LOCUS       NM_007102                604 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens guanylate cyclase activator 2B (GUCA2B), mRNA.
ACCESSION   NM_007102
VERSION     NM_007102.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Fruhbeck,G., Becerril,S., Martin,M., Ramirez,B., Valenti,V.,
            Moncada,R., Catalan,V., Gomez-Ambrosi,J., Silva,C., Burrell,M.A.,
            Escalada,J. and Rodriguez,A.
  TITLE     High plasma and lingual uroguanylin as potential contributors to
            changes in food preference after sleeve gastrectomy
  JOURNAL   Metabolism 128, 155119 (2022)
   PUBMED   34990711
  REMARK    GeneRIF: High plasma and lingual uroguanylin as potential
            contributors to changes in food preference after sleeve
            gastrectomy.
REFERENCE   2  (bases 1 to 604)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 604)
  AUTHORS   Folgueira,C., Barja-Fernandez,S., Gonzalez-Saenz,P., Castelao,C.,
            Vazquez-Cobela,R., Pena-Leon,V., Ruiz-Pinon,M., Casanueva,F.F.,
            Dieguez,C., Leis,R., Nogueiras,R. and Seoane,L.M.
  TITLE     Circulating Pro-Uroguanylin Levels In Children And Their Relation
            To Obesity, Sex And Puberty
  JOURNAL   Sci Rep 8 (1), 14541 (2018)
   PUBMED   30266914
  REMARK    GeneRIF: This study investigates pro-uroguanylin circulating levels
            in children with obesity and its relationship with obesity, sex and
            pubertal development. Sexual dimorphism exists in circulating
            pro-uroguanylin levels with respect to Body Mass Index.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 604)
  AUTHORS   Fernandez-Cachon,M.L., Pedersen,S.L., Rigbolt,K.T., Zhang,C.,
            Fabricius,K., Hansen,H.H., Elster,L., Fink,L.N., Schafer,M.,
            Rhee,N.A., Langholz,E., Wandall,E., Friis,S.U., Vilmann,P.,
            Kristiansen,V.B., Schmidt,C., Schreiter,K., Breitschopf,K.,
            Hubschle,T., Jorsal,T., Vilsboll,T., Schmidt,T., Theis,S.,
            Knop,F.K., Larsen,P.J. and Jelsing,J.
  TITLE     Guanylin and uroguanylin mRNA expression is increased following
            Roux-en-Y gastric bypass, but guanylins do not play a significant
            role in body weight regulation and glycemic control
  JOURNAL   Peptides 101, 32-43 (2018)
   PUBMED   29289697
  REMARK    GeneRIF: Guanylin and uroguanylin, as well as their prohormones, do
            not seem to play a significant role in body weight regulation and
            glycemic control, suggesting that guanylin-family peptides do not
            show promise as targets for the treatment of obesity or diabetes.
REFERENCE   5  (bases 1 to 604)
  AUTHORS   Rahbi,H., Narayan,H., Jones,D.J. and Ng,L.L.
  TITLE     The uroguanylin system and human disease
  JOURNAL   Clin Sci (Lond) 123 (12), 659-668 (2012)
   PUBMED   22877138
  REMARK    Review article
REFERENCE   6  (bases 1 to 604)
  AUTHORS   Miyazato,M., Nakazato,M., Matsukura,S., Kangawa,K. and Matsuo,H.
  TITLE     Genomic structure and chromosomal localization of human uroguanylin
  JOURNAL   Genomics 43 (3), 359-365 (1997)
   PUBMED   9268639
REFERENCE   7  (bases 1 to 604)
  AUTHORS   Miyazato,M., Nakazato,M., Yamaguchi,H., Date,Y., Kojima,M.,
            Kangawa,K., Matsuo,H. and Matsukura,S.
  TITLE     Cloning and characterization of a cDNA encoding a precursor for
            human uroguanylin
  JOURNAL   Biochem Biophys Res Commun 219 (2), 644-648 (1996)
   PUBMED   8605041
REFERENCE   8  (bases 1 to 604)
  AUTHORS   Hill,O., Cetin,Y., Cieslak,A., Magert,H.J. and Forssmann,W.G.
  TITLE     A new human guanylate cyclase-activating peptide (GCAP-II,
            uroguanylin): precursor cDNA and colonic expression
  JOURNAL   Biochim Biophys Acta 1253 (2), 146-149 (1995)
   PUBMED   8519795
REFERENCE   9  (bases 1 to 604)
  AUTHORS   Hess,R., Kuhn,M., Schulz-Knappe,P., Raida,M., Fuchs,M., Klodt,J.,
            Adermann,K., Kaever,V., Cetin,Y. and Forssmann,W.G.
  TITLE     GCAP-II: isolation and characterization of the circulating form of
            human uroguanylin
  JOURNAL   FEBS Lett 374 (1), 34-38 (1995)
   PUBMED   7589507
REFERENCE   10 (bases 1 to 604)
  AUTHORS   Kita,T., Smith,C.E., Fok,K.F., Duffin,K.L., Moore,W.M.,
            Karabatsos,P.J., Kachur,J.F., Hamra,F.K., Pidhorodeckyj,N.V.,
            Forte,L.R. et al.
  TITLE     Characterization of human uroguanylin: a member of the guanylin
            peptide family
  JOURNAL   Am J Physiol 266 (2 Pt 2), F342-F348 (1994)
   PUBMED   8141334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114492.6, U34279.1, BC093781.1 and Z50753.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007102.2.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate multiple protein products, including
            uroguanylin, a member of the guanylin family of peptides and an
            endogenous ligand of the guanylate cyclase-C receptor. Binding of
            this peptide to its cognate receptor stimulates an increase in
            cyclic GMP and may regulate salt and water homeostasis in the
            intestine and kidneys. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279826.2155.1, U34279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372581.2/ ENSP00000361662.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC114492.6         90632-90642
            12-18               U34279.1           1-7
            19-58               BC093781.1         1-40
            59-603              Z50753.1           39-583
            604-604             U34279.1           592-592
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..604
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /note="guanylate cyclase activator 2B"
                     /db_xref="GeneID:2981"
                     /db_xref="HGNC:HGNC:4683"
                     /db_xref="MIM:601271"
     exon            1..131
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..380
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /note="uroguanylin; prepro-uroguanylin"
                     /codon_start=1
                     /product="guanylate cyclase activator 2B preproprotein"
                     /protein_id="NP_009033.1"
                     /db_xref="CCDS:CCDS464.1"
                     /db_xref="GeneID:2981"
                     /db_xref="HGNC:HGNC:4683"
                     /db_xref="MIM:601271"
                     /translation="MGCRAASGLLPGVAVVLLLLLQSTQSVYIQYQGFRVQLESMKKL
                     SDLEAQWAPSPRLQAQSLLPAVCHHPALPQDLQPVCASQEASSIFKTLRTIANDDCEL
                     CVNVACTGCL"
     exon            132..318
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /inference="alignment:Splign:2.1.0"
     exon            319..604
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      587..592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /note="hexamer: AATAAA"
     polyA_site      604
                     /gene="GUCA2B"
                     /gene_synonym="GCAP-II; UGN"
                     /note="major polyA site"
ORIGIN      
        1 gggagacggt ggacagcggc agggggaacc cagggagcgc gatgggctgc agggctgcat
       61 cagggctcct gccaggagtg gccgtggtcc tcctgctgct gctgcagagc acacagtcag
      121 tctacatcca gtaccaaggc ttccgggtcc agctggaatc catgaagaag ctgagtgacc
      181 tggaggcaca gtgggcaccc agcccccgcc tgcaggccca gagcctcctg cccgccgtgt
      241 gccaccaccc tgctctgcct caggaccttc agcctgtctg cgcctcgcag gaggcttcca
      301 gcatcttcaa gaccctgagg accatcgcta acgacgactg tgagctgtgt gtgaacgttg
      361 cgtgtaccgg ctgcctctga gatagccctg ggtaccctga gcccaccagg gacacctcgc
      421 ccttcagccc accaccctgg caggcttcca tccccgtcca tgctcaagat gggtccctgg
      481 ccaccatggt catcaccacc cttccagggc ctgagcagct ggatctggta caaagcaatc
      541 ggacatagag ttggaggggg aggcccctga ggcagcccag ctcctgaata aagattctac
      601 aaca
//
