaka,Y., Tanaka,M., Ikeda,E., Komatsu,S.,
            Kato,S. and Yoshimura,Y.
  TITLE     Expression of human oocyte-specific linker histone protein and its
            incorporation into sperm chromatin during fertilization
  JOURNAL   Fertil Steril 93 (4), 1134-1141 (2010)
   PUBMED   19147139
  REMARK    GeneRIF: After intracytoplasmic sperm injection, the assembly of
            H1FOO on sperm chromatin during decondensation seems to occur very
            quickly, and hH1FOO protein is localized in all oocytes from
            primordial to Graafian follicles.
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1212)
  AUTHORS   Teranishi,T., Tanaka,M., Kimoto,S., Ono,Y., Miyakoshi,K., Kono,T.
            and Yoshimura,Y.
  TITLE     Rapid replacement of somatic linker histones with the
            oocyte-specific linker histone H1foo in nuclear transfer
  JOURNAL   Dev Biol 266 (1), 76-86 (2004)
   PUBMED   14729479
REFERENCE   8  (bases 1 to 1212)
  AUTHORS   Gao,S., Chung,Y.G., Parseghian,M.H., King,G.J., Adashi,E.Y. and
            Latham,K.E.
  TITLE     Rapid H1 linker histone transitions following fertilization or
            somatic cell nuclear transfer: evidence for a uniform developmental
            program in mice
  JOURNAL   Dev Biol 266 (1), 62-75 (2004)
   PUBMED   14729478
REFERENCE   9  (bases 1 to 1212)
  AUTHORS   Tanaka,Y., Kato,S., Tanaka,M., Kuji,N. and Yoshimura,Y.
  TITLE     Structure and expression of the human oocyte-specific histone H1
            gene elucidated by direct RT-nested PCR of a single oocyte
  JOURNAL   Biochem Biophys Res Commun 304 (2), 351-357 (2003)
   PUBMED   12711322
  REMARK    GeneRIF: Structure and gene expression of osH1.
REFERENCE   10 (bases 1 to 1212)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080007.26.
            
            On Jan 15, 2020 this sequence version replaced NM_153833.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. The protein encoded is a replication-independent
            histone that is a member of the histone H1 family. This gene
            contains introns, unlike most histone genes. The related mouse gene
            is expressed only in oocytes. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158091.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000324382.7/
                                               ENSP00000319799.2
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, longest protein
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC080007.26        23492-23623         c
            133-422             AC080007.26        19118-19407         c
            423-786             AC080007.26        17434-17797         c
            787-851             AC080007.26        15989-16053         c
            852-1212            AC080007.26        15331-15691         c
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..1212
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /note="H1.8 linker histone"
                     /db_xref="GeneID:132243"
                     /db_xref="HGNC:HGNC:18463"
     exon            1..132
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1085
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oocyte-specific histone H1; histone H1oo; oocyte-specific
                     linker histone H1; H1 histone family member O oocyte
                     specific; histone H1.8"
                     /codon_start=1
                     /product="histone H1.8 isoform 1"
                     /protein_id="NP_722575.1"
                     /db_xref="CCDS:CCDS3064.1"
                     /db_xref="GeneID:132243"
                     /db_xref="HGNC:HGNC:18463"
                     /translation="MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHS
                     SLPVGRRHPPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALA
                     TGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKP
                     SEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVP
                     PKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAAS
                     PTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKA
                     SSSKVSSQRAEA"
     exon            133..422
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..786
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..851
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1212
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /note="hexamer: AATAAA"
     polyA_site      1212
                     /gene="H1-8"
                     /gene_synonym="H1.8; H1FOO; H1oo; osH1"
                     /note="major polyA site"
ORIGIN      
        1 ctcacacccg ggtgaggggt ctgctggctg cacctgtcgg tctcatggct cctgggagcg
       61 tcaccagcga catctcaccc tcctcgactt ccacagcagg atcatccagg tctcctgaat
      121 ctgaaaagcc aggcccgagc cacggcggtg tcccaccagg aggcccgagc cacagcagcc
      181 tcccggtggg acgccgccac cccccggtgc tacgcatggt gctggaggcg ctgcaggctg
      241 gggagcagcg ccggggcacg tcggtggcag ctatcaagct ctacatcctg cacaagtacc
      301 caacagtgga cgtcctccgc ttcaagtacc tgctgaagca ggcgctggcc actggcatgc
      361 gccgtggcct cctcgccagg cccctcaact ccaaagccag gggggccact ggcagcttca
      421 aattagttcc caagcacaag aagaaaatcc agcccaggaa gatggccccc gcgacggctc
      481 ccaggagagc gggtgaggcc aaggggaagg gccccaagaa accaagtgag gccaaggagg
      541 accctcccaa cgtgggcaag gtgaaaaagg cagccaagag gccagcaaag gtgcagaagc
      601 ctcctcccaa gccaggcgca gccacagaga aggctcgcaa gcaaggcggc gcggccaagg
      661 acaccagggc acagtcggga gaggctagga aggtgccccc caagccagac aaggccatgc
      721 gggcaccttc cagtgctggt gggctcagca ggaaggcaaa ggccaaaggc agcaggagca
      781 gccaaggaga tgctgaggcc tacaggaaaa ccaaagctga gagtaagagt tcaaaaccca
      841 cggccagcaa ggtcaagaat ggtgctgctt ccccgaccaa aaagaaggtg gtggccaagg
      901 ccaaggcccc taaagctggg caggggccaa acaccaaggc tgctgctcct gctaagggca
      961 gtgggtccaa ggtggtacct gcacatttgt ccaggaagac agaggccccc aagggcccta
     1021 gaaaggctgg gctgcccatc aaggcctcat catccaaagt gtccagccag agggctgaag
     1081 cttagggcca gaggcagggg cggagagaga ccgagcctct gccctagttt ttattcttca
     1141 actaaccact gctctattta tttcattgta agctatttat caataaagac ttttgtttct
     1201 ttttcctcac aa
//
