LOCUS       NM_005321                787 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens H1.4 linker histone, cluster member (H1-4), mRNA.
ACCESSION   NM_005321
VERSION     NM_005321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 787)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 787)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 787)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 787)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 787)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 787)
  AUTHORS   Strom,R., Santoro,R., D'Erme,M., Mastrantonio,S., Reale,A.,
            Marenzi,S., Zardo,G. and Caiafa,P.
  TITLE     Specific variants of H1 histone regulate CpG methylation in
            eukaryotic DNA
  JOURNAL   Gene 157 (1-2), 253-256 (1995)
   PUBMED   7607502
REFERENCE   7  (bases 1 to 787)
  AUTHORS   Parseghian,M.H., Henschen,A.H., Krieglstein,K.G. and Hamkalo,B.A.
  TITLE     A proposal for a coherent mammalian histone H1 nomenclature
            correlated with amino acid sequences
  JOURNAL   Protein Sci 3 (4), 575-587 (1994)
   PUBMED   8003976
REFERENCE   8  (bases 1 to 787)
  AUTHORS   Burkardt,D. and Tatton-Brown,K.
  TITLE     HIST1H1E Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33270410
REFERENCE   9  (bases 1 to 787)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
REFERENCE   10 (bases 1 to 787)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H1. Isolation and amino acid sequence of a
            main variant, H1b
  JOURNAL   J Biochem 100 (2), 359-368 (1986)
   PUBMED   3782055
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353759.8.
            
            On Dec 3, 2019 this sequence version replaced NM_005321.2.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: CR988914.1, BC099632.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000304218.6/
                                             ENSP00000307705.4
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AL353759.8         62710-63496
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..787
                     /gene="H1-4"
                     /gene_synonym="dJ221C16.5; H1.4; H1E; H1F4; H1s-4;
                     HIST1H1E; RMNS"
                     /note="H1.4 linker histone, cluster member"
                     /db_xref="GeneID:3008"
                     /db_xref="HGNC:HGNC:4718"
                     /db_xref="MIM:142220"
     exon            1..787
                     /gene="H1-4"
                     /gene_synonym="dJ221C16.5; H1.4; H1E; H1F4; H1s-4;
                     HIST1H1E; RMNS"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..722
                     /gene="H1-4"
                     /gene_synonym="dJ221C16.5; H1.4; H1E; H1F4; H1s-4;
                     HIST1H1E; RMNS"
                     /note="histone H1b; H1 histone family, member 4; histone
                     1, H1e; histone H1s-4; histone cluster 1, H1e; histone
                     cluster 1 H1 family member e"
                     /codon_start=1
                     /product="histone H1.4"
                     /protein_id="NP_005312.1"
                     /db_xref="CCDS:CCDS4586.1"
                     /db_xref="GeneID:3008"
                     /db_xref="HGNC:HGNC:4718"
                     /db_xref="MIM:142220"
                     /translation="MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELI
                     TKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGAS
                     GSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGAATPKKSAKKTPKKAKK
                     PAAAAGAKKAKSPKKAKAAKPKKAPKSPAKAKAVKPKAAKPKTAKPKAAKPKKAAAKK
                     K"
     polyA_site      787
                     /gene="H1-4"
                     /gene_synonym="dJ221C16.5; H1.4; H1E; H1F4; H1s-4;
                     HIST1H1E; RMNS"
                     /note="major polyA site"
ORIGIN      
        1 cgagtcccgg ccagtgcctc tgcttccggc tcgaattgct ctcgctcacg cttgccttca
       61 acatgtccga gactgcgcct gccgcgcccg ctgctccggc ccctgccgag aagactcccg
      121 tgaagaagaa ggcccgcaag tctgcaggtg cggccaagcg caaagcgtct gggcccccgg
      181 tgtccgagct cattactaaa gctgttgccg cctccaagga gcgcagcggc gtatctttgg
      241 ccgctctcaa gaaagcgctg gcagccgctg gctatgacgt ggagaagaac aacagccgca
      301 tcaagctggg tctcaagagc ctggtgagca agggcaccct ggtgcagacc aagggcaccg
      361 gcgcgtcggg ttccttcaaa ctcaacaaga aggcggcctc tggggaagcc aagcctaagg
      421 ctaaaaaggc aggcgcggcc aaggccaaga agccagcagg agcggcgaag aagcccaaga
      481 aggcgacggg ggcggccacc cccaagaaga gcgccaagaa gaccccaaag aaggcgaaga
      541 agccggctgc agctgctgga gccaaaaaag cgaaaagccc gaaaaaggcg aaagcagcca
      601 agccaaaaaa ggcgcccaag agcccagcga aggccaaagc agttaaaccc aaggcggcta
      661 aaccaaagac cgccaagccc aaggcagcca agccaaagaa ggcggcagcc aagaaaaagt
      721 agaaagttcc tttggccaac tgcttagaag cccaacacaa cccaaaggct cttttcagag
      781 ccaccca
//
