LOCUS       NM_001347885            5444 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens GVQW motif containing 3 (GVQW3), transcript variant 5,
            mRNA.
ACCESSION   NM_001347885
VERSION     NM_001347885.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5444)
  AUTHORS   Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd
            C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E,
            Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K,
            Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC,
            Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES
            and Sakaki Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002360.4 and BC040665.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001347885.1.
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 3' coding region, resulting in a frameshift and an early
            stop codon compared to variant 1. The encoded isoform (d) is
            shorter and has a distinct C-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.234931.1,
                                           SRR5189667.51058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529331.2/ ENSP00000489195.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-971               AP002360.4         96941-97911
            972-5438            AP002360.4         119278-123744
            5439-5444           BC040665.1         5357-5362
FEATURES             Location/Qualifiers
     source          1..5444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..5444
                     /gene="GVQW3"
                     /note="GVQW motif containing 3"
                     /db_xref="GeneID:100506127"
                     /db_xref="HGNC:HGNC:51239"
     exon            1..971
                     /gene="GVQW3"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..1070
                     /gene="GVQW3"
                     /note="isoform d is encoded by transcript variant 5; GVQW
                     motif-containing protein 3; protein GVQW3"
                     /codon_start=1
                     /product="protein GVQW3 isoform d"
                     /protein_id="NP_001334814.1"
                     /db_xref="CCDS:CCDS86231.1"
                     /db_xref="GeneID:100506127"
                     /db_xref="HGNC:HGNC:51239"
                     /translation="MSDRYLEQRISIKFCVKLNKSASETHHLLKEAYGDEVMSRARVF
                     DWHKRFKEGREDVRDDARSGRPVTHRTDDNIQKVKDLVCSNRQLTVRMMAEELNLDKE
                     TVRLILKENLNMRKISAKVISGVLKGEPKPRKLDFRSDLSKETRKNSSCLRKKRRNLT
                     MLPRLVSNSLSQGILPPWPPKALGLSA"
     exon            972..5444
                     /gene="GVQW3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GVQW3"
                     /note="hexamer: TATAAA"
     polyA_site      1425
                     /gene="GVQW3"
                     /note="major polyA site"
     regulatory      5419..5424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GVQW3"
                     /note="hexamer: ATTAAA"
     polyA_site      5444
                     /gene="GVQW3"
ORIGIN      
        1 atgcgcgcct gtctcccggg acgctagagc aggcggttcc tgggctgctc cggtaggttt
       61 ggcgtgcgcg ggtttctgca gatctagggc gagcttgcac gttacatcac cgatgcatct
      121 cttcttgctt gcttaatttg ccaccactta ggcctttctt gcagaattcg ccatatactc
      181 cttaagggcc gcggaatcgg agcgaccttg gtgactggca aactctcggc agatgtgcgt
      241 gcactggttt gatgcagacg tggttgtagg cgatttaatt tttcccagct ttgcagcgac
      301 tgttggcttc ccagaacgga tctccccagc ctcgactgga agctgaggga caaaaattca
      361 taaaagcaat tactctttcc cggcgaggct tctagaagag caagaagagc gatatgatta
      421 cacctgcagc cctataaaga ttgatctgtc cgtctttccc ttacagtcgt ggcctgttaa
      481 acgttcctgt gttgttcagt gccagaatga gtgaccgcta tttagaacaa aggattagta
      541 tcaaattttg cgtgaaattg aacaagtctg caagtgagac ccaccatctt ttaaaagaag
      601 cttatgggga tgaagtcatg tcaagggcca gagtttttga ctggcacaaa aggtttaaag
      661 aaggacggga agatgttcga gatgatgccc gaagtgggcg tccagtcacc caccgaacag
      721 atgacaatat ccagaaggtc aaggacttgg tttgttcaaa caggcagtta accgtgagga
      781 tgatggctga agagttaaat ttagacaaag aaactgttag gctcattttg aaagaaaact
      841 tgaacatgag gaagatttct gcaaaagtta tttcgggtgt tttgaagggt gagcctaaac
      901 cacgaaaact tgactttcgg tccgatcttt caaaggaaac taggaaaaat agctcatgtt
      961 tgaggaaaaa gagacggaac ctcactatgt tgcccaggct ggtctcgaac tccttgtctc
     1021 aagggatcct cccaccttgg cctcccaaag ctctgggatt atcagcatga gccaccatgc
     1081 caagccaaaa ccaggagttc aatggtgtaa attccagtct gagtccacag gccgaagagc
     1141 gaggagtgct gatgtacaag ggcaggagaa gatggatgtc acagctcaag aagcgagaac
     1201 aaatttgccc ttctatcttt ttgttctatt caggtcctca atgaattgga tgatgtccat
     1261 gcacattagg gagggctgcc tcttcattac tcggtctacc aattcaaatg ctaatctctt
     1321 ccggaaacat ccccacagac acacccagaa ataatgtttt cccatctatc tcagtacccc
     1381 atgatccagt caagtgaaca tataaaattg gctgtcacat ctccattttg tttatttatt
     1441 tacttattta ttttagacta gttaagttca gtagtgagaa agagggaagg aatagaacga
     1501 ggagttcaat ctgtgactga cagtgaacaa ttgattgaga taactcacta cctttggacc
     1561 agccatctcc attttataaa taagaaaact gaagctcaga aaggttgtct aaactgccaa
     1621 agccatagaa ctttaagtgc ggaaataggt tttgtgttca atctgcttct ctataaaatc
     1681 ccatacagga catccaggca tctaaaaggt agctcagtat ctctgccttc tctccattgt
     1741 tagccttgat ggacaatttt tgctggagca aatattctga aaaagattcc tcctgtttcc
     1801 tatgggagta gacagcaagc aggtgaagcc gggctctctt gagcctggga ccccccggta
     1861 ggagcatttg gctggaaaga tgtggaagtc aataagcatt tcctccacca cccagaagca
     1921 tctccaagct caggcaggag gtgggcagtg aaggggaata ccaagcatcc tgcacatcag
     1981 gtagaaggag gaagcccagg ccatggcagg acttacctgt tgagtcctgc tgggtttggg
     2041 caatgtctca gcagagactg gcatactctc aggcttttca cttccttcct tagactgggg
     2101 gcgcctcttg ccctgtgcat cttgcacaaa gcctggtcct gagtaggtgc cctgcaaagg
     2161 tgcaggggat caatgggggt gactgagtct aactgaagaa aaagaaggca tttcaagtct
     2221 ctataggttg gggactttaa tgagtgtaaa tagctaccct ttattgagca ttgtttatgt
     2281 gtggacactt tttatgcatg tatattggaa tatttttagc tgtaagtaat gataactaac
     2341 agtgacttaa ataagtagtt attttctggc ataataagaa ttccaaaggt gctcctttgg
     2401 tctttccatc ttggttacaa gatggctgtg acaccctgcc ctcacctcca agttcaaggc
     2461 aggcaggggt tgggaggtgc ggacagttca gactcagcag tcctgtttca tcaggaaagc
     2521 aaaagctctc ccagtaactc ccagcagagt tctactaaat ctcattggcc caagggagct
     2581 gcagtggtag gtaacaagga gcaaatggct tttgggtagc cagtcaacag ggtctgccat
     2641 gtgcatagaa agcacagtat gtatttggca tggagtcggt actcaataag cattagctat
     2701 ttggcgtgcc tgtgtgtgtt tgtgtgtctg cgtgtggtta tatgtatatt ttccattttc
     2761 ccaaacagtc cttggaagta gcatcctcct ttactaatgg gacctaacac acagctggca
     2821 aaaggcacag ttagagccac acatcagact catttctttc tgactgaagt ctgagggctc
     2881 tttccattgc catgctatgt tccaccctcc ccttcaactg cccctctaaa gtcttgtctt
     2941 ggagtcacat gaggtccaag tgggcttgat gaagaaagaa tagggaagga gatcagatca
     3001 gtactgttgt ccaggctgga gcgcagttga ttgtagctca ctgcagcctc caactccatg
     3061 gctcaagtga tcctcctgcc tcagccttcc aagtagctag gacaacaggt gcgtgctacc
     3121 atgcatggct aattaattaa aagaattttt tttggtagag acagggtctc actatgttgc
     3181 ccaggctggt cttgaactcc tgggctccag tgatcctccc ccttcagcct cccaaagtgc
     3241 tagaattaca ggcattagcc accatgcctg gcctggagat cagttctttt ttactttttt
     3301 ttgagacagg ctctccctat gtcaccgagg ctacagtgca gtggttcaat cgcagctcac
     3361 tgtagcctct atctcctggg ctcaagtgat cctcccacct cagcctcctg agtagctggg
     3421 actagaggca tgtatcacca tgcccagcta atttttgcat tttttgtaga gtcagggttt
     3481 caccctgttg cccactctgg tctcaaactc ctgggctcaa ccaatctgcc cacctaggcc
     3541 tcccaaaatg ctgggactat aggtgtgagc cactgcacct ggcctggagc tcagttctga
     3601 aataagttga cacctgtccc tggggctatc cacagagtaa cgatgaagtc atgagaggag
     3661 gttcaataac tgtgtgctag agtcatacct ccacctgagt gcagccactt tggaatggtc
     3721 aggctagaag gttcagcctt tattctgatg atgccactac tgcccagaac tcctctggga
     3781 ctctttgcaa gttgcaaaag acctcaatct cattactgta atattgcacc tcatttctga
     3841 ccccaaaccc agctgcagct tctcatctca cgaatttcaa gtgacttttg actattgcca
     3901 aaaatcaaaa atcattccct gaaaacagaa tctattgtaa tttagatgca aaagaatgtg
     3961 ttgtctgctt tgcagccaat tttcaaataa aaaagaaatg tttaaagcag tggaagcact
     4021 gtttaaataa atatgccggg ccaggcgtgg tggctcacgc ctgtaatccc agcactttag
     4081 gaggccaagg cgggtcgatc acgaagtcag gagatcgaga ccaacctggc taacacagtg
     4141 aaaccccgtc tctaccaaaa atacaaaaaa ttagctggga gtggtggcgg gtgcctgtag
     4201 tcccagctat ttgggaggct gaggcaggag aatggcaaga acctgggagg cggagcttgc
     4261 agtgagccaa ggtcacacca ctgcactcca gcctgggcta cagagcgaga ctctgtctca
     4321 aaaaataaat aaaataaaat aaaataaata aataaataaa tatgccctcc caggttgaca
     4381 tcttggaaga ggataactct aagtttggtt gtataatttc tgctgtgttt aagaaaaatt
     4441 acttaacttg tgagacatta tgaaaaggat gctggacttg gtaaagatac aaatgggctt
     4501 ataatgttgg tcaggtgaga catgttgcat tggtgaaatt ataaattgat attgttttct
     4561 cagagcaatt tcgcaatgag catcacgaag ctttaaagag tttaaaccac accggtcaca
     4621 gtggttcacg cctgtaatcc caatactttg ggaggccgag gtgggcagat cacaagtcag
     4681 gagctagaga ccagcctggt caacatggtg aaaccccttc tctactaaaa atacaaaaat
     4741 tagctgggtg tggtggtgca tgcctgtaat cccagctact cgggaggctg aggcaggagc
     4801 atcgcttgaa cctgggaggt ggaggttgca gtgagctgag atcgcaccac tgcactccag
     4861 cctgggcggc agagcaagac tccctctcaa aaaaaaaaaa aaaaaaaaaa aaaaagaatt
     4921 taagccagtt gacctaggaa tcttctagga cgatttctta ggaatctttc ttaggaaaac
     4981 agtcagagat gcagacaaag atttatgtaa cagccattca ttgcagactt atttgtaaaa
     5041 gtagtaaaaa gaaggaaata acccaaatgt cccacaatgg agaaattgtt aagaaaatta
     5101 cagcatactc attaagtgaa ataatgcagc tatttaagat gatgttttta aagaactgtc
     5161 aatgatgttt gaagatgttc acaataagat aggtgataaa acagactata aaaccacatg
     5221 cattatatag tcccattttt actttctgta tgctaaaaca aacccctcaa gatagatcca
     5281 aaacattacc agtggtttga tctgggtgat gaaattataa gtgattttaa acttgcttca
     5341 ttatgctttt atatatataa tttttcttat tataacaata aatattactt ttgtagttag
     5401 aaaatatgta taatgaacat taaaattact tgttaagaaa gaaa
//
