LOCUS       NM_001520               7090 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens general transcription factor IIIC subunit 1 (GTF3C1),
            transcript variant 1, mRNA.
ACCESSION   NM_001520
VERSION     NM_001520.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7090)
  AUTHORS   Basu,M., Bhatt,R., Sharma,A., Boopathi,R., Das,S. and Kundu,T.K.
  TITLE     The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine
            Acetyltransferase Targets Histone H3K18
  JOURNAL   J Biochem 175 (2), 205-213 (2024)
   PUBMED   37963603
  REMARK    GeneRIF: The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a
            Lysine Acetyltransferase Targets Histone H3K18.
            Erratum:[J Biochem. 2024 Apr 29;175(5):573. doi:
            10.1093/jb/mvae025.. PMID: 38478019]
REFERENCE   2  (bases 1 to 7090)
  AUTHORS   Sachs,P., Bergmaier,P., Treutwein,K. and Mermoud,J.E.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7090)
  AUTHORS   Vezzoli,M., de Llobet Cucalon,L.I., Di Vona,C., Morselli,M.,
            Montanini,B., de la Luna,S., Teichmann,M., Dieci,G. and Ferrari,R.
  TITLE     TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation
            in Human Stem Cells
  JOURNAL   Int J Mol Sci 24 (4), 3624 (2023)
   PUBMED   36835038
  REMARK    GeneRIF: TFIIIC as a Potential Epigenetic Modulator of Histone
            Acetylation in Human Stem Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7090)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 7090)
  AUTHORS   Crepaldi,L., Policarpi,C., Coatti,A., Sherlock,W.T.,
            Jongbloets,B.C., Down,T.A. and Riccio,A.
  TITLE     Binding of TFIIIC to sine elements controls the relocation of
            activity-dependent neuronal genes to transcription factories
  JOURNAL   PLoS Genet 9 (8), e1003699 (2013)
   PUBMED   23966877
  REMARK    GeneRIF: These findings reveal a novel and essential regulatory
            function of both SINEs and TFIIIC in mediating gene relocation and
            transcription
REFERENCE   6  (bases 1 to 7090)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     DNA topoisomerase I and PC4 can interact with human TFIIIC to
            promote both accurate termination and transcription reinitiation by
            RNA polymerase III
  JOURNAL   Mol Cell 1 (5), 749-757 (1998)
   PUBMED   9660958
REFERENCE   7  (bases 1 to 7090)
  AUTHORS   Lagna,G., Kovelman,R., Sukegawa,J. and Roeder,R.G.
  TITLE     Cloning and characterization of an evolutionarily divergent
            DNA-binding subunit of mammalian TFIIIC
  JOURNAL   Mol Cell Biol 14 (5), 3053-3064 (1994)
   PUBMED   8164661
REFERENCE   8  (bases 1 to 7090)
  AUTHORS   L'Etoile,N.D., Fahnestock,M.L., Shen,Y., Aebersold,R. and Berk,A.J.
  TITLE     Human transcription factor IIIC box B binding subunit
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1652-1656 (1994)
   PUBMED   8127861
REFERENCE   9  (bases 1 to 7090)
  AUTHORS   Kovelman,R. and Roeder,R.G.
  TITLE     Purification and characterization of two forms of human
            transcription factor IIIC
  JOURNAL   J Biol Chem 267 (34), 24446-24456 (1992)
   PUBMED   1447193
REFERENCE   10 (bases 1 to 7090)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP283960.1, BC137229.1, BC044857.2 and CA414192.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001520.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648143.1, CR627430.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356183.9/ ENSP00000348510.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BP283960.1         11-14
            5-6307              BC137229.1         1-6303
            6308-6847           BC044857.2         2892-3431
            6848-7090           CA414192.1         18-260              c
FEATURES             Location/Qualifiers
     source          1..7090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..7090
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /note="general transcription factor IIIC subunit 1"
                     /db_xref="GeneID:2975"
                     /db_xref="HGNC:HGNC:4664"
                     /db_xref="MIM:603246"
     exon            1..244
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..6353
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /note="isoform 1 is encoded by transcript variant 1;
                     general transcription factor 3C polypeptide 1; general
                     transcription factor IIIC, polypeptide 1 (alpha subunit);
                     TF3C-alpha; TFIIIC 220 kDa subunit; TFIIIC box B-binding
                     subunit; transcription factor IIIC subunit alpha;
                     transcription factor IIIC 220 kDa subunit; general
                     transcription factor IIIC, polypeptide 1, alpha 220kDa"
                     /codon_start=1
                     /product="general transcription factor 3C polypeptide 1
                     isoform 1"
                     /protein_id="NP_001511.2"
                     /db_xref="CCDS:CCDS32414.1"
                     /db_xref="GeneID:2975"
                     /db_xref="HGNC:HGNC:4664"
                     /db_xref="MIM:603246"
                     /translation="MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQ
                     EFLWRALATHPGISFYEEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPIHM
                     ILENKDGIQGSCRYFKERKNITNDIRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYR
                     ALIGQEGDPDLKLPDFSYCILERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNK
                     NGLITMQSHVIRLPTGAQQHSILLLLNRFHVDRRSKYDILMEKLSVMLSTRTNHIETL
                     GKLREELGLCERTFKRLYQYMLNAGLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLK
                     LLKEFKRNDHDDDEDEEVISKTVPPVDIVFERDMLTQTYDLIERRGTKGISQAEIRVA
                     MNVGKLEARMLCRLLQRFKVVKGFMEDEGRQRTTKYISCVFAEESDLSRQYQREKARS
                     ELLTTVSLASMQEESLLPEGEDTFLSESDSEEERSSSKRRGRGSQKDTRASANLRPKT
                     QPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEERACQSLASRDSLLDTSSVSEPNVSF
                     VSHCADSNSGDIAVIEEVRMENPKESSSSLKTGRHSSGQDKPHETYRLLKRRNLIIEA
                     VTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQD
                     GIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTANRVKTSQPPVPQGEAEEDSQ
                     GKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYHPIVVPGLGRSLGFLPKMP
                     RLRVVHMFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAGVRPSSSGSAWEACSEA
                     PSKGSQDGVTWEAEVELATETVYVDDASWMRYIPPIPVHRDFGFGWALVSDILLCLPL
                     SIFIQIVQVSYKVDNLEEFLNDPLKKHTLIRFLPRPIRQQLLYKRRYIFSVVENLQRL
                     CYMGLLQFGPTEKFQDKDQVFIFLKKNAVIVDTTICDPHYNLARSSRPFERRLYVLNS
                     MQDVENYWFDLQCVCLNTPLGVVRCPRVRKNSSTDQGSDEEGSLQKEQESAMDKHNLE
                     RKCAMLEYTTGSREVVDEGLIPGDGLGAAGLDSSFYGHLKRNWIWTSYIINQAKKENT
                     AAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVGSELCAGWEEQFEVDREPSLD
                     RNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDEADQSALQRMTRLR
                     VTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRA
                     RYIVKNPQAYLNYKVCLAEVYQDKALVGDFMNRRGDYDDPKVCANEFKEFVEKLKEKF
                     SSALRNSNLEIPDTLQELFARYRVLAIGDEKDQTRKEDELNSVDDIHFLVLQNLIQST
                     LALSDSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSLVNRRRVNHTLGPKKNRAL
                     PFVPMSYQLSQTYYRIFTWRFPSTICTESFQFLDRMRAAGKLDQPDRFSFKDQDNNEP
                     TNDMVAFSLDGPGGNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEVIKSLGKDG
                     SLEDDEDEEDDLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDSI
                     VVNSCQMKFQLRCTPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQENTCSLEEFV
                     LQLELSGYSPEDLTAALEILEAIIATGCFGIDKEELRRRFSALEKAGGGRTRTFADCI
                     QALLEQHQVLEVGGNTARLVAMGSAWPWLLHSVRLKDREDADIQREDPQARPLEGSSS
                     EDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPG
                     AEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPRG
                     FTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPVCKGMMEAMLYHIMTRPGI
                     PESSLLRHYQGVLQPVAVLELLQGLESLGCIRKRWLRKPRPVSLFSTPVVEEVEVPSS
                     LDESPMAFYEPTLDCTLRLGRVFPHEVNWNKWIHL"
     exon            245..454
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            455..631
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            632..775
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            776..872
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            873..996
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1149
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1265
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1575
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1793
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1930
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2084
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2188
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2373
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2655
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2801
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2899
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2996
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3174
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3316
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3452
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3534
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3723
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3881
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..4024
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4106
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4219
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4282
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4376
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4549
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4837
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..5097
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5098..5378
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5379..5895
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..5947
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5948..6140
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6141..7090
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7070..7075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /note="hexamer: ATTAAA"
     polyA_site      7090
                     /gene="GTF3C1"
                     /gene_synonym="TFIIIC; TFIIIC220; TFIIICalpha"
                     /note="major polyA site"
ORIGIN      
        1 gggcgccgcc gactgaagta gcaatggacg cgctggagtc gttgttggac gaagtcgctc
       61 tggaggggct cgatggcctg tgtctgccag cgctgtggag ccggctggag acgcgagtgc
      121 cgcccttccc gctgcctttg gaaccctgca cgcaggagtt tctctggcgg gccctcgcca
      181 cgcacccggg catcagcttc tatgaggagc ctcgggagcg acccgaccta cagctccagg
      241 accggtatga agaaattgat ttggaaactg gaattttgga gtctaggagg gacccggtgg
      301 ctttggagga tgtctacccc attcatatga tcttagagaa taaggatggc atccagggct
      361 catgccgcta ctttaaggag aggaaaaaca ttaccaatga catcagaacc aagtccttgc
      421 agcctcgctg tacaatggtg gaagcctttg acaggtgggg gaagaaactg atcatcgttg
      481 cctcccaggc catgcggtac agggccttga taggccagga gggggatccc gacctgaagc
      541 tgcccgactt ctcctactgc atcctggaac ggctaggccg gtccaggtgg caaggggagc
      601 tccagcgaga ccttcacacc actgctttca aggttgatgc tgggaagctg cactatcaca
      661 gaaaaatttt gaacaaaaac gggctgatta caatgcagtc ccatgtgatc cgattaccca
      721 ctggagccca gcaacactca atcctcctcc tactgaaccg gtttcatgtg gacaggagga
      781 gcaaatacga catcctcatg gagaagcttt cggtcatgct gagcacacgg actaaccaca
      841 tagagacgct gggaaagctg agggaagagc tggggctgtg cgaaaggacg tttaagcgtc
      901 tgtaccagta tatgctgaac gccgggctag ccaaggtggt gtctcttcgc ttgcaagaga
      961 tccaccctga atgtggacct tgtaagacaa agaaagggac cgacgtcatg gttcggtgcc
     1021 tcaagctgct gaaggaattt aaacggaatg accatgatga tgacgaggac gaggaggtca
     1081 tctccaagac agtgcctcca gtggacattg tgttcgagcg ggatatgctc acacagacct
     1141 acgacctcat tgagcgcaga ggcacgaaag gaatttccca agctgaaatc cgagtggcta
     1201 tgaatgtggg aaaactagaa gcaagaatgc tgtgccgact tcttcaaaga ttcaaagttg
     1261 tcaagggatt catggaagac gaaggtcggc agcgaaccac caagtacatt tcctgcgtgt
     1321 ttgcagagga gagcgaccta agccggcagt accaaagaga gaaggcccgc agcgagctct
     1381 tgaccaccgt gagcctggcg tctatgcagg aggagtcgct tctgcctgaa ggcgaggaca
     1441 ccttcctctc tgagtcggac agtgaggagg agaggagcag cagcaagcgg agaggcagag
     1501 ggtcccagaa agacacaaga gcctctgcaa acctccggcc caagacccag cctcatcact
     1561 ccaccccaac caagggtggg tggaaagttg taaacctaca cccattgaaa aagcagccgc
     1621 cctccttccc aggagctgct gaagagagag cctgccagag ccttgccagc agggacagcc
     1681 tcttagatac cagcagcgtc tcagaaccca acgtgtcctt tgtctcccac tgtgcggaca
     1741 gcaacagtgg tgacatagct gtgatcgagg aggtccggat ggaaaaccca aaggagagta
     1801 gcagttccct gaagactggg aggcacagct caggccaaga caaaccacac gaaacttacc
     1861 gactgctgaa acgcaggaat ctgatcatag aagctgtcac caatcttcgc ttaatcgaga
     1921 gtttattcac gattcagaag atgatcatgg atcaggagaa gcaggaaggc gtgtccacca
     1981 agtgctgcaa gaagtccatt gtccgcttgg tgcggaacct gtctgaggaa ggtctcttgc
     2041 gattgtatcg gaccactgtc attcaagatg gcatcaagaa gaaggtggat ctggtggtgc
     2101 acccgtccat ggaccagaac gaccctctag tgagaagtgc catcgagcag gtccgcttcc
     2161 ggatctccaa ttcaagcaca gccaacaggg ttaaaacttc ccagcctcca gtgccccaag
     2221 gggaggcaga agaagacagt caaggaaaag agggcccaag tggatcaggg gactctcagc
     2281 tgagtgcttc ctctagatca gaaagtggac ggatgaaaaa aagtgataat aaaatgggca
     2341 taaccccgct tagaaattat caccccattg tagttcccgg actggggcgt tctctaggat
     2401 ttctgcccaa aatgcctcgc ctgcgggtgg tccacatgtt tctgtggtac ctcatctacg
     2461 ggcaccctgc cagcaacacc gtggagaagc caagcttcat cagtgaacgg agaacgataa
     2521 agcaggagtc aggcagggca ggcgtccggc cgtcctcctc tggaagtgcc tgggaggcct
     2581 gctctgaagc cccatctaaa ggcagccaag atggtgtcac ctgggaggct gaagtggagc
     2641 ttgccacgga gacagtgtat gtcgacgatg cctcgtggat gcgctacatc cccccaatcc
     2701 cagtccacag ggacttcggc tttggctggg ctctcgtcag cgacatcctc ctctgccttc
     2761 ccctctccat cttcatccag attgtgcaag tcagctacaa ggtggacaac ctggaggaat
     2821 ttctgaacga cccgctgaag aagcacacgc tgatccgctt tctccccagg cccattcggc
     2881 agcagcttct gtacaagagg cgttacattt tttcggtggt ggagaacctt cagaggctgt
     2941 gctacatggg gctgctacag tttggtccca cggaaaagtt tcaggataaa gatcaggtct
     3001 ttatcttctt gaagaagaat gcagtcattg ttgacactac catctgcgac ccacattaca
     3061 acctggcccg cagcagccgg cccttcgaga ggcgcctcta tgtcctgaac tcaatgcagg
     3121 atgtggaaaa ctactggttt gacctgcagt gcgtctgcct caacacccca ctaggcgtgg
     3181 tgcgctgccc gcgcgtcagg aagaacagca gcacagacca gggcagcgac gaggagggca
     3241 gcctgcagaa ggagcaggag agcgccatgg acaagcacaa cctggagcgc aagtgcgcca
     3301 tgctggagta caccactgga agccgtgagg tggtggatga aggcttgatc cctggagatg
     3361 ggctgggtgc cgcagggctc gattccagct tctacggaca cctcaagcgc aactggatct
     3421 ggaccagcta catcatcaac caggccaaaa aggagaacac tgccgcagag aatggactca
     3481 cagtgaggct ccagacattt ctgtccaagc gcccaatgcc cctcagtgcc agaggcaaca
     3541 gcaggttgaa tatttggggg gaagcaagag taggctccga gctctgtgct ggctgggaag
     3601 agcagtttga ggtggaccga gagccctcgc tggaccgaaa ccggagagtg aggggtggga
     3661 aaagccagaa gcggaagcgg ctgaagaagg accctgggaa gaagatcaag agaaagaaga
     3721 aaggagagtt cccaggagaa aaaagcaaaa ggctgcgcta ccatgatgaa gccgaccaga
     3781 gtgccctgca gcggatgacg cggcttcgtg tcacctggtc tatgcaggag gatgggctgc
     3841 ttgtgctgtg ccgcattgcc agcaatgtcc tcaacaccaa ggtgaagggc ccatttgtca
     3901 cctggcaggt ggtacgggac attttgcatg ccacgtttga agagtctttg gataaaacat
     3961 ctcattccgt tggacgaaga gctcgctaca tagtcaaaaa cccacaggcc tatctcaact
     4021 ataaagtgtg cctggccgag gtgtaccagg ataaagcact tgttggagat ttcatgaatc
     4081 gaagaggtga ctatgatgac ccaaaggttt gtgccaacga gtttaaagaa tttgtggaga
     4141 agcttaaaga aaagttcagt tcagccctaa ggaattctaa ccttgaaatc ccagacacac
     4201 tccaggagct gttcgccagg taccgagttt tggcaattgg ggatgaaaaa gatcaaacca
     4261 ggaaagagga tgaacttaac agcgtggatg acatccactt tctggtgctt cagaacctga
     4321 tccagagcac gctggccctc tcagacagtc agatgaagtc ctaccagtca ttccagactt
     4381 tccgcctcta tcgggagtac aaggaccacg ttcttgtgaa ggccttcatg gagtgccaga
     4441 agaggagctt ggtcaaccgg cgccgggtca accacacgct gggccccaag aagaaccggg
     4501 ccctcccctt cgtgccaatg tcctaccagc tatcccagac ctactacagg atttttacgt
     4561 ggcgatttcc aagcaccatc tgcacggagt cattccagtt tttggacaga atgcgggctg
     4621 ccggcaagtt ggaccagcct gatcgtttct ctttcaaaga ccaggataat aacgagccca
     4681 caaacgacat ggtggccttt tcactggacg gccctggagg aaattgtgtg gccgtcctga
     4741 ccctcttctc tctgggcctc atttctgtgg atgtcaggat cccggagcag atcatcgtgg
     4801 tagacagctc aatggtggag aatgaggtca tcaaaagctt ggggaaggac ggcagcctgg
     4861 aggatgacga ggatgaagag gatgacttgg acgaaggtgt agggggcaag cgccggagca
     4921 tggaggtgaa acctgcgcaa gcctcccaca ccaactacct gctgatgagg ggctactact
     4981 cccccggcat cgtcagcacc cgcaacctca accccaacga cagcattgtg gtcaactcct
     5041 gccagatgaa gttccagctc cgctgcaccc ctgtgcccgc ccggctcagg cccgctgccg
     5101 ctcctctgga agagctaaca atgggaacct cctgcctccc tgatacgttc accaagctga
     5161 taaaccccca ggaaaacacc tgcagcttgg aggagtttgt cctccagctg gagctgtctg
     5221 ggtatagtcc cgaagacctg actgctgcct tggagatctt ggaagccatt atagccacgg
     5281 gttgttttgg gattgacaag gaggagctgc gcagacggtt ctcggccttg gagaaggcag
     5341 gtggtgggcg caccaggaca ttcgcagatt gcatccaggc cctcctggag cagcatcagg
     5401 tgctggaggt cggtggcaac actgcgcgcc tggtagccat gggctctgcc tggccttggc
     5461 tcctgcactc cgtgcggctg aaagacagag aagacgccga catccagaga gaagaccccc
     5521 aggccagacc cctggagggg tcttccagtg aggacagccc ccccgagggg caggcacctc
     5581 cttctcacag cccccggggc accaagaggc gcgccagctg ggccagtgag aatggggaga
     5641 ccgacgccga gggcacccag atgacccctg ccaagaggcc agcgctccag gactcaaatt
     5701 tggcccccag ccttgggccc ggagctgaag atggggcaga agcccaggcc ccatctccac
     5761 ccccagctct tgaagacacc gctgcagcgg gagcagcaca ggaagaccaa gagggtgtcg
     5821 gtgagttcag ttccccaggc caagagcagc tgagcggcca ggcgcagcct ccagagggct
     5881 ctgaagaccc cagagggttc acagagagtt tcggagctgc caacatctcc caggcagcac
     5941 gggaaaggga ctgtgagagt gtctgcttca tcggccggcc gtggcgtgtc gtggatggcc
     6001 acctgaacct tcctgtatgc aagggtatga tggaggccat gctgtaccac atcatgacca
     6061 ggcctggcat ccccgagagc tccctgctgc gccactacca gggggtcctg cagcccgtcg
     6121 ccgtgctgga gttgctccag ggcctggagt ccctcggctg catccggaag cgctggctga
     6181 gaaagccaag gcctgtctcg ctcttctcta cacccgtggt ggaagaggtg gaagtgccct
     6241 ccagcctgga cgagagcccc atggctttct atgagcccac cttggactgt accctccggc
     6301 tgggccgtgt gttcccccac gaggtcaact ggaacaagtg gatccacctc taggacccct
     6361 gtgggcgtcc cctccctccc agccaccgcc tgccacacca ctcctgcctg gtgctcggca
     6421 gaccccactg tgccctggcc ttgggtctgc cgagcctcct gcagcagggg acgggtgctt
     6481 tggccagagt cacagactga cacgtttccc actgtactgg aactctggaa agaggggctc
     6541 cccgacctgc ccatccccca ggctcttctg ggccttcccc ttgggaactg gcctcatcac
     6601 actgggagtt ggtgcttctt gtctctgggt ctccagagtt tgccccgcct gtgcacacct
     6661 cacattccag actctagcca tctcggcagg atctcctggc tccttgagtg cccaggtgcc
     6721 accaagagga agggccttgt gggatacacc ttgcagaata gggatcggtg tgccccgctg
     6781 cgaggggccc cccatggggg ctgtggcccc tccgcaggca ggacatccca acccctggct
     6841 gggactgaac cacccagagc ggagcggctc ccttttcagc cttgtgagtc acctggcagg
     6901 ccccagctgg gctggctgtc cgtgtccctc agcctggctg gtgattcctt gcaggccaga
     6961 aatgaagagt ccctgtaggt tttggttttg tttgttttat tttgttcttt cacctttttt
     7021 cctcattaaa aaaaaaaagt ccctgtggag tgtacttatt tattttttga ttaaagggaa
     7081 gtaaaatgca
//
