LOCUS       NM_001394503            3693 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 5, mRNA.
ACCESSION   NM_001394503
VERSION     NM_001394503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074117.7, AC109828.4 and AC013413.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2673569.1,
                                           SRR14038195.1989983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC074117.7         189304-189329
            27-112              AC074117.7         195669-195754
            113-383             AC109828.4         9453-9723           c
            384-705             AC109828.4         8971-9292           c
            706-991             AC109828.4         8093-8378           c
            992-1086            AC109828.4         4071-4165           c
            1087-1164           AC109828.4         3626-3703           c
            1165-1263           AC109828.4         3389-3487           c
            1264-1491           AC109828.4         2343-2570           c
            1492-1603           AC109828.4         2062-2173           c
            1604-1712           AC109828.4         1743-1851           c
            1713-1738           AC109828.4         119-144             c
            1739-1868           AC013413.6         116647-116776       c
            1869-2013           AC013413.6         112371-112515       c
            2014-2175           AC013413.6         112113-112274       c
            2176-2263           AC013413.6         111836-111923       c
            2264-2392           AC013413.6         111460-111588       c
            2393-2545           AC013413.6         111029-111181       c
            2546-2653           AC013413.6         110169-110276       c
            2654-3693           AC013413.6         108846-109885       c
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3693
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..26
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            27..112
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            113..383
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2872
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform b is encoded by transcript variant 5;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform b"
                     /protein_id="NP_001381432.1"
                     /db_xref="CCDS:CCDS1749.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLA
                     WKWHLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERWDVSFF
                     TGGPLWALDWCPVPEGAGASQYVALFSSPDMNETHPLSQLHSGPGLLQLWGLGTLQQE
                     SCPGNRAHFVYGIACDNGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKV
                     LLFSLPHPEALLAQQPPDAVKPAIYKVQCVATLQVGSMQATDPSECGQCLSLAWMPTR
                     PHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKA
                     NSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYG
                     LCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALN
                     PINVKRPVERRFPIYKADLIPYQDSPEGPDHSSASSGVPNPPKARTYTETVNHHYLLF
                     QDTDLGSFHDLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGG
                     QSGLVRIHFVRGLASPLGHRMQLESRAHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            384..705
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            706..991
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1086
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1164
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1263
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1491
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1603
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1712
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1738
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1868
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2013
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2175
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2263
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2392
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2545
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2653
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..3693
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      3221
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      3670..3675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      3693
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgaggtgtt tttcagcttg agtgtgcgtc agaatcccct
       61 gaagagcttg ttaaaacaca aggtgctggc cccatccaga attgctgatt cggggcagcc
      121 attttggggg gtgctgatgg atacctgcgg ggtcggctat gttgccctgg gggaggccgg
      181 ccccgtgggg aacatgactg tggtagactc tcctggacaa gaggtgctaa atcagcttga
      241 tgtcaagacc tcttcagaaa tgaccagtgc agaggcttcc gtagagatgt cattacctac
      301 ccctttgcct ggatttgagg attctcctga tcagaggagg ctccctccag agcaggaaag
      361 cctctccaga ctggaacagc cagatctttc ttcagagatg tcaaaggtct caaagcctag
      421 ggcctcaaag cctggccgga agagaggtgg taggacacga aaaggcccca aaaggcccca
      481 acagcctaat cctccatcag ccccactggt tcctggtctc ttagatcaat ccaaccctct
      541 gtccaccccc atgcctaaga aacgaggtcg aaagtccaag gcagagctgc tgctgctgaa
      601 gttgtcaaaa gacctagatc ggccagaatc tcaatctcca aagaggcccc ctgaggactt
      661 tgagacccct tctggggaac gaccccgccg aagggctgcc caagtggcac ttctgtatct
      721 tcaggaactg gctgaagagc tctcaacagc cctgcctgcc cctgtgtcct gtcctgaggg
      781 ccccaaggtg agcagcccca ccaaaccgaa gaagatccgg cagccagcag cctgtccagg
      841 tggagaagag gtggatggtg ctccacggga tgaagacttt tttctccagg ttgaggctga
      901 agatgtggaa gaaagtgagg gcccaagtga gagctcatct gaacctgagc ctgtagtgcc
      961 ccgaagcacc ccacgaggat ctacttcagg gaaacagaaa ccacactgcc gaggaatggc
     1021 tcccaatggc ttaccaaatc atatcatggc tcctgtttgg aagtgcctcc atctcaccaa
     1081 ggacttccga gagcagaaac attcatactg ggagtttgct gagtggattc ctttagcctg
     1141 gaagtggcac ttgttatctg agcttgaggc cgctccctac ctgccccagg aggagaagtc
     1201 tccattgttt tctgtacaac gtgaagggct acctgaagat ggcaccctct accgaataaa
     1261 cagatttagc tcgatcacag cacatccaga gcgctgggat gtgtccttct tcacgggggg
     1321 accgctctgg gctctggact ggtgcccagt gccagagggg gcaggagcct cgcaatatgt
     1381 ggctcttttc tccagccctg acatgaatga gacacaccca ctgagccagc ttcattcggg
     1441 tcctgggctg ctccagctct ggggccttgg gaccttgcag caagaaagct gtcctggcaa
     1501 cagggcccac tttgtctatg ggattgcttg tgacaacggc tgcatctggg acctcaagtt
     1561 ctgccccagt ggagcatggg aacttccagg cacccctcgg aaggctcctc tcctgccccg
     1621 gttgggtctc ttggctctgg cctgctcaga cgggaaagta ctgctattca gtctacccca
     1681 tccggaggcc ctgctggctc agcaaccccc agatgcagtg aagcctgcca tatataaggt
     1741 acaatgtgtg gcaactctgc aggtggggtc tatgcaagct acagacccct ctgagtgtgg
     1801 tcagtgcctt agcctggcct ggatgcctac caggccccac caacacctag ctgctggata
     1861 ttataatggc atggtggttt tctggaacct tcccactaac tcacccctgc agcggatacg
     1921 gctctctgat ggctccttaa agctctaccc cttccagtgt ttcctagccc atgaccaggc
     1981 tgtgcgtacc cttcaatggt gcaaagctaa cagccatttc cttgtctctg cggggagtga
     2041 ccggaaaatc aaattctggg accttcgacg tccttacgaa cccataaact ctatcaagcg
     2101 cttcttgagt acagaactgg cctggctgct tccctacaat ggtgtcactg tggctcagga
     2161 caactgctat gcctcttatg gactctgtgg gattcattat attgacgctg gttaccttgg
     2221 tttcaaggcc tacttcactg ctcctcgaaa aggcaccgtt tggagtcttt caggatccga
     2281 ctggcttggg acaatagctg caggagatat atccggggag ctcattgctg ctatattacc
     2341 agatatggca ctgaatccaa taaatgtcaa gcgacctgta gagcgaagat ttcctatata
     2401 taaagcagat ctgataccgt atcaggacag tcctgaaggt ccagaccatt cttctgcttc
     2461 atctggggtc cccaaccctc ctaaggctcg aacttacact gaaactgtca accatcacta
     2521 cttgctcttt caagacacag atttgggttc attccatgat ctgctccgta gagaaccaat
     2581 gctgcgcatg caggagggag aggggcattc tcaactctgc ctggacaggc tgcagctgga
     2641 ggctattcat aaggtacgtt tcagcccaaa cctggactcc tatggatggc tggtatctgg
     2701 ggggcagtca gggctggttc gaatccattt tgtccgtgga ctcgcctccc cactgggcca
     2761 ccgtatgcag cttgaaagcc gagcccactt caatgctatg ttccaaccat cctcccccac
     2821 tagacggcct ggcttctctc caaccagcca tcgccttctg cccactccct agccttggcc
     2881 cacaccagat ccttggagtg aagtcggtca agaacaaatg gcccctatgc acagagccat
     2941 aggaactggg ggccttccct ggacagtgat catgccaggc ctggaccttt aggcctgcct
     3001 ccccaggact ccttagatcc cactctttct acagacttct gtgatcacag ccccctgcgg
     3061 gcaggggggc tctccctcca ccaactctca aggctcctca gcctaagact atggctcatg
     3121 agaaacactc aggcctgacc taggcttggg agtcaaactg ctcatattga gcatattgtt
     3181 aagtgggtaa agccaagtaa aggtactggg tgtttttgtg accacttgtg aatgggtgta
     3241 tggagaactg aaaagggtat ctgcatgaag gctcctgtct gactattcca ggatccaata
     3301 ttactgcctt ctgaaacttc ctctttaggg taaccatcat gtatgcccac gagggtgata
     3361 gtaattcgtg agactgaagt tgcttagagt acttctttga ccaaggaata ccacagacac
     3421 cctaccgata gaacagtggc tcagatctta cttgctcctg cttacgaagt attcccaatc
     3481 actggtcatc tgaccctact tgaacactcc tgaacagtca tgttttttaa aatcttcctt
     3541 tatatcaagt cagagagtat acttctataa atttcactca tggatgttag gaaatctagt
     3601 catcttccct gtgattgccc tgttaagtat ttaaccatag ctatcatgtg tttcccaaat
     3661 cttctctaga ttaaatatct tcagttactt caa
//
