LOCUS       NM_033107               7489 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens GTP binding protein 10 (GTPBP10), transcript variant
            2, mRNA.
ACCESSION   NM_033107
VERSION     NM_033107.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7489)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7489)
  AUTHORS   Maiti,P., Kim,H.J., Tu,Y.T. and Barrientos,A.
  TITLE     Human GTPBP10 is required for mitoribosome maturation
  JOURNAL   Nucleic Acids Res 46 (21), 11423-11437 (2018)
   PUBMED   30321378
  REMARK    GeneRIF: GTPBP10 primarily ensures proper mtLSU maturation and
            ultimately serves to coordinate mtSSU and mtLSU accumulation
REFERENCE   3  (bases 1 to 7489)
  AUTHORS   Lavdovskaia,E., Kolander,E., Steube,E., Mai,M.M., Urlaub,H. and
            Richter-Dennerlein,R.
  TITLE     The human Obg protein GTPBP10 is involved in mitoribosomal
            biogenesis
  JOURNAL   Nucleic Acids Res 46 (16), 8471-8482 (2018)
   PUBMED   30085210
  REMARK    GeneRIF: Our results suggest that GTPBP10 is a ribosome biogenesis
            factor of the mtLSU required for late stages of maturation.
REFERENCE   4  (bases 1 to 7489)
  AUTHORS   van Meurs,J.B., Pare,G., Schwartz,S.M., Hazra,A., Tanaka,T.,
            Vermeulen,S.H., Cotlarciuc,I., Yuan,X., Malarstig,A.,
            Bandinelli,S., Bis,J.C., Blom,H., Brown,M.J., Chen,C., Chen,Y.D.,
            Clarke,R.J., Dehghan,A., Erdmann,J., Ferrucci,L., Hamsten,A.,
            Hofman,A., Hunter,D.J., Goel,A., Johnson,A.D., Kathiresan,S.,
            Kampman,E., Kiel,D.P., Kiemeney,L.A., Chambers,J.C., Kraft,P.,
            Lindemans,J., McKnight,B., Nelson,C.P., O'Donnell,C.J., Psaty,B.M.,
            Ridker,P.M., Rivadeneira,F., Rose,L.M., Seedorf,U., Siscovick,D.S.,
            Schunkert,H., Selhub,J., Ueland,P.M., Vollenweider,P., Waeber,G.,
            Waterworth,D.M., Watkins,H., Witteman,J.C., den Heijer,M.,
            Jacques,P., Uitterlinden,A.G., Kooner,J.S., Rader,D.J.,
            Reilly,M.P., Mooser,V., Chasman,D.I., Samani,N.J. and Ahmadi,K.R.
  TITLE     Common genetic loci influencing plasma homocysteine concentrations
            and their effect on risk of coronary artery disease
  JOURNAL   Am J Clin Nutr 98 (3), 668-676 (2013)
   PUBMED   23824729
REFERENCE   5  (bases 1 to 7489)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 7489)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   7  (bases 1 to 7489)
  AUTHORS   Hirano,Y., Ohniwa,R.L., Wada,C., Yoshimura,S.H. and Takeyasu,K.
  TITLE     Human small G proteins, ObgH1, and ObgH2, participate in the
            maintenance of mitochondria and nucleolar architectures
  JOURNAL   Genes Cells 11 (11), 1295-1304 (2006)
   PUBMED   17054726
  REMARK    GeneRIF: Knock-down of ObgH1 by RNAi induced mitochondria
            elongation, whereas knock-down of ObgH2 resulted in the
            disorganization of the nucleolar architecture.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002064.1, AC006153.2, AK294325.1, AK095561.1, AK125553.1 and
            T65158.1.
            
            On Jun 2, 2019 this sequence version replaced NM_033107.3.
            
            Summary: Small G proteins, such as GTPBP10, act as molecular
            switches that play crucial roles in the regulation of fundamental
            cellular processes such as protein synthesis, nuclear transport,
            membrane trafficking, and signal transduction (Hirano et al., 2006
            [PubMed 17054726]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and it encodes the longer protein (isoform 2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.157525.1,
                                           SRR1803611.57067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222511.11/ ENSP00000222511.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC002064.1         138989-139047
            60-253              AC002064.1         145089-145282
            254-345             AC002064.1         146731-146822
            346-490             AC002064.1         147359-147503
            491-564             AC006153.2         8414-8487
            565-617             AC006153.2         10561-10613
            618-725             AC006153.2         13766-13873
            726-803             AC006153.2         14393-14470
            804-927             AC006153.2         19215-19338
            928-1119            AC006153.2         21151-21342
            1120-1743           AK294325.1         884-1507
            1744-2096           AK095561.1         1785-2137
            2097-2107           AK125553.1         1145-1155
            2108-2108           AC006153.2         22331-22331
            2109-3250           AK125553.1         1156-2297
            3251-7453           AC006153.2         23474-27676
            7454-7489           T65158.1           11-46               c
FEATURES             Location/Qualifiers
     source          1..7489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..7489
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="GTP binding protein 10"
                     /db_xref="GeneID:85865"
                     /db_xref="HGNC:HGNC:25106"
                     /db_xref="MIM:610920"
     exon            1..59
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1190
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein obg homolog 2; GTP binding protein 10 (putative)"
                     /codon_start=1
                     /product="GTP-binding protein 10 isoform 2"
                     /protein_id="NP_149098.2"
                     /db_xref="CCDS:CCDS5617.1"
                     /db_xref="GeneID:85865"
                     /db_xref="HGNC:HGNC:25106"
                     /db_xref="MIM:610920"
                     /translation="MVHCSCVLFRKYGNFIDKLRLFTRGGSGGMGYPRLGGEGGKGGD
                     VWVVAQNRMTLKQLKDRYPRKRFVAGVGANSKISALKGSKGKDCEIPVPVGISVTDEN
                     GKIIGELNKENDRILVAQGGLGGKLLTNFLPLKGQKRIIHLDLKLIADVGLVGFPNAG
                     KSSLLSCVSHAKPAIADYAFTTLKPELGKIMYSDFKQISVADLPGLIEGAHMNKGMGH
                     KFLKHIERTRQLLFVVDISGFQLSSHTQYRTAFETIILLTKELELYKEELQTKPALLA
                     VNKMDLPDAQDKFHELMSQLQNPKDFLHLFEKNMIPERTVEFQHIIPISAVTGEGIEE
                     LKNCIRKSLDEQANQENDALHKKQLLNLWISDTMSSTEPPSKHAVTTSKMDII"
     exon            60..253
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            254..345
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            346..490
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..564
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            565..617
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            618..725
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            726..803
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            804..927
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     exon            928..7489
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1195..1200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="hexamer: ATTAAA"
     polyA_site      1221
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="major polyA site"
     regulatory      2910..2915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
     regulatory      6854..6859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="hexamer: TATAAA"
     polyA_site      6873
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
     regulatory      7027..7032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="hexamer: ATTAAA"
     polyA_site      7049
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
     regulatory      7468..7473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
                     /note="hexamer: AATAAA"
     polyA_site      7489
                     /gene="GTPBP10"
                     /gene_synonym="ObgH2; UG0751c10"
ORIGIN      
        1 agaaggtttc ctggcctgtt gcagccatgg tgcattgcag ttgcgtgttg ttcagaaagt
       61 atggaaattt catcgataag ctaagactct tcaccagggg aggatccggt ggaatgggtt
      121 atcctcgttt aggtggagaa ggtggaaaag gtggtgatgt ctgggttgta gcccagaaca
      181 gaatgacttt aaaacaactt aaagacaggt atcctcggaa acggtttgtg gctggagtag
      241 gagcaaacag caaaattagt gcactgaaag gctccaaagg aaaagactgt gaaatccctg
      301 tgcctgtggg tatttcagta actgatgaaa atggtaaaat tataggagaa ctcaataaag
      361 aaaatgacag aattttggta gctcaaggag gtcttggtgg taaattactt acaaatttct
      421 taccattgaa aggccagaaa cgaataattc accttgatct aaaacttata gctgatgtag
      481 gcctagtagg attcccaaat gctggaaaat cctctttgct aagttgtgtt tctcatgcaa
      541 aacctgcaat tgcagattac gcatttacaa cattaaagcc tgaacttgga aagataatgt
      601 acagtgattt caaacagata tcagtagctg atcttccggg tttaatagaa ggagcacata
      661 tgaacaaagg aatgggccac aaattcctca agcatataga aagaactaga caactacttt
      721 ttgttgttga tatttctgga tttcagcttt cttctcacac tcaatacagg acagcttttg
      781 aaaccataat actgcttaca aaagagttgg aattgtacaa agaggaactt cagacaaaac
      841 ctgcactctt ggcagttaat aaaatggact tgccagatgc ccaagataag ttccatgaat
      901 tgatgagcca gctccagaat cctaaagatt ttctgcattt atttgaaaaa aacatgattc
      961 cagagaggac tgtagagttc caacatatca tccccatatc tgcagttact ggagaaggaa
     1021 tcgaagaatt aaagaattgt ataagaaagt cactggatga acaggccaac caggaaaatg
     1081 atgcacttca taagaaacag ttgcttaatt tgtggatttc tgatacaatg tcttctactg
     1141 agccaccatc aaagcatgct gttactactt ccaaaatgga tataatttaa atatattaaa
     1201 aatggtattg atggaacagt atttaatgct taaaaacaag gaaatccttt catctgtgac
     1261 aacctggagg acatgttaag taaaataagc caggcttaga aagacaaatg ctgcataatc
     1321 tcactgtgga atcttaagtt gaactcatag aaggagagaa tagaatggtg gttatcaagg
     1381 gctggtgggg cagtggagga ttgaggagat attggtcaaa atttacaaaa tttcagttag
     1441 acaaggcaac tgagttcaag agatctgttg tacagcttgg tgactgtaat taacaacaat
     1501 gtattttgaa agtcactgag taaattttaa gtggtttttc caaaaaagca cataaggtaa
     1561 tgcacgttaa ttagctatat tgagccattc cacaatgtat agatatttca aaacatgtta
     1621 cacatgataa atccagtttt tctacgtcat tttttaaaat tatatttaat ttttttattt
     1681 tgaaagtttt ttcacagatc ttttttttag tattattacc ttctgatata tgtgtcatta
     1741 ttgaagaacc atacctttta aagttattat tttgtaatta agtatgtcaa cagtaaaaaa
     1801 taaccagtgg ccaggcatgg tggctcatgc ctgtaatccc agcacttttc ggaggccgag
     1861 gagggcagat cacttgaggt caggagttca agaccagcct ggccaacatg gcgaaacccc
     1921 gtctctacta aaaatataaa aaattagcca ggcatagtgg cgcatgcctg ttgtagcccc
     1981 agctactcaa gaggctgagg caggagaatt gcttgaacgc gggaggtgga ggatacaatg
     2041 aacccgaggt cgcgccactg cacttcagcc tgggtgacag agctagactc catctcaaaa
     2101 aaaaaaaaga gctaaaaaat tacattttac aagtttatgg ccagcccacc tgtaataaca
     2161 ttctctgata ttcctttact taggatgtcc ctattgagat cattttttaa atttatgtgg
     2221 aaggattctc tagattatta ttagaatgag caattcagtt ttgtttgttt ttgagcctgt
     2281 cttgtacctg gttgcactaa atatataata gttatctttt gtggagacct taaaacccta
     2341 aatttgaata catgttcaat gatagtaaag atatgacaga aactagaaga tagctgttta
     2401 tgatttgagc ttttggaaaa ttttcgtttc ttgaatgtaa tagtattttt tcctgaattg
     2461 gaggagactg atctatattg tttcattttt cttttgtcct agtctatttc actttctttt
     2521 gtcataatct atttaatttc ccactttctt attttagtaa agagagaata aatagcaagt
     2581 gcaggccagg catggtggtg caggccagac atagcggtac atgcctgtaa tcctagcact
     2641 ttgggatgcc aaggcgggag gattgcttga gcccaggagt tcatgcctga gcaacatagc
     2701 aagaccctgg ctctctataa aacagaaaac gcaaacttta atattatcaa caatcaatat
     2761 attataagag attgcaattt ctaagtttct acctgagtgt ttcacaaata caaactggac
     2821 attttccctt taaatgagtt ttattataaa atgtacatat tgattgtaaa aacaaaaaat
     2881 tcaaatagta caaaagcata taagtaacta ataaaagctc cctttctgca ttaggcccct
     2941 cagttcttcc cagggaaaat gattaatagt ttacattctt gcagaaattt tttatgtata
     3001 aatttttacc caaatgaatt cattatataa attttttcca acttagtgtt tttttacata
     3061 atagtagcaa gttaaaaaat tgtacttcag gccaggcacg gtgggtcacg cctgttaatc
     3121 tcagcacttt gggaggctga ggcaggaaga ccacttgagg tcaggagttc aagaccagcc
     3181 tggccaacat ggtgaaaacc catctctact aaaatacaaa aatcagctgg gcatggtggc
     3241 gcatgtctgt aatcccagct actcgggagg ctgaggcagg agaatcgctt gaacccggga
     3301 ggcggaggtt gcagtgagct gagattgcgc cattgcactc cagcctggag gacaagaggg
     3361 agacttcctc tcaaaaaaca aaatattgta cttcaaaaaa ttattcttca atgctatttt
     3421 taaattacta gaaattattt tggaatttaa tgttgcatac agcctgagat atggctgttc
     3481 accctttggt aaagtattaa agaaaaataa tgcattgttc tcagcttaaa tttttttctg
     3541 atttgacaac atgagtgatg ttttcccagt attatttcaa ttatatttgt tttattttct
     3601 gttcctcact cctacctctc attccagtcc ccaaactggc ttttctttta tttctttttt
     3661 cttcattgct gatgtattta ttgagcaatg tcctgtatca ggcactgtcc aaggtgctgt
     3721 atgtgccatg ttgaagagaa cagacaggac ctactgtcct tgtatatctt gcctttgata
     3781 acagaaactg caggggattg gaatagcctc tttacaagaa aagaataaga gtgaggaaaa
     3841 gcgtttggaa tttatagtga tcacagtgac caggttttgt attgggtatg ttttacattt
     3901 gtaacttcag tgctattttt ttttaagctc cattgttttc taaatgtaaa caagtatcaa
     3961 tgtaaggaca gtttcatcag gtgaatatca gaagtactga caccataatc tcattttgca
     4021 ctgtggcaaa gggtagtaga tgtgtgttca ggattatttg ctctgtcagt agtgcccagg
     4081 gtgccactcc atgactaacc gaaacatttt attatgtgac tcactaagat gttcaattca
     4141 ttagtatttt ctggttactc aaagtgtact ctatgtacct ttttttgacc tttgattttt
     4201 attctgatgg agaagatcag attccttttt tatcttataa aaaataattt tgaaacaaag
     4261 acttattttg aagtaagtct tttaacatta tctcagatgc attttatttt gtccttaagt
     4321 aagacttttc atttttacct ttcaaaatgc aattttcaaa atatatgctt ttttgaaaca
     4381 cttattatgt tactgaataa ccagagtatt aaattcaatg tacagcaaat ttttacaaag
     4441 tcccagtagt tcttgcagag ctttctataa tatcagattt atttaccatc atgaaatatg
     4501 tttatacagt attaagtata ttgtactatg aagttggacc tgcacactga aaaattccaa
     4561 aatacctatt atgttgtgct ttttgtgata tatattcata ttattatttg tcataacaag
     4621 gtgaactttt ttaaaatggt aaacatgtat tagttacata atcaggaaaa aagtcatctt
     4681 ttataatgag aaaaattagg tcaaggatat ttcaggtttt atccaattag atttcttgta
     4741 aagttatgtg ttttctttta tctcagtgct tatttgcttt gcaaggatga aggttagaga
     4801 ttcctttcag tagttaatga aagctacaga cttgtcttgc cgaaaaatgt acataaacac
     4861 ataaactatt ttccaagcag tttcacagtg tttgcaaagt tcagattgaa aacccagttt
     4921 tacaaatccc atctacaaat ttgcattgtc attaagatat attaaaaata atttttcaaa
     4981 gcaacagcac agatgcactt taaaactgta gcttaaaaat aaaaattagt aatataactt
     5041 gtgtaaacct acacaaaaga taaaagatat cttattgcaa aaatagggca acattttgtt
     5101 ttaaagacca aatagtgaat tgaatttaat gcatatcttt aaatccttaa tagtatctca
     5161 aatctggttt aaatctgtct ctccttaacg gaatagaaag tgaaacaaat ccagaaatct
     5221 tgttcgagta catggtctgt gctagtaatc atatctaaag tggtaatgtt accatatgct
     5281 gggtactggg ctgagtaaat cacatatttt aacttattta aacactgcac tgtattgcct
     5341 gctagcgatg tcattttttt aaagttggat ggtgaataca tgagttgttt tttaaactct
     5401 tttgggagcc taaaaaattt gaattttttt ttttcccccc ccagacggag tctcgctctc
     5461 ttgccaggct ggagtgcagt gacattatct tggctcactg cagcctctga ttccctggtt
     5521 caagcaattc tcctgcctca gcctcccgag tagctgggat tacaggcatc caccaccacg
     5581 tccagctaat ttttgtattt ttagtagaga cggggtttca ccatgttggc caggatggga
     5641 aaatttttta aaagacattt attaaaaaaa aatgtctatg ccttatcaaa gtttataact
     5701 caagaattaa tgagataaac agtggacaaa aagtgttggc agataacatg cataatttta
     5761 attaaaagtt aagcagtgaa aaataaacat ctttttttct taaagagata tttcatatct
     5821 gttctatttg tttagtttta tttattcttt ttagagacag ggtctctctg tggagtgcag
     5881 tggcatgatt atagccctct gcggcctcaa tcttcagggc ttaagttatc ctcctgcctc
     5941 atcctcccaa gtagctagga ctacaagtgt gtgccaccat acctggctaa tttttaaaaa
     6001 ctattttgta gagacagggt cttactatgt tgcccagagt ggtcttgaac tcccatcctc
     6061 atggaatcct cccacttcag tctctgaaag tgctaggatt ataggcatga gccatttatg
     6121 cccagccagt tttctttttt ctaattgaag cttggcaagc agagggaaat gtattaggga
     6181 aatagcttta gttttgagtg ggtgtcagta gccagctgaa gaaaaagcaa aatgaaatag
     6241 gtagtagaaa tgagaaaggg agagagggaa gaagaaaaaa atggatgttg gaaagttgtt
     6301 gcatgtctct ctggatagct cagaagtatc agttgtggtt attgcctcac ttggcttttg
     6361 taagcatgaa aaagccaggg acaatttcaa ctaccatttc tgaccatcat caaccacaaa
     6421 ttttaggcaa tttgttagaa ttttttttaa atgttcttaa tagttgttgg gtacctggga
     6481 gatttcagag aaagtaatca cctttgtata tattattaat gtgtttataa tagaaattaa
     6541 attctttggg atgtacaggt aagataagct atgtgaagca tagctgttat ccaagtcgtg
     6601 tgcctttgaa atacttggaa tttgaagaac aggacatgca gcttatgtta taattaattt
     6661 gcgagcaata tatggcatga tagtattttc ttatctaaat tctgagtgca ttgaaagttt
     6721 aaagcaaagg acaaaagctt cctttgttca tggcccatat tccagtatat ttttctgaaa
     6781 ctgccaatat tttctgatcg gtactttcat ttttctagtt ggttaccaaa tactgttatt
     6841 ggtattattt ctatataaaa ggctttaaga agactatagt ataattttct taagaaaaaa
     6901 gacatgatta taagctaaaa tatgccttcg gttttgtgtg ctacaaattg agggagattg
     6961 agaatatttt aaatcaaggg cagacattga gtaaaagctt atgactttgg atggatttga
     7021 aacatgatta aatgacagag taaataaaag cccctagtca agtgaattct aatgggggaa
     7081 ataagaggac tatataaaaa ttgaacctct gttttgaaaa caaatctttc caggaagtgg
     7141 taccactctg gggtcaagag aaattgtaag aacaataaaa tgagcacaca tgaccttcct
     7201 ttcctataaa aatatgaagc agaaaactcc cccatgattt cctcatgttg cttagaatag
     7261 tgtgtatttc agaacttttc catttaatat ttttggacca cagttgactg aaactgagga
     7321 tgggaggaag ggatgcttaa aaccttggat agtaccaaac cctatatata ttatgttttt
     7381 ttctatatat acacagctat gataaagttc ataaattagg cacagtaaga gattaaaaat
     7441 attaaattgg gccaattaat atattgtaat aaaagctatg ttaatgtgg
//
