LOCUS       NM_005320                776 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H1.3 linker histone, cluster member (H1-3), mRNA.
ACCESSION   NM_005320
VERSION     NM_005320.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Garciaz,S., N'guyen Dasi,L., Finetti,P., Chevalier,C., Vernerey,J.,
            Poplineau,M., Platet,N., Audebert,S., Pophillat,M., Camoin,L.,
            Bertucci,F., Calmels,B., Recher,C., Birnbaum,D., Chabannon,C.,
            Vey,N. and Duprez,E.
  TITLE     Epigenetic down-regulation of the HIST1 locus predicts better
            prognosis in acute myeloid leukemia with NPM1 mutation
  JOURNAL   Clin Epigenetics 11 (1), 141 (2019)
   PUBMED   31606046
  REMARK    GeneRIF: Data suggest that NPM1mut AML prognosis depends on the
            epigenetic silencing of the HIST1 cluster and that, among the
            H3K27me3 silenced histone genes, HIST1H1D plays a role in AML blast
            differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 776)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 776)
  AUTHORS   Parseghian,M.H., Henschen,A.H., Krieglstein,K.G. and Hamkalo,B.A.
  TITLE     A proposal for a coherent mammalian histone H1 nomenclature
            correlated with amino acid sequences
  JOURNAL   Protein Sci 3 (4), 575-587 (1994)
   PUBMED   8003976
REFERENCE   8  (bases 1 to 776)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
REFERENCE   9  (bases 1 to 776)
  AUTHORS   Allen,B.S., Stein,J.L., Stein,G.S. and Ostrer,H.
  TITLE     Single-copy flanking sequences in human histone gene clusters map
            to chromosomes 1 and 6
  JOURNAL   Genomics 10 (2), 486-488 (1991)
   PUBMED   2071153
REFERENCE   10 (bases 1 to 776)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H1. Isolation and amino acid sequences of
            three minor variants, H1a, H1c, and H1d
  JOURNAL   J Biochem 106 (5), 844-857 (1989)
   PUBMED   2613692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_005320.2.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK312845.1, BC104874.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000244534.7/
                                             ENSP00000244534.6
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AL031777.5         39594-40369         c
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..776
                     /gene="H1-3"
                     /gene_synonym="H1.3; H1D; H1F3; H1s-2; HIST1H1D"
                     /note="H1.3 linker histone, cluster member"
                     /db_xref="GeneID:3007"
                     /db_xref="HGNC:HGNC:4717"
                     /db_xref="MIM:142210"
     exon            1..776
                     /gene="H1-3"
                     /gene_synonym="H1.3; H1D; H1F3; H1s-2; HIST1H1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..720
                     /gene="H1-3"
                     /gene_synonym="H1.3; H1D; H1F3; H1s-2; HIST1H1D"
                     /note="H1 histone family, member 3; histone 1, H1d;
                     histone H1c; histone cluster 1 H1 family member d; histone
                     H1s-2; histone cluster 1, H1d"
                     /codon_start=1
                     /product="histone H1.3"
                     /protein_id="NP_005311.1"
                     /db_xref="CCDS:CCDS4597.1"
                     /db_xref="GeneID:3007"
                     /db_xref="HGNC:HGNC:4717"
                     /db_xref="MIM:142210"
                     /translation="MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSEL
                     ITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGA
                     SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVK
                     KPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAP
                     KKK"
ORIGIN      
        1 atgctgttct gacagtttga gattacttat tgtcttttct gggaagacaa aaacatgtcg
       61 gagactgctc cacttgctcc taccattcct gcacccgcag aaaaaacacc tgtgaagaaa
      121 aaggcgaaga aggcaggcgc aactgctggg aaacgcaaag catccggacc cccagtatct
      181 gagcttatca ccaaggcagt ggcagcttct aaggagcgca gcggcgtttc tctggccgcg
      241 cttaagaaag cgcttgcggc tgctggctac gatgtagaaa aaaacaacag ccgtatcaag
      301 cttggcctca agagcttggt gagcaaaggt actctggtgc agaccaaagg taccggtgct
      361 tctggctcct tcaaactcaa caagaaagcg gcttccgggg aaggcaaacc caaggccaaa
      421 aaggctggcg cagccaagcc taggaagcct gctggggcag ccaagaagcc caagaaggtg
      481 gctggcgccg ctaccccgaa gaaaagcatc aaaaagactc ctaagaaggt aaagaagcca
      541 gcaaccgctg ctgggaccaa gaaagtggcc aagagtgcga aaaaggtgaa aacacctcag
      601 ccaaaaaaag ctgccaagag tccagctaag gccaaagccc ctaagcccaa ggcggccaag
      661 cctaagtcgg ggaagccgaa ggttacaaag gcaaagaagg cagctccgaa gaaaaagtga
      721 aactggcggg acgttcccct ttgaaaattt taaacggctc ttttcagagc caccca
//
