LOCUS       NM_001522               3728 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens guanylate cyclase 2F, retinal (GUCY2F), mRNA.
ACCESSION   NM_001522
VERSION     NM_001522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3728)
  AUTHORS   Peshenko,I.V., Olshevskaya,E.V. and Dizhoor,A.M.
  TITLE     Retinal degeneration-3 protein attenuates photoreceptor
            degeneration in transgenic mice expressing dominant mutation of
            human retinal guanylyl cyclase
  JOURNAL   J Biol Chem 297 (4), 101201 (2021)
   PUBMED   34537244
  REMARK    GeneRIF: Retinal degeneration-3 protein attenuates photoreceptor
            degeneration in transgenic mice expressing dominant mutation of
            human retinal guanylyl cyclase.
REFERENCE   2  (bases 1 to 3728)
  AUTHORS   Blackford,A., Parmigiani,G., Kensler,T.W., Wolfgang,C., Jones,S.,
            Zhang,X., Parsons,D.W., Lin,J.C., Leary,R.J., Eshleman,J.R.,
            Goggins,M., Jaffee,E.M., Iacobuzio-Donahue,C.A., Maitra,A.,
            Klein,A., Cameron,J.L., Olino,K., Schulick,R., Winter,J.,
            Vogelstein,B., Velculescu,V.E., Kinzler,K.W. and Hruban,R.H.
  TITLE     Genetic mutations associated with cigarette smoking in pancreatic
            cancer
  JOURNAL   Cancer Res 69 (8), 3681-3688 (2009)
   PUBMED   19351817
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3728)
  AUTHORS   Helten,A., Saftel,W. and Koch,K.W.
  TITLE     Expression level and activity profile of membrane bound guanylate
            cyclase type 2 in rod outer segments
  JOURNAL   J Neurochem 103 (4), 1439-1446 (2007)
   PUBMED   17868328
  REMARK    GeneRIF: Mutants of GC-activating protein 2 modulated ROS-GC2 in a
            manner different from their action on ROS-GC1 indicating that the
            Ca2+ sensitivity of the Ca2+ sensor is controlled by the mode of
            target-sensor interaction.
REFERENCE   4  (bases 1 to 3728)
  AUTHORS   Wood,L.D., Calhoun,E.S., Silliman,N., Ptak,J., Szabo,S.,
            Powell,S.M., Riggins,G.J., Wang,T.L., Yan,H., Gazdar,A., Kern,S.E.,
            Pennacchio,L., Kinzler,K.W., Vogelstein,B. and Velculescu,V.E.
  TITLE     Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers
  JOURNAL   Hum Mutat 27 (10), 1060-1061 (2006)
   PUBMED   16941478
  REMARK    GeneRIF: Results show GUCY2F gene was implicated in the
            pathogenesis of breast, lung, and pancreatic cancers and it may be
            useful targets for diagnostic and therapeutic intervention in
            selected patients.
REFERENCE   5  (bases 1 to 3728)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   6  (bases 1 to 3728)
  AUTHORS   Laura,R.P. and Hurley,J.B.
  TITLE     The kinase homology domain of retinal guanylyl cyclases 1 and 2
            specifies the affinity and cooperativity of interaction with
            guanylyl cyclase activating protein-2
  JOURNAL   Biochemistry 37 (32), 11264-11271 (1998)
   PUBMED   9698373
REFERENCE   7  (bases 1 to 3728)
  AUTHORS   Yang,R.B. and Garbers,D.L.
  TITLE     Two eye guanylyl cyclases are expressed in the same photoreceptor
            cells and form homomers in preference to heteromers
  JOURNAL   J Biol Chem 272 (21), 13738-13742 (1997)
   PUBMED   9153227
REFERENCE   8  (bases 1 to 3728)
  AUTHORS   Yang,R.B., Fulle,H.J. and Garbers,D.L.
  TITLE     Chromosomal localization and genomic organization of genes encoding
            guanylyl cyclase receptors expressed in olfactory sensory neurons
            and retina
  JOURNAL   Genomics 31 (3), 367-372 (1996)
   PUBMED   8838319
REFERENCE   9  (bases 1 to 3728)
  AUTHORS   Lowe,D.G., Dizhoor,A.M., Liu,K., Gu,Q., Spencer,M., Laura,R., Lu,L.
            and Hurley,J.B.
  TITLE     Cloning and expression of a second photoreceptor-specific membrane
            retina guanylyl cyclase (RetGC), RetGC-2
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5535-5539 (1995)
   PUBMED   7777544
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031387.4 and L37378.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001522.2.
            
            Summary: The protein encoded by this gene is a guanylyl cyclase
            found predominantly in photoreceptors in the retina. The encoded
            protein is thought to be involved in resynthesis of cGMP after
            light activation of the visual signal transduction cascade,
            allowing a return to the dark state. This protein is a single-pass
            type I membrane protein. Defects in this gene may be a cause of
            X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no transcript sequence was available
            to make the entire refseq consistent with the reference genome
            assembly. The extent of this transcript is supported by transcript
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L37378.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2161674
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218006.3/ ENSP00000218006.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL031387.4         67051-67080
            31-1192             L37378.1           24-1185
            1193-1193           AL031387.4         83850-83850
            1194-3728           L37378.1           1187-3721
FEATURES             Location/Qualifiers
     source          1..3728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3-q23"
     gene            1..3728
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /note="guanylate cyclase 2F, retinal"
                     /db_xref="GeneID:2986"
                     /db_xref="HGNC:HGNC:4691"
                     /db_xref="MIM:300041"
     exon            1..221
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..1036
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3633
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /EC_number="4.6.1.2"
                     /note="guanylate cyclase 2D-like, membrane
                     (retina-specific); guanylate cyclase F; rod outer segment
                     membrane guanylate cyclase 2"
                     /codon_start=1
                     /product="retinal guanylyl cyclase 2"
                     /protein_id="NP_001513.2"
                     /db_xref="CCDS:CCDS14545.1"
                     /db_xref="GeneID:2986"
                     /db_xref="HGNC:HGNC:4691"
                     /db_xref="MIM:300041"
                     /translation="MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSL
                     PQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNE
                     DCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKI
                     SYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGV
                     VLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTY
                     VFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARG
                     EIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQ
                     LMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADA
                     KCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILL
                     TLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIY
                     EGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTE
                     FCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRF
                     VLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIM
                     QEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQ
                     RPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKL
                     LTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYT
                     LFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM
                     PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVT
                     ILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQP
                     VEIAAFQRRKAERQLVRNKP"
     exon            1037..1338
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1693
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1778
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1875
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2007
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2097
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2274
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2431
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2581
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2730
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2894
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3087
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3262
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3361
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3456
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3545
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3634
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3728
                     /gene="GUCY2F"
                     /gene_synonym="CYGF; GC-F; GUC2DL; GUC2F; RETGC-2;
                     ROS-GC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatccaagtc ttggtctgcg gatgctgaag agtgattttc aaaacattta ctaacgcttt
       61 caattattta ccccattaat ggaatttgtc aacagactgg agtccttgac aggattgtga
      121 atgcatagag gatgcaaaga aatggacaca ctgaggtagc tatgccagtg gtctgcatgc
      181 gcaggcagta aactgaagac atttgagcgg tgaattactt ggcatttgga aacaccaccg
      241 tctgtgtcgg gaaagcagaa taactctcca gtatctcgtc attagcttgc tggaagcagg
      301 agggctatgt tcctgggact cgggcgcttt tctcgccttg ttctctggtt tgcggctttc
      361 aggaaactgc tgggacacca tggccttgca tctgccaagt tcctgtggtg cttgtgcctt
      421 ctgtctgtca tgtcccttcc gcagcaggtg tggacactcc cctacaagat aggggtggtg
      481 ggcccttggg cttgtgattc gctgttttca aaggccctgc ctgaggttgc tgcgcgatta
      541 gccattgagc gaatcaaccg ggacccatct tttgacctga gttattcttt tgaatacgtg
      601 attctcaatg aagactgcca gacttcgagg gctctctcca gtttcatttc ccaccaccag
      661 atggcctcag gatttattgg acctaccaac cctggctact gcgaggcagc ctcgctcctg
      721 ggaaacagct gggacaaagg aattttctct tgggcttgtg tgaattatga attagacaat
      781 aaaattagct acccgacctt ttctcggaca ctcccttctc ccatccgggt gcttgtaact
      841 gtcatgaaat atttccagtg ggctcatgct ggagtcattt cctcagatga agacatttgg
      901 gtgcatacag ccaatcgagt cgcaagtgct cttcggagcc acggcttacc tgtaggggtc
      961 gtcctgacca caggacaaga cagccaaagc atgcggaaag ccctccagag gattcaccag
     1021 gcagacagaa ttcgcataat catcatgtgt atgcattcag ctttgattgg gggagagact
     1081 cagatgcatc tcttggaatg tgctcatgat ctgaaaatga ctgatggaac ctacgtcttt
     1141 gttccttatg atgccctgct ctacagttta ccttataagc acacccccta ccgggtccta
     1201 aggaacaacc caaagctccg ggaagcctat gatgcagtgt tgaccattac agtggagtcc
     1261 caagaaaaga ccttctatca agccttcaca gaggcagcag caagaggtga aattcctgag
     1321 aagctggagt tcgatcaagt ttcaccgttg tttggaacca tctacaattc aatttacttt
     1381 atcgcacaag ccatgaataa tgctatgaaa gaaaatggac aggctggtgc tgccagcctg
     1441 gttcagcatt ccagaaacat gcagttccat ggattcaacc agttgatgag gacagattca
     1501 aatggaaatg gaatttcaga atatgtaatc ctggacacca acttgaaaga atgggaactc
     1561 catagcacct acactgtgga catggaaatg gagctgctac gtttcggagg gacccctatt
     1621 cacttccctg gtggcaggcc ccctagagca gatgcaaaat gctggtttgc agaagggaag
     1681 atctgccatg gaggcatcga ccctgccttt gccatgatgg tctgccttac tttgcttata
     1741 gccctgctgt ctattaatgg atttgcttac tttataaggc gtcgtataaa taaaatccag
     1801 ttgatcaaag gacccaatag aattctactg actttggagg atgtaacgtt tatcaatccc
     1861 cactttggca gtaagagagg aagtcgtgcc agtgtaagct tccagattac ctcagaggtc
     1921 caaagtggga ggtccccaag actctccttt tcttcaggga gtctaactcc agctacctat
     1981 gaaaactcca acatagcgat ttatgagggt gattgggtgt ggctgaaaaa gttctccctt
     2041 ggagattttg gagaccttaa gtccatcaaa tcaagagcaa gtgatgtgtt cgaaatgatg
     2101 aaggacttgc gtcatgagaa tattaaccct ttattgggtt tcttctatga ttcggggatg
     2161 tttgccattg tgacagaatt ctgttcccga gggagcctag aagacatact gacaaatcaa
     2221 gatgtgaaac ttgactggat gtttaaatca tcactcttgc tggatctcat aaagggcatg
     2281 aagtacttac accacagaga gtttgttcat gggaggctaa agtctcgaaa ctgtgtggta
     2341 gatgggcgtt ttgtactaaa agtgacagat tatggcttta acgacatctt agaaatgctg
     2401 agactctctg aagaggaatc ttctatggaa gagctgctgt ggacggcccc tgaactgttg
     2461 agagctccaa gaggcagcag gttaggttct tttgcaggag atgtctatag ctttgccatc
     2521 atcatgcaag aagtgatggt ccggggtacc ccattctgca tgatggatct gccagctcaa
     2581 gaaatcataa acagacttaa gaagcctcct cctgtgtaca gaccagtagt tcctcctgag
     2641 catgcccctc cagaatgtct ccagctgatg aagcagtgct gggctgaggc tgcagaacaa
     2701 cgaccaactt ttgatgaaat atttaaccag tttaaaactt ttaataaagg gaagaagacc
     2761 aatattattg attctatgct tcggatgttg gagcaatatt ctagcaactt ggaagatttg
     2821 attcgggagc ggactgaaga gctggaaatt gaaaaacaga aaacggaaaa gcttctaaca
     2881 cagatgctac caccatcagt tgctgaatct ctcaaaaagg gctgcacagt tgaacctgag
     2941 ggctttgact tggtcacctt gtacttcagc gacattgtgg gcttcacaac catttcagcc
     3001 atgagtgagc ccattgaggt cgtggatctt ctgaatgacc tgtacacact ctttgatgca
     3061 ataattggca gtcatgatgt ctacaaggta gagaccattg gagatgccta catggtggct
     3121 tcaggcctcc caaagaggaa tggcagtagg catgcagctg agattgcaaa catgtcctta
     3181 gatatcctga gctctgtggg cactttcaag atgcggcaca tgccagaagt gccggtccga
     3241 attcgaattg gccttcactc agggccggtt gttgctggag tggtgggcct caccatgccc
     3301 agatactgct tgtttggaga cactgtgaac acagcttctc ggatggaatc tacaggctta
     3361 ccttatcgca ttcatgtcag tctcagcact gttacaattc ttcaaaatct gagtgagggc
     3421 tatgaagtgg agcttcgagg aagaacagag ctcaagggca aaggcacaga ggaaaccttc
     3481 tggctgattg ggaaaaaagg cttcatgaag ccccttcctg tgcccccacc agtggacaaa
     3541 gatgggcaag tgggccatgg cctgcaacca gtggagattg cagccttcca aagaagaaaa
     3601 gcagaaaggc agttggtgag aaacaagcca taaggggcaa agggctccag gatttgaatc
     3661 ttctcttggt gaggcaatgg gaaagctcac ttcagttcaa gaaattgttc tgcctgggca
     3721 agaaatta
//
