LOCUS       NM_016426               2983 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens G2 and S-phase expressed 1 (GTSE1), mRNA.
ACCESSION   NM_016426
VERSION     NM_016426.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2983)
  AUTHORS   Yan,G., Li,G., Gao,X., Liu,J., Li,Y., Li,J. and Zhou,H.
  TITLE     GTSE1: A potential prognostic and diagnostic biomarker in various
            tumors including lung adenocarcinoma
  JOURNAL   Clin Respir J 18 (5), e13757 (2024)
   PUBMED   38715380
  REMARK    GeneRIF: GTSE1: A potential prognostic and diagnostic biomarker in
            various tumors including lung adenocarcinoma.
REFERENCE   2  (bases 1 to 2983)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 2983)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 2983)
  AUTHORS   Xie,C., Xiang,W., Shen,H. and Shen,J.
  TITLE     GTSE1 is possibly involved in the DNA damage repair and cisplatin
            resistance in osteosarcoma
  JOURNAL   J Orthop Surg Res 16 (1), 713 (2021)
   PUBMED   34876170
  REMARK    GeneRIF: GTSE1 is possibly involved in the DNA damage repair and
            cisplatin resistance in osteosarcoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2983)
  AUTHORS   Chen,L., Zhong,Y., Yang,X., Zhang,Q. and Wu,X.
  TITLE     Downregulation of GTSE1 leads to the inhibition of proliferation,
            migration, and Warburg effect in cervical cancer by blocking LHDA
            expression
  JOURNAL   J Obstet Gynaecol Res 47 (11), 3913-3922 (2021)
   PUBMED   34482592
  REMARK    GeneRIF: Downregulation of GTSE1 leads to the inhibition of
            proliferation, migration, and Warburg effect in cervical cancer by
            blocking LHDA expression.
REFERENCE   6  (bases 1 to 2983)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2983)
  AUTHORS   Monte,M., Benetti,R., Collavin,L., Marchionni,L., Del Sal,G. and
            Schneider,C.
  TITLE     hGTSE-1 expression stimulates cytoplasmic localization of p53
  JOURNAL   J Biol Chem 279 (12), 11744-11752 (2004)
   PUBMED   14707141
  REMARK    GeneRIF: requires an intact nuclear export signal and functional
            Mdm2 for the regulation of p53
REFERENCE   8  (bases 1 to 2983)
  AUTHORS   Monte,M., Benetti,R., Buscemi,G., Sandy,P., Del Sal,G. and
            Schneider,C.
  TITLE     The cell cycle-regulated protein human GTSE-1 controls DNA
            damage-induced apoptosis by affecting p53 function
  JOURNAL   J Biol Chem 278 (32), 30356-30364 (2003)
   PUBMED   12750368
  REMARK    GeneRIF: GTSE-1 controls DNA damage-induced apoptosis by affecting
            p53 function
REFERENCE   9  (bases 1 to 2983)
  AUTHORS   Monte,M., Collavin,L., Lazarevic,D., Utrera,R., Dragani,T.A. and
            Schneider,C.
  TITLE     Cloning, chromosome mapping and functional characterization of a
            human homologue of murine gtse-1 (B99) gene
  JOURNAL   Gene 254 (1-2), 229-236 (2000)
   PUBMED   10974554
REFERENCE   10 (bases 1 to 2983)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z93024.1 and AL031588.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016426.6.
            
            Summary: The protein encoded by this gene is only expressed in the
            S and G2 phases of the cell cycle, where it colocalizes with
            cytoplasmic tubulin and microtubules. In response to DNA damage,
            the encoded protein accumulates in the nucleus and binds the tumor
            suppressor protein p53, shuttling it out of the nucleus and
            repressing its ability to induce apoptosis. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075828.1, AK025563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454366.2/ ENSP00000415430.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                Z93024.1           5149-5210           c
            63-162              Z93024.1           4601-4700           c
            163-220             AL031588.1         121924-121981       c
            221-845             AL031588.1         121188-121812       c
            846-1010            AL031588.1         117826-117990       c
            1011-1134           AL031588.1         116118-116241       c
            1135-1515           AL031588.1         113719-114099       c
            1516-1588           AL031588.1         106869-106941       c
            1589-1807           AL031588.1         103477-103695       c
            1808-2009           AL031588.1         101242-101443       c
            2010-2219           AL031588.1         100564-100773       c
            2220-2983           AL031588.1         99321-100084        c
FEATURES             Location/Qualifiers
     source          1..2983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..2983
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /note="G2 and S-phase expressed 1"
                     /db_xref="GeneID:51512"
                     /db_xref="HGNC:HGNC:13698"
                     /db_xref="MIM:607477"
     exon            1..62
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            63..162
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2303
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /note="protein B99 homolog; G-2 and S-phase expressed 1;
                     Lnc_bc060912"
                     /codon_start=1
                     /product="G2 and S phase-expressed protein 1"
                     /protein_id="NP_057510.5"
                     /db_xref="CCDS:CCDS14074.2"
                     /db_xref="GeneID:51512"
                     /db_xref="HGNC:HGNC:13698"
                     /db_xref="MIM:607477"
                     /translation="MEGGGGRDEPSACRAGDVNMDDPKKEDILLLADEKFDFDLSLSS
                     SSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVY
                     KEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTS
                     LKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCT
                     AHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHR
                     DVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGP
                     VWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGA
                     SSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIR
                     RRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHST
                     PVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSS
                     EPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTA
                     TEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAV
                     GSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF"
     exon            163..220
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            221..845
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1010
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1134
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1515
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1588
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1807
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2009
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2219
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2983
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2960..2965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="GTSE1"
                     /gene_synonym="B99"
                     /note="major polyA site"
ORIGIN      
        1 gtctcccggc gccgcgttta aatccgtgcc ggaggcgcgt cctgcatcgt ctgccgcttt
       61 ggtgacttct gacagctctc tccatggaag gaggcggcgg ccgcgatgag ccttcagcct
      121 gccgggcagg ggacgtgaac atggatgacc ctaagaagga agacattctt cttttggccg
      181 atgaaaaatt tgacttcgat ctttcattgt cttcttcgag tgcaaatgaa gatgatgaag
      241 tcttcttcgg accctttgga cataaagaaa gatgtattgc tgccagcttg gaattaaata
      301 atccggttcc cgaacagcct ccgttgccca catctgagag tccctttgcc tggagccctc
      361 tggccgggga gaagttcgtg gaggtgtaca aagaagctca cttactggct ttacacattg
      421 agagcagcag ccggaaccag gcagcccaag ctgccaagcc tgaagaccct cggagccagg
      481 gcgtggaaag attcatacag gagtcaaaat taaaaataaa cctctttgag aaagaaaagg
      541 aaatgaagaa aagccccacg tctcttaaaa gggagacata ctacctgtca gacagcccct
      601 tgctggggcc ccctgtgggt gagcctcggc tcttggcctc ctccccggcc ctgcccagct
      661 ctggtgccca ggcccgcctc acccgggcgc cggggcctcc gcactctgct catgctttgc
      721 ccagggaatc atgcactgct catgctgcaa gtcaggcagc gactcagagg aagcccggga
      781 ccaaattgct gctgcctcga gcggcctctg ttagaggaag aagcatccct ggggctgcgg
      841 agaagcccaa gaaagagatt ccagctagtc cttccaggac aaaaatccca gctgagaagg
      901 aatcccaccg ggatgttctc cctgacaaac ctgccccggg tgctgtcaat gtgccggccg
      961 ccggaagcca cttgggccag ggcaagcggg cgatccctgt tccaaacaag ttggggctga
     1021 agaagaccct gttaaaagca cccggctcta ccagcaatct cgcaaggaag tcctcctcgg
     1081 ggcctgtttg gagcggggca tccagtgcgt gcacatcccc agcagtgggc aaagctaaat
     1141 caagtgaatt tgcaagtatt cctgcaaata gctcccggcc tctgtcaaac atcagcaagt
     1201 caggcagaat gggacccgcc atgctgcggc cagctctgcc tgcaggccct gtgggggcat
     1261 cctcctggca ggccaagcgg gtcgatgttt ctgagctggc agcggagcag ctcacggcac
     1321 ccccctcagc atcccccacc caaccccaga ctccggaagg tggcggccag tggctgaact
     1381 ccagttgcgc ttggtcagaa tcttctcaat tgaataagac tagaagtatc agacggcgag
     1441 attcctgtct aaattccaag acaaaggtta tgcctactcc tacaaatcaa tttaaaattc
     1501 ctaagttttc tattggtgac tccccggaca gctcaacacc aaagctttcg cgggcacagc
     1561 ggccgcagtc gtgcacgtca gttggcaggg tcactgtcca cagcaccccg gttagacgct
     1621 catctgggcc agcaccacaa agcctgctga gcgcatggcg tgtgtcagcc ttgcccacac
     1681 ccgccagccg gcgctgctct ggccttccac cgatgacccc caaaacgatg cccagggccg
     1741 tgggctctcc cctgtgtgtg ccagctcgga gacgttcctc tgagccccgc aagaactctg
     1801 caatgagaac tgaaccaaca agggagagca acagaaagac agattccagg ctggtggatg
     1861 tgtcccctga caggggttct cctccttccc gtgtgcctca ggcacttaac ttttctccag
     1921 aggaaagcga ttctactttc tccaaaagta ctgccacaga agtagctcgg gaggaagcca
     1981 agccgggtgg agatgcagcc cctagtgagg ctcttcttgt agatatcaaa ctggaaccac
     2041 tcgcggtcac tccagatgct gcaagccagc ccctcattga ccttcctctc atcgacttct
     2101 gcgatacccc agaagcacac gtggctgtag gatctgaaag caggcctctg atcgacctca
     2161 tgacaaacac tccagacatg aataaaaatg tggccaaacc ttcaccggtg gtgggacagc
     2221 tcatagacct gagctcccct ctgatccagc tgagccctga ggctgacaag gagaacgtgg
     2281 attccccact cctcaagttc taagccgaac caaatccttt gccttgaaag aacagcccta
     2341 aagtggtttt caaccctcag aaacaagctt taggctggtc gcagtggctt acacttgtaa
     2401 ccctagaact tgggaggctg aggtgggcgg attacttgag cccaggagtt cgggaccagc
     2461 ctgggaaata tagtgaaact cctgtcccta caaaaaatac aaaaattagc cgggtgtggt
     2521 agtgcatgcc tgtagtccca gctacttggg aggctgaagt gggaggatgg cctgagctca
     2581 aggagatgca ggctgcagtg ggctgtgatt gtgccactgc actccagcct gggcaccaat
     2641 gtgagaacct gtcttggaaa aaaaaaaaaa gaaacatgtt ttagtagaag ttttatttga
     2701 aaaagaaaaa taagcataaa tatattccca gtgctggaga gggtgggctg agggactggg
     2761 gccagcacgg accacccaag gcctctgctt cccgccgcca ccctcctcgc tgccattctc
     2821 tgggctggaa tgtgaagcct cagtcactct aaatgaagaa ttttcttttg aatgttttgt
     2881 atgtaaaata gcaagtggct atttttaaag ttaagtttgt ataaatagtt agatattcta
     2941 gatttacatt aaattgtaaa ataaatggac ttattgaagc ata
//
