LOCUS       NM_001394516            3379 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 17, mRNA.
ACCESSION   NM_001394516
VERSION     NM_001394516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 3379)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 3379)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 3379)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 3379)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 3379)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 3379)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074117.7, AC109828.4 and AC013413.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.186131.1,
                                           SRR14038195.2096767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC074117.7         189304-189329
            27-297              AC109828.4         9453-9723           c
            298-619             AC109828.4         8971-9292           c
            620-905             AC109828.4         8093-8378           c
            906-1000            AC109828.4         4071-4165           c
            1001-1078           AC109828.4         3626-3703           c
            1079-1177           AC109828.4         3389-3487           c
            1178-1289           AC109828.4         2062-2173           c
            1290-1398           AC109828.4         1743-1851           c
            1399-1424           AC109828.4         119-144             c
            1425-1554           AC013413.6         116647-116776       c
            1555-1699           AC013413.6         112371-112515       c
            1700-1861           AC013413.6         112113-112274       c
            1862-1949           AC013413.6         111836-111923       c
            1950-2078           AC013413.6         111460-111588       c
            2079-2231           AC013413.6         111029-111181       c
            2232-2339           AC013413.6         110169-110276       c
            2340-3379           AC013413.6         108846-109885       c
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3379
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..26
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            27..297
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2558
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform g is encoded by transcript variant 17;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform g"
                     /protein_id="NP_001381445.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLA
                     WKWHLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINSPGNRAHFVYGIACDNG
                     CIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPPD
                     AVKPAIYKVQCVATLQVGSMQATDPSECGQCLSLAWMPTRPHQHLAAGYYNGMVVFWN
                     LPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLVSAGSDRKIKFWD
                     LRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYF
                     TAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALNPINVKRPVERRFPIYKAD
                     LIPYQDSPEGPDHSSASSGVPNPPKARTYTETVNHHYLLFQDTDLGSFHDLLRREPML
                     RMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLASPLG
                     HRMQLESRAHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            298..619
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            620..905
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1000
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1078
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1177
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1289
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1398
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1424
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1554
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1699
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1861
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1949
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2078
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2231
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2339
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..3379
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      2907
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      3379
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgagggggc agccattttg gggggtgctg atggatacct
       61 gcggggtcgg ctatgttgcc ctgggggagg ccggccccgt ggggaacatg actgtggtag
      121 actctcctgg acaagaggtg ctaaatcagc ttgatgtcaa gacctcttca gaaatgacca
      181 gtgcagaggc ttccgtagag atgtcattac ctaccccttt gcctggattt gaggattctc
      241 ctgatcagag gaggctccct ccagagcagg aaagcctctc cagactggaa cagccagatc
      301 tttcttcaga gatgtcaaag gtctcaaagc ctagggcctc aaagcctggc cggaagagag
      361 gtggtaggac acgaaaaggc cccaaaaggc cccaacagcc taatcctcca tcagccccac
      421 tggttcctgg tctcttagat caatccaacc ctctgtccac ccccatgcct aagaaacgag
      481 gtcgaaagtc caaggcagag ctgctgctgc tgaagttgtc aaaagaccta gatcggccag
      541 aatctcaatc tccaaagagg ccccctgagg actttgagac cccttctggg gaacgacccc
      601 gccgaagggc tgcccaagtg gcacttctgt atcttcagga actggctgaa gagctctcaa
      661 cagccctgcc tgcccctgtg tcctgtcctg agggccccaa ggtgagcagc cccaccaaac
      721 cgaagaagat ccggcagcca gcagcctgtc caggtggaga agaggtggat ggtgctccac
      781 gggatgaaga cttttttctc caggttgagg ctgaagatgt ggaagaaagt gagggcccaa
      841 gtgagagctc atctgaacct gagcctgtag tgccccgaag caccccacga ggatctactt
      901 cagggaaaca gaaaccacac tgccgaggaa tggctcccaa tggcttacca aatcatatca
      961 tggctcctgt ttggaagtgc ctccatctca ccaaggactt ccgagagcag aaacattcat
     1021 actgggagtt tgctgagtgg attcctttag cctggaagtg gcacttgtta tctgagcttg
     1081 aggccgctcc ctacctgccc caggaggaga agtctccatt gttttctgta caacgtgaag
     1141 ggctacctga agatggcacc ctctaccgaa taaacagtcc tggcaacagg gcccactttg
     1201 tctatgggat tgcttgtgac aacggctgca tctgggacct caagttctgc cccagtggag
     1261 catgggaact tccaggcacc cctcggaagg ctcctctcct gccccggttg ggtctcttgg
     1321 ctctggcctg ctcagacggg aaagtactgc tattcagtct accccatccg gaggccctgc
     1381 tggctcagca acccccagat gcagtgaagc ctgccatata taaggtacaa tgtgtggcaa
     1441 ctctgcaggt ggggtctatg caagctacag acccctctga gtgtggtcag tgccttagcc
     1501 tggcctggat gcctaccagg ccccaccaac acctagctgc tggatattat aatggcatgg
     1561 tggttttctg gaaccttccc actaactcac ccctgcagcg gatacggctc tctgatggct
     1621 ccttaaagct ctaccccttc cagtgtttcc tagcccatga ccaggctgtg cgtacccttc
     1681 aatggtgcaa agctaacagc catttccttg tctctgcggg gagtgaccgg aaaatcaaat
     1741 tctgggacct tcgacgtcct tacgaaccca taaactctat caagcgcttc ttgagtacag
     1801 aactggcctg gctgcttccc tacaatggtg tcactgtggc tcaggacaac tgctatgcct
     1861 cttatggact ctgtgggatt cattatattg acgctggtta ccttggtttc aaggcctact
     1921 tcactgctcc tcgaaaaggc accgtttgga gtctttcagg atccgactgg cttgggacaa
     1981 tagctgcagg agatatatcc ggggagctca ttgctgctat attaccagat atggcactga
     2041 atccaataaa tgtcaagcga cctgtagagc gaagatttcc tatatataaa gcagatctga
     2101 taccgtatca ggacagtcct gaaggtccag accattcttc tgcttcatct ggggtcccca
     2161 accctcctaa ggctcgaact tacactgaaa ctgtcaacca tcactacttg ctctttcaag
     2221 acacagattt gggttcattc catgatctgc tccgtagaga accaatgctg cgcatgcagg
     2281 agggagaggg gcattctcaa ctctgcctgg acaggctgca gctggaggct attcataagg
     2341 tacgtttcag cccaaacctg gactcctatg gatggctggt atctgggggg cagtcagggc
     2401 tggttcgaat ccattttgtc cgtggactcg cctccccact gggccaccgt atgcagcttg
     2461 aaagccgagc ccacttcaat gctatgttcc aaccatcctc ccccactaga cggcctggct
     2521 tctctccaac cagccatcgc cttctgccca ctccctagcc ttggcccaca ccagatcctt
     2581 ggagtgaagt cggtcaagaa caaatggccc ctatgcacag agccatagga actgggggcc
     2641 ttccctggac agtgatcatg ccaggcctgg acctttaggc ctgcctcccc aggactcctt
     2701 agatcccact ctttctacag acttctgtga tcacagcccc ctgcgggcag gggggctctc
     2761 cctccaccaa ctctcaaggc tcctcagcct aagactatgg ctcatgagaa acactcaggc
     2821 ctgacctagg cttgggagtc aaactgctca tattgagcat attgttaagt gggtaaagcc
     2881 aagtaaaggt actgggtgtt tttgtgacca cttgtgaatg ggtgtatgga gaactgaaaa
     2941 gggtatctgc atgaaggctc ctgtctgact attccaggat ccaatattac tgccttctga
     3001 aacttcctct ttagggtaac catcatgtat gcccacgagg gtgatagtaa ttcgtgagac
     3061 tgaagttgct tagagtactt ctttgaccaa ggaataccac agacacccta ccgatagaac
     3121 agtggctcag atcttacttg ctcctgctta cgaagtattc ccaatcactg gtcatctgac
     3181 cctacttgaa cactcctgaa cagtcatgtt ttttaaaatc ttcctttata tcaagtcaga
     3241 gagtatactt ctataaattt cactcatgga tgttaggaaa tctagtcatc ttccctgtga
     3301 ttgccctgtt aagtatttaa ccatagctat catgtgtttc ccaaatcttc tctagattaa
     3361 atatcttcag ttacttcaa
//
