LOCUS       NM_198682               1687 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens glycophorin E (MNS blood group) (GYPE), transcript
            variant 2, mRNA.
ACCESSION   NM_198682
VERSION     NM_198682.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Watanabe-Okochi,N., Tsuneyama,H., Isa,K., Sasaki,K., Suzuki,Y.,
            Yabe,R., Tsuno,N.H., Nakajima,K., Ogasawara,K. and Uchikawa,M.
  TITLE     Novel hybrid genes and a splice site mutation encoding the Sta
            antigen among Japanese blood donors
  JOURNAL   Vox Sang 115 (8), 756-766 (2020)
   PUBMED   32394466
  REMARK    GeneRIF: Novel hybrid genes and a splice site mutation encoding the
            St(a) antigen among Japanese blood donors.
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Louzada,S., Algady,W., Weyell,E., Zuccherato,L.W., Brajer,P.,
            Almalki,F., Scliar,M.O., Naslavsky,M.S., Yamamoto,G.L.,
            Duarte,Y.A.O., Passos-Bueno,M.R., Zatz,M., Yang,F. and Hollox,E.J.
  TITLE     Structural variation of the malaria-associated human glycophorin
            A-B-E region
  JOURNAL   BMC Genomics 21 (1), 446 (2020)
   PUBMED   32600246
  REMARK    GeneRIF: Structural variation of the malaria-associated human
            glycophorin A-B-E region.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Wang,H.Y., Tang,H., Shen,C.K. and Wu,C.I.
  TITLE     Rapidly evolving genes in human. I. The glycophorins and their
            possible role in evading malaria parasites
  JOURNAL   Mol Biol Evol 20 (11), 1795-1804 (2003)
   PUBMED   12949139
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Huang,C.H., Chen,Y. and Blumenfeld,O.O.
  TITLE     A novel St(a) glycophorin produced via gene conversion of
            pseudoexon III from glycophorin E to glycophorin A gene
  JOURNAL   Hum Mutat 15 (6), 533-540 (2000)
   PUBMED   10862083
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Kudo,S., Onda,M. and Fukuda,M.
  TITLE     Characterization of glycophorin A transcripts: control by the
            common erythroid-specific promoter and alternative usage of
            different polyadenylation signals
  JOURNAL   J Biochem 116 (1), 183-192 (1994)
   PUBMED   7798177
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Huang,C.H., Skov,F., Daniels,G., Tippett,P. and Blumenfeld,O.O.
  TITLE     Molecular analysis of human glycophorin MiIX gene shows a silent
            segment transfer and untemplated mutation resulting from gene
            conversion via sequence repeats
  JOURNAL   Blood 80 (9), 2379-2387 (1992)
   PUBMED   1421409
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Cartron,J.P. and Rahuel,C.
  TITLE     Human erythrocyte glycophorins: protein and gene structure analyses
  JOURNAL   Transfus Med Rev 6 (2), 63-92 (1992)
   PUBMED   1591491
  REMARK    Review article
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Vignal,A., London,J., Rahuel,C. and Cartron,J.P.
  TITLE     Promoter sequence and chromosomal organization of the genes
            encoding glycophorins A, B and E
  JOURNAL   Gene 95 (2), 289-293 (1990)
   PUBMED   2249783
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Vignal,A., Rahuel,C., London,J., Cherif Zahar,B., Schaff,S.,
            Hattab,C., Okubo,Y. and Cartron,J.P.
  TITLE     A novel gene member of the human glycophorin A and B gene family.
            Molecular cloning and expression
  JOURNAL   Eur J Biochem 191 (3), 619-625 (1990)
   PUBMED   2390989
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Kudo,S. and Fukuda,M.
  TITLE     Identification of a novel human glycophorin, glycophorin E, by
            isolation of genomic clones and complementary DNA clones utilizing
            polymerase chain reaction
  JOURNAL   J Biol Chem 265 (2), 1102-1110 (1990)
   PUBMED   2295603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017864.1, BC064396.1 and
            AC109812.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198682.2.
            
            Summary: The protein encoded by this gene is a sialoglycoprotein
            and a type I membrane protein. It is a member of a gene family with
            GPA and GPB genes. This encoded protein might carry the M blood
            group antigen. GYPA, GYPB, and GYPE are organized in tandem on
            chromosome 4. This gene might have derived from an ancestral gene
            common to the GPB gene by gene duplication. Two alternatively
            spliced transcript variants encoding the same protein have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017864.1, SRR5189661.80131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358615.9/ ENSP00000351430.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC017864.1         1-39
            40-89               BC064396.1         1-50
            90-1683             BC017864.1         90-1683
            1684-1685           BC064396.1         1645-1646
            1686-1687           AC109812.5         36068-36069         c
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..1687
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /note="glycophorin E (MNS blood group)"
                     /db_xref="GeneID:2996"
                     /db_xref="HGNC:HGNC:4705"
                     /db_xref="MIM:138590"
     exon            1..89
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..289
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /note="glycophorin-E; glycophorin A"
                     /codon_start=1
                     /product="glycophorin-E precursor"
                     /protein_id="NP_941391.2"
                     /db_xref="CCDS:CCDS47138.1"
                     /db_xref="GeneID:2996"
                     /db_xref="HGNC:HGNC:4705"
                     /db_xref="MIM:138590"
                     /translation="MYGKIIFVLLLSGIVSISASSTTGVAMHTSTSSSVTKSYISSQT
                     NGITLINWWAMARVIFEVMLVVVGMIILISYCIR"
     exon            90..188
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /inference="alignment:Splign:2.1.0"
     exon            189..298
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1687
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /note="hexamer: AATAAA"
     polyA_site      1687
                     /gene="GYPE"
                     /gene_synonym="GPE; GYPA; MiIX; MNS"
                     /note="major polyA site"
ORIGIN      
        1 gtctttggta gtttttttgc actaacttca ggagccagct cgtgatctca ggatgtatgg
       61 aaaaataatc tttgtattac tattgtcagg aattgtgagc atatcagcat caagtaccac
      121 tggtgtggca atgcacactt caacctcttc ttcagtcaca aagagttaca tctcatcaca
      181 gacaaatggg ataacactca ttaattggtg ggcgatggct cgtgttattt ttgaggtgat
      241 gcttgttgtt gttggaatga tcatcttaat ttcttactgt attcgatgac tgataaaggt
      301 tttcatgcct ctgggattga gattagagga agaaagcaaa gaaaggacat ttttttactt
      361 cactgttcat ggtgtaattg tgtgcctgac ggctgtagct actaacttgg cttacgttga
      421 ctggctacta agggactcta ggagtcagaa actaaatgct gagtctctca aaggcgtaga
      481 gagaatttca gagggcctta ccatgacatg aggattaaac tccagttctg cccgattctc
      541 atcacgaaat ccttatccca tgcctcattg tgtttggtgt ccccttgcct aggggacagt
      601 cctcctgggt aagatcagca agataactct tcagtcacat tccatttgat actttgaata
      661 ctctgaggtc cttacccacc aaatggatgg aattcagctg ctcaatcact gcctttctca
      721 gaactcggtt gtccaaccac aattcccttt cccttaggat agggctatat tggcaaaatg
      781 ccgcccgaac agactgctga cagtaaacca aatattagtt tctctcacct tcttgaaggc
      841 atttacagtc tttgtaagct tttctcctag attttccctt tcctgttcct gcttagattc
      901 taagaatgaa gtgcatcctt ctccttttct tcattaggtg aagtgggatt tacccattac
      961 catatattca ccaccaggtc actgacgaga gactccagtg aatcgctttc cctctgcatt
     1021 cctctccttg tacagactag agggtcacat tgtgtaaagc ctaacatagc cctgcaaaga
     1081 gatctggccc cagcagtgaa cacaaactca gtaattctct ttagagtgag gtggtaatca
     1141 gtgcctcttg gtttcagccg tggtcctagt ggctacttat ggaagaatag gaatagttcc
     1201 acaacatcct gtaacattgg cttacctgta tattatatgc cacccgtaac cataaaaaca
     1261 ccaggattta ggttccttga aggtaatgac tatgggtccc tctctgtgga agaatactga
     1321 atagaagaga gaaatcactc aatatgtgga atgactgata tggtttggct gtgttcccac
     1381 tcaaatctca tcttgaattg tagttccaat aatccccaca tgtcatggga ggaacccagt
     1441 gggaggtact tgaatcattg cggtggtttc ccctgtgcta ttctcatgat agtgagtaaa
     1501 ttctcacata atctgatagt tttataaagg agcttccccc ttcactcagc tctcattctt
     1561 ctccttcctg ccactatgta agaaagatgt gtttgtttcc cctttggtca tgattgtaag
     1621 tatcctgaga ccttcccagc catgcaaaac tgtagatcaa taaaacctct ttcctttata
     1681 aattaca
//
