LOCUS       NM_001284254            3435 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens guanylyl cyclase domain containing 1 (GUCD1),
            transcript variant 5, mRNA.
ACCESSION   NM_001284254 XM_005261758
VERSION     NM_001284254.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   He,Y. and He,X.
  TITLE     MicroRNA-370 Regulates Cellepithelial-Mesenchymal Transition,
            Migration, Invasion, and Prognosis of Hepatocellular Carcinoma by
            Targeting GUCD1
  JOURNAL   Yonsei Med J 60 (3), 267-276 (2019)
   PUBMED   30799589
  REMARK    GeneRIF: miR-370 suppressed Hepatocellular carcinoma cell
            metastasis and epithelial-mesenchymal transition via regulating
            GUCD1.
            Erratum:[Yonsei Med J. 2019 Apr;60(4):402. doi:
            10.3349/ymj.2019.60.4.402.. PMID: 30900430]
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   Bellet,M.M., Piobbico,D., Bartoli,D., Castelli,M., Pieroni,S.,
            Brunacci,C., Chiacchiaretta,M., Del Sordo,R., Fallarino,F.,
            Sidoni,A., Puccetti,P., Romani,L., Servillo,G. and Della Fazia,M.A.
  TITLE     NEDD4 controls the expression of GUCD1, a protein upregulated in
            proliferating liver cells
  JOURNAL   Cell Cycle 13 (12), 1902-1911 (2014)
   PUBMED   24743017
  REMARK    GeneRIF: The expression and function of a ubiquitous protein,
            GUCD1, were characterized, it might have a role in regulating
            normal and abnormal cell growth in the liver.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA776135.1, BC070109.1, DA937738.1, BC041568.1 and AK025242.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001284254.1.
            
            Transcript Variant: This variant (5) contains an alternate 5'
            terminal exon and it thus differs in the 5' UTR and 5' coding
            region, and it uses an alternate in-frame splice site in the 3'
            coding region, compared to variant 1. The encoded isoform (e) has a
            distinct N-terminus and is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070109.1, SRR18074969.1594865.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435822.6/ ENSP00000405985.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA776135.1         45-65
            22-932              BC070109.1         196-1106
            933-1319            DA937738.1         145-531
            1320-1510           BC041568.1         143-333
            1511-3435           AK025242.1         545-2469
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..3435
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /note="guanylyl cyclase domain containing 1"
                     /db_xref="GeneID:83606"
                     /db_xref="HGNC:HGNC:14237"
                     /db_xref="MIM:619171"
     exon            1..190
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..867
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /note="isoform e is encoded by transcript variant 5;
                     CG13760 gene product [Drosophila melanogaster] homolog;
                     guanylyl cyclase domain-containing protein 1; protein
                     GUCD1"
                     /codon_start=1
                     /product="protein GUCD1 isoform e"
                     /protein_id="NP_001271183.1"
                     /db_xref="CCDS:CCDS63426.1"
                     /db_xref="GeneID:83606"
                     /db_xref="HGNC:HGNC:14237"
                     /db_xref="MIM:619171"
                     /translation="MRTEAEAAGPPLEPGDFVQLPVPVIQQLYHWDCGLACSRMVLRY
                     LGQLDDSEFERALQKLQLTRSIWTIDLAYLMHHFGVRHRFCTQTLGVDKGYKNQSFYR
                     KHFDTEETRVNQLFAQAKACKVLVEKCTVSVKDIQAHLAQGHVAIVLVNSGVLHCDLC
                     SSPVKYCCFTPSGHHCFCRTPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISN
                     FEEARTSYGTDEDILFVYLDS"
     exon            191..275
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     exon            276..441
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     exon            442..533
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..775
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     exon            776..3435
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3411..3416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="GUCD1"
                     /gene_synonym="C22orf13; LLN4"
                     /note="major polyA site"
ORIGIN      
        1 agccgccgcc tcccgttctc tcctccgcag cggcggcggt ggcggagaag gaactcgaca
       61 cgcaccgacc gccctcccgc cccagccgaa gcggaagctg tagcccgctc tgggccgggg
      121 ccatgggcgc cccgcgccgc ccgggtcatg aggacggagg cggaggcagc ggggccgccg
      181 ctcgagcccg gggactttgt gcaactgcct gtgcccgtca tccagcagct ctaccactgg
      241 gactgtggcc tggcctgctc caggatggtg ctgcggtacc tgggccagct ggacgacagt
      301 gagtttgaga gagccctgca gaagctgcag ctgaccagga gcatctggac catcgacctg
      361 gcctacctga tgcaccactt tggcgtgagg caccgcttct gtacccagac cctgggtgtc
      421 gacaagggct acaagaacca gtccttctac aggaagcact ttgacacaga agagacccgg
      481 gtgaatcagc tgtttgcaca agcaaaggcc tgcaaggtgc tggtggagaa atgcacagtg
      541 agtgtgaagg acatccaggc gcacctggct cagggccatg tggccatcgt gctggtgaac
      601 tcgggggtgc tgcactgtga cctgtgctcc agccctgtca agtactgctg cttcaccccc
      661 agtggccacc actgcttctg ccgcactcct gactaccagg gccacttcat cgtgctgcgt
      721 ggctacaacc gggccactgg ctgcatcttc tacaacaacc cagcctatgc cgaccgaatg
      781 tgcagcacca gcatcagtaa ctttgaggag gccagaacca gctatggcac agatgaggac
      841 atcctctttg tctacttgga cagctgacag caggagcctg gtgcgcctag gccctcggac
      901 cccatcccca ccccagccgg gcccgctcag gatgccctgg cccaggcttg gggctgctgg
      961 ggttggaatg tggaactgca gcctcagccc atctggcaga gtcccaggaa ctcggagact
     1021 ggcacagctg ctttgtctgc cagtgccgtg tgttgtcatg tcactcaccc caagcacctg
     1081 ctggctgctg gaagcatacc ccaagacccc aagccttgac tccagctgcg cccacaggaa
     1141 gtccagtccc gacagtgccc ttgttgcctt tgagccagat ccatggcaat ggtctcccca
     1201 cagaccgcag gactgagcct ggagagagaa gttgcttgac ggatgccact tgtcaggaca
     1261 gtatgtgagt gtctggagac agcatagctg accccaatcc cccagggctg aggacccctc
     1321 caggcccctc tctcctggaa gtgctgcata tgcccctgtg cccagtggtt gatgatacca
     1381 ccaccacctg cctacccatg ggcccaagtt tctgtggctc attacagggc atctgacccc
     1441 tgccacccag catagacaca cctcacagct gccctgccat gcagagccct ggccgctgga
     1501 gactcttaaa gcccccacag ccctccaggt cctccagctc tgtcagatgg agggctctcg
     1561 ggcctagatc ccactggtag gcctcgtggc tggcagcagt gctctgggaa taaacagctg
     1621 ccctagcccc agagggatcc ctgcacccag gaggcctcct gacaccagcc aaaatcctga
     1681 cagcagggtc tgccctcttg agtgtgggga gcccctagtc ctttaaggtt ggctgctaag
     1741 gcctgtgctc caaagcaacg ggctggggca gcctgcagct gcccacccaa cctggtcttc
     1801 acaccagatt gcacaggata ctgggtcttg tctatcttga tggagaagag gggttcctgc
     1861 ccaggatctt acaacacagc aagtagcata gagctctttc cttcctcttt tttggggagg
     1921 ttggggtcag gggttgtttc tttgagattt aagttttcat ttttgagggg taatcacctt
     1981 caagtaaaac agtaatagca agagtgaagg tactttggaa ccactaacac ctctgcacag
     2041 ggcagttagc cagctcaagt tctttttcag agaaagggac ttggccagtg gtttaagtac
     2101 ctgccccttc acctctcaga cgaggcagct gacgaggcag ctggcccagt cttgggagtc
     2161 tgctcaggac agtggtggag ctgggtcttg aaccccagtc tgcacctaaa aaactaaagg
     2221 aaatggattt tttttttttt ttttgagacg gagactcact ctgttgccca gactggagtg
     2281 cagtggcacg atcttggctt actacaacct ccgcctcctg ggttcaagcg atcctcctgc
     2341 ctcagccccc cactagctgg gactacaggc acatgccacc atgcccggct aatttttttg
     2401 tatttttagt agagaccagg cttcgccatg ttggccaggc tggtctcgaa cccctgagct
     2461 caggtgatcc acctgcctcg gcctcccaaa gtgggaaatg ggtcattttc aaaggggcaa
     2521 cagtgatacc atccctgcac tcctgggtcc tgctcttcca atgcccaagg catggcatgg
     2581 tggcagctgt gcccccgccc attgctttgg agcacagatg actctggggg cagaggtggg
     2641 ctctgtttag gagggcagtg agaccaccca gccaaattgc ttctcaaccc tagacaaagc
     2701 ctttggccaa gagggaggtg ctgttagttg ggcagccctt ctgggtttca gagaccggtg
     2761 ttggctctag actggtctca tctccattgc cttaatgcca ggtggcccag gagtacccat
     2821 gcacagcagc tgtggggtgt gggcatcttc aggtggtgtt ctggtaaaat tgttagaata
     2881 gctgtatgaa ggaaaccagt gggaggaaat gaagttttca ggatggtggg atgtgattta
     2941 gacagtgcac atgctgttag ggctgtcact agggagtggc cttcatggag ggtggtaaca
     3001 gcacctcagt ccagccaaaa tgtttagaaa cactcagtct ctggtcccag aggatggctt
     3061 ctcagggcat gccacaagtt aaaggtcacc ttcctgaaag atgaatgaga aagctgccca
     3121 ttctcaagac tcatctgcct agggagggtc acagaggcag gatgtaagac acactgtgtt
     3181 gcattcttgc acaagtcatg aaaatggagc cagagagcct ggacatcagg gacttttgcc
     3241 cacagcacat gacaccgaca gctgcccagc ctgttcacat gctggggacc agcacagcac
     3301 ctgaagccat gtgggacagt tgggctttgt tcattctagc cacggggatg aaagggatct
     3361 tttgcattgc agagatttta tatatatttt gtttgtaatg agccattctc aataaacatt
     3421 attctcactg caaaa
//
