LOCUS       NM_001159390             935 bp    mRNA    linear   PRI 26-JAN-2025
DEFINITION  Homo sapiens guanylate kinase 1 (GUK1), transcript variant 1, mRNA.
ACCESSION   NM_001159390
VERSION     NM_001159390.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 935)
  AUTHORS   Wang,Y., Anderson,E.P. and Tatakis,D.N.
  TITLE     Whole transcriptome analysis of smoker palatal mucosa identifies
            multiple downregulated innate immunity genes
  JOURNAL   J Periodontol 91 (6), 756-766 (2020)
   PUBMED   31682009
  REMARK    GeneRIF: GUK1 expression in healthy palatal mucosa is strongly
            negatively correlated with serum cotinine levels
REFERENCE   4  (bases 1 to 935)
  AUTHORS   Khan,N., Shah,P.P., Ban,D., Trigo-Mourino,P., Carneiro,M.G.,
            DeLeeuw,L., Dean,W.L., Trent,J.O., Beverly,L.J., Konrad,M., Lee,D.
            and Sabo,T.M.
  TITLE     Solution structure and functional investigation of human guanylate
            kinase reveals allosteric networking and a crucial role for the
            enzyme in cancer
  JOURNAL   J Biol Chem 294 (31), 11920-11933 (2019)
   PUBMED   31201273
REFERENCE   5  (bases 1 to 935)
  AUTHORS   Wimberg,H., Janssen-Bienhold,U. and Koch,K.W.
  TITLE     Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by
            Retinal Degeneration Protein 3
  JOURNAL   Front Mol Neurosci 11, 52 (2018)
   PUBMED   29515371
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 935)
  AUTHORS   Savitskii,I.V.
  TITLE     [Increase in 5'-nucleotidase and decrease in guanylate kinase
            activity in the brain and liver of irradiated rats]
  JOURNAL   Ukr Biokhim Zh (1978) 62 (2), 110-114 (1990)
   PUBMED   2164269
REFERENCE   7  (bases 1 to 935)
  AUTHORS   Field,A.K., Davies,M.E., DeWitt,C., Perry,H.C., Liou,R.,
            Germershausen,J., Karkas,J.D., Ashton,W.T., Johnston,D.B. and
            Tolman,R.L.
  TITLE     9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective
            inhibitor of herpes group virus replication
  JOURNAL   Proc Natl Acad Sci U S A 80 (13), 4139-4143 (1983)
   PUBMED   6306664
REFERENCE   8  (bases 1 to 935)
  AUTHORS   Boritzki,T.J., Jackson,R.C., Morris,H.P. and Weber,G.
  TITLE     Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase
            in rat hepatomas and kidney tumors
  JOURNAL   Biochim Biophys Acta 658 (1), 102-110 (1981)
   PUBMED   6260205
REFERENCE   9  (bases 1 to 935)
  AUTHORS   Dallapiccola,B., Lungarotti,M.S., Falorni,A., Magnani,M. and
            Dacha,M.
  TITLE     Evidence for the assignment of GUK 1 gene locus to 1q32 leads to
            q43 segment from gene dosage effect
  JOURNAL   Ann Genet 23 (2), 83-85 (1980)
   PUBMED   6249178
REFERENCE   10 (bases 1 to 935)
  AUTHORS   Agarwal,K.C., Miech,R.P. and Parks,R.E. Jr.
  TITLE     Guanylate kinases from human erythrocytes, hog brain, and rat liver
  JOURNAL   Methods Enzymol 51, 483-490 (1978)
   PUBMED   211390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM790067.1, BC091480.1 and
            AW083682.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001159390.1.
            
            Summary: The protein encoded by this gene is an enzyme that
            catalyzes the transfer of a phosphate group from ATP to guanosine
            monophosphate (GMP) to form guanosine diphosphate (GDP). The
            encoded protein is thought to be a good target for cancer
            chemotherapy. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (1) contains an alternate coding
            exon in the 3' end compared to variant 5, that causes a frameshift.
            The resulting isoform (a) has a shorter and distinct C-terminus
            compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG701366.1, BC091480.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453943.6/ ENSP00000401832.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BM790067.1         52-80
            30-930              BC091480.1         1-901
            931-935             AW083682.1         5-9                 c
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..935
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /note="guanylate kinase 1"
                     /db_xref="GeneID:2987"
                     /db_xref="HGNC:HGNC:4693"
                     /db_xref="MIM:139270"
     exon            1..85
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..681
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /EC_number="2.7.4.8"
                     /note="isoform a is encoded by transcript variant 1;
                     ATP:GMP phosphotransferase; GMP kinase"
                     /codon_start=1
                     /product="guanylate kinase isoform a"
                     /protein_id="NP_001152862.1"
                     /db_xref="CCDS:CCDS53481.1"
                     /db_xref="GeneID:2987"
                     /db_xref="HGNC:HGNC:4693"
                     /db_xref="MIM:139270"
                     /translation="MLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKR
                     LLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLY
                     GTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNT
                     ETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA
                     "
     exon            86..199
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            200..241
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            242..338
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            339..477
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            478..562
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            563..648
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     exon            649..935
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      906..911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /note="hexamer: AATAAA"
     polyA_site      935
                     /gene="GUK1"
                     /gene_synonym="GMK; MTDPS21"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcgga agaggtggcc ccggatgctg cggcgcccgc tggccgggct ggctgcggcc
       61 gccctgggcc gggccccacc ggacggcatg tcgggcccca ggcctgtggt gctgagcggg
      121 ccttcgggag ctgggaagag caccctgctg aagaggctgc tccaggagca cagcggcatc
      181 tttggcttca gcgtgtccca taccacgagg aacccgaggc ccggcgagga gaacggcaaa
      241 gattactact ttgtaaccag ggaggtgatg cagcgtgaca tagcagccgg cgacttcatc
      301 gagcatgccg agttctcggg gaacctgtat ggcacgagca aggtggcggt gcaggccgtg
      361 caggccatga accgcatctg tgtgctggac gtggacctgc agggtgtgcg gaacatcaag
      421 gccaccgatc tgcggcccat ctacatctct gtgcagccgc cttcactgca cgtgctggag
      481 cagcggctgc ggcagcgcaa cactgaaacc gaggagagcc tggtgaagcg gctggctgct
      541 gcccaggccg acatggagag cagcaaggag cccggcctgt ttgatgtggt catcattaac
      601 gacagcctgg accaggccta cgcagagctg aaggaggcgc tctctgagga aatcaagaaa
      661 gctcaaagga ccggcgcctg aggcttgctg tctgttctcg gcaccccggg cccatacagg
      721 accagggcag cagcattgag ccaccccctt ggcaggcgat acggcagctc tgtgcccttg
      781 gccagcatgt ggagtggagg agatgctgcc cctgtggttg gaacatcctg gggtgacccc
      841 cgacccagcc tcgctgggct gtcccctgtc cctatctctc actctggacc cagggctgac
      901 atcctaataa aataactgtt ggattagaaa ctcca
//
