LOCUS       NM_001206774            1767 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 3 (GTF3C3),
            transcript variant 2, mRNA.
ACCESSION   NM_001206774
VERSION     NM_001206774.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1767)
  AUTHORS   Huang,S., Chen,J., Wang,H., Sun,B., Wang,H., Zhang,Z., Zhang,X. and
            Chen,Z.
  TITLE     Influenza A virus matrix protein 1 interacts with hTFIIIC102-s, a
            short isoform of the polypeptide 3 subunit of human general
            transcription factor IIIC
  JOURNAL   Arch Virol 154 (7), 1101-1110 (2009)
   PUBMED   19521658
REFERENCE   4  (bases 1 to 1767)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   5  (bases 1 to 1767)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   6  (bases 1 to 1767)
  AUTHORS   Koch,H.B., Zhang,R., Verdoodt,B., Bailey,A., Zhang,C.D., Yates,J.R.
            3rd, Menssen,A. and Hermeking,H.
  TITLE     Large-scale identification of c-MYC-associated proteins using a
            combined TAP/MudPIT approach
  JOURNAL   Cell Cycle 6 (2), 205-217 (2007)
   PUBMED   17314511
REFERENCE   7  (bases 1 to 1767)
  AUTHORS   Zhan,Y., Hegde,R., Srinivasula,S.M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Death effector domain-containing proteins DEDD and FLAME-3 form
            nuclear complexes with the TFIIIC102 subunit of human transcription
            factor IIIC
  JOURNAL   Cell Death Differ 9 (4), 439-447 (2002)
   PUBMED   11965497
  REMARK    GeneRIF: DEDD and FLAME-3 form nuclear complexes with TFIIIC102
REFERENCE   8  (bases 1 to 1767)
  AUTHORS   Hsieh,Y.J., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of two evolutionarily conserved
            subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their
            involvement in functional interactions with TFIIIB and RNA
            polymerase III
  JOURNAL   Mol Cell Biol 19 (7), 4944-4952 (1999)
   PUBMED   10373544
REFERENCE   9  (bases 1 to 1767)
  AUTHORS   Behar,G., Coleclough,C., Houlgatte,R., Auffray,C. and Lefkovits,I.
  TITLE     Human lymphocyte cDNA ordered library analyzed by 2D gel
            electrophoresis. 3. Analysis of individual clones
  JOURNAL   Appl Theor Electrophor 5 (2), 99-105 (1995)
   PUBMED   8573604
REFERENCE   10 (bases 1 to 1767)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB078021.1, AF465407.1 and
            AC012486.9.
            
            On May 31, 2019 this sequence version replaced NM_001206774.1.
            
            Summary: The protein encoded by this gene is part of the TFIIIC2
            complex, which binds to the promoters of small nuclear and
            cytoplasmic RNA genes in order to recruit RNA polymerase III. The
            TFIIIC2 complex is composed of six subunits. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) lacks multiple exons from the
            3' end and has an alternate 3' segment, compared to variant 1. The
            resulting isoform (2) has a much shorter and distinct C-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465407.1, SRR1660803.146605.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB078021.1         86-109
            25-1760             AF465407.1         1-1736
            1761-1767           AC012486.9         38607-38613         c
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..1767
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="general transcription factor IIIC subunit 3"
                     /db_xref="GeneID:9330"
                     /db_xref="HGNC:HGNC:4666"
                     /db_xref="MIM:604888"
     exon            1..174
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1314
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="isoform 2 is encoded by transcript variant 2;
                     general transcription factor 3C polypeptide 3; TF3C-gamma;
                     TFIIIC 102 kDa subunit; transcription factor IIIC subunit
                     gamma; general transcription factor IIIC, polypeptide 3,
                     102kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 3
                     isoform 2"
                     /protein_id="NP_001193703.1"
                     /db_xref="CCDS:CCDS56153.1"
                     /db_xref="GeneID:9330"
                     /db_xref="HGNC:HGNC:4666"
                     /db_xref="MIM:604888"
                     /translation="MSGFSPELIDYLEGKISFEEFERRREERKTREKKSLQEKGKLSA
                     EENPDDSEVPSSSGINSTKSQDKDVNEGETSDGVRKSVHKVFASMLGENEDDEEEEEE
                     EEEEEEEEETPEQPTAGDVFVLEMVLNRETKKMMKEKRPRSKLPRALRGLMGEANIRF
                     ARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSDTE
                     EWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRR
                     ILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEAFSKHQGLVSMEDVNIAAE
                     LYISNKQYDKALEIITDFSGIVLEKKTSEEGTSEENKAPENVTCTIPDGVPIDITVKL
                     MVCLVHLNILEPLNVCNKICT"
     exon            175..286
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            287..483
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            484..607
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            608..799
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            800..965
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1113
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1186
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1767
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1452..1457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="hexamer: ACTAAA"
     polyA_site      1469
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="major polyA site"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="hexamer: AATAAA"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="hexamer: AATACA"
     polyA_site      1760
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
     polyA_site      1767
                     /gene="GTF3C3"
                     /gene_synonym="TFIIIC102; TFiiiC2-102; TFIIICgamma"
                     /note="major polyA site"
ORIGIN      
        1 agcttctgga aggcgctgct cttccggttc tctgtcccgg ttcctggggt tgcacagaca
       61 gaccctgtaa acatgtcagg gttcagtccg gaactcatcg actacttgga agggaaaatc
      121 tcctttgagg agttcgaacg gcggagagaa gagagaaaaa cccgcgagaa gaaaagtctt
      181 caggaaaaag gcaagttatc agctgaagaa aatcccgatg actctgaagt tccatcatca
      241 tcaggaatta actctaccaa atcccaagac aaagatgtca atgaaggaga aacatcagat
      301 ggagtgagga agtcagttca caaggtcttt gcttccatgc ttggagagaa tgaagatgat
      361 gaggaggaag aggaagaaga ggaggaggag gaggaggagg aagaaacacc tgagcaaccc
      421 actgcgggcg atgtatttgt attggagatg gttctcaatc gtgaaaccaa gaaaatgatg
      481 aaagagaaaa ggcctcggag taaacttccc agagctctga gaggtctcat gggtgaagcc
      541 aacattcgtt ttgctcgagg agaacgtgaa gaggcgatat tgatgtgcat ggaaatcata
      601 agacaagctc ctctggctta tgagccattc tctactctag ccatgatata tgaggaccaa
      661 ggtgacatgg aaaaatcatt gcagtttgag ttgattgctg cgcatttaaa tcccagtgac
      721 acagaagaat gggttagact ggcagaaatg tctctggaac aagacaatat taagcaggct
      781 attttttgct atacaaaagc tcttaaatat gaacctacta atgtccgtta tctgtgggag
      841 cgatcaagcc tttatgaaca gatgggtgat cataaaatgg ccatggatgg ttataggcgt
      901 attttaaacc ttttgtctcc atctgatggc gaacgtttta tgcagctggc tagagatatg
      961 gcaaagagtt actatgaagc caatgatgtt acttctgcta ttaacataat tgatgaagct
     1021 ttctcaaaac accagggcct agtctccatg gaagatgtta acatagcagc tgaactatat
     1081 atttctaaca aacagtatga caaagctttg gagataatta cagatttttc tggaattgtg
     1141 ctggaaaaaa aaacttcaga agaaggcacc tcagaagaga ataaagctcc tgagaatgtt
     1201 acctgcacta tacctgatgg cgtgccaata gatatcacag tgaagttgat ggtctgcctt
     1261 gtacatctca acattcttga accacttaat gtatgtaaca agatctgcac ttgagatact
     1321 tcagatcaaa tgcaccatct cttttcttta gatgtcaaga aattataact tgaccctaga
     1381 gtttcacatt tcttaataac caaggaggta acaataagca tcaaataatt ttgtatgaat
     1441 atcttataaa aactaaaatt gttttgcaat tgggcttaca gtaatttatt tttcttttaa
     1501 aataacaatc taaagatcat aatttgagat tgtctttaga ccatttgaga ttgtcattag
     1561 ataattggta ataattctga cagctattct tttttgcgga ctttggacca agtatattat
     1621 tgaaaaaaaa aaagtactta gcatctactt tgtaaacctt aggataagat attgagtaaa
     1681 atatacaaat ccataccctc atgggttggg atgctttttt gttttaatgg gattagataa
     1741 taaaataaat acataacata tacggga
//
