LOCUS       NM_001394514            3529 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 15, mRNA.
ACCESSION   NM_001394514
VERSION     NM_001394514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3529)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3529)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 3529)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3529)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 3529)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 3529)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 3529)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 3529)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 3529)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 3529)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074117.7, AC109828.4 and AC013413.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC074117.7         189304-189329
            27-297              AC109828.4         9453-9723           c
            298-619             AC109828.4         8971-9292           c
            620-905             AC109828.4         8093-8378           c
            906-1000            AC109828.4         4071-4165           c
            1001-1099           AC109828.4         3389-3487           c
            1100-1327           AC109828.4         2343-2570           c
            1328-1439           AC109828.4         2062-2173           c
            1440-1548           AC109828.4         1743-1851           c
            1549-1574           AC109828.4         119-144             c
            1575-1704           AC013413.6         116647-116776       c
            1705-1849           AC013413.6         112371-112515       c
            1850-2011           AC013413.6         112113-112274       c
            2012-2099           AC013413.6         111836-111923       c
            2100-2228           AC013413.6         111460-111588       c
            2229-2381           AC013413.6         111029-111181       c
            2382-2489           AC013413.6         110169-110276       c
            2490-3529           AC013413.6         108846-109885       c
FEATURES             Location/Qualifiers
     source          1..3529
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3529
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..26
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            27..297
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2708
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform e is encoded by transcript variant 15;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform e"
                     /protein_id="NP_001381443.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFEAAPYLPQEEKSPLFSV
                     QREGLPEDGTLYRINRFSSITAHPERWDVSFFTGGPLWALDWCPVPEGAGASQYVALF
                     SSPDMNETHPLSQLHSGPGLLQLWGLGTLQQESCPGNRAHFVYGIACDNGCIWDLKFC
                     PSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPPDAVKPAIYK
                     VQCVATLQVGSMQATDPSECGQCLSLAWMPTRPHQHLAAGYYNGMVVFWNLPTNSPLQ
                     RIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLVSAGSDRKIKFWDLRRPYEPI
                     NSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTV
                     WSLSGSDWLGTIAAGDISGELIAAILPDMALNPINVKRPVERRFPIYKADLIPYQDSP
                     EGPDHSSASSGVPNPPKARTYTETVNHHYLLFQDTDLGSFHDLLRREPMLRMQEGEGH
                     SQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLASPLGHRMQLESR
                     AHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            298..619
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            620..905
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1000
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1099
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1327
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1439
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1548
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1574
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1704
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1849
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2011
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2099
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2228
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2381
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2489
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..3529
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      3057
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      3529
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgagggggc agccattttg gggggtgctg atggatacct
       61 gcggggtcgg ctatgttgcc ctgggggagg ccggccccgt ggggaacatg actgtggtag
      121 actctcctgg acaagaggtg ctaaatcagc ttgatgtcaa gacctcttca gaaatgacca
      181 gtgcagaggc ttccgtagag atgtcattac ctaccccttt gcctggattt gaggattctc
      241 ctgatcagag gaggctccct ccagagcagg aaagcctctc cagactggaa cagccagatc
      301 tttcttcaga gatgtcaaag gtctcaaagc ctagggcctc aaagcctggc cggaagagag
      361 gtggtaggac acgaaaaggc cccaaaaggc cccaacagcc taatcctcca tcagccccac
      421 tggttcctgg tctcttagat caatccaacc ctctgtccac ccccatgcct aagaaacgag
      481 gtcgaaagtc caaggcagag ctgctgctgc tgaagttgtc aaaagaccta gatcggccag
      541 aatctcaatc tccaaagagg ccccctgagg actttgagac cccttctggg gaacgacccc
      601 gccgaagggc tgcccaagtg gcacttctgt atcttcagga actggctgaa gagctctcaa
      661 cagccctgcc tgcccctgtg tcctgtcctg agggccccaa ggtgagcagc cccaccaaac
      721 cgaagaagat ccggcagcca gcagcctgtc caggtggaga agaggtggat ggtgctccac
      781 gggatgaaga cttttttctc caggttgagg ctgaagatgt ggaagaaagt gagggcccaa
      841 gtgagagctc atctgaacct gagcctgtag tgccccgaag caccccacga ggatctactt
      901 cagggaaaca gaaaccacac tgccgaggaa tggctcccaa tggcttacca aatcatatca
      961 tggctcctgt ttggaagtgc ctccatctca ccaaggactt tgaggccgct ccctacctgc
     1021 cccaggagga gaagtctcca ttgttttctg tacaacgtga agggctacct gaagatggca
     1081 ccctctaccg aataaacaga tttagctcga tcacagcaca tccagagcgc tgggatgtgt
     1141 ccttcttcac ggggggaccg ctctgggctc tggactggtg cccagtgcca gagggggcag
     1201 gagcctcgca atatgtggct cttttctcca gccctgacat gaatgagaca cacccactga
     1261 gccagcttca ttcgggtcct gggctgctcc agctctgggg ccttgggacc ttgcagcaag
     1321 aaagctgtcc tggcaacagg gcccactttg tctatgggat tgcttgtgac aacggctgca
     1381 tctgggacct caagttctgc cccagtggag catgggaact tccaggcacc cctcggaagg
     1441 ctcctctcct gccccggttg ggtctcttgg ctctggcctg ctcagacggg aaagtactgc
     1501 tattcagtct accccatccg gaggccctgc tggctcagca acccccagat gcagtgaagc
     1561 ctgccatata taaggtacaa tgtgtggcaa ctctgcaggt ggggtctatg caagctacag
     1621 acccctctga gtgtggtcag tgccttagcc tggcctggat gcctaccagg ccccaccaac
     1681 acctagctgc tggatattat aatggcatgg tggttttctg gaaccttccc actaactcac
     1741 ccctgcagcg gatacggctc tctgatggct ccttaaagct ctaccccttc cagtgtttcc
     1801 tagcccatga ccaggctgtg cgtacccttc aatggtgcaa agctaacagc catttccttg
     1861 tctctgcggg gagtgaccgg aaaatcaaat tctgggacct tcgacgtcct tacgaaccca
     1921 taaactctat caagcgcttc ttgagtacag aactggcctg gctgcttccc tacaatggtg
     1981 tcactgtggc tcaggacaac tgctatgcct cttatggact ctgtgggatt cattatattg
     2041 acgctggtta ccttggtttc aaggcctact tcactgctcc tcgaaaaggc accgtttgga
     2101 gtctttcagg atccgactgg cttgggacaa tagctgcagg agatatatcc ggggagctca
     2161 ttgctgctat attaccagat atggcactga atccaataaa tgtcaagcga cctgtagagc
     2221 gaagatttcc tatatataaa gcagatctga taccgtatca ggacagtcct gaaggtccag
     2281 accattcttc tgcttcatct ggggtcccca accctcctaa ggctcgaact tacactgaaa
     2341 ctgtcaacca tcactacttg ctctttcaag acacagattt gggttcattc catgatctgc
     2401 tccgtagaga accaatgctg cgcatgcagg agggagaggg gcattctcaa ctctgcctgg
     2461 acaggctgca gctggaggct attcataagg tacgtttcag cccaaacctg gactcctatg
     2521 gatggctggt atctgggggg cagtcagggc tggttcgaat ccattttgtc cgtggactcg
     2581 cctccccact gggccaccgt atgcagcttg aaagccgagc ccacttcaat gctatgttcc
     2641 aaccatcctc ccccactaga cggcctggct tctctccaac cagccatcgc cttctgccca
     2701 ctccctagcc ttggcccaca ccagatcctt ggagtgaagt cggtcaagaa caaatggccc
     2761 ctatgcacag agccatagga actgggggcc ttccctggac agtgatcatg ccaggcctgg
     2821 acctttaggc ctgcctcccc aggactcctt agatcccact ctttctacag acttctgtga
     2881 tcacagcccc ctgcgggcag gggggctctc cctccaccaa ctctcaaggc tcctcagcct
     2941 aagactatgg ctcatgagaa acactcaggc ctgacctagg cttgggagtc aaactgctca
     3001 tattgagcat attgttaagt gggtaaagcc aagtaaaggt actgggtgtt tttgtgacca
     3061 cttgtgaatg ggtgtatgga gaactgaaaa gggtatctgc atgaaggctc ctgtctgact
     3121 attccaggat ccaatattac tgccttctga aacttcctct ttagggtaac catcatgtat
     3181 gcccacgagg gtgatagtaa ttcgtgagac tgaagttgct tagagtactt ctttgaccaa
     3241 ggaataccac agacacccta ccgatagaac agtggctcag atcttacttg ctcctgctta
     3301 cgaagtattc ccaatcactg gtcatctgac cctacttgaa cactcctgaa cagtcatgtt
     3361 ttttaaaatc ttcctttata tcaagtcaga gagtatactt ctataaattt cactcatgga
     3421 tgttaggaaa tctagtcatc ttccctgtga ttgccctgtt aagtatttaa ccatagctat
     3481 catgtgtttc ccaaatcttc tctagattaa atatcttcag ttacttcaa
//
