LOCUS       NM_005318               2204 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H1.0 linker histone (H1-0), mRNA.
ACCESSION   NM_005318
VERSION     NM_005318.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Bhandari,S.K., Wiest,N., Sallmyr,A., Du,R., Ferry,L., Defossez,P.A.
            and Tomkinson,A.E.
  TITLE     Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase
            I-deficient cells but abnormal chromatin levels of non-replicative
            histone H1
  JOURNAL   Sci Rep 13 (1), 4363 (2023)
   PUBMED   36928068
  REMARK    GeneRIF: Unchanged PCNA and DNMT1 dynamics during replication in
            DNA ligase I-deficient cells but abnormal chromatin levels of
            non-replicative histone H1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   Lubin,E., Bryant,L., Aicher,J., Li,D. and Bhoj,E.
  TITLE     Analysis of histone variant constraint and tissue expression
            suggests five potential novel human disease genes: H2AFY2, H2AFZ,
            H2AFY, H2AFV, H1F0
  JOURNAL   Hum Genet 141 (8), 1409-1421 (2022)
   PUBMED   35072799
  REMARK    GeneRIF: Analysis of histone variant constraint and tissue
            expression suggests five potential novel human disease genes:
            H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.
REFERENCE   4  (bases 1 to 2204)
  AUTHORS   Burge,N.L., Thuma,J.L., Hong,Z.Z., Jamison,K.B., Ottesen,J.J. and
            Poirier,M.G.
  TITLE     H1.0 C Terminal Domain Is Integral for Altering Transcription
            Factor Binding within Nucleosomes
  JOURNAL   Biochemistry 61 (8), 625-638 (2022)
   PUBMED   35377618
REFERENCE   5  (bases 1 to 2204)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2204)
  AUTHORS   Parseghian,M.H., Clark,R.F., Hauser,L.J., Dvorkin,N., Harris,D.A.
            and Hamkalo,B.A.
  TITLE     Fractionation of human H1 subtypes and characterization of a
            subtype-specific antibody exhibiting non-uniform nuclear staining
  JOURNAL   Chromosome Res 1 (2), 127-139 (1993)
   PUBMED   7511470
REFERENCE   7  (bases 1 to 2204)
  AUTHORS   Albig,W., Drabent,B., Kunz,J., Kalff-Suske,M., Grzeschik,K.H. and
            Doenecke,D.
  TITLE     All known human H1 histone genes except the H1(0) gene are
            clustered on chromosome 6
  JOURNAL   Genomics 16 (3), 649-654 (1993)
   PUBMED   8325638
REFERENCE   8  (bases 1 to 2204)
  AUTHORS   Doenecke,D. and Tonjes,R.
  TITLE     Differential distribution of lysine and arginine residues in the
            closely related histones H1 and H5. Analysis of a human H1 gene
  JOURNAL   J Mol Biol 187 (3), 461-464 (1986)
   PUBMED   3084796
REFERENCE   9  (bases 1 to 2204)
  AUTHORS   Pehrson,J. and Cole,R.D.
  TITLE     Histone H10 accumulates in growth-inhibited cultured cells
  JOURNAL   Nature 285 (5759), 43-44 (1980)
   PUBMED   7374750
REFERENCE   10 (bases 1 to 2204)
  AUTHORS   Dreikorn,K. and Rohl,L.
  TITLE     Preservation and transplantation of human cadaver kidneys.
            Experiences with the Gamgro perfusion unit
  JOURNAL   Scand J Urol Nephrol 8 (1), 19-26 (1974)
   PUBMED   4595808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z97630.11.
            
            On Dec 3, 2019 this sequence version replaced NM_005318.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-independent histone that is a member of the histone H1
            family. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC029046.1, SRR1803611.99720.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000340857.4/
                                               ENSP00000344504.2
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 7374750
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2204              Z97630.11          13098-15301
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2204
                     /gene="H1-0"
                     /gene_synonym="H1.0; H10; H1F0; H1FV"
                     /note="H1.0 linker histone"
                     /db_xref="GeneID:3005"
                     /db_xref="HGNC:HGNC:4714"
                     /db_xref="MIM:142708"
     exon            1..2204
                     /gene="H1-0"
                     /gene_synonym="H1.0; H10; H1F0; H1FV"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..901
                     /gene="H1-0"
                     /gene_synonym="H1.0; H10; H1F0; H1FV"
                     /note="H1.0, H1(0), H1-0; histone H1'; histone H1(0); H1
                     histone family member 0"
                     /codon_start=1
                     /product="histone H1.0"
                     /protein_id="NP_005309.1"
                     /db_xref="CCDS:CCDS13956.1"
                     /db_xref="GeneID:3005"
                     /db_xref="HGNC:HGNC:4714"
                     /db_xref="MIM:142708"
                     /translation="MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAG
                     SSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPK
                     KSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKP
                     KTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1-0"
                     /gene_synonym="H1.0; H10; H1F0; H1FV"
                     /note="hexamer: AATAAA"
     polyA_site      2204
                     /gene="H1-0"
                     /gene_synonym="H1.0; H10; H1F0; H1FV"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggag ctgggaaaag ggaggcagag gaggcggagg cagaggcaga ggcagaggca
       61 gagcccgagc ccggtgccga gaccaagcga cagaccggcg gggctgggcc tcgcaaagcc
      121 ggctcggcga gctctcccga cacccgagcc ggggaggaaa agcagcgact cctcgctcgc
      181 atccccggga gccgcactcc agactggccc ggtagtcagg ggctcaggag cagatcccga
      241 ggcaggcttt gctcagcctc cgacgagggc tggccctttg gaaggcgcct tcaacagccg
      301 gaccagacag gccaccatga ccgagaattc cacgtccgcc cctgcggcca agcccaagcg
      361 ggccaaggcc tccaagaagt ccacagacca ccccaagtat tcagacatga tcgtggctgc
      421 catccaggcc gagaagaacc gcgctggctc ctcgcgccag tccattcaga agtatatcaa
      481 gagccactac aaggtgggtg agaacgctga ctcgcagatc aagttgtcca tcaagcgcct
      541 ggtcaccacc ggtgtcctca agcagaccaa aggggtgggg gcctcggggt ccttccggct
      601 agccaagagc gacgaaccca agaagtcagt ggccttcaag aagaccaaga aggaaatcaa
      661 gaaggtagcc acgccaaaga aggcatccaa gcccaagaag gctgcctcca aagccccaac
      721 caagaaaccc aaagccaccc cggtcaagaa ggccaagaag aagctggctg ccacgcccaa
      781 gaaagccaaa aaacccaaga ctgtcaaagc caagccggtc aaggcatcca agcccaaaaa
      841 ggccaaacca gtgaaaccca aagcaaagtc cagtgccaag agggccggca agaagaagtg
      901 acaatgaagt cttttcttgc ggacactccc tcctgtctcc tattttctgt aaataatttt
      961 ctcctttttt ctctcttgat gctcaccacc accttttgcc cccttctgtt ctgactttat
     1021 aagagacagg atttggattc ttcagaaatt acagaataat tcatttttcc ttaaccagtt
     1081 gtgcaaggac agcaacaacc aatctaatga tgagaatgta cttatatttt gttttgctat
     1141 taacctactt acggggttag ggatttgcgg ggggggcttg tgtgttttgt tggcttgttt
     1201 gccatgaagg tagatgtggg tggggagaag acacaaggca gtttgttctg gctagatgag
     1261 agggaaccca ggaattgtga ggttagcagg aatatcttta gggtgagtga gttttctttg
     1321 agttgggcac ccgttgtgag agtttcagaa cctttggcca gcaggagaga ggtggtaggg
     1381 agcagccagc cggcaaagga aggaggggga aaaaaaccgc caccgggctg acttccacct
     1441 cccagtggtg agcagtgggg gcccaaaccc agtttccttc tcatttttgt tagtttgcgc
     1501 tttcggcctc cctattttct tagggaaggg gagtggggtc caagtgacag ctggatggga
     1561 gaagccatag tttctcccag tcagctagga tgtagccatt gggggatctt tgtggcttca
     1621 gcaaattctc ttgttaaacc ggagtgaaaa cttcagggga agggtgggga gtcagccaag
     1681 tgcctcagtg tgccctgttg aaacttaggt ttttccacgc aatcgatgga ttgtgtccta
     1741 ggaagacttt tcttttcctc tggatttttg ttcctcctgt acaagaggtg tctttgcttg
     1801 gtttggtggg gctgcggcca cttaaaacct cccgatctct ttttgagtcc tttattataa
     1861 gtagttgtag ctgcgggagg gggaggggga gtgggcgggc agtggatagt aagacttact
     1921 gcagtcgatt tgggatttgc taagtagttt tacagagcta gatctgtgtg catgtgtgtg
     1981 tttgtgtata tatacatatc tagggctagt acttagtttc acacccggga gctgggagaa
     2041 aaaacctgta cagttgtctt tctcttattt ttaataaaat agaaaaatcg cgcacttgcg
     2101 cgtccccccc ccaccccctt ttttaaacaa gtgttacttg tgccgggaaa attttgctgt
     2161 ctttgtaatt ttaaaacttt aaaataaatt ggaaaaggga gaaa
//
