LOCUS       NM_001035521            3607 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIIC subunit 2 (GTF3C2),
            transcript variant 2, mRNA.
ACCESSION   NM_001035521
VERSION     NM_001035521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Peng,F., Zhou,Y., Wang,J., Guo,B., Wei,Y., Deng,H., Wu,Z.,
            Zhang,C., Shi,K., Li,Y., Wang,X., Shore,P., Zhao,S. and Deng,W.
  TITLE     The transcription factor Sp1 modulates RNA polymerase III gene
            transcription by controlling BRF1 and GTF3C2 expression in human
            cells
  JOURNAL   J Biol Chem 295 (14), 4617-4630 (2020)
   PUBMED   32115405
  REMARK    GeneRIF: The transcription factor Sp1 modulates RNA polymerase III
            gene transcription by controlling BRF1 and GTF3C2 expression in
            human cells.
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Dumay-Odelot,H., Marck,C., Durrieu-Gaillard,S., Lefebvre,O.,
            Jourdain,S., Prochazkova,M., Pflieger,A. and Teichmann,M.
  TITLE     Identification, molecular cloning, and characterization of the
            sixth subunit of human transcription factor TFIIIC
  JOURNAL   J Biol Chem 282 (23), 17179-17189 (2007)
   PUBMED   17409385
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Oettel,S., Hartel,F., Kober,I., Iben,S. and Seifart,K.H.
  TITLE     Human transcription factors IIIC2, IIIC1 and a novel component
            IIIC0 fulfil different aspects of DNA binding to various pol III
            genes
  JOURNAL   Nucleic Acids Res 25 (12), 2440-2447 (1997)
   PUBMED   9171097
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Sinn,E., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta)
            whose presence correlates with activation of RNA polymerase
            III-mediated transcription by adenovirus E1A expression and serum
            factors
  JOURNAL   Genes Dev 9 (6), 675-685 (1995)
   PUBMED   7729686
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB286393.1, D13636.1 and BC020981.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001035521.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13636.1, SRR14038196.1969124.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264720.8/ ENSP00000264720.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB286393.1         272-282
            12-2395             D13636.1           1-2384
            2396-3607           BC020981.1         2375-3586
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3607
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="general transcription factor IIIC subunit 2"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
     exon            1..26
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            27..297
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2786
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="isoform b is encoded by transcript variant 2;
                     general transcription factor 3C polypeptide 2; TFIIIC 110
                     kDa subunit; transcription factor IIIC subunit beta;
                     transcription factor IIIC 110 kDa subunit; general
                     transcription factor IIIC, polypeptide 2, beta 110kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 2
                     isoform b"
                     /protein_id="NP_001030598.1"
                     /db_xref="CCDS:CCDS1749.1"
                     /db_xref="GeneID:2976"
                     /db_xref="HGNC:HGNC:4665"
                     /db_xref="MIM:604883"
                     /translation="MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTS
                     AEASVEMSLPTPLPGFEDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRK
                     RGGRTRKGPKRPQQPNPPSAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDL
                     DRPESQSPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKV
                     SSPTKPKKIRQPAACPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPR
                     STPRGSTSGKQKPHCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLA
                     WKWHLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERWDVSFF
                     TGGPLWALDWCPVPEGAGASQYVALFSSPDMNETHPLSQLHSGPGLLQLWGLGTLQQE
                     SCPGNRAHFVYGIACDNGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKV
                     LLFSLPHPEALLAQQPPDAVKPAIYKVQCVATLQVGSMQATDPSECGQCLSLAWMPTR
                     PHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKA
                     NSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYG
                     LCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALN
                     PINVKRPVERRFPIYKADLIPYQDSPEGPDHSSASSGVPNPPKARTYTETVNHHYLLF
                     QDTDLGSFHDLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGG
                     QSGLVRIHFVRGLASPLGHRMQLESRAHFNAMFQPSSPTRRPGFSPTSHRLLPTP"
     exon            298..619
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            620..905
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1000
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1078
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1177
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1405
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1517
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1626
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1652
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1782
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1927
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2089
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2177
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2306
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2459
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2567
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..3607
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: AGTAAA"
     polyA_site      3135
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
     regulatory      3584..3589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="hexamer: ATTAAA"
     polyA_site      3607
                     /gene="GTF3C2"
                     /gene_synonym="TF3C-beta; TFIIIC-BETA; TFIIIC110"
                     /note="major polyA site"
ORIGIN      
        1 agacttccgg aaggactttg gcgagggggc agccattttg gggggtgctg atggatacct
       61 gcggggtcgg ctatgttgcc ctgggggagg ccggccccgt ggggaacatg actgtggtag
      121 actctcctgg acaagaggtg ctaaatcagc ttgatgtcaa gacctcttca gaaatgacca
      181 gtgcagaggc ttccgtagag atgtcattac ctaccccttt gcctggattt gaggattctc
      241 ctgatcagag gaggctccct ccagagcagg aaagcctctc cagactggaa cagccagatc
      301 tttcttcaga gatgtcaaag gtctcaaagc ctagggcctc aaagcctggc cggaagagag
      361 gtggtaggac acgaaaaggc cccaaaaggc cccaacagcc taatcctcca tcagccccac
      421 tggttcctgg tctcttagat caatccaacc ctctgtccac ccccatgcct aagaaacgag
      481 gtcgaaagtc caaggcagag ctgctgctgc tgaagttgtc aaaagaccta gatcggccag
      541 aatctcaatc tccaaagagg ccccctgagg actttgagac cccttctggg gaacgacccc
      601 gccgaagggc tgcccaagtg gcacttctgt atcttcagga actggctgaa gagctctcaa
      661 cagccctgcc tgcccctgtg tcctgtcctg agggccccaa ggtgagcagc cccaccaaac
      721 cgaagaagat ccggcagcca gcagcctgtc caggtggaga agaggtggat ggtgctccac
      781 gggatgaaga cttttttctc caggttgagg ctgaagatgt ggaagaaagt gagggcccaa
      841 gtgagagctc atctgaacct gagcctgtag tgccccgaag caccccacga ggatctactt
      901 cagggaaaca gaaaccacac tgccgaggaa tggctcccaa tggcttacca aatcatatca
      961 tggctcctgt ttggaagtgc ctccatctca ccaaggactt ccgagagcag aaacattcat
     1021 actgggagtt tgctgagtgg attcctttag cctggaagtg gcacttgtta tctgagcttg
     1081 aggccgctcc ctacctgccc caggaggaga agtctccatt gttttctgta caacgtgaag
     1141 ggctacctga agatggcacc ctctaccgaa taaacagatt tagctcgatc acagcacatc
     1201 cagagcgctg ggatgtgtcc ttcttcacgg ggggaccgct ctgggctctg gactggtgcc
     1261 cagtgccaga gggggcagga gcctcgcaat atgtggctct tttctccagc cctgacatga
     1321 atgagacaca cccactgagc cagcttcatt cgggtcctgg gctgctccag ctctggggcc
     1381 ttgggacctt gcagcaagaa agctgtcctg gcaacagggc ccactttgtc tatgggattg
     1441 cttgtgacaa cggctgcatc tgggacctca agttctgccc cagtggagca tgggaacttc
     1501 caggcacccc tcggaaggct cctctcctgc cccggttggg tctcttggct ctggcctgct
     1561 cagacgggaa agtactgcta ttcagtctac cccatccgga ggccctgctg gctcagcaac
     1621 ccccagatgc agtgaagcct gccatatata aggtacaatg tgtggcaact ctgcaggtgg
     1681 ggtctatgca agctacagac ccctctgagt gtggtcagtg ccttagcctg gcctggatgc
     1741 ctaccaggcc ccaccaacac ctagctgctg gatattataa tggcatggtg gttttctgga
     1801 accttcccac taactcaccc ctgcagcgga tacggctctc tgatggctcc ttaaagctct
     1861 accccttcca gtgtttccta gcccatgacc aggctgtgcg tacccttcaa tggtgcaaag
     1921 ctaacagcca tttccttgtc tctgcgggga gtgaccggaa aatcaaattc tgggaccttc
     1981 gacgtcctta cgaacccata aactctatca agcgcttctt gagtacagaa ctggcctggc
     2041 tgcttcccta caatggtgtc actgtggctc aggacaactg ctatgcctct tatggactct
     2101 gtgggattca ttatattgac gctggttacc ttggtttcaa ggcctacttc actgctcctc
     2161 gaaaaggcac cgtttggagt ctttcaggat ccgactggct tgggacaata gctgcaggag
     2221 atatatccgg ggagctcatt gctgctatat taccagatat ggcactgaat ccaataaatg
     2281 tcaagcgacc tgtagagcga agatttccta tatataaagc agatctgata ccgtatcagg
     2341 acagtcctga aggtccagac cattcttctg cttcatctgg ggtccccaac cctcctaagg
     2401 ctcgaactta cactgaaact gtcaaccatc actacttgct ctttcaagac acagatttgg
     2461 gttcattcca tgatctgctc cgtagagaac caatgctgcg catgcaggag ggagaggggc
     2521 attctcaact ctgcctggac aggctgcagc tggaggctat tcataaggta cgtttcagcc
     2581 caaacctgga ctcctatgga tggctggtat ctggggggca gtcagggctg gttcgaatcc
     2641 attttgtccg tggactcgcc tccccactgg gccaccgtat gcagcttgaa agccgagccc
     2701 acttcaatgc tatgttccaa ccatcctccc ccactagacg gcctggcttc tctccaacca
     2761 gccatcgcct tctgcccact ccctagcctt ggcccacacc agatccttgg agtgaagtcg
     2821 gtcaagaaca aatggcccct atgcacagag ccataggaac tgggggcctt ccctggacag
     2881 tgatcatgcc aggcctggac ctttaggcct gcctccccag gactccttag atcccactct
     2941 ttctacagac ttctgtgatc acagccccct gcgggcaggg gggctctccc tccaccaact
     3001 ctcaaggctc ctcagcctaa gactatggct catgagaaac actcaggcct gacctaggct
     3061 tgggagtcaa actgctcata ttgagcatat tgttaagtgg gtaaagccaa gtaaaggtac
     3121 tgggtgtttt tgtgaccact tgtgaatggg tgtatggaga actgaaaagg gtatctgcat
     3181 gaaggctcct gtctgactat tccaggatcc aatattactg ccttctgaaa cttcctcttt
     3241 agggtaacca tcatgtatgc ccacgagggt gatagtaatt cgtgagactg aagttgctta
     3301 gagtacttct ttgaccaagg aataccacag acaccctacc gatagaacag tggctcagat
     3361 cttacttgct cctgcttacg aagtattccc aatcactggt catctgaccc tacttgaaca
     3421 ctcctgaaca gtcatgtttt ttaaaatctt cctttatatc aagtcagaga gtatacttct
     3481 ataaatttca ctcatggatg ttaggaaatc tagtcatctt ccctgtgatt gccctgttaa
     3541 gtatttaacc atagctatca tgtgtttccc aaatcttctc tagattaaat atcttcagtt
     3601 acttcaa
//
