LOCUS       NM_001521               3683 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 1, mRNA.
ACCESSION   NM_001521
VERSION     NM_001521.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 3683)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 3683)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 3683)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 3683)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA399212.1, D13636.1 and BC020981.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001521.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1550760.1,
                                           SRR14243140.434462.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               DA399212.1         266-533
            269-2471            D13636.1           182-2384
            2472-3683           BC020981.1         2375-3586
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3683
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..26
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            27..102
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            103..373
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2862
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform b is encoded by transcript variant 1;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform b"
                     /protein_id="NP_001512.1"
                     /db_xref="CCDS:CCDS1749.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLA
                     WKWHLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERWDVSFF
                     TGGPLWALDWCPVPEGAGASQYVALFSSPDMNETHPLSQLHSGPGLLQLWGLGTLQQE
                     SCPGNRAHFVYGIACDNGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKV
                     LLFSLPHPEALLAQQPPDAVKPAIYKVQCVATLQVGSMQATDPSECGQCLSLAWMPTR
                     PHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKA
                     NSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYG
                     LCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALN
                     PINVKRPVERRFPIYKADLIPYQDSPEGPDHSSASSGVPNPPKARTYTETVNHHYLLF
                     QDTDLGSFHDLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGG
                     QSGLVRIHFVRGLASPLGHRMQLESRAHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            374..695
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            696..981
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1076
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1154
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1253
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1481
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1593
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1702
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1728
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1858
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2003
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2165
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2253
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2382
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2535
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2643
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..3683
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      3211
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      3683
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgaggcttg agtgtgcgtc agaatcccct gaagagcttg
       61 ttaaaacaca aggtgctggc cccatccaga attgctgatt cggggcagcc attttggggg
      121 gtgctgatgg atacctgcgg ggtcggctat gttgccctgg gggaggccgg ccccgtgggg
      181 aacatgactg tggtagactc tcctggacaa gaggtgctaa atcagcttga tgtcaagacc
      241 tcttcagaaa tgaccagtgc agaggcttcc gtagagatgt cattacctac ccctttgcct
      301 ggatttgagg attctcctga tcagaggagg ctccctccag agcaggaaag cctctccaga
      361 ctggaacagc cagatctttc ttcagagatg tcaaaggtct caaagcctag ggcctcaaag
      421 cctggccgga agagaggtgg taggacacga aaaggcccca aaaggcccca acagcctaat
      481 cctccatcag ccccactggt tcctggtctc ttagatcaat ccaaccctct gtccaccccc
      541 atgcctaaga aacgaggtcg aaagtccaag gcagagctgc tgctgctgaa gttgtcaaaa
      601 gacctagatc ggccagaatc tcaatctcca aagaggcccc ctgaggactt tgagacccct
      661 tctggggaac gaccccgccg aagggctgcc caagtggcac ttctgtatct tcaggaactg
      721 gctgaagagc tctcaacagc cctgcctgcc cctgtgtcct gtcctgaggg ccccaaggtg
      781 agcagcccca ccaaaccgaa gaagatccgg cagccagcag cctgtccagg tggagaagag
      841 gtggatggtg ctccacggga tgaagacttt tttctccagg ttgaggctga agatgtggaa
      901 gaaagtgagg gcccaagtga gagctcatct gaacctgagc ctgtagtgcc ccgaagcacc
      961 ccacgaggat ctacttcagg gaaacagaaa ccacactgcc gaggaatggc tcccaatggc
     1021 ttaccaaatc atatcatggc tcctgtttgg aagtgcctcc atctcaccaa ggacttccga
     1081 gagcagaaac attcatactg ggagtttgct gagtggattc ctttagcctg gaagtggcac
     1141 ttgttatctg agcttgaggc cgctccctac ctgccccagg aggagaagtc tccattgttt
     1201 tctgtacaac gtgaagggct acctgaagat ggcaccctct accgaataaa cagatttagc
     1261 tcgatcacag cacatccaga gcgctgggat gtgtccttct tcacgggggg accgctctgg
     1321 gctctggact ggtgcccagt gccagagggg gcaggagcct cgcaatatgt ggctcttttc
     1381 tccagccctg acatgaatga gacacaccca ctgagccagc ttcattcggg tcctgggctg
     1441 ctccagctct ggggccttgg gaccttgcag caagaaagct gtcctggcaa cagggcccac
     1501 tttgtctatg ggattgcttg tgacaacggc tgcatctggg acctcaagtt ctgccccagt
     1561 ggagcatggg aacttccagg cacccctcgg aaggctcctc tcctgccccg gttgggtctc
     1621 ttggctctgg cctgctcaga cgggaaagta ctgctattca gtctacccca tccggaggcc
     1681 ctgctggctc agcaaccccc agatgcagtg aagcctgcca tatataaggt acaatgtgtg
     1741 gcaactctgc aggtggggtc tatgcaagct acagacccct ctgagtgtgg tcagtgcctt
     1801 agcctggcct ggatgcctac caggccccac caacacctag ctgctggata ttataatggc
     1861 atggtggttt tctggaacct tcccactaac tcacccctgc agcggatacg gctctctgat
     1921 ggctccttaa agctctaccc cttccagtgt ttcctagccc atgaccaggc tgtgcgtacc
     1981 cttcaatggt gcaaagctaa cagccatttc cttgtctctg cggggagtga ccggaaaatc
     2041 aaattctggg accttcgacg tccttacgaa cccataaact ctatcaagcg cttcttgagt
     2101 acagaactgg cctggctgct tccctacaat ggtgtcactg tggctcagga caactgctat
     2161 gcctcttatg gactctgtgg gattcattat attgacgctg gttaccttgg tttcaaggcc
     2221 tacttcactg ctcctcgaaa aggcaccgtt tggagtcttt caggatccga ctggcttggg
     2281 acaatagctg caggagatat atccggggag ctcattgctg ctatattacc agatatggca
     2341 ctgaatccaa taaatgtcaa gcgacctgta gagcgaagat ttcctatata taaagcagat
     2401 ctgataccgt atcaggacag tcctgaaggt ccagaccatt cttctgcttc atctggggtc
     2461 cccaaccctc ctaaggctcg aacttacact gaaactgtca accatcacta cttgctcttt
     2521 caagacacag atttgggttc attccatgat ctgctccgta gagaaccaat gctgcgcatg
     2581 caggagggag aggggcattc tcaactctgc ctggacaggc tgcagctgga ggctattcat
     2641 aaggtacgtt tcagcccaaa cctggactcc tatggatggc tggtatctgg ggggcagtca
     2701 gggctggttc gaatccattt tgtccgtgga ctcgcctccc cactgggcca ccgtatgcag
     2761 cttgaaagcc gagcccactt caatgctatg ttccaaccat cctcccccac tagacggcct
     2821 ggcttctctc caaccagcca tcgccttctg cccactccct agccttggcc cacaccagat
     2881 ccttggagtg aagtcggtca agaacaaatg gcccctatgc acagagccat aggaactggg
     2941 ggccttccct ggacagtgat catgccaggc ctggaccttt aggcctgcct ccccaggact
     3001 ccttagatcc cactctttct acagacttct gtgatcacag ccccctgcgg gcaggggggc
     3061 tctccctcca ccaactctca aggctcctca gcctaagact atggctcatg agaaacactc
     3121 aggcctgacc taggcttggg agtcaaactg ctcatattga gcatattgtt aagtgggtaa
     3181 agccaagtaa aggtactggg tgtttttgtg accacttgtg aatgggtgta tggagaactg
     3241 aaaagggtat ctgcatgaag gctcctgtct gactattcca ggatccaata ttactgcctt
     3301 ctgaaacttc ctctttaggg taaccatcat gtatgcccac gagggtgata gtaattcgtg
     3361 agactgaagt tgcttagagt acttctttga ccaaggaata ccacagacac cctaccgata
     3421 gaacagtggc tcagatctta cttgctcctg cttacgaagt attcccaatc actggtcatc
     3481 tgaccctact tgaacactcc tgaacagtca tgttttttaa aatcttcctt tatatcaagt
     3541 cagagagtat acttctataa atttcactca tggatgttag gaaatctagt catcttccct
     3601 gtgattgccc tgttaagtat ttaaccatag ctatcatgtg tttcccaaat cttctctaga
     3661 ttaaatatct tcagttactt caa
//
