LOCUS       NM_005459                977 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens guanylate cyclase activator 1C (GUCA1C), transcript
            variant 1, mRNA.
ACCESSION   NM_005459 XM_946373
VERSION     NM_005459.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Avesani,A., Bielefeld,L., Weisschuh,N., Marino,V., Mazzola,P.,
            Stingl,K., Haack,T.B., Koch,K.W. and Dell'Orco,D.
  TITLE     Molecular Properties of Human Guanylate Cyclase-Activating Protein
            3 (GCAP3) and Its Possible Association with Retinitis Pigmentosa
  JOURNAL   Int J Mol Sci 23 (6), 3240 (2022)
   PUBMED   35328663
  REMARK    GeneRIF: Molecular Properties of Human Guanylate Cyclase-Activating
            Protein 3 (GCAP3) and Its Possible Association with Retinitis
            Pigmentosa.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Morales-Camara,S., Alexandre-Moreno,S., Bonet-Fernandez,J.M.,
            Atienzar-Aroca,R., Aroca-Aguilar,J.D., Ferre-Fernandez,J.J.,
            Mendez,C.D., Morales,L., Fernandez-Sanchez,L., Cuenca,N.,
            Coca-Prados,M., Martinez-de-la-Casa,J.M., Garcia-Feijoo,J. and
            Escribano,J.
  TITLE     Role of GUCA1C in Primary Congenital Glaucoma and in the Retina:
            Functional Evaluation in Zebrafish
  JOURNAL   Genes (Basel) 11 (5), 550 (2020)
   PUBMED   32422965
  REMARK    GeneRIF: Role of GUCA1C in Primary Congenital Glaucoma and in the
            Retina: Functional Evaluation in Zebrafish.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Stephen,R., Palczewski,K. and Sousa,M.C.
  TITLE     The crystal structure of GCAP3 suggests molecular mechanism of
            GCAP-linked cone dystrophies
  JOURNAL   J Mol Biol 359 (2), 266-275 (2006)
   PUBMED   16626734
  REMARK    GeneRIF: Results report the crystal structure of unmyristoylated
            human guanylate cyclase-activating protein 3 (GCAP3) with calcium
            bound.
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Imanishi,Y., Li,N., Sokal,I., Sowa,M.E., Lichtarge,O., Wensel,T.G.,
            Saperstein,D.A., Baehr,W. and Palczewski,K.
  TITLE     Characterization of retinal guanylate cyclase-activating protein 3
            (GCAP3) from zebrafish to man
  JOURNAL   Eur J Neurosci 15 (1), 63-78 (2002)
   PUBMED   11860507
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Haeseleer,F., Sokal,I., Li,N., Pettenati,M., Rao,N., Bronson,D.,
            Wechter,R., Baehr,W. and Palczewski,K.
  TITLE     Molecular characterization of a third member of the guanylyl
            cyclase-activating protein subfamily
  JOURNAL   J Biol Chem 274 (10), 6526-6535 (1999)
   PUBMED   10037746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016948.4, AV732101.1, AF110002.1, AF110003.1, C20850.1 and
            AC080135.16.
            
            On Nov 23, 2018 this sequence version replaced NM_005459.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110002.1, AB593147.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261047.8/ ENSP00000261047.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC016948.4         37309-37357         c
            50-106              AV732101.1         1-57
            107-330             AF110002.1         1-224
            331-559             AF110003.1         153-381
            560-966             AF110002.1         454-860
            967-974             C20850.1           60-67
            975-977             AC080135.16        10751-10753
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..977
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /note="guanylate cyclase activator 1C"
                     /db_xref="GeneID:9626"
                     /db_xref="HGNC:HGNC:4680"
                     /db_xref="MIM:605128"
     exon            1..321
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..747
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanylyl cyclase-activating protein 3; GCAP 3"
                     /codon_start=1
                     /product="guanylyl cyclase-activating protein 3 isoform 1"
                     /protein_id="NP_005450.3"
                     /db_xref="CCDS:CCDS2954.1"
                     /db_xref="GeneID:9626"
                     /db_xref="HGNC:HGNC:4680"
                     /db_xref="MIM:605128"
                     /translation="MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLL
                     GLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDA
                     DGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMA
                     KDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK"
     exon            322..471
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..559
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..977
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /note="hexamer: ATTAAA"
     polyA_site      977
                     /gene="GUCA1C"
                     /gene_synonym="GCAP3"
                     /note="major polyA site"
ORIGIN      
        1 agagtagctt tctgagggca tatgttagcc ttcagtttta gtgaggagta agggactaaa
       61 tccagcaaaa acttaagtga aaacaacctg aggaaaagct gtagactgtg agtcaagatg
      121 gggaatggca aatctatagc tggtgatcag aaagcagttc ctacacaaga gacccatgtg
      181 tggtacagaa catttatgat ggaatatcca tccggcctgc aaacactaca tgaatttaag
      241 acacttttgg gtctgcaagg tctgaatcag aaggccaata aacatattga tcaagtttat
      301 aatacctttg acacgaacaa ggatggattt gttgactttt tggagtttat tgctgctgta
      361 aatctaatca tgcaagaaaa aatggagcaa aaattaaaat ggtattttaa gctgtatgat
      421 gctgatggaa atggttctat tgacaaaaat gaactactgg acatgttcat ggcggtacaa
      481 gccctcaatg gccagcaaac tctgagtcct gaagaattca tcaacttggt gttccataag
      541 atcgatataa acaatgatgg ggaattgact ttagaagaat ttatcaatgg catggcaaaa
      601 gatcaggatc tcctggagat tgtttacaag agcttcgact tctccaatgt gctgagagta
      661 atctgtaatg ggaagcagcc agacatggag acagactcct ccaaatctcc tgacaaggct
      721 ggtctaggga aggtgaaaat gaagtagctg tgagaatacc tgtcccagct atcaatgagc
      781 acaacatttc agtagagaag aaatagaatc ttccccatgt acatgctgtt gatttcaggt
      841 ctttgttata attcatatag gcttgtgaat atagcactta ttttaatcca gtagagactt
      901 gcataaagat cctaaacaga tgcattgttg cttttctgtg ctgtctctgc agattaaaac
      961 ataatgatta cactaaa
//
