LOCUS       NM_005325                756 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H1.1 linker histone, cluster member (H1-1), mRNA.
ACCESSION   NM_005325
VERSION     NM_005325.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 756)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 756)
  AUTHORS   Salih,A., Boscolo Galazzo,I., Raisi-Estabragh,Z., Rauseo,E.,
            Gkontra,P., Petersen,S.E., Lekadir,K., Altmann,A., Radeva,P. and
            Menegaz,G.
  TITLE     Brain age estimation at tract group level and its association with
            daily life measures, cardiac risk factors and genetic variants
  JOURNAL   Sci Rep 11 (1), 20563 (2021)
   PUBMED   34663856
  REMARK    GeneRIF: Brain age estimation at tract group level and its
            association with daily life measures, cardiac risk factors and
            genetic variants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 756)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 756)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 756)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 756)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   7  (bases 1 to 756)
  AUTHORS   Gurley,L.R., Valdez,J.G. and Buchanan,J.S.
  TITLE     Characterization of the mitotic specific phosphorylation site of
            histone H1. Absence of a consensus sequence for the p34cdc2/cyclin
            B kinase
  JOURNAL   J Biol Chem 270 (46), 27653-27660 (1995)
   PUBMED   7499230
REFERENCE   8  (bases 1 to 756)
  AUTHORS   Burfeind,P., Hoyer-Fender,S., Doenecke,D., Hochhuth,C. and Engel,W.
  TITLE     Expression and chromosomal mapping of the gene encoding the human
            histone H1.1
  JOURNAL   Hum Genet 94 (6), 633-639 (1994)
   PUBMED   7989039
REFERENCE   9  (bases 1 to 756)
  AUTHORS   Du Clos,T.W., Zlock,L.T. and Marnell,L.
  TITLE     Definition of a C-reactive protein binding determinant on histones
  JOURNAL   J Biol Chem 266 (4), 2167-2171 (1991)
   PUBMED   1989977
REFERENCE   10 (bases 1 to 756)
  AUTHORS   Eick,S., Nicolai,M., Mumberg,D. and Doenecke,D.
  TITLE     Human H1 histones: conserved and varied sequence elements in two H1
            subtype genes
  JOURNAL   Eur J Cell Biol 49 (1), 110-115 (1989)
   PUBMED   2759094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_005325.3.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC112140.1, EL736229.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000244573.5/
                                             ENSP00000244573.4
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-756               U91328.1           123272-124027
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..756
                     /gene="H1-1"
                     /gene_synonym="H1.1; H1A; H1F1; HIST1; HIST1H1A"
                     /note="H1.1 linker histone, cluster member"
                     /db_xref="GeneID:3024"
                     /db_xref="HGNC:HGNC:4715"
                     /db_xref="MIM:142709"
     exon            1..756
                     /gene="H1-1"
                     /gene_synonym="H1.1; H1A; H1F1; HIST1; HIST1H1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..703
                     /gene="H1-1"
                     /gene_synonym="H1.1; H1A; H1F1; HIST1; HIST1H1A"
                     /note="H1 histone family, member 1; histone 1, H1a;
                     histone H1a; histone cluster 1, H1a; histone cluster 1 H1
                     family member a"
                     /codon_start=1
                     /product="histone H1.1"
                     /protein_id="NP_005316.1"
                     /db_xref="CCDS:CCDS4569.1"
                     /db_xref="GeneID:3024"
                     /db_xref="HGNC:HGNC:4715"
                     /db_xref="MIM:142709"
                     /translation="MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVS
                     ELIVQAASSSKERGGVSLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGT
                     GASGSFKLNKKASSVETKPGASKVATKTKATGASKKLKKATGASKKSVKTPKKAKKPA
                     ATRKSSKNPKKPKTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK"
ORIGIN      
        1 gcatcctgct tcgtcaggtt tataccactt tatttggtgt gctgtgttag tcaccatgtc
       61 tgaaacagtg cctcccgccc ccgccgcttc tgctgctcct gagaaacctt tagctggcaa
      121 gaaggcaaag aaacctgcta aggctgcagc agcctccaag aaaaaacccg ctggcccttc
      181 cgtgtcagag ctgatcgtgc aggctgcttc ctcctctaag gagcgtggtg gtgtgtcgtt
      241 ggcagctctt aaaaaggcgc tggcggccgc aggctacgac gtggagaaga acaacagccg
      301 cattaagctg ggcattaaga gcctggtaag caagggaacg ttggtgcaga caaagggtac
      361 cggagcctcg ggttccttca agctcaacaa gaaggcgtcc tccgtggaaa ccaagcccgg
      421 cgcctcaaag gtggctacaa aaactaaggc aacgggtgca tctaaaaagc tcaaaaaggc
      481 cacgggggct agcaaaaaga gcgtcaagac tccgaaaaag gctaaaaagc ctgcggcaac
      541 aaggaaatcc tccaagaatc caaaaaaacc caaaactgta aagcccaaga aagtagctaa
      601 aagccctgct aaagctaagg ctgtaaaacc caaggcggcc aaggctaggg tgacgaagcc
      661 aaagactgcc aaacccaaga aagcggcacc caagaaaaag taaattcagt tagaagtttc
      721 ttctagtaac ccaacggctc ttttaagagc caccta
//
