LOCUS       NP_036218                886 aa            linear   PRI 19-SEP-2024
DEFINITION  general transcription factor 3C polypeptide 3 isoform 1 [Homo
            sapiens].
ACCESSION   NP_036218
VERSION     NP_036218.1
DBSOURCE    REFSEQ: accession NM_012086.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 886)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 886)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 886)
  AUTHORS   Huang,S., Chen,J., Wang,H., Sun,B., Wang,H., Zhang,Z., Zhang,X. and
            Chen,Z.
  TITLE     Influenza A virus matrix protein 1 interacts with hTFIIIC102-s, a
            short isoform of the polypeptide 3 subunit of human general
            transcription factor IIIC
  JOURNAL   Arch Virol 154 (7), 1101-1110 (2009)
   PUBMED   19521658
REFERENCE   4  (residues 1 to 886)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   5  (residues 1 to 886)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   6  (residues 1 to 886)
  AUTHORS   Koch,H.B., Zhang,R., Verdoodt,B., Bailey,A., Zhang,C.D., Yates,J.R.
            3rd, Menssen,A. and Hermeking,H.
  TITLE     Large-scale identification of c-MYC-associated proteins using a
            combined TAP/MudPIT approach
  JOURNAL   Cell Cycle 6 (2), 205-217 (2007)
   PUBMED   17314511
REFERENCE   7  (residues 1 to 886)
  AUTHORS   Zhan,Y., Hegde,R., Srinivasula,S.M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Death effector domain-containing proteins DEDD and FLAME-3 form
            nuclear complexes with the TFIIIC102 subunit of human transcription
            factor IIIC
  JOURNAL   Cell Death Differ 9 (4), 439-447 (2002)
   PUBMED   11965497
  REMARK    GeneRIF: DEDD and FLAME-3 form nuclear complexes with TFIIIC102
REFERENCE   8  (residues 1 to 886)
  AUTHORS   Hsieh,Y.J., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of two evolutionarily conserved
            subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their
            involvement in functional interactions with TFIIIB and RNA
            polymerase III
  JOURNAL   Mol Cell Biol 19 (7), 4944-4952 (1999)
   PUBMED   10373544
REFERENCE   9  (residues 1 to 886)
  AUTHORS   Behar,G., Coleclough,C., Houlgatte,R., Auffray,C. and Lefkovits,I.
  TITLE     Human lymphocyte cDNA ordered library analyzed by 2D gel
            electrophoresis. 3. Analysis of individual clones
  JOURNAL   Appl Theor Electrophor 5 (2), 99-105 (1995)
   PUBMED   8573604
REFERENCE   10 (residues 1 to 886)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314718.1 and AC012486.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is part of the TFIIIC2
            complex, which binds to the promoters of small nuclear and
            cytoplasmic RNA genes in order to recruit RNA polymerase III. The
            TFIIIC2 complex is composed of six subunits. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.87922.1,
                                           SRR1803614.88328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263956.8/ ENSP00000263956.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     Protein         1..886
                     /product="general transcription factor 3C polypeptide 3
                     isoform 1"
                     /note="general transcription factor 3C polypeptide 3;
                     TF3C-gamma; TFIIIC 102 kDa subunit; transcription factor
                     IIIC subunit gamma; general transcription factor IIIC,
                     polypeptide 3, 102kDa"
                     /calculated_mol_wt=101142
     Region          1..121
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:22223895; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Site            43
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          <146..351
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          149..182
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          152..177
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          183..216
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          183..211
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(184,187..188,191..192,194,218,221..222,225..226,
                     228..229,252,255..256,259..260,263)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          216..246
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          217..250
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          251..278
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          252..284
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          286..316
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          290..323
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          326..361
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          408..>514
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          421..454
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Site            order(422,425..426,429..430,432,457,460..461,464..465,
                     467..468,491,494..495,498..499,502)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          422..449
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          454..485
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          456..489
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          490..514
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          491..523
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          729..>842
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          733..766
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Site            order(741..742,744,768,771..772,775,778,780..781,812,
                     815..816,819..820,823)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          766..806
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          811..844
                     /region_name="TPR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5Q9.1)"
     Region          811..839
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          845..880
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..886
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /coded_by="NM_012086.5:73..2733"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2316.1"
                     /db_xref="GeneID:9330"
                     /db_xref="HGNC:HGNC:4666"
                     /db_xref="MIM:604888"
ORIGIN      
        1 msgfspelid ylegkisfee ferrreerkt rekkslqekg klsaeenpdd sevpsssgin
       61 stksqdkdvn egetsdgvrk svhkvfasml geneddeeee eeeeeeeeee etpeqptagd
      121 vfvlemvlnr etkkmmkekr prsklpralr glmgeanirf argereeail mcmeiirqap
      181 layepfstla miyedqgdme kslqfeliaa hlnpsdteew vrlaemsleq dnikqaifcy
      241 tkalkyeptn vrylwerssl yeqmgdhkma mdgyrrilnl lspsdgerfm qlardmaksy
      301 yeandvtsai niideafskh qglvsmedvn iaaelyisnk qydkaleiit dfsgivlekk
      361 tseegtseen kapenvtcti pdgvpiditv klmvclvhln ileplnpllt tlveqnpedm
      421 gdlyldvaea fldvgeynsa lpllsalvcs erynlavvwl rhaeclkalg ymeraaesyg
      481 kvvdlaplhl darislstlq qqlgqpekal ealepmydpd tlaqdanaaq qelklllhrs
      541 tllfsqgkmy gyvdtlltml amllkvamnr aqvclisssk sgerhlylik vsrdkisdsn
      601 dqesancdak aifavltsvl tkddwwnlll kaiyslcdls rfqeaellvd ssleyysfyd
      661 drqkrkeley fglsaaildk nfrkaynyir imvmenvnkp qlwnifnqvt mhsqdvrhhr
      721 fclrlmlknp enhalcvlng hnafvsgsfk halgqyvqaf rthpdeplys fcigltfihm
      781 asqkyvlrrh alivqgfsfl nrylslrgpc qesfynlgrg lhqlglihla ihyyqkalel
      841 pplvvegiel dqldlrrdia ynlsliyqss gntgmaqtll ytycsi
//
