LOCUS       NM_181788               1300 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens H1.7 linker histone (H1-7), mRNA.
ACCESSION   NM_181788
VERSION     NM_181788.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   Tanaka,H., Matsuoka,Y., Onishi,M., Kitamura,K., Miyagawa,Y.,
            Nishimura,H., Tsujimura,A., Okuyama,A. and Nishimune,Y.
  TITLE     Expression profiles and single-nucleotide polymorphism analysis of
            human HANP1/H1T2 encoding a histone H1-like protein
  JOURNAL   Int J Androl 29 (2), 353-359 (2006)
   PUBMED   16533358
  REMARK    GeneRIF: h-HANP1 is expressed in the testes and its genomic
            construct also intronless as mouse Hanp1. We found that the h-HANP1
            coding region have 5 single-nucleotide polymorphisms in Japanese
            men.
REFERENCE   9  (bases 1 to 1300)
  AUTHORS   Tanaka,H., Iguchi,N., Isotani,A., Kitamura,K., Toyama,Y.,
            Matsuoka,Y., Onishi,M., Masai,K., Maekawa,M., Toshimori,K.,
            Okabe,M. and Nishimune,Y.
  TITLE     HANP1/H1T2, a novel histone H1-like protein involved in nuclear
            formation and sperm fertility
  JOURNAL   Mol Cell Biol 25 (16), 7107-7119 (2005)
   PUBMED   16055721
REFERENCE   10 (bases 1 to 1300)
  AUTHORS   Martianov,I., Brancorsini,S., Catena,R., Gansmuller,A., Kotaja,N.,
            Parvinen,M., Sassone-Corsi,P. and Davidson,I.
  TITLE     Polar nuclear localization of H1T2, a histone H1 variant, required
            for spermatid elongation and DNA condensation during spermiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (8), 2808-2813 (2005)
   PUBMED   15710904
  REMARK    GeneRIF: H1T2 is a protein required for proper cell restructuring
            and DNA condensation during the elongation phase of spermiogenesis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY302593.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-independent histone that is a member of the histone H1
            family. The related mouse gene encodes a testis specific protein
            that is required for spermatogenesis and male fertility. [provided
            by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY302593.1, HM005636.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000335017.1/
                                               ENSP00000334805.1
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..1300
                     /gene="H1-7"
                     /gene_synonym="H1.7; H1FNT; H1T2"
                     /note="H1.7 linker histone"
                     /db_xref="GeneID:341567"
                     /db_xref="HGNC:HGNC:24893"
                     /db_xref="MIM:618565"
     exon            1..1300
                     /gene="H1-7"
                     /gene_synonym="H1.7; H1FNT; H1T2"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1080
                     /gene="H1-7"
                     /gene_synonym="H1.7; H1FNT; H1T2"
                     /note="HANP1; haploid germ cell-specific nuclear protein
                     1; histone H1t2; histone H1.7; H1 histone family member N,
                     testis specific; testis secretory sperm-binding protein Li
                     223n"
                     /codon_start=1
                     /product="testis-specific H1 histone"
                     /protein_id="NP_861453.1"
                     /db_xref="CCDS:CCDS8762.1"
                     /db_xref="GeneID:341567"
                     /db_xref="HGNC:HGNC:24893"
                     /db_xref="MIM:618565"
                     /translation="MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEK
                     TVGGPSRGCSSSVLRVSQLVLQAISTHKGLTLAALKKELRNAGYEVRRKSGRHEAPRG
                     QAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEGTRAPWRTPAAPRSSRRRRQP
                     LRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGATAADEGRG
                     QAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1-7"
                     /gene_synonym="H1.7; H1FNT; H1T2"
                     /note="hexamer: AATGAA"
     polyA_site      1300
                     /gene="H1-7"
                     /gene_synonym="H1.7; H1FNT; H1T2"
                     /note="major polyA site"
ORIGIN      
        1 taaggaactg tgggtagatg gtttgcagga ccacatacac acacaaaata gccgactaaa
       61 gaaagcggtg gagatcgaga tcagtaagtt tgatttggga acaaaaccct ggagactcta
      121 taggtaggtg actgttgggg gtggacaggc gctgaagact tggattggtt tagacctaga
      181 aggaagtggc atttgattgg ttattataag tgaaaagggc ccctccccgg gtgagatatg
      241 ccagccccat aattaggacc tgaaaatctc tgccaggcct gcctttgtga cgtggcccag
      301 tctacctcag ctatggaaca ggccttgact ggtgaggccc aaagccggtg gccccgcaga
      361 ggcgggagtg gggccatggc tgaggcgcct gggcccagtg gcgaatcccg aggacactca
      421 gccactcagc tgccagcgga aaaaactgtc gggggaccat cgaggggctg ctcaagctcc
      481 gtgctcagag tgtcccagtt ggtgctccag gccatctcca ctcacaaagg gctgactctg
      541 gcagctctca agaaggagct ccgaaacgcc ggctacgaag tgcgcaggaa gagcggccgc
      601 cacgaagcgc ccagggggca ggccaaggcc acgctcctcc gggtcagcgg cagcgacgcc
      661 gccggctact tcagggtctg gaaggttccc aagcccagga gaaagccggg acgcgcgagg
      721 caagaggagg gcacgcgcgc tccctggagg accccagccg cgccccggag ctcccggagg
      781 cgccgccagc cccttcgcaa ggcggccagg aaggccagag aagtgtggag acggaacgcg
      841 agggcgaaag ccaaggccaa tgccagggcg aggaggacca ggagggcaag gccgagagcc
      901 aaggagccgc cgtgtgccag agccaaggag gaagcgggag cgacagcggc agacgagggg
      961 cgaggacagg ccgtgaagga agacaccacg ccgaggtcag ggaaggacaa gaggcgaagc
     1021 tccaagccca gggaagagaa gcaggagccc aagaagcccg cacagcggac catccagtag
     1081 ccaacgcggg ctaaaaccga ccggacatct agcgggcagg ggaagactcc actaaagact
     1141 tccacaaaga cctcccctaa atctgaaggt cttcctgatc cagttgggaa tgcatcttgt
     1201 gggagcagct tcactcccac cacggaccaa tgcctttccc ccataggccc caagaagagc
     1261 ggctgtcaca ctcattgaaa tgaaatggac ctctagacca
//
