LOCUS       NM_006026               1516 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens H1.10 linker histone (H1-10), mRNA.
ACCESSION   NM_006026
VERSION     NM_006026.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Zhang,Y., Lin,W., Yang,Y., Zhu,S., Chen,Y., Wang,H. and Teng,L.
  TITLE     MEF2D facilitates liver metastasis of gastric cancer cells through
            directly inducing H1X under IL-13 stimulation
  JOURNAL   Cancer Lett 591, 216878 (2024)
   PUBMED   38609001
  REMARK    GeneRIF: MEF2D facilitates liver metastasis of gastric cancer cells
            through directly inducing H1X under IL-13 stimulation.
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Salinas-Pena,M., Serna-Pujol,N. and Jordan,A.
  TITLE     Genomic profiling of six human somatic histone H1 variants denotes
            that H1X accumulates at recently incorporated transposable elements
  JOURNAL   Nucleic Acids Res 52 (4), 1793-1813 (2024)
   PUBMED   38261975
  REMARK    GeneRIF: Genomic profiling of six human somatic histone H1 variants
            denotes that H1X accumulates at recently incorporated transposable
            elements.
REFERENCE   3  (bases 1 to 1516)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1516)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   5  (bases 1 to 1516)
  AUTHORS   Mayor,R., Izquierdo-Bouldstridge,A., Millan-Arino,L., Bustillos,A.,
            Sampaio,C., Luque,N. and Jordan,A.
  TITLE     Genome distribution of replication-independent histone H1 variants
            shows H1.0 associated with nucleolar domains and H1X associated
            with RNA polymerase II-enriched regions
  JOURNAL   J Biol Chem 290 (12), 7474-7491 (2015)
   PUBMED   25645921
REFERENCE   6  (bases 1 to 1516)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1516)
  AUTHORS   Takata,H., Matsunaga,S., Morimoto,A., Ono-Maniwa,R., Uchiyama,S.
            and Fukui,K.
  TITLE     H1.X with different properties from other linker histones is
            required for mitotic progression
  JOURNAL   FEBS Lett 581 (20), 3783-3788 (2007)
   PUBMED   17632103
REFERENCE   8  (bases 1 to 1516)
  AUTHORS   Happel,N., Schulze,E. and Doenecke,D.
  TITLE     Characterisation of human histone H1x
  JOURNAL   Biol Chem 386 (6), 541-551 (2005)
   PUBMED   16006241
  REMARK    GeneRIF: comparison of primary aa sequence with other human H1
            subtypes, and H1x from different species, generation of specific
            antibody, expression in different cell lines
REFERENCE   9  (bases 1 to 1516)
  AUTHORS   Garcia,B.A., Busby,S.A., Barber,C.M., Shabanowitz,J., Allis,C.D.
            and Hunt,D.F.
  TITLE     Characterization of phosphorylation sites on histone H1 isoforms by
            tandem mass spectrometry
  JOURNAL   J Proteome Res 3 (6), 1219-1227 (2004)
   PUBMED   15595731
REFERENCE   10 (bases 1 to 1516)
  AUTHORS   Yamamoto,T. and Horikoshi,M.
  TITLE     Cloning of the cDNA encoding a novel subtype of histone H1
  JOURNAL   Gene 173 (2), 281-285 (1996)
   PUBMED   8964515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC137695.3.
            
            On Nov 22, 2018 this sequence version replaced NM_006026.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H1 family. [provided by RefSeq, Oct
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC010435.1, D64142.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000333762.6/
                                               ENSP00000329662.4
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25645921
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1516              AC137695.3         71077-72592         c
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..1516
                     /gene="H1-10"
                     /gene_synonym="H1.10; H1FX; H1X"
                     /note="H1.10 linker histone"
                     /db_xref="GeneID:8971"
                     /db_xref="HGNC:HGNC:4722"
                     /db_xref="MIM:602785"
     exon            1..1516
                     /gene="H1-10"
                     /gene_synonym="H1.10; H1FX; H1X"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1026
                     /gene="H1-10"
                     /gene_synonym="H1.10; H1FX; H1X"
                     /note="histone H1x; H1 histone family member X"
                     /codon_start=1
                     /product="histone H1.10"
                     /protein_id="NP_006017.1"
                     /db_xref="CCDS:CCDS3057.1"
                     /db_xref="GeneID:8971"
                     /db_xref="HGNC:HGNC:4722"
                     /db_xref="MIM:602785"
                     /translation="MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQ
                     PGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTL
                     LQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKK
                     PARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1-10"
                     /gene_synonym="H1.10; H1FX; H1X"
                     /note="hexamer: AATAAA"
     polyA_site      1516
                     /gene="H1-10"
                     /gene_synonym="H1.10; H1FX; H1X"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcagc gcgcacgccc agcgagttcc agaggcgcca gtggaagctg cggcggcggt
       61 gtctcgcgtt cggcgggatt tctcttcgct ccggctcggc ctaggtctac gtccccagct
      121 ccagccgccg gctcggactc ggtctctgac ccccaactcg gtcccctagt ccggccccgg
      181 ctccgggccc cccaaccctc gctccggccc ggcccggccc ccaccccagc cctgccgccc
      241 ggccccaggc ccggccgcgg ccgctcccgc ctggagccgc cgcgcgcccc cagcccccct
      301 gcaccccctc ggcccctcgc cttcctcttc ccggcgcggc cccccggctt ccgcgcgccg
      361 cccgccacca atcctcttgc taccatgtcc gtggagctcg aggaggccct gccagtgacg
      421 accgccgagg gaatggccaa gaaggtgacc aaggctggcg gctcggcggc gttgtcccca
      481 tctaagaaga ggaagaatag caagaagaag aaccagccgg gcaagtacag ccagctggtg
      541 gtggagacca tccgtaggct gggcgagcgc aacggctcgt cgctggccaa gatctacacc
      601 gaggccaaga aggttccgtg gttcgaccag cagaatgggc gcacctacct caagtactcg
      661 atcaaggcgc tggtgcagaa cgacacgctt ctgcaggtga agggcaccgg cgccaacggt
      721 tccttcaagc tcaaccgcaa gaagctggag ggcggcgggg agcggcgcgg agccccggcg
      781 gccgccaccg ccccggcccc caccgcgcac aaagcgaaga aggcagcccc gggcgcggcc
      841 ggctcccggc gcgcggacaa gaagcccgcc aggggccaga agccggagca gcgctcgcac
      901 aagaagggcg ctggcgccaa gaaggacaaa ggcggcaagg ccaagaagac ggcggccgcc
      961 gggggcaaga aggtgaagaa ggcggccaag cccagcgtcc ccaaagtgcc caagggccgc
     1021 aagtgagcgt gtcggccggt cagagcggcc ggcgtgggct tttcggtgtt tttgtttttc
     1081 taccccaagt gacgtagatt ttgtacggct cacgccggcc ggggccgcga ggcctggtct
     1141 gagcctcagg gaggggcccc gggtcctctc agtctttccc ctcccccaac gatgtagcgt
     1201 ttttcgttgt ttgctttagg tttttgaaac agccccggcg acgcctctat tggctctcgg
     1261 ccttggcaac ggccgtcgtc atggttactg gcccctaggc gccgatggcc gaggccgcgc
     1321 ctgcccaccg ggcggggtcg ctggttggcc gggcccaggc gcgcggggac gcggaggccg
     1381 cgcatccttt cccagctccc caccctcctt gcctttgggt gcgcgacaaa caatcgctcc
     1441 gggctcaggg ctgcgcggct cttcccttca ttccatgggc ctttttttgg gcacaataaa
     1501 gcgtttaaac ctttca
//
