LOCUS       NM_138408                788 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 6 (GTF3C6),
            mRNA.
ACCESSION   NM_138408
VERSION     NM_138408.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 788)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF361496.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138408.3.
            
            Summary: RNA polymerases are unable to initiate RNA synthesis in
            the absence of additional proteins called general transcription
            factors (GTFs). GTFs assemble in a complex on the DNA promoter and
            recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1,
            MIM 603246) are essential for RNA polymerase III to make a number
            of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM
            180420), tRNA, and adenovirus-associated (VA) RNA of both cellular
            and viral origin.[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361496.1, SRR1163657.272789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329970.8/ ENSP00000357863.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               AF361496.1         147-934
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..788
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /note="general transcription factor IIIC subunit 6"
                     /db_xref="GeneID:112495"
                     /db_xref="HGNC:HGNC:20872"
                     /db_xref="MIM:611784"
     exon            1..121
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..706
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /note="transcription factor IIIC 35kDa; TFIIIC 35 kDa
                     subunit; transcription factor IIIC subunit 6;
                     transcription factor IIIC 35 kDa subunit; general
                     transcription factor IIIC, polypeptide 6, alpha 35kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 6"
                     /protein_id="NP_612417.1"
                     /db_xref="CCDS:CCDS5087.1"
                     /db_xref="GeneID:112495"
                     /db_xref="HGNC:HGNC:20872"
                     /db_xref="MIM:611784"
                     /translation="MAAAADERSPEDGEDEEEEEQLVLVELSGIIDSDFLSKCENKCK
                     VLGIDTERPILQVDSCVFAGEYEDTLGTCVIFEENVEHADTEGNNKTVLKYKCHTMKK
                     LSMTRTLLTEKKEGEENIGGVEWLQIKDNDFSYRPNMICNFLHENEDEEVVASAPDKS
                     LELEEEEIQMNDSSNLSCEQEKPMHLEIEDSGPLIDIPSETEGSVFMETQMLP"
     exon            122..202
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     exon            203..266
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     exon            267..311
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     exon            312..425
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     exon            426..788
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /note="hexamer: AATAAT"
     polyA_site      788
                     /gene="GTF3C6"
                     /gene_synonym="bA397G5.3; C6orf51; TFIIIC35"
                     /note="major polyA site"
ORIGIN      
        1 gtactcaaga tggcggctcc gggcgggcgt ggccagtgac tagaaggcga ggcgccgcgg
       61 gaccatggcg gcggcggcgg acgagcggag tccagaggac ggagaagacg aggaagagga
      121 ggagcagttg gttctggtgg aattatcagg aattattgat tcagacttcc tctcaaaatg
      181 tgaaaataaa tgcaaggttt tgggcattga cactgagagg cccattctgc aagtggacag
      241 ctgtgtcttt gctggggagt atgaagacac tctagggacc tgtgttatat ttgaagaaaa
      301 tgttgaacat gctgatacag aaggcaataa taaaacagtg ctaaaatata aatgccatac
      361 aatgaagaag ctcagcatga caagaactct cctgacagag aagaaggaag gagaagaaaa
      421 cataggtggg gtggaatggc tgcaaataaa ggataatgat ttctcctatc gacccaacat
      481 gatttgtaac tttctacatg aaaatgaaga cgaagaagtg gtagcttcag ccccagataa
      541 atctttggaa ttggaagagg aagagattca aatgaacgac agttcaaacc tgagttgtga
      601 acaggagaaa ccaatgcact tggaaataga agattctggt cctcttattg atataccttc
      661 tgagacagaa ggttctgttt ttatggaaac tcaaatgctg ccttagaaat cactcctaga
      721 tgaaatgttt ctcataataa cttgtcaaga actttttaga gttgttacat aaaaataatt
      781 gctgtgta
//
