LOCUS       NM_001318909            4259 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 3, mRNA.
ACCESSION   NM_001318909 XM_005264273
VERSION     NM_001318909.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4259)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 4259)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4259)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 4259)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 4259)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 4259)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 4259)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 4259)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 4259)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074117.7, AC109828.4 and AC013413.6.
            
            On Apr 23, 2021 this sequence version replaced NM_001318909.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647092.1, SRR18074969.1217880.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               AC074117.7         189304-189981
            679-949             AC109828.4         9453-9723           c
            950-1271            AC109828.4         8971-9292           c
            1272-1557           AC109828.4         8093-8378           c
            1558-1652           AC109828.4         4071-4165           c
            1653-1730           AC109828.4         3626-3703           c
            1731-1829           AC109828.4         3389-3487           c
            1830-2057           AC109828.4         2343-2570           c
            2058-2169           AC109828.4         2062-2173           c
            2170-2278           AC109828.4         1743-1851           c
            2279-2304           AC109828.4         119-144             c
            2305-2434           AC013413.6         116647-116776       c
            2435-2579           AC013413.6         112371-112515       c
            2580-2741           AC013413.6         112113-112274       c
            2742-2829           AC013413.6         111836-111923       c
            2830-2958           AC013413.6         111460-111588       c
            2959-3111           AC013413.6         111029-111181       c
            3112-3219           AC013413.6         110169-110276       c
            3220-4259           AC013413.6         108846-109885       c
FEATURES             Location/Qualifiers
     source          1..4259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4259
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..678
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            679..949
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             703..3438
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform b is encoded by transcript variant 3;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform b"
                     /protein_id="NP_001305838.2"
                     /db_xref="CCDS:CCDS1749.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLA
                     WKWHLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERWDVSFF
                     TGGPLWALDWCPVPEGAGASQYVALFSSPDMNETHPLSQLHSGPGLLQLWGLGTLQQE
                     SCPGNRAHFVYGIACDNGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKV
                     LLFSLPHPEALLAQQPPDAVKPAIYKVQCVATLQVGSMQATDPSECGQCLSLAWMPTR
                     PHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKA
                     NSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYG
                     LCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALN
                     PINVKRPVERRFPIYKADLIPYQDSPEGPDHSSASSGVPNPPKARTYTETVNHHYLLF
                     QDTDLGSFHDLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGG
                     QSGLVRIHFVRGLASPLGHRMQLESRAHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            950..1271
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1557
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1652
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1730
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1829
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2057
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2169
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2278
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2304
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2434
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2579
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2741
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2829
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2958
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3111
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3219
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..4259
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      3787
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      4259
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgagggtga gtgtatcgcc gcagcgggtg tgtggggggc
       61 cccacaatta ctcctccccc ttcttttgcc atagcactaa gatattggga acaaactcct
      121 ggctccgctc ttctcccagc cacagcagcg cgcctttcag cgtctgcgct cctacagagc
      181 accatcatgc tccgcacctt ccctactgtg gccaccgtgc accccccatc tctgcaagcc
      241 tcgggtcttg ccctcctccc ccacgcggtg tcggtaacgc ggaagcctgt gtccgggcgt
      301 aggcgctgca tacgtagcgt ccctcgaact cggcgaacct acagtagtcc ttgttagaaa
      361 aaccagggct cctctcccgc acaggctagg ggagaaatct accttcacgc ccaggactga
      421 agaagggcag gtgatggccc ctagagtggt tgtgggtcaa tctctttcag ctgtgtccca
      481 gcctcttcct cgaggaggct ctttaacccc gagggttgtg ccccgcgcgc tgcaacgcca
      541 ttggcgtaac caagggccag ttgtgtttcc ctgtctagtc cttttgtccc gtggcaagtt
      601 ggctgcctgt tggggaagtc agaggtggcg acttcaactc cgtcggaggc aactcacttt
      661 gttggaggga tgtatagggg gcagccattt tggggggtgc tgatggatac ctgcggggtc
      721 ggctatgttg ccctggggga ggccggcccc gtggggaaca tgactgtggt agactctcct
      781 ggacaagagg tgctaaatca gcttgatgtc aagacctctt cagaaatgac cagtgcagag
      841 gcttccgtag agatgtcatt acctacccct ttgcctggat ttgaggattc tcctgatcag
      901 aggaggctcc ctccagagca ggaaagcctc tccagactgg aacagccaga tctttcttca
      961 gagatgtcaa aggtctcaaa gcctagggcc tcaaagcctg gccggaagag aggtggtagg
     1021 acacgaaaag gccccaaaag gccccaacag cctaatcctc catcagcccc actggttcct
     1081 ggtctcttag atcaatccaa ccctctgtcc acccccatgc ctaagaaacg aggtcgaaag
     1141 tccaaggcag agctgctgct gctgaagttg tcaaaagacc tagatcggcc agaatctcaa
     1201 tctccaaaga ggccccctga ggactttgag accccttctg gggaacgacc ccgccgaagg
     1261 gctgcccaag tggcacttct gtatcttcag gaactggctg aagagctctc aacagccctg
     1321 cctgcccctg tgtcctgtcc tgagggcccc aaggtgagca gccccaccaa accgaagaag
     1381 atccggcagc cagcagcctg tccaggtgga gaagaggtgg atggtgctcc acgggatgaa
     1441 gacttttttc tccaggttga ggctgaagat gtggaagaaa gtgagggccc aagtgagagc
     1501 tcatctgaac ctgagcctgt agtgccccga agcaccccac gaggatctac ttcagggaaa
     1561 cagaaaccac actgccgagg aatggctccc aatggcttac caaatcatat catggctcct
     1621 gtttggaagt gcctccatct caccaaggac ttccgagagc agaaacattc atactgggag
     1681 tttgctgagt ggattccttt agcctggaag tggcacttgt tatctgagct tgaggccgct
     1741 ccctacctgc cccaggagga gaagtctcca ttgttttctg tacaacgtga agggctacct
     1801 gaagatggca ccctctaccg aataaacaga tttagctcga tcacagcaca tccagagcgc
     1861 tgggatgtgt ccttcttcac ggggggaccg ctctgggctc tggactggtg cccagtgcca
     1921 gagggggcag gagcctcgca atatgtggct cttttctcca gccctgacat gaatgagaca
     1981 cacccactga gccagcttca ttcgggtcct gggctgctcc agctctgggg ccttgggacc
     2041 ttgcagcaag aaagctgtcc tggcaacagg gcccactttg tctatgggat tgcttgtgac
     2101 aacggctgca tctgggacct caagttctgc cccagtggag catgggaact tccaggcacc
     2161 cctcggaagg ctcctctcct gccccggttg ggtctcttgg ctctggcctg ctcagacggg
     2221 aaagtactgc tattcagtct accccatccg gaggccctgc tggctcagca acccccagat
     2281 gcagtgaagc ctgccatata taaggtacaa tgtgtggcaa ctctgcaggt ggggtctatg
     2341 caagctacag acccctctga gtgtggtcag tgccttagcc tggcctggat gcctaccagg
     2401 ccccaccaac acctagctgc tggatattat aatggcatgg tggttttctg gaaccttccc
     2461 actaactcac ccctgcagcg gatacggctc tctgatggct ccttaaagct ctaccccttc
     2521 cagtgtttcc tagcccatga ccaggctgtg cgtacccttc aatggtgcaa agctaacagc
     2581 catttccttg tctctgcggg gagtgaccgg aaaatcaaat tctgggacct tcgacgtcct
     2641 tacgaaccca taaactctat caagcgcttc ttgagtacag aactggcctg gctgcttccc
     2701 tacaatggtg tcactgtggc tcaggacaac tgctatgcct cttatggact ctgtgggatt
     2761 cattatattg acgctggtta ccttggtttc aaggcctact tcactgctcc tcgaaaaggc
     2821 accgtttgga gtctttcagg atccgactgg cttgggacaa tagctgcagg agatatatcc
     2881 ggggagctca ttgctgctat attaccagat atggcactga atccaataaa tgtcaagcga
     2941 cctgtagagc gaagatttcc tatatataaa gcagatctga taccgtatca ggacagtcct
     3001 gaaggtccag accattcttc tgcttcatct ggggtcccca accctcctaa ggctcgaact
     3061 tacactgaaa ctgtcaacca tcactacttg ctctttcaag acacagattt gggttcattc
     3121 catgatctgc tccgtagaga accaatgctg cgcatgcagg agggagaggg gcattctcaa
     3181 ctctgcctgg acaggctgca gctggaggct attcataagg tacgtttcag cccaaacctg
     3241 gactcctatg gatggctggt atctgggggg cagtcagggc tggttcgaat ccattttgtc
     3301 cgtggactcg cctccccact gggccaccgt atgcagcttg aaagccgagc ccacttcaat
     3361 gctatgttcc aaccatcctc ccccactaga cggcctggct tctctccaac cagccatcgc
     3421 cttctgccca ctccctagcc ttggcccaca ccagatcctt ggagtgaagt cggtcaagaa
     3481 caaatggccc ctatgcacag agccatagga actgggggcc ttccctggac agtgatcatg
     3541 ccaggcctgg acctttaggc ctgcctcccc aggactcctt agatcccact ctttctacag
     3601 acttctgtga tcacagcccc ctgcgggcag gggggctctc cctccaccaa ctctcaaggc
     3661 tcctcagcct aagactatgg ctcatgagaa acactcaggc ctgacctagg cttgggagtc
     3721 aaactgctca tattgagcat attgttaagt gggtaaagcc aagtaaaggt actgggtgtt
     3781 tttgtgacca cttgtgaatg ggtgtatgga gaactgaaaa gggtatctgc atgaaggctc
     3841 ctgtctgact attccaggat ccaatattac tgccttctga aacttcctct ttagggtaac
     3901 catcatgtat gcccacgagg gtgatagtaa ttcgtgagac tgaagttgct tagagtactt
     3961 ctttgaccaa ggaataccac agacacccta ccgatagaac agtggctcag atcttacttg
     4021 ctcctgctta cgaagtattc ccaatcactg gtcatctgac cctacttgaa cactcctgaa
     4081 cagtcatgtt ttttaaaatc ttcctttata tcaagtcaga gagtatactt ctataaattt
     4141 cactcatgga tgttaggaaa tctagtcatc ttccctgtga ttgccctgtt aagtatttaa
     4201 ccatagctat catgtgtttc ccaaatcttc tctagattaa atatcttcag ttacttcaa
//
