LOCUS       NM_016315               3294 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens GULP PTB domain containing engulfment adaptor 1
            (GULP1), transcript variant 1, mRNA.
ACCESSION   NM_016315
VERSION     NM_016315.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Tatenuma,T., Matsukawa,T., Goto,T., Jiang,G., Sharma,A.,
            Najafi,M.A.E., Teramoto,Y. and Miyamoto,H.
  TITLE     GULP1 as a Downstream Effector of the Estrogen Receptor-beta
            Modulates Cisplatin Sensitivity in Bladder Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (6), 557-565 (2024)
   PUBMED   39467629
  REMARK    GeneRIF: GULP1 as a Downstream Effector of the Estrogen
            Receptor-beta Modulates Cisplatin Sensitivity in Bladder Cancer.
REFERENCE   2  (bases 1 to 3294)
  AUTHORS   Hayashi,M., Guida,E., Inokawa,Y., Goldberg,R., Reis,L.O., Ooki,A.,
            Pilli,M., Sadhukhan,P., Woo,J., Choi,W., Izumchenko,E.,
            Gonzalez,L.M., Marchionni,L., Zhavoronkov,A., Brait,M.,
            Bivalacqua,T., Baras,A., Netto,G.J., Koch,W., Singh,A. and
            Hoque,M.O.
  TITLE     GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial
            carcinoma
  JOURNAL   Sci Signal 13 (645) (2020)
   PUBMED   32817372
  REMARK    GeneRIF: GULP1 regulates the NRF2-KEAP1 signaling axis in
            urothelial carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3294)
  AUTHORS   Chau,D.D., Yung,K.W., Chan,W.W., An,Y., Hao,Y., Chan,H.E., Ngo,J.C.
            and Lau,K.F.
  TITLE     Attenuation of amyloid-beta generation by atypical protein kinase
            C-mediated phosphorylation of engulfment adaptor PTB domain
            containing 1 threonine 35
  JOURNAL   FASEB J 33 (11), 12019-12035 (2019)
   PUBMED   31373844
  REMARK    GeneRIF: Results indicate that GULP, engulfment adaptor PTB domain
            containing 1 (GULP1) threonine 35 (T35) phosphorylation is a
            mechanism for the regulation of GULP1-amyloid beta precursor
            protein (APP) interaction and thereby APP processing.
REFERENCE   4  (bases 1 to 3294)
  AUTHORS   Gong,J., Gaitanos,T.N., Luu,O., Huang,Y., Gaitanos,L., Lindner,J.,
            Winklbauer,R. and Klein,R.
  TITLE     Gulp1 controls Eph/ephrin trogocytosis and is important for cell
            rearrangements during development
  JOURNAL   J Cell Biol 218 (10), 3455-3471 (2019)
   PUBMED   31409653
  REMARK    GeneRIF: the phagocytic adaptor protein Gulp1 regulates
            EphB/ephrinB trogocytosis to achieve efficient cell rearrangements
            of cultured cells and during embryonic development
REFERENCE   5  (bases 1 to 3294)
  AUTHORS   Faralli,J.A., Desikan,H., Peotter,J., Kanneganti,N., Weinhaus,B.,
            Filla,M.S. and Peters,D.M.
  TITLE     Genomic/proteomic analyses of dexamethasone-treated human
            trabecular meshwork cells reveal a role for GULP1 and ABR in
            phagocytosis
  JOURNAL   Mol Vis 25, 237-254 (2019)
   PUBMED   31516309
  REMARK    GeneRIF: The knockdown of GULP1 and ABR using siRNAs decreased
            phagocytosis by 40%.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3294)
  AUTHORS   Park,S.Y., Kang,K.B., Thapa,N., Kim,S.Y., Lee,S.J. and Kim,I.S.
  TITLE     Requirement of adaptor protein GULP during stabilin-2-mediated cell
            corpse engulfment
  JOURNAL   J Biol Chem 283 (16), 10593-10600 (2008)
   PUBMED   18230608
  REMARK    GeneRIF: GULP is a likely downstream molecule in the
            stabilin-2-mediated signaling pathway and plays an important role
            in stabilin-2-mediated phagocytosis
REFERENCE   7  (bases 1 to 3294)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 3294)
  AUTHORS   Su,H.P., Nakada-Tsukui,K., Tosello-Trampont,A.C., Li,Y., Bu,G.,
            Henson,P.M. and Ravichandran,K.S.
  TITLE     Interaction of CED-6/GULP, an adapter protein involved in
            engulfment of apoptotic cells with CED-1 and CD91/low density
            lipoprotein receptor-related protein (LRP)
  JOURNAL   J Biol Chem 277 (14), 11772-11779 (2002)
   PUBMED   11729193
  REMARK    GeneRIF: Interaction of CED-6/GULP, an adapter protein involved in
            engulfment of apoptotic cells with CED-1 and CD91/low density
            lipoprotein receptor-related protein (LRP).
REFERENCE   9  (bases 1 to 3294)
  AUTHORS   Liu,Q.A. and Hengartner,M.O.
  TITLE     Human CED-6 encodes a functional homologue of the Caenorhabditis
            elegans engulfment protein CED-6
  JOURNAL   Curr Biol 9 (22), 1347-1350 (1999)
   PUBMED   10574771
REFERENCE   10 (bases 1 to 3294)
  AUTHORS   Smits,E., Van Criekinge,W., Plaetinck,G. and Bogaert,T.
  TITLE     The human homologue of Caenorhabditis elegans CED-6 specifically
            promotes phagocytosis of apoptotic cells
  JOURNAL   Curr Biol 9 (22), 1351-1354 (1999)
   PUBMED   10574763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK055718.1, AK314498.1,
            AF200715.1, AL080142.1 and AC092598.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016315.3.
            
            Summary: The protein encoded by this gene is an adapter protein
            necessary for the engulfment of apoptotic cells by phagocytes.
            Several transcript variants, some protein coding and some thought
            not to be protein coding, have been found for this gene. [provided
            by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1), as well as variants 4, 5, and
            6-10, encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.125906.1, AK314498.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409830.6/ ENSP00000386732.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AK055718.1         206-414
            210-1285            AK314498.1         209-1284
            1286-2443           AF200715.1         1256-2413
            2444-3193           AL080142.1         1319-2068
            3194-3194           AC092598.2         27412-27412
            3195-3294           AL080142.1         2070-2169
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1-q32.2"
     gene            1..3294
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /note="GULP PTB domain containing engulfment adaptor 1"
                     /db_xref="GeneID:51454"
                     /db_xref="HGNC:HGNC:18649"
                     /db_xref="MIM:608165"
     exon            1..293
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            294..420
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            421..492
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1379
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /note="isoform a is encoded by transcript variant 1;
                     engulfment adapter protein; PTB domain adaptor protein
                     CED-6; PTB domain-containing engulfment adapter protein 1;
                     GULP, engulfment adaptor PTB domain containing 1; cell
                     death protein 6 homolog; PTB domain adapter protein CED-6"
                     /codon_start=1
                     /product="PTB domain-containing engulfment adapter protein
                     1 isoform a"
                     /protein_id="NP_057399.1"
                     /db_xref="CCDS:CCDS2295.1"
                     /db_xref="GeneID:51454"
                     /db_xref="HGNC:HGNC:18649"
                     /db_xref="MIM:608165"
                     /translation="MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTE
                     VVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCA
                     DDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDV
                     ETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFD
                     MIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSK
                     LDEMQEGFKMGLTLEGTVFCLDPLDSRC"
     exon            493..554
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            555..626
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            627..725
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            864..980
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1073
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1212
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1307
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..3294
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /note="hexamer: AATAAA"
     polyA_site      3294
                     /gene="GULP1"
                     /gene_synonym="CED-6; CED6; GULP"
                     /note="major polyA site"
ORIGIN      
        1 gttcccggcc gggagcgacc cggagtcccc agccccgcgt cccagctgcc gccagcgcca
       61 gttttggatt cggcggatta ggaagaggag ggagggggga gagagcgcga agagggaggg
      121 gaccgaagct ggagggtccc gagtccagcg ccgtgttggc gtagagaaac tttccctctc
      181 ggcctcggag acggcgcccc ggccgtgccg gagtggagat cgccaggctc ggaggaaccg
      241 gcagctctcc acgcccctgc ccgaagcctg acccgactgc ctctctcagt gagttattta
      301 tgattccatc tgatatacat aggagagaaa ctgatagaag aattctgatg gcaactgtat
      361 gatagaagct atataaagtc aagtgtccat tttctttcaa ctatatttga gcatacccag
      421 gatttaagtc gtggaactga acatttattt ggctgatcct catcatgaac cgtgctttta
      481 gcaggaagaa agacaaaaca tggatgcata cacctgaagc tttatcaaaa catttcattc
      541 cctataatgc aaagtttctt ggcagtacag aagtggaaca gccaaaagga acagaagttg
      601 tgagagatgc tgtaaggaaa ctaaagtttg caagacatat caagaaatct gaaggccaga
      661 aaattcctaa agtggagttg caaatatcaa tttatggagt aaaaattcta gaacccaaaa
      721 caaaggaagt tcaacacaat tgccagcttc atagaatatc tttttgtgca gatgataaaa
      781 ctgacaagag gatattcact ttcatatgca aagattctga gtcaaataaa catttgtgct
      841 atgtatttga cagcgaaaag tgtgctgaag agatcacttt aacaattggc caagcatttg
      901 acctggcata caggaaattt ctagaatcag gaggaaaaga tgttgaaaca agaaaacaga
      961 tcgcagggtt acaaaaaaga atccaagact tagaaacaga aaatatggaa cttaaaaata
     1021 aagtacaaga tttggaaaac caactgagaa taactcaagt atcagcacct ccagcaggca
     1081 gtatgacacc taagtcgccc tccactgaca tctttgatat gattccattt tctccaatat
     1141 cacaccagtc ttcgatgcct actcgcaatg gcacacagcc acctccagta cctagtagat
     1201 ctactgagat taaacgggac ctgtttggag cagaaccttt tgacccattt aactgtggag
     1261 cagcagattt ccctccagat attcaatcaa aattagatga gatgcaggag gggttcaaaa
     1321 tgggactaac tcttgaaggc acagtatttt gtctcgaccc gttagacagt aggtgctgac
     1381 atcaagaaca agaaatcctg attcatgtta aatgtgtttg tatacacatg tcatttatta
     1441 ttattacttt aagataggta ttattcatgt gtcaatgttt ttgaatattt taatattttg
     1501 aaaattttct cagttaaatt tcctcacctt cactattgat ctgtaatttt tattttaaaa
     1561 acagcttact gtaaagtaga tcatactttt atgttccttt ctgtttctac tgtagatgaa
     1621 tttgtaattg aaagacatat tatacaaata cctgccttgt gtctgagttc tatttagtta
     1681 gcatcttgaa atttgtattc attttccaga tggctagttt attaatgatt tcccaaaagc
     1741 cataccttaa agataacttt ttaaattctg aagagacatg ccaatgtcaa actaaacatg
     1801 ttctgttttt aaaccaacaa acatgttact attcattgga cagatatcat tttatgtata
     1861 aatactgttc acatcactgg gaaaatgtaa actttaaaca taatgccaca aggtcactaa
     1921 tttctagcag gtaaaattat aaggatataa attccaataa taaaccaaat gtatttagag
     1981 tatttattag taaatgcaag gtgatgttag ttatgatcag ttatactcta aatatttaat
     2041 ttgttttata aaggtagtga aaaaatgaaa atttgctatt tattaaaaaa cattaaattt
     2101 cattccaaat gagataagtg atattactat aacatctaag catcatctga tttgatattc
     2161 cctaaaaaac atttggaata tatgctatct atagattcag tatctactac ccatatttac
     2221 tttaccaaat atatttctcc tcactgcata aggactactc ttctcatatt ttcttctttg
     2281 atgaagatat ttttcaccaa agtttatttt gtgatgccct cttggttttg atactttaaa
     2341 atctgtggca cccgttctac atgaattatc aatatttggt aaattcaatc tgtatttgtt
     2401 ttgttaaagt caaaaatctc attttccaaa aaaaaaaaaa aaacccagtt actgctcagt
     2461 ttagtcttga acatgagcaa taaaattctc ttgcatttca ttattgatgt gctgatgaac
     2521 ctggactttt aaaaatattt gtttcctata cctttaccct ttacctaaca gactaatttg
     2581 tactcagtaa aacaaaaatt tatggtcaaa atttctaact tggttcatca cattataaga
     2641 taaataaatt aaattaatga aaatgtgact tagagtaggg gtagccctca aaaatagatt
     2701 tatcatttac tcattggaat tttcttcaag tgttaaaggt acattttcac taggaaaaga
     2761 aatcaaatat gcttatgcaa tatatatttg tgtgtttttc cttaatgtta tatggtatat
     2821 atgagccttc ttgtttagtt tcttttatct gctaagttgt accttaatta gagggcaata
     2881 tatgtttcat aaagaagagt ctttataatt ttgtttgtca gatagtattt tggaatttgt
     2941 ataataagga tgtttagaag ccatataagt ggcttttttt aacagataga atttgtattt
     3001 ttattgtact ttaaaaagat ttatgtaata ggtatatatt tagtggccat ttattatcaa
     3061 tggtaacaca atggagtact aagatggtat ttgcacattt aagatatgtt actttaccaa
     3121 tttttaatgg taatcaactc tgctactggc atgatgaaat agtacataac tggtcattaa
     3181 ttatgaacat ttatttctcc agtgcgtttt tatgaagatc tggttgaaaa ttgtatttct
     3241 atgtaaactc aacgatatgt ttggttttcc tgaaaataaa tgattttaaa taaa
//
