LOCUS       NM_144594                807 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens gametocyte specific factor 1 (GTSF1), mRNA.
ACCESSION   NM_144594
VERSION     NM_144594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Ipsaro,J.J., O'Brien,P.A., Bhattacharya,S., Palmer,A.G. 3rd and
            Joshua-Tor,L.
  TITLE     Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons
  JOURNAL   Cell Rep 34 (13), 108914 (2021)
   PUBMED   33789107
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Huntriss,J., Lu,J., Hemmings,K., Bayne,R., Anderson,R.,
            Rutherford,A., Balen,A., Elder,K. and Picton,H.M.
  TITLE     Isolation and expression of the human gametocyte-specific factor 1
            gene (GTSF1) in fetal ovary, oocytes, and preimplantation embryos
  JOURNAL   J Assist Reprod Genet 34 (1), 23-31 (2017)
   PUBMED   27646122
  REMARK    GeneRIF: To our knowledge, this report is the first to describe the
            expression of the human GTSF1 gene in human gametes and
            preimplantation embryos.
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Litvinov,I.V., Cordeiro,B., Huang,Y., Zargham,H., Pehr,K.,
            Dore,M.A., Gilbert,M., Zhou,Y., Kupper,T.S. and Sasseville,D.
  TITLE     Ectopic expression of cancer-testis antigens in cutaneous T-cell
            lymphoma patients
  JOURNAL   Clin Cancer Res 20 (14), 3799-3808 (2014)
   PUBMED   24850846
  REMARK    GeneRIF: SYCP1, cTAGE1, and GTSF1 are expressed in cutaneous T-cell
            lymphoma, but not in normal skin or benign inflammatory dermatoses.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098819.1 and BE503352.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144594.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.18635.1,
                                           SRR5189658.222449.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305879.8/ ENSP00000304185.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-803               AK098819.1         4-806
            804-807             BE503352.1         16-19               c
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..807
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /note="gametocyte specific factor 1"
                     /db_xref="GeneID:121355"
                     /db_xref="HGNC:HGNC:26565"
                     /db_xref="MIM:617484"
     exon            1..57
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            58..102
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..590
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /note="family with sequence similarity 112, member B;
                     asterix"
                     /codon_start=1
                     /product="gametocyte-specific factor 1"
                     /protein_id="NP_653195.2"
                     /db_xref="CCDS:CCDS8881.1"
                     /db_xref="GeneID:121355"
                     /db_xref="HGNC:HGNC:26565"
                     /db_xref="MIM:617484"
                     /translation="MEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDV
                     ASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPP
                     CDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPW
                     KNNGNAQ"
     exon            103..203
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            204..330
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            331..414
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            415..478
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            574..610
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     exon            611..807
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      786..791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /note="hexamer: AATAAA"
     polyA_site      807
                     /gene="GTSF1"
                     /gene_synonym="Cue110; FAM112B"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgggg cttgcgtggg aggaaggtga ctgtgaggaa ggtgtgtgtc caccgagcac
       61 ttggattcag cttcttcatt tccaacatgg aagaaactta caccgactcc ctggaccctg
      121 agaagctatt gcaatgcccc tatgacaaaa accatcaaat cagggcttgc aggtttcctt
      181 atcatcttat caagtgcaga aagaatcatc ctgatgttgc aagcaaattg gctacttgtc
      241 ccttcaatgc tcgccaccag gttcctcgag ctgaaattag tcatcatatc tcaagctgtg
      301 atgacagaag ttgtattgag caagatgttg tcaaccaaac caggagcctt agacaagaga
      361 ctctggctga gagcacttgg cagtgccctc cttgcgatga agactgggat aaagatttgt
      421 gggagcagac cagcacccca tttgtctggg gcacaactca ctactctgac aacaacagcc
      481 ctgcgagcaa catagttaca gaacataaga ataacctggc ttcaggcatg cgagttccca
      541 aatctctgcc gtatgttctg ccatggaaaa acaatggaaa tgcacagtaa ctgaatacct
      601 atctcatcaa atgccagacc ctagaagact gttgcttctt cttctaccag tgggttctca
      661 ttttcctcct aatctaatta tagaatggta aactccctgt gactttccaa actgacaagc
      721 acactttttt cctcccccct tgaatcctca tttaatgcaa gaaccctcat actcagaagc
      781 ttccaaataa acctttgata cagattg
//
