LOCUS       NM_005323                724 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens H1.6 linker histone, cluster member (H1-6), mRNA.
ACCESSION   NM_005323
VERSION     NM_005323.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Tani,R., Hayakawa,K., Tanaka,S. and Shiota,K.
  TITLE     Linker histone variant H1T targets rDNA repeats
  JOURNAL   Epigenetics 11 (4), 288-302 (2016)
   PUBMED   27018843
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Machida,S., Hayashida,R., Takaku,M., Fukuto,A., Sun,J.,
            Kinomura,A., Tashiro,S. and Kurumizaka,H.
  TITLE     Relaxed Chromatin Formation and Weak Suppression of Homologous
            Pairing by the Testis-Specific Linker Histone H1T
  JOURNAL   Biochemistry 55 (4), 637-646 (2016)
   PUBMED   26757249
  REMARK    GeneRIF: These results suggested that the testis-specific linker
            histone, H1T, possesses a specific function to produce the
            chromatin architecture required for proper chromosome regulation,
            such as homologous recombination.
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Koppel,D.A., Wolfe,S.A., Fogelfeld,L.A., Merchant,P.S., Prouty,L.
            and Grimes,S.R.
  TITLE     Primate testicular histone H1t genes are highly conserved and the
            human H1t gene is located on chromosome 6
  JOURNAL   J Cell Biochem 54 (2), 219-230 (1994)
   PUBMED   8175896
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Albig,W., Drabent,B., Kunz,J., Kalff-Suske,M., Grzeschik,K.H. and
            Doenecke,D.
  TITLE     All known human H1 histone genes except the H1(0) gene are
            clustered on chromosome 6
  JOURNAL   Genomics 16 (3), 649-654 (1993)
   PUBMED   8325638
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Drabent,B., Kardalinou,E. and Doenecke,D.
  TITLE     Structure and expression of the human gene encoding testicular H1
            histone (H1t)
  JOURNAL   Gene 103 (2), 263-268 (1991)
   PUBMED   1889752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_005323.3.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069517.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard
                                                (PMID:8175896)
            MANE Ensembl match               :: ENST00000338379.6/
                                                ENSP00000341214.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            replication-dependent histone    :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               U91328.1           32924-33647
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..724
                     /gene="H1-6"
                     /gene_synonym="dJ221C16.2; H1.6; H1FT; H1t; HIST1H1T"
                     /note="H1.6 linker histone, cluster member"
                     /db_xref="GeneID:3010"
                     /db_xref="HGNC:HGNC:4720"
                     /db_xref="MIM:142712"
     exon            1..724
                     /gene="H1-6"
                     /gene_synonym="dJ221C16.2; H1.6; H1FT; H1t; HIST1H1T"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..666
                     /gene="H1-6"
                     /gene_synonym="dJ221C16.2; H1.6; H1FT; H1t; HIST1H1T"
                     /note="H1 histone family, member T (testis-specific);
                     histone 1, H1t; testicular H1 histone; histone cluster 1,
                     H1t; histone cluster 1 H1 family member t"
                     /codon_start=1
                     /product="histone H1t"
                     /protein_id="NP_005314.2"
                     /db_xref="CCDS:CCDS34349.1"
                     /db_xref="GeneID:3010"
                     /db_xref="HGNC:HGNC:4720"
                     /db_xref="MIM:142712"
                     /translation="MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSV
                     SKLITEALSVSQERVGMSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRG
                     TGASGSFKLSKKVIPKSTRSKAKKSVSAKTKKLVLSRDSKSPKTAKTNKRAKKPRATT
                     PKTVRSGRKAKGAKGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK"
ORIGIN      
        1 atgcttttcg ctggttatta catcttgcgt ttctctgttg ttatgtctga aaccgtgcct
       61 gcagcttctg ccagtgctgg tgtagccgct atggagaaac ttccaaccaa gaagcgaggg
      121 aggaagccgg ctggcttgat aagtgcaagt cgcaaagtgc cgaacctctc tgtgtccaag
      181 ttgatcaccg aggccctttc agtgtcacag gaacgagtag gtatgtcttt ggttgcgctc
      241 aagaaggcat tggccgctgc tggctacgac gtagagaaga ataacagccg catcaaactg
      301 tccctcaaga gcttagtgaa caagggaatc ctggtgcaaa ccaggggtac tggtgcttcc
      361 ggttccttta agcttagtaa gaaggtgatt cctaaatcta ccagaagcaa ggctaaaaag
      421 tcagtttctg ccaagaccaa gaagctggtt ttatccaggg actccaagtc accaaagact
      481 gctaaaacca ataagagagc caagaagccg agagcgacaa ctcctaaaac tgttaggagc
      541 gggagaaagg ctaaaggagc caagggtaag caacagcaga agagcccagt gaaggcaagg
      601 gcttcgaagt caaaattgac ccaacatcat gaagttaatg ttagaaaggc cacatctaag
      661 aagtaaagag ctttccggga ggccaatttg gaaagaaccc aaaggctctt ttaagagcca
      721 ccca
//
