LOCUS       NM_002104               1506 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens granzyme K (GZMK), mRNA.
ACCESSION   NM_002104
VERSION     NM_002104.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Richardson,K.C., Aubert,A., Turner,C.T., Nabai,L., Hiroyasu,S.,
            Pawluk,M.A., Cederberg,R.A., Zhao,H., Jung,K., Burleigh,A.,
            Crawford,R.I. and Granville,D.J.
  TITLE     Granzyme K mediates IL-23-dependent inflammation and keratinocyte
            proliferation in psoriasis
  JOURNAL   Front Immunol 15, 1398120 (2024)
   PUBMED   38903528
  REMARK    GeneRIF: Granzyme K mediates IL-23-dependent inflammation and
            keratinocyte proliferation in psoriasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Koga,R., Maehara,T., Aoyagi,R., Munemura,R., Murakami,Y., Doi,A.,
            Kono,M., Yamamoto,H., Niiro,H., Kiyoshima,T., Tanabe,M., Nakano,T.,
            Matsukuma,Y., Kawano,M., Stone,J.H., Pillai,S., Nakamura,S. and
            Kawano,S.
  TITLE     Granzyme K- and amphiregulin-expressing cytotoxic T cells and
            activated extrafollicular B cells are potential drivers of
            IgG4-related disease
  JOURNAL   J Allergy Clin Immunol 153 (4), 1095-1112 (2024)
   PUBMED   38092138
  REMARK    GeneRIF: Granzyme K- and amphiregulin-expressing cytotoxic T cells
            and activated extrafollicular B cells are potential drivers of
            IgG4-related disease.
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Waggiallah,H.A., Eltayeb,M.M., Hjazi,A.M. and Elmosaad,Y.M.
  TITLE     High expression of angiotensin-converting enzyme 2 receptor
            (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in
            platelets lead to thrombosis formation in COVID-19 patients
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (5), 1847-1856 (2024)
   PUBMED   38497867
  REMARK    GeneRIF: High expression of angiotensin-converting enzyme 2
            receptor (ACE-2), transmembrane protease serine (TMPRSS), and
            P-selectin in platelets lead to thrombosis formation in COVID-19
            patients.
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Turner,C.T., Zeglinski,M.R., Boivin,W., Zhao,H., Pawluk,M.A.,
            Richardson,K.C., Chandrabalan,A., Bird,P., Ramachandran,R.,
            Sehmi,R., Lima,H., Gauvreau,G. and Granville,D.J.
  TITLE     Granzyme K contributes to endothelial microvascular damage and
            leakage during skin inflammation
  JOURNAL   Br J Dermatol 189 (3), 279-291 (2023)
   PUBMED   36652225
  REMARK    GeneRIF: Granzyme K contributes to endothelial microvascular damage
            and leakage during skin inflammation.
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Duquette,D., Harmon,C., Zaborowski,A., Michelet,X., O'Farrelly,C.,
            Winter,D., Koay,H.F. and Lynch,L.
  TITLE     Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues,
            and Tumors, Responding to Cytokines Rather than TCR Stimulation
  JOURNAL   J Immunol 211 (4), 633-647 (2023)
   PUBMED   37449888
  REMARK    GeneRIF: Human Granzyme K Is a Feature of Innate T Cells in Blood,
            Tissues, and Tumors, Responding to Cytokines Rather than TCR
            Stimulation.
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Sayers,T.J., Lloyd,A.R., McVicar,D.W., O'Connor,M.D., Kelly,J.M.,
            Carter,C.R., Wiltrout,T.A., Wiltrout,R.H. and Smyth,M.J.
  TITLE     Cloning and expression of a second human natural killer cell
            granule tryptase, HNK-Tryp-2/granzyme 3
  JOURNAL   J Leukoc Biol 59 (5), 763-768 (1996)
   PUBMED   8656064
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Przetak,M.M., Yoast,S. and Schmidt,B.F.
  TITLE     Cloning of cDNA for human granzyme 3
  JOURNAL   FEBS Lett 364 (3), 268-271 (1995)
   PUBMED   7758581
REFERENCE   8  (bases 1 to 1506)
  AUTHORS   Baker,E., Sayers,T.J., Sutherland,G.R. and Smyth,M.J.
  TITLE     The genes encoding NK cell granule serine proteases, human
            tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to
            chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte
            granule tryptases
  JOURNAL   Immunogenetics 40 (3), 235-237 (1994)
   PUBMED   8039831
REFERENCE   9  (bases 1 to 1506)
  AUTHORS   Shi,L., Kam,C.M., Powers,J.C., Aebersold,R. and Greenberg,A.H.
  TITLE     Purification of three cytotoxic lymphocyte granule serine proteases
            that induce apoptosis through distinct substrate and target cell
            interactions
  JOURNAL   J Exp Med 176 (6), 1521-1529 (1992)
   PUBMED   1460416
REFERENCE   10 (bases 1 to 1506)
  AUTHORS   Hameed,A., Lowrey,D.M., Lichtenheld,M. and Podack,E.R.
  TITLE     Characterization of three serine esterases isolated from human IL-2
            activated killer cells
  JOURNAL   J Immunol 141 (9), 3142-3147 (1988)
   PUBMED   3262682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034238.4 and BC035802.1.
            
            On May 17, 2019 this sequence version replaced NM_002104.2.
            
            Summary: This gene product is a member of a group of related serine
            proteases from the cytoplasmic granules of cytotoxic lymphocytes.
            Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share
            the remarkable ability to recognize, bind, and lyse specific target
            cells. They are thought to protect their host by lysing cells
            bearing on their surface 'nonself' antigens, usually peptides or
            proteins resulting from infection by intracellular pathogens. The
            protein described here lacks consensus sequences for
            N-glycosylation present in other granzymes. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.268483.1, AK312074.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231009.3/ ENSP00000231009.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC034238.4         43946-43968
            24-1068             BC035802.1         1-1045
            1069-1506           AC034238.4         53823-54260
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..1506
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /note="granzyme K"
                     /db_xref="GeneID:3003"
                     /db_xref="HGNC:HGNC:4711"
                     /db_xref="MIM:600784"
     exon            1..131
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..862
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /EC_number="3.4.21.-"
                     /note="tryptase II; granzyme K (granzyme 3; tryptase II);
                     granzyme K (serine protease, granzyme 3; tryptase II);
                     NK-Tryp-2; fragmentin-3; NK-tryptase-2"
                     /codon_start=1
                     /product="granzyme K precursor"
                     /protein_id="NP_002095.1"
                     /db_xref="CCDS:CCDS3964.1"
                     /db_xref="GeneID:3003"
                     /db_xref="HGNC:HGNC:4711"
                     /db_xref="MIM:600784"
                     /translation="MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASI
                     QYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKF
                     IPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPD
                     SLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPL
                     ICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNLVPPHTN"
     exon            132..279
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..430
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..700
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..1506
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /note="hexamer: AATAAA"
     polyA_site      1068
                     /gene="GZMK"
                     /gene_synonym="TRYP2"
                     /note="major polyA site"
ORIGIN      
        1 agaatcttct tccttcatca caggatcaac acatttcatc tgggcttctt aaatctaaat
       61 ctttaaaatg actaagtttt cttccttttc tctgtttttc ctaatagttg gggcttatat
      121 gactcatgtg tgtttcaata tggaaattat tggagggaaa gaagtgtcac ctcattccag
      181 gccatttatg gcctccatcc agtatggcgg acatcacgtt tgtggaggtg ttctgattga
      241 tccacagtgg gtgctgacag cagcccactg ccaatatcgg tttaccaaag gccagtctcc
      301 cactgtggtt ttaggcgcac actctctctc aaagaatgag gcctccaaac aaacactgga
      361 gatcaaaaaa tttataccat tctcaagagt tacatcagat cctcaatcaa atgatatcat
      421 gctggttaag cttcaaacag ccgcaaaact caataaacat gtcaagatgc tccacataag
      481 atccaaaacc tctcttagat ctggaaccaa atgcaaggtt actggctggg gagccaccga
      541 tccagattca ttaagacctt ctgacaccct gcgagaagtc actgttactg tcctaagtcg
      601 aaaactttgc aacagccaaa gttactacaa cggcgaccct tttatcacca aagacatggt
      661 ctgtgcagga gatgccaaag gccagaagga ttcctgtaag ggtgactcag ggggcccctt
      721 gatctgtaaa ggtgtcttcc acgctatagt ctctggaggt catgaatgtg gtgttgccac
      781 aaagcctgga atctacaccc tgttaaccaa gaaataccag acttggatca aaagcaacct
      841 tgtcccgcct catacaaatt aagttacaaa taattttatt ggatgcactt gcttcttttt
      901 tcctaatatg ctcgcaggtt agagttgggt gtaagtaaag cagagcacat atggggtcca
      961 tttttgcact tgtaagtcat tttattaagg aatcaagttc tttttcactt gtatcactga
     1021 tgtatttcta ccatgctggt tttattctaa ataaaattta gaagactctc tgtttgtctt
     1081 ttatcacatg aagtaatatc tgcccccatt gcacccacac tcgccaaagg gcaataaggt
     1141 cactgaataa aacagtaatg gtaccacctt caactaggtg taacttctgc tggatcatcc
     1201 taagttgttg ggttgttttc ttttcattgt tgtgataaca ttgaacatga gataggccct
     1261 tgcaacaaat gtttaagggt atgatacatt attgttaact ataggcatga tcttgcagtg
     1321 cagatctcta gaactgcttc atctcatata aatgaaactt tatgccagtt gaatagcagc
     1381 tctctatttc cccaccaccc ccatcctctg gcaaccccat tctactctaa gcttctatga
     1441 gtttgtattt tttaaatata aatcataaat ataaatatcc taattcaagc aagcagctta
     1501 tacaaa
//
