LOCUS       NM_005319                731 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H1.2 linker histone, cluster member (H1-2), mRNA.
ACCESSION   NM_005319
VERSION     NM_005319.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 731)
  AUTHORS   Song,Y., Li,H., Lian,R., Dou,X., Li,S., Xie,J., Li,X., Feng,R. and
            Li,Z.
  TITLE     Histone H1.2 Inhibited EMCV Replication through Enhancing
            MDA5-Mediated IFN-beta Signaling Pathway
  JOURNAL   Viruses 16 (2), 174 (2024)
   PUBMED   38399950
  REMARK    GeneRIF: Histone H1.2 Inhibited EMCV Replication through Enhancing
            MDA5-Mediated IFN-beta Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 731)
  AUTHORS   Saumer,P., Scheffner,M., Marx,A. and Stengel,F.
  TITLE     Interactome of intact chromatosome variants with site-specifically
            ubiquitylated and acetylated linker histone H1.2
  JOURNAL   Nucleic Acids Res 52 (1), 101-113 (2024)
   PUBMED   37994785
  REMARK    GeneRIF: Interactome of intact chromatosome variants with
            site-specifically ubiquitylated and acetylated linker histone H1.2.
REFERENCE   3  (bases 1 to 731)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 731)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 731)
  AUTHORS   Kamimura,R., Uchida,D., Kanno,S.I., Shiraishi,R., Hyodo,T.,
            Sawatani,Y., Shimura,M., Hasegawa,T., Tsubura-Okubo,M., Yaguchi,E.,
            Komiyama,Y., Fukumoto,C., Izumi,S., Fujita,A., Wakui,T. and
            Kawamata,H.
  TITLE     Identification of Binding Proteins for TSC22D1 Family Proteins
            Using Mass Spectrometry
  JOURNAL   Int J Mol Sci 22 (20), 10913 (2021)
   PUBMED   34681573
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 731)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 731)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 731)
  AUTHORS   Parseghian,M.H., Henschen,A.H., Krieglstein,K.G. and Hamkalo,B.A.
  TITLE     A proposal for a coherent mammalian histone H1 nomenclature
            correlated with amino acid sequences
  JOURNAL   Protein Sci 3 (4), 575-587 (1994)
   PUBMED   8003976
REFERENCE   9  (bases 1 to 731)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H1. Isolation and amino acid sequences of
            three minor variants, H1a, H1c, and H1d
  JOURNAL   J Biochem 106 (5), 844-857 (1989)
   PUBMED   2613692
REFERENCE   10 (bases 1 to 731)
  AUTHORS   Eick,S., Nicolai,M., Mumberg,D. and Doenecke,D.
  TITLE     Human H1 histones: conserved and varied sequence elements in two H1
            subtype genes
  JOURNAL   Eur J Cell Biol 49 (1), 110-115 (1989)
   PUBMED   2759094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_005319.3.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK290947.1, CK126083.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000343677.4/
                                             ENSP00000339566.3
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               U91328.1           84589-85319
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..731
                     /gene="H1-2"
                     /gene_synonym="H1.2; H1C; H1F2; H1s-1; HIST1H1C"
                     /note="H1.2 linker histone, cluster member"
                     /db_xref="GeneID:3006"
                     /db_xref="HGNC:HGNC:4716"
                     /db_xref="MIM:142710"
     exon            1..731
                     /gene="H1-2"
                     /gene_synonym="H1.2; H1C; H1F2; H1s-1; HIST1H1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..684
                     /gene="H1-2"
                     /gene_synonym="H1.2; H1C; H1F2; H1s-1; HIST1H1C"
                     /note="histone H1d; H1 histone family, member 2; histone
                     1, H1c; histone H1c; histone H1s-1; histone cluster 1,
                     H1c; histone cluster 1 H1 family member c"
                     /codon_start=1
                     /product="histone H1.2"
                     /protein_id="NP_005310.1"
                     /db_xref="CCDS:CCDS4577.1"
                     /db_xref="GeneID:3006"
                     /db_xref="HGNC:HGNC:4716"
                     /db_xref="MIM:142710"
                     /translation="MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELI
                     TKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGAS
                     GSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKK
                     PAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK"
ORIGIN      
        1 atcggcgctt tgccacttgt acccgagttt ttgattctca acatgtccga gactgctcct
       61 gccgctcccg ctgccgcgcc tcctgcggag aaggcccctg taaagaagaa ggcggccaaa
      121 aaggctgggg gtacgcctcg taaggcgtct ggtcccccgg tgtcagagct catcaccaag
      181 gctgtggccg cctctaaaga gcgtagcgga gtttctctgg ctgctctgaa aaaagcgttg
      241 gctgccgccg gctatgatgt ggagaaaaac aacagccgta tcaaacttgg tctcaagagc
      301 ctggtgagca agggcactct ggtgcaaacg aaaggcaccg gtgcttctgg ctcctttaaa
      361 ctcaacaaga aggcagcctc cggggaagcc aagcccaagg ttaaaaaggc gggcggaacc
      421 aaacctaaga agccagttgg ggcagccaag aagcccaaga aggcggctgg cggcgcaact
      481 ccgaagaaga gcgctaagaa aacaccgaag aaagcgaaga agccggccgc ggccactgta
      541 accaagaaag tggctaagag cccaaagaag gccaaggttg cgaagcccaa gaaagctgcc
      601 aaaagtgctg ctaaggctgt gaagcccaag gccgctaagc ccaaggttgt caagcctaag
      661 aaggcggcgc ccaagaagaa ataggcgaac gcctacttct aaaacccaaa aggctctttt
      721 cagagccacc a
//
