LOCUS       NM_004963               3858 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.
ACCESSION   NM_004963
VERSION     NM_004963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3858)
  AUTHORS   Rampuria,P., Mosyak,L., Root,A.R., Svenson,K., Agostino,M.J. and
            LaVallie,E.R.
  TITLE     Molecular insights into recognition of GUCY2C by T-cell engaging
            bispecific antibody anti-GUCY2CxCD3
  JOURNAL   Sci Rep 13 (1), 13408 (2023)
   PUBMED   37591971
  REMARK    GeneRIF: Molecular insights into recognition of GUCY2C by T-cell
            engaging bispecific antibody anti-GUCY2CxCD3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3858)
  AUTHORS   Caveney,N.A., Tsutsumi,N. and Garcia,K.C.
  TITLE     Structural insight into guanylyl cyclase receptor hijacking of the
            kinase-Hsp90 regulatory mechanism
  JOURNAL   Elife 12, 86784 (2023)
   PUBMED   37535399
  REMARK    GeneRIF: Structural insight into guanylyl cyclase receptor
            hijacking of the kinase-Hsp90 regulatory mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3858)
  AUTHORS   Barton,J.R., Londregan,A.K., Alexander,T.D., Entezari,A.A.,
            Bar-Ad,S., Cheng,L., Lepore,A.C., Snook,A.E., Covarrubias,M. and
            Waldman,S.A.
  TITLE     Intestinal neuropod cell GUCY2C regulates visceral pain
  JOURNAL   J Clin Invest 133 (4), e165578 (2023)
   PUBMED   36548082
  REMARK    GeneRIF: Intestinal neuropod cell GUCY2C regulates visceral pain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3858)
  AUTHORS   Cohen,M.B., Gold,B.D., Xanthakos,S.A., CaJacob,N., Weissman,T.,
            Bartolini,W., Boinpally,R., Mallick,M., Reasner,D.S., O'Dea,C.R.,
            Kwak,H. and Ge,P.
  TITLE     Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum and
            Colon of Children
  JOURNAL   J Pediatr Gastroenterol Nutr 73 (6), 703-709 (2021)
   PUBMED   34508047
  REMARK    GeneRIF: Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum
            and Colon of Children.
REFERENCE   5  (bases 1 to 3858)
  AUTHORS   Satoh,T., Wang,L., Espinosa-Diez,C., Wang,B., Hahn,S.A., Noda,K.,
            Rochon,E.R., Dent,M.R., Levine,A.R., Baust,J.J., Wyman,S., Wu,Y.L.,
            Triantafyllou,G.A., Tang,Y., Reynolds,M., Shiva,S., Hilaire,C.S.,
            Gomez,D., Goncharov,D.A., Goncharova,E.A., Chan,S.Y., Straub,A.C.,
            Lai,Y.C., McTiernan,C.F. and Gladwin,M.T.
  TITLE     Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent
            Downregulation of Soluble Guanylate Cyclase and Contributes to
            Exercise-Induced Pulmonary Hypertension in Heart Failure With
            Preserved Ejection Fraction
  JOURNAL   Circulation 144 (8), 615-637 (2021)
   PUBMED   34157861
  REMARK    GeneRIF: Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent
            Downregulation of Soluble Guanylate Cyclase and Contributes to
            Exercise-Induced Pulmonary Hypertension in Heart Failure With
            Preserved Ejection Fraction.
REFERENCE   6  (bases 1 to 3858)
  AUTHORS   Mann,E.A., Jump,M.L. and Glenella,R.A.
  TITLE     Cell line-specific transcriptional activation of the promoter of
            the human guanylyl cyclase C/heat-stable enterotoxin/receptor gene
  JOURNAL   Biochim Biophys Acta 1305 (1-2), 7-10 (1996)
   PUBMED   8605253
REFERENCE   7  (bases 1 to 3858)
  AUTHORS   Sugawara,T., Holt,J.A., Driscoll,D., Strauss,J.F. 3rd, Lin,D.,
            Miller,W.L., Patterson,D., Clancy,K.P., Hart,I.M., Clark,B.J. et
            al.
  TITLE     Human steroidogenic acute regulatory protein: functional activity
            in COS-1 cells, tissue-specific expression, and mapping of the
            structural gene to 8p11.2 and a pseudogene to chromosome 13
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 4778-4782 (1995)
   PUBMED   7761400
REFERENCE   8  (bases 1 to 3858)
  AUTHORS   Mann,E.A., Cohen,M.B. and Giannella,R.A.
  TITLE     Comparison of receptors for Escherichia coli heat-stable
            enterotoxin: novel receptor present in IEC-6 cells
  JOURNAL   Am J Physiol 264 (1 Pt 1), G172-G178 (1993)
   PUBMED   8381596
REFERENCE   9  (bases 1 to 3858)
  AUTHORS   Singh,S., Singh,G., Heim,J.M. and Gerzer,R.
  TITLE     Isolation and expression of a guanylate cyclase-coupled heat stable
            enterotoxin receptor cDNA from a human colonic cell line
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1455-1463 (1991)
   PUBMED   1718270
REFERENCE   10 (bases 1 to 3858)
  AUTHORS   de Sauvage,F.J., Camerato,T.R. and Goeddel,D.V.
  TITLE     Primary structure and functional expression of the human receptor
            for Escherichia coli heat-stable enterotoxin
  JOURNAL   J Biol Chem 266 (27), 17912-17918 (1991)
   PUBMED   1680854
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010168.6, AW848739.1,
            M73489.1, AC007545.13 and S57551.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004963.3.
            
            Summary: This gene encodes a transmembrane protein that functions
            as a receptor for endogenous peptides guanylin and uroguanylin, and
            the heat-stable E. coli enterotoxin. The encoded protein activates
            the cystic fibrosis transmembrane conductance regulator. Mutations
            in this gene are associated with familial diarrhea (autosomal
            dominant) and meconium ileus (autosomal recessive). [provided by
            RefSeq, Nov 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M73489.1, S57551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261170.5/ ENSP00000261170.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC010168.6         94575-94588
            15-104              AW848739.1         1-90
            105-993             M73489.1           2-890
            994-994             AC007545.13        72973-72973         c
            995-2172            M73489.1           892-2069
            2173-2173           AC007545.13        37142-37142         c
            2174-3848           M73489.1           2071-3745
            3849-3858           S57551.1           3772-3781
FEATURES             Location/Qualifiers
     source          1..3858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..3858
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /note="guanylate cyclase 2C"
                     /db_xref="GeneID:2984"
                     /db_xref="HGNC:HGNC:4688"
                     /db_xref="MIM:601330"
     exon            1..368
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3373
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /EC_number="4.6.1.2"
                     /note="heat-stable enterotoxin receptor; guanylyl cyclase
                     C; STA receptor; intestinal guanylate cyclase"
                     /codon_start=1
                     /product="guanylyl cyclase C precursor"
                     /protein_id="NP_004954.2"
                     /db_xref="CCDS:CCDS8664.1"
                     /db_xref="GeneID:2984"
                     /db_xref="HGNC:HGNC:4688"
                     /db_xref="MIM:601330"
                     /translation="MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGN
                     SAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEG
                     LDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRL
                     MSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSH
                     ELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLF
                     NDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGH
                     MLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYK
                     VLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVA
                     LLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKY
                     DKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCER
                     GSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDS
                     RMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYT
                     LSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKK
                     IETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNF
                     MLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSF
                     DHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPG
                     LPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL
                     KRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMI
                     ANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF"
     exon            369..481
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            482..546
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            547..762
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            763..884
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            885..981
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1099
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1235
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1321
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1433
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1515
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1621
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1684
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1756
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1861
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1948
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2081
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2219
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2308
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2400
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2559
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2752
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2927
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3026
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3121
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3198
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3858
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /note="hexamer: AATAAA"
     polyA_site      3858
                     /gene="GUCY2C"
                     /gene_synonym="DIAR6; GC-C; GCC; GUC2C; HSER; MECIL;
                     MUCIL; STAR"
                     /note="major polyA site"
ORIGIN      
        1 gaccagttgg gcatgaccag agagaagcgt ggggaagagt gggctgaggg actccactag
       61 aggctgtcca tctggattcc ctgcctccct aggagcccaa cagagcaaag caagtgggca
      121 caaggagtat ggttctaacg tgattggggt catgaagacg ttgctgttgg acttggcttt
      181 gtggtcactg ctcttccagc ccgggtggct gtcctttagt tcccaggtga gtcagaactg
      241 ccacaatggc agctatgaaa tcagcgtcct gatgatgggc aactcagcct ttgcagagcc
      301 cctgaaaaac ttggaagatg cggtgaatga ggggctggaa atagtgagag gacgtctgca
      361 aaatgctggc ctaaatgtga ctgtgaacgc tactttcatg tattcggatg gtctgattca
      421 taactcaggc gactgccgga gtagcacctg tgaaggcctc gacctactca ggaaaatttc
      481 aaatgcacaa cggatgggct gtgtcctcat agggccctca tgtacatact ccaccttcca
      541 gatgtacctt gacacagaat tgagctaccc catgatctca gctggaagtt ttggattgtc
      601 atgtgactat aaagaaacct taaccaggct gatgtctcca gctagaaagt tgatgtactt
      661 cttggttaac ttttggaaaa ccaacgatct gcccttcaaa acttattcct ggagcacttc
      721 gtatgtttac aagaatggta cagaaactga ggactgtttc tggtacctta atgctctgga
      781 ggctagcgtt tcctatttct cccacgaact cggctttaag gtggtgttaa gacaagataa
      841 ggagtttcag gatatcttaa tggaccacaa caggaaaagc aatgtgatta ttatgtgtgg
      901 tggtccagag ttcctctaca agctgaaggg tgaccgagca gtggctgaag acattgtcat
      961 tattctagtg gatcttttca atgaccagta ctttgaggac aatgtcacag cccctgacta
     1021 tatgaaaaat gtccttgttc tgacgctgtc tcctgggaat tcccttctaa atagctcttt
     1081 ctccaggaat ctatcaccaa caaaacgaga ctttgctctt gcctatttga atggaatcct
     1141 gctctttgga catatgctga agatatttct tgaaaatgga gaaaatatta ccacccccaa
     1201 atttgctcat gctttcagga atctcacttt tgaagggtat gacggtccag tgaccttgga
     1261 tgactggggg gatgttgaca gtaccatggt gcttctgtat acctctgtgg acaccaagaa
     1321 atacaaggtt cttttgacct atgataccca cgtaaataag acctatcctg tggatatgag
     1381 ccccacattc acttggaaga actctaaact tcctaatgat attacaggcc ggggccctca
     1441 gatcctgatg attgcagtct tcaccctcac tggagctgtg gtgctgctcc tgctcgtcgc
     1501 tctcctgatg ctcagaaaat atagaaaaga ttatgaactt cgtcagaaaa aatggtccca
     1561 cattcctcct gaaaatatct ttcctctgga gaccaatgag accaatcatg ttagcctcaa
     1621 gatcgatgat gacaaaagac gagatacaat ccagagacta cgacagtgca aatacgacaa
     1681 aaagcgagtg attctcaaag atctcaagca caatgatggt aatttcactg aaaaacagaa
     1741 gatagaattg aacaagttgc ttcagattga ctattacaac ctgaccaagt tctacggcac
     1801 agtgaaactt gataccatga tcttcggggt gatagaatac tgtgagagag gatccctccg
     1861 ggaagtttta aatgacacaa tttcctaccc tgatggcaca ttcatggatt gggagtttaa
     1921 gatctctgtc ttgtatgaca ttgctaaggg aatgtcatat ctgcactcca gtaagacaga
     1981 agtccatggt cgtctgaaat ctaccaactg cgtagtggac agtagaatgg tggtgaagat
     2041 cactgatttt ggctgcaatt ccattttacc tccaaaaaag gacctgtgga cagctccaga
     2101 gcacctccgc caagccaaca tctctcagaa aggagatgtg tacagctatg ggatcatcgc
     2161 acaggagatc atcctgcgga aagaaacctt ctacactttg agctgtcggg accggaatga
     2221 gaagattttc agagtggaaa attccaatgg aatgaaaccc ttccgcccag atttattctt
     2281 ggaaacagca gaggaaaaag agctagaagt gtacctactt gtaaaaaact gttgggagga
     2341 agatccagaa aagagaccag atttcaaaaa aattgagact acacttgcca agatatttgg
     2401 actttttcat gaccaaaaaa atgaaagcta tatggatacc ttgatccgac gtctacagct
     2461 atattctcga aacctggaac atctggtaga ggaaaggaca cagctgtaca aggcagagag
     2521 ggacagggct gacagactta actttatgtt gcttccaagg ctagtggtaa agtctctgaa
     2581 ggagaaaggc tttgtggagc cggaactata tgaggaagtt acaatctact tcagtgacat
     2641 tgtaggtttc actactatct gcaaatacag cacccccatg gaagtggtgg acatgcttaa
     2701 tgacatctat aagagttttg accacattgt tgatcatcat gatgtctaca aggtggaaac
     2761 catcggtgat gcgtacatgg tggctagtgg tttgcctaag agaaatggca atcggcatgc
     2821 aatagacatt gccaagatgg ccttggaaat cctcagcttc atggggacct ttgagctgga
     2881 gcatcttcct ggcctcccaa tatggattcg cattggagtt cactctggtc cctgtgctgc
     2941 tggagttgtg ggaatcaaga tgcctcgtta ttgtctattt ggagatacgg tcaacacagc
     3001 ctctaggatg gaatccactg gcctcccttt gagaattcac gtgagtggct ccaccatagc
     3061 catcctgaag agaactgagt gccagttcct ttatgaagtg agaggagaaa catacttaaa
     3121 gggaagagga aatgagacta cctactggct gactgggatg aaggaccaga aattcaacct
     3181 gccaacccct cctactgtgg agaatcaaca gcgtttgcaa gcagaatttt cagacatgat
     3241 tgccaactct ttacagaaaa gacaggcagc agggataaga agccaaaaac ccagacgggt
     3301 agccagctat aaaaaaggca ctctggaata cttgcagctg aataccacag acaaggagag
     3361 cacctatttt taaacctaaa tgaggtataa ggactcacac aaattaaaat acagctgcac
     3421 tgaggcagcg acctcaagtg tcctgaaagc ttacattttc ctgagacctc aatgaagcag
     3481 aaatgtactt aggcttggct gccctgtctg gaacatggac tttcttgcat gaatcagatg
     3541 tgtgttctca gtgaaataac taccttccac tctggaacct tattccagca gttgttccag
     3601 ggagcttcta cctggaaaag aaaagaaatg aatagactat ctagaacttg agaagatttt
     3661 attcttattt catttatttt ttgtttgttt atttttatcg tttttgttta ctggctttcc
     3721 ttctgtattc ataagatttt ttaaattgtc ataattatat tttaaatacc catcttcatt
     3781 aaagtatatt taactcataa tttttgcaga aaatatgcta tatattaggc aagaataaaa
     3841 gctaaaggtt tcccaaaa
//
