LOCUS       NM_005322                797 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H1.5 linker histone, cluster member (H1-5), mRNA.
ACCESSION   NM_005322
VERSION     NM_005322.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 797)
  AUTHORS   Murray-Nerger,L.A., Lozano,C., Burton,E.M., Liao,Y.,
            Ungerleider,N.A., Guo,R. and Gewurz,B.E.
  TITLE     The nucleic acid binding protein SFPQ represses EBV lytic
            reactivation by promoting histone H1 expression
  JOURNAL   Nat Commun 15 (1), 4156 (2024)
   PUBMED   38755141
  REMARK    GeneRIF: The nucleic acid binding protein SFPQ represses EBV lytic
            reactivation by promoting histone H1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 797)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 797)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 797)
  AUTHORS   Melters,D.P. and Dalal,Y.
  TITLE     Nano-Surveillance: Tracking Individual Molecules in a Sea of
            Chromatin
  JOURNAL   J Mol Biol 433 (6), 166720 (2021)
   PUBMED   33221335
  REMARK    GeneRIF: Nano-Surveillance: Tracking Individual Molecules in a Sea
            of Chromatin.
            Review article
REFERENCE   5  (bases 1 to 797)
  AUTHORS   Luzhetskaya,O.P., Sedykh,S.E. and Nevinsky,G.A.
  TITLE     How Human H1 Histone Recognizes DNA
  JOURNAL   Molecules 25 (19), 4556 (2020)
   PUBMED   33028027
  REMARK    GeneRIF: How Human H1 Histone Recognizes DNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 797)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 797)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H1. Isolation and amino acid sequences of
            three minor variants, H1a, H1c, and H1d
  JOURNAL   J Biochem 106 (5), 844-857 (1989)
   PUBMED   2613692
REFERENCE   8  (bases 1 to 797)
  AUTHORS   Collar,D.G., Wright,K.L., van Wijnen,A.J., Ramsey,A.L., Lian,J.,
            Stein,J.L. and Stein,G.S.
  TITLE     The human H1 histone gene FNC16 is functionally expressed in
            proliferating HeLa S3 cells and is down-regulated during terminal
            differentiation in HL60 cells
  JOURNAL   J Biol Chem 263 (31), 15860-15863 (1988)
   PUBMED   3182772
REFERENCE   9  (bases 1 to 797)
  AUTHORS   van Wijnen,A.J., Wright,K.L., Massung,R.F., Gerretsen,M.,
            Stein,J.L. and Stein,G.S.
  TITLE     Two target sites for protein binding in the promoter region of a
            cell cycle regulated human H1 histone gene
  JOURNAL   Nucleic Acids Res 16 (2), 571-592 (1988)
   PUBMED   2829131
REFERENCE   10 (bases 1 to 797)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H1. Isolation and amino acid sequence of a
            main variant, H1b
  JOURNAL   J Biochem 100 (2), 359-368 (1986)
   PUBMED   3782055
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98744.2.
            
            On Dec 3, 2019 this sequence version replaced NM_005322.2.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the small histone gene cluster on chromosome
            6p22-p21.3. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069101.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000331442.5/
                                             ENSP00000330074.4
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-797               Z98744.2           30533-31329         c
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..797
                     /gene="H1-5"
                     /gene_synonym="H1; H1.5; H1B; H1F5; H1s-3; HIST1H1B"
                     /note="H1.5 linker histone, cluster member"
                     /db_xref="GeneID:3009"
                     /db_xref="HGNC:HGNC:4719"
                     /db_xref="MIM:142711"
     exon            1..797
                     /gene="H1-5"
                     /gene_synonym="H1; H1.5; H1B; H1F5; H1s-3; HIST1H1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..740
                     /gene="H1-5"
                     /gene_synonym="H1; H1.5; H1B; H1F5; H1s-3; HIST1H1B"
                     /note="H1 histone family, member 5; histone H1b; histone
                     H1s-3; histone 1, H1b; histone H1a; histone cluster 1,
                     H1b; histone cluster 1 H1 family member b"
                     /codon_start=1
                     /product="histone H1.5"
                     /protein_id="NP_005313.1"
                     /db_xref="CCDS:CCDS4635.1"
                     /db_xref="GeneID:3009"
                     /db_xref="HGNC:HGNC:4719"
                     /db_xref="MIM:142711"
                     /translation="MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVS
                     ELITKAVAASKERNGLSLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGT
                     GASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAK
                     KPAAAGVKKVAKSPKKAKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKA
                     KKAAAKKK"
ORIGIN      
        1 aacgcaaaac ctgctcttta gatttcgagc ttattctctt ctagcagttt cttgccacca
       61 tgtcggaaac cgctcctgcc gagacagcca ccccagcgcc ggtggagaaa tccccggcta
      121 agaagaaggc aactaagaag gctgccggcg ccggcgctgc taagcgcaaa gcgacggggc
      181 ccccagtctc agagctgatc accaaggctg tggctgcttc taaggagcgc aatggccttt
      241 ctttggcagc ccttaagaag gccttagcgg ccggtggcta cgacgtggag aagaataaca
      301 gccgcattaa gctgggcctc aagagcttgg tgagcaaggg caccctggtg cagaccaagg
      361 gcactggtgc ttctggctcc tttaaactca acaagaaggc ggcctccggg gaagccaagc
      421 ccaaagccaa gaaggcaggc gccgctaaag ctaagaagcc cgcgggggcc acgcctaaga
      481 aggccaagaa ggctgcaggg gcgaaaaagg cagtgaagaa gactccgaag aaggcgaaga
      541 agcccgcggc ggctggcgtc aaaaaggtgg cgaagagccc taagaaggcc aaggccgctg
      601 ccaaaccgaa aaaggcaacc aagagtcctg ccaagcccaa ggcagttaag ccgaaggcgg
      661 caaagcccaa agccgctaag cccaaagcag caaaacctaa agctgcaaag gccaagaagg
      721 cggctgccaa aaagaagtag gaagctggcg tgtgaaaacc gcaacaaagc cccaaaggct
      781 cttttcagag ccaccca
//
