LOCUS       NM_012341               4656 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.
ACCESSION   NM_012341
VERSION     NM_012341.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4656)
  AUTHORS   Xue,Q., Zhu,Z., Xue,Z., Yang,F., Cao,W., Liu,X., Liu,H. and
            Zheng,H.
  TITLE     NOG1 downregulates type I interferon production by targeting
            phosphorylated interferon regulatory factor 3
  JOURNAL   PLoS Pathog 19 (7), e1011511 (2023)
   PUBMED   37410776
  REMARK    GeneRIF: NOG1 downregulates type I interferon production by
            targeting phosphorylated interferon regulatory factor 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4656)
  AUTHORS   Zhou,Q., Yin,Y., Yu,M., Gao,D., Sun,J., Yang,Z., Weng,J., Chen,W.,
            Atyah,M., Shen,Y., Ye,Q., Li,C.W., Hung,M.C., Dong,Q., Zhou,C. and
            Ren,N.
  TITLE     GTPBP4 promotes hepatocellular carcinoma progression and metastasis
            via the PKM2 dependent glucose metabolism
  JOURNAL   Redox Biol 56, 102458 (2022)
   PUBMED   36116159
  REMARK    GeneRIF: GTPBP4 promotes hepatocellular carcinoma progression and
            metastasis via the PKM2 dependent glucose metabolism.
REFERENCE   3  (bases 1 to 4656)
  AUTHORS   Cao,X., Khitun,A., Harold,C.M., Bryant,C.J., Zheng,S.J.,
            Baserga,S.J. and Slavoff,S.A.
  TITLE     Nascent alt-protein chemoproteomics reveals a pre-60S assembly
            checkpoint inhibitor
  JOURNAL   Nat Chem Biol 18 (6), 643-651 (2022)
   PUBMED   35393574
REFERENCE   4  (bases 1 to 4656)
  AUTHORS   Zhang,N., Shen,H., Huang,S., Wang,F., Liu,H., Xie,F., Jiang,L. and
            Chen,X.
  TITLE     LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4
            expression by sponging miR-873-5p in hepatocellular carcinoma
  JOURNAL   Eur J Histochem 65 (4), 3300 (2021)
   PUBMED   34783233
  REMARK    GeneRIF: LncRNA FGD5-AS1 functions as an oncogene to upregulate
            GTPBP4 expression by sponging miR-873-5p in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4656)
  AUTHORS   Zhu,R., Guo,W., Xu,X.J. and Zhu,L.
  TITLE     An Integrating Immune-Related Signature to Improve Prognosis of
            Hepatocellular Carcinoma
  JOURNAL   Comput Math Methods Med 2020, 8872329 (2020)
   PUBMED   33204302
  REMARK    GeneRIF: An Integrating Immune-Related Signature to Improve
            Prognosis of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4656)
  AUTHORS   Lee,H., Kim,D., Dan,H.C., Wu,E.L., Gritsko,T.M., Cao,C.,
            Nicosia,S.V., Golemis,E.A., Liu,W., Coppola,D., Brem,S.S.,
            Testa,J.R. and Cheng,J.Q.
  TITLE     Identification and characterization of putative tumor suppressor
            NGB, a GTP-binding protein that interacts with the
            neurofibromatosis 2 protein
  JOURNAL   Mol Cell Biol 27 (6), 2103-2119 (2007)
   PUBMED   17210637
  REMARK    GeneRIF: NGB is a tumor suppressor that regulates and requires
            merlin to suppress cell proliferation
REFERENCE   7  (bases 1 to 4656)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4656)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   9  (bases 1 to 4656)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 4656)
  AUTHORS   Laping,N.J., Olson,B.A. and Zhu,Y.
  TITLE     Identification of a novel nuclear guanosine triphosphate-binding
            protein differentially expressed in renal disease
  JOURNAL   J Am Soc Nephrol 12 (5), 883-890 (2001)
   PUBMED   11316846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359878.13 and AC022536.13.
            
            On Nov 23, 2018 this sequence version replaced NM_012341.2.
            
            Summary: GTP-binding proteins are GTPases and function as molecular
            switches that can flip between two states: active, when GTP is
            bound, and inactive, when GDP is bound. 'Active' in this context
            usually means that the molecule acts as a signal to trigger other
            events in the cell. When an extracellular ligand binds to a
            G-protein-linked receptor, the receptor changes its conformation
            and switches on the trimeric G proteins that associate with it by
            causing them to eject their GDP and replace it with GTP. The switch
            is turned off when the G protein hydrolyzes its own bound GTP,
            converting it back to GDP. But before that occurs, the active
            protein has an opportunity to diffuse away from the receptor and
            deliver its message for a prolonged period to its downstream
            target. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.97392.1,
                                           SRR1803617.178516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360803.9/ ENSP00000354040.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL359878.13        169504-169597
            95-265              AL359878.13        173559-173729
            266-369             AL359878.13        176999-177102
            370-506             AL359878.13        177176-177312
            507-607             AL359878.13        178278-178378
            608-700             AL359878.13        180073-180165
            701-892             AL359878.13        181747-181938
            893-958             AL359878.13        182018-182083
            959-1048            AC022536.13        117755-117844       c
            1049-1159           AC022536.13        116534-116644       c
            1160-1237           AC022536.13        114627-114704       c
            1238-1289           AC022536.13        114082-114133       c
            1290-1390           AC022536.13        113142-113242       c
            1391-1588           AC022536.13        111000-111197       c
            1589-1654           AC022536.13        109350-109415       c
            1655-1798           AC022536.13        107766-107909       c
            1799-4656           AC022536.13        103730-106587       c
FEATURES             Location/Qualifiers
     source          1..4656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..4656
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="GTP binding protein 4"
                     /db_xref="GeneID:23560"
                     /db_xref="HGNC:HGNC:21535"
                     /db_xref="MIM:619169"
     exon            1..94
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1951
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="G protein-binding protein CRFG; nucleolar
                     GTP-binding protein 1; GTP-binding protein NGB; chronic
                     renal failure gene protein"
                     /codon_start=1
                     /product="GTP-binding protein 4"
                     /protein_id="NP_036473.2"
                     /db_xref="CCDS:CCDS31132.1"
                     /db_xref="GeneID:23560"
                     /db_xref="HGNC:HGNC:21535"
                     /db_xref="MIM:619169"
                     /translation="MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIR
                     HFYMRKVKFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIA
                     KNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSR
                     LPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQ
                     VVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIR
                     PLFINKPLIVVANKCDVKRIAELSEDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTE
                     ACDRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEE
                     SRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKL
                     EELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRM
                     PRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVAR
                     SGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSG
                     KRKAGKKDRR"
     exon            95..265
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..369
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..506
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..607
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..700
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..892
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..958
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1048
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1159
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1237
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1289
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1390
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1588
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1654
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1798
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..4656
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="major polyA site"
     regulatory      2474..2479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="hexamer: AATAAA"
     polyA_site      2492
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="major polyA site"
     regulatory      4629..4634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
                     /note="hexamer: AATAAA"
     polyA_site      4656
                     /gene="GTPBP4"
                     /gene_synonym="CRFG; NGB; NOG1"
ORIGIN      
        1 ggaagttccg ggagtgccaa gtacccgcgt gcatacggct gccggcatgg cacattacaa
       61 cttcaagaaa attacggtgg tgccgtccgc caaggacttc atagacctca cgttgtcgaa
      121 gactcaacga aagactccaa ccgttattca taaacattac caaatacatc gcattagaca
      181 tttttacatg agaaaagtca aatttactca acagaattac catgatagac tttcacaaat
      241 tctaacagat ttccccaaat tggatgatat tcatccgttc tatgctgatt tgatgaatat
      301 tctctacgac aaggatcatt acaagttggc tctggggcaa ataaatattg ccaaaaattt
      361 agtggacaat gttgctaaag attatgtgcg actgatgaag tatggcgact ctctctaccg
      421 ctgcaaacag ctgaagcgtg cggccctggg acggatgtgc acagtgatca agaggcagaa
      481 gcagagtttg gagtatttgg agcaagtgcg tcagcattta tcccgtttgc caaccattga
      541 tccgaatacc aggaccctgc ttttgtgtgg gtacccaaat gttgggaagt ccagcttcat
      601 caacaaggtg acgagagcag acgtggatgt ccagccctat gcgttcacaa ccaagtctct
      661 gtttgttggg cacatggatt ataagtatct acgttggcag gttgtagaca ctcctgggat
      721 cctggaccac cctctggagg ataggaacac catcgagatg caggccatca ctgccctggc
      781 ccacctccgt gctgcggtcc tgtatgtgat ggatttgtct gagcagtgtg ggcatgggct
      841 gagggagcag ctagaactct tccagaacat cagacctctc ttcatcaaca agcctctcat
      901 agttgtagcc aacaaatgtg atgtgaagag aatagctgaa ctttctgaag atgatcagaa
      961 aatatttaca gatttgcagt ctgaaggatt ccctgtaata gagaccagca ccctgactga
     1021 ggaaggtgtt attaaagtta aaacagaggc ttgcgatagg cttttggctc atcgagtgga
     1081 aaccaaaatg aagggaaata aagtgaatga ggtgctgaat agactgcacc tggctatccc
     1141 aaccaggagg gacgataagg agaggccccc tttcatccct gaaggagtgg tggctcgcag
     1201 gaagaggatg gaaactgagg agtccaggaa gaagagggaa cgagatcttg agctggaaat
     1261 gggagatgat tatattttgg atcttcagaa gtactgggat ttaatgaatt tgtctgaaaa
     1321 acatgataag ataccagaaa tctgggaagg ccataatata gctgattata ttgatccagc
     1381 catcatgaag aaattggaag aattagaaaa agaagaagag ctgagaacag ctgctggaga
     1441 gtatgacagt gtatctgaga gtgaagacga agagatgctg gaaatccgac agctggcaaa
     1501 gcaaattcga gagaaaaaga agttgaaaat tctggagtcc aaagaaaaga atacacaggg
     1561 acccaggatg ccgcgaactg ctaagaaggt tcagaggaca gttttggaga aggagatgcg
     1621 tagtcttggt gttgacatgg acgataaaga cgatgcccat tacgcagtcc aggcaagaag
     1681 atcccggagc atcactagga aaagaaagcg ggaagactct gctcccccgt cctctgtggc
     1741 ccggagtggg agttgctctc gaactccacg tgacgtttct ggtcttaggg atgtcaagat
     1801 ggtgaagaaa gccaagacta tgatgaagaa tgctcagaag aagatgaatc ggttggggaa
     1861 gaaaggggag gcggatagac acgtgtttga tatgaagccc aagcacttgc tgtctgggaa
     1921 gaggaaagct ggtaaaaagg acaggagata gtatccgttt ggttggcgtg gcttcgctag
     1981 agtgttgctg tttatttcct ggtttggcac agtatggttt catgaaattg gagctctgta
     2041 taaactgaaa aagacaaaat aagtaaagca cttgttgctt tgctgaaaac tatggttaac
     2101 cctatatagg tgtgggaaat ttttgtcact gcataatatt acaaatattt tgagtagaca
     2161 gtgtttccac atttaatgga gtatcagttg cttcagattt tcagaactgg gaagatttac
     2221 tggtttaact aggttgtttt tgatggagaa aaaccttatt ttcttttgta agagctggga
     2281 gcaaacacgt ttatgagtgt gtcggaatcc cgtgcttaaa atacgctctt aaattatttt
     2341 ctagtcttat tttacaatgt ctcattgtag tctgtcttca actattttat ccaaaataaa
     2401 cctccagaag aaagtagttt tcatttactt agctcatgtt ttggtttagt tatagtcgct
     2461 atggatttgg ccaaataaaa aggcaaacaa catgacattt ctattttgtt ttaaagcaaa
     2521 aatacttttg ggggagtaaa atgttgctgg aggcattagg caattaaata tgggcattct
     2581 cctatttctg tggcccgtcc ctgaagttac atgttcagta aaacacaaaa acaccgccaa
     2641 tgccacctca aaagcacctg ctggggagcg ttggggtgaa gagctgtggg gtcggaggga
     2701 cctgcccagg ggtccgtgtg ctcctggagc tccaaagaca cacaggggtc caagagccac
     2761 cacggataag ttatcaagtc acacaatcaa cattatagct gaggaaagga ctttagttaa
     2821 tcacacttct ggattacatg tggcaatttt aaaaatttac cagggctggg ctgggcgcag
     2881 gggctcaagc ctgtagttcc agcactttgg gaggccgagg tgggcagatc aggaggtcag
     2941 gagttcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaaat
     3001 tagccatgcg tggtggtggg catctgtaat cctagctgct cgggaggcta aggcaggaga
     3061 attgcttgag cccagaggcg gaggttgcag tgagccgaga tcgtgccact gcactccagc
     3121 ctgggtgaca gagagagact ccgtgtgaaa aaaaaaaaaa aaataccagg tctggttttt
     3181 gaaattcttt ctccgtatta aacaccaaaa cttaacatat agtttacttt gtgttaaaca
     3241 acaacagtat ggccgggcgc ggcagctcat gcctgtaatc ccagcacttt gggaggccga
     3301 ggcaggcgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccccg
     3361 tctctactaa aaatacaaaa aattagctgg gtgtggtggc gggcgcctgt agtcccaact
     3421 acttgggagg ctgaggcagg agaatggctt gaacccggga ggcggagctt gcagtgagcc
     3481 aagatcgcac cactgcactc cagcctggtc gacagcgaga ctccatctca aaaaaaaaaa
     3541 aaaaatacca ggtctggttt ttgaaattct ttctccgtat taaacaccaa aacttaacat
     3601 atagtttact ttgtgttaaa caacaacagt atgttttaaa gcaagtatgt ctttatttgt
     3661 aagcatatta ctgaaacgat caaatgaaca gaagtggata aacgtcgagt cacttggctg
     3721 agaccatacg catcttccgt actgcttgta ttaggatgca agattgaatg tgtctttttt
     3781 ttaaaaatgc agccttgtgt tgcactctga aataagtgat ttaaaaagaa aaacatgata
     3841 cagagatccc atcctgacct tggaggcttg gataaagctg tggggagaca gcctcatggt
     3901 ccagccaggc tagtccgcct gcttcaggac tctcaagatc tccccaagac tttcaggatc
     3961 agctgctgtt aatcaaacaa gtgcttataa aatggaaatt gggacaaagg aaatgttaaa
     4021 tttcctccct gcaaccaggc agatgagaaa tatggaaata aggaaaaggg aaaatgaaga
     4081 tatgacaaag ttgatgaaaa ggttgaaata gtgatttata catgatgggc aatcaagtgc
     4141 cccttttgcc ctgttttttg gagagggtgt atcattgcct caatggtgcg tctgcctgca
     4201 ctgagggcat tacacatggc tgactcgacc tccctgcctc tcacactctg tgtattttgt
     4261 gaagctccac aaacggggtc acgtcatcca ggtgaggcca ccaccggtac agaaacctct
     4321 cggcaatggt tcttagccag ggggtgactt tgacttcacc cctcgcctcc ctctccagca
     4381 gctcccacag ctcctcctgg gacaggtaga ggatgctttt cgtttcactg ggatccgggt
     4441 tcagagtgac gtttttcctc acaagcagaa ggtaacaaat ttcatgctct ccccaaattc
     4501 tgtctgattt tgccttgtgg tgatagattg tcatgaacac aatgtcctct ggagaaatct
     4561 attgacagaa attggtgcag tgttaacaac gctaatgtaa aacacagaat ttacagaaaa
     4621 atagagaaaa taaacacatt tgttttcctc agaaaa
//
