LOCUS       NM_002097               1443 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens general transcription factor IIIA (GTF3A), mRNA.
ACCESSION   NM_002097 XM_001715623 XM_001716951 XM_001717641
VERSION     NM_002097.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Anuraga,G., Tang,W.C., Phan,N.N., Ta,H.D.K., Liu,Y.H., Wu,Y.F.,
            Lee,K.H. and Wang,C.Y.
  TITLE     Comprehensive Analysis of Prognostic and Genetic Signatures for
            General Transcription Factor III (GTF3) in Clinical Colorectal
            Cancer Patients Using Bioinformatics Approaches
  JOURNAL   Curr Issues Mol Biol 43 (1), 2-20 (2021)
   PUBMED   33925358
  REMARK    GeneRIF: Comprehensive Analysis of Prognostic and Genetic
            Signatures for General Transcription Factor III (GTF3) in Clinical
            Colorectal Cancer Patients Using Bioinformatics Approaches.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Speliotes,E.K., Willer,C.J., Berndt,S.I., Monda,K.L.,
            Thorleifsson,G., Jackson,A.U., Lango Allen,H., Lindgren,C.M.,
            Luan,J., Magi,R., Randall,J.C., Vedantam,S., Winkler,T.W., Qi,L.,
            Workalemahu,T., Heid,I.M., Steinthorsdottir,V., Stringham,H.M.,
            Weedon,M.N., Wheeler,E., Wood,A.R., Ferreira,T., Weyant,R.J.,
            Segre,A.V., Estrada,K., Liang,L., Nemesh,J., Park,J.H.,
            Gustafsson,S., Kilpelainen,T.O., Yang,J., Bouatia-Naji,N., Esko,T.,
            Feitosa,M.F., Kutalik,Z., Mangino,M., Raychaudhuri,S., Scherag,A.,
            Smith,A.V., Welch,R., Zhao,J.H., Aben,K.K., Absher,D.M., Amin,N.,
            Dixon,A.L., Fisher,E., Glazer,N.L., Goddard,M.E., Heard-Costa,N.L.,
            Hoesel,V., Hottenga,J.J., Johansson,A., Johnson,T., Ketkar,S.,
            Lamina,C., Li,S., Moffatt,M.F., Myers,R.H., Narisu,N., Perry,J.R.,
            Peters,M.J., Preuss,M., Ripatti,S., Rivadeneira,F., Sandholt,C.,
            Scott,L.J., Timpson,N.J., Tyrer,J.P., van Wingerden,S.,
            Watanabe,R.M., White,C.C., Wiklund,F., Barlassina,C., Chasman,D.I.,
            Cooper,M.N., Jansson,J.O., Lawrence,R.W., Pellikka,N.,
            Prokopenko,I., Shi,J., Thiering,E., Alavere,H., Alibrandi,M.T.,
            Almgren,P., Arnold,A.M., Aspelund,T., Atwood,L.D., Balkau,B.,
            Balmforth,A.J., Bennett,A.J., Ben-Shlomo,Y., Bergman,R.N.,
            Bergmann,S., Biebermann,H., Blakemore,A.I., Boes,T.,
            Bonnycastle,L.L., Bornstein,S.R., Brown,M.J., Buchanan,T.A.,
            Busonero,F., Campbell,H., Cappuccio,F.P., Cavalcanti-Proenca,C.,
            Chen,Y.D., Chen,C.M., Chines,P.S., Clarke,R., Coin,L., Connell,J.,
            Day,I.N., den Heijer,M., Duan,J., Ebrahim,S., Elliott,P.,
            Elosua,R., Eiriksdottir,G., Erdos,M.R., Eriksson,J.G.,
            Facheris,M.F., Felix,S.B., Fischer-Posovszky,P., Folsom,A.R.,
            Friedrich,N., Freimer,N.B., Fu,M., Gaget,S., Gejman,P.V.,
            Geus,E.J., Gieger,C., Gjesing,A.P., Goel,A., Goyette,P.,
            Grallert,H., Grassler,J., Greenawalt,D.M., Groves,C.J.,
            Gudnason,V., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Hall,A.S., Havulinna,A.S., Hayward,C., Heath,A.C., Hengstenberg,C.,
            Hicks,A.A., Hinney,A., Hofman,A., Homuth,G., Hui,J., Igl,W.,
            Iribarren,C., Isomaa,B., Jacobs,K.B., Jarick,I., Jewell,E.,
            John,U., Jorgensen,T., Jousilahti,P., Jula,A., Kaakinen,M.,
            Kajantie,E., Kaplan,L.M., Kathiresan,S., Kettunen,J., Kinnunen,L.,
            Knowles,J.W., Kolcic,I., Konig,I.R., Koskinen,S., Kovacs,P.,
            Kuusisto,J., Kraft,P., Kvaloy,K., Laitinen,J., Lantieri,O.,
            Lanzani,C., Launer,L.J., Lecoeur,C., Lehtimaki,T., Lettre,G.,
            Liu,J., Lokki,M.L., Lorentzon,M., Luben,R.N., Ludwig,B.,
            Manunta,P., Marek,D., Marre,M., Martin,N.G., McArdle,W.L.,
            McCarthy,A., McKnight,B., Meitinger,T., Melander,O., Meyre,D.,
            Midthjell,K., Montgomery,G.W., Morken,M.A., Morris,A.P., Mulic,R.,
            Ngwa,J.S., Nelis,M., Neville,M.J., Nyholt,D.R., O'Donnell,C.J.,
            O'Rahilly,S., Ong,K.K., Oostra,B., Pare,G., Parker,A.N., Perola,M.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Polasek,O., Pouta,A.,
            Rafelt,S., Raitakari,O., Rayner,N.W., Ridderstrale,M., Rief,W.,
            Ruokonen,A., Robertson,N.R., Rzehak,P., Salomaa,V., Sanders,A.R.,
            Sandhu,M.S., Sanna,S., Saramies,J., Savolainen,M.J., Scherag,S.,
            Schipf,S., Schreiber,S., Schunkert,H., Silander,K., Sinisalo,J.,
            Siscovick,D.S., Smit,J.H., Soranzo,N., Sovio,U., Stephens,J.,
            Surakka,I., Swift,A.J., Tammesoo,M.L., Tardif,J.C.,
            Teder-Laving,M., Teslovich,T.M., Thompson,J.R., Thomson,B.,
            Tonjes,A., Tuomi,T., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Viikari,J., Visvikis-Siest,S., Vitart,V., Vogel,C.I., Voight,B.F.,
            Waite,L.L., Wallaschofski,H., Walters,G.B., Widen,E., Wiegand,S.,
            Wild,S.H., Willemsen,G., Witte,D.R., Witteman,J.C., Xu,J.,
            Zhang,Q., Zgaga,L., Ziegler,A., Zitting,P., Beilby,J.P.,
            Farooqi,I.S., Hebebrand,J., Huikuri,H.V., James,A.L., Kahonen,M.,
            Levinson,D.F., Macciardi,F., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Ridker,P.M., Stumvoll,M., Beckmann,J.S., Boeing,H.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Collins,F.S., Cupples,L.A., Smith,G.D., Erdmann,J., Froguel,P.,
            Gronberg,H., Gyllensten,U., Hall,P., Hansen,T., Harris,T.B.,
            Hattersley,A.T., Hayes,R.B., Heinrich,J., Hu,F.B., Hveem,K.,
            Illig,T., Jarvelin,M.R., Kaprio,J., Karpe,F., Khaw,K.T.,
            Kiemeney,L.A., Krude,H., Laakso,M., Lawlor,D.A., Metspalu,A.,
            Munroe,P.B., Ouwehand,W.H., Pedersen,O., Penninx,B.W., Peters,A.,
            Pramstaller,P.P., Quertermous,T., Reinehr,T., Rissanen,A.,
            Rudan,I., Samani,N.J., Schwarz,P.E., Shuldiner,A.R., Spector,T.D.,
            Tuomilehto,J., Uda,M., Uitterlinden,A., Valle,T.T., Wabitsch,M.,
            Waeber,G., Wareham,N.J., Watkins,H., Wilson,J.F., Wright,A.F.,
            Zillikens,M.C., Chatterjee,N., McCarroll,S.A., Purcell,S.,
            Schadt,E.E., Visscher,P.M., Assimes,T.L., Borecki,I.B.,
            Deloukas,P., Fox,C.S., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., Mohlke,K.L., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., van Duijn,C.M., Wichmann,H.E.,
            Frayling,T.M., Thorsteinsdottir,U., Abecasis,G.R., Barroso,I.,
            Boehnke,M., Stefansson,K., North,K.E., McCarthy,M.I.,
            Hirschhorn,J.N., Ingelsson,E. and Loos,R.J.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat Genet 42 (11), 937-948 (2010)
   PUBMED   20935630
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Weser,S., Riemann,J., Seifart,K.H. and Meissner,W.
  TITLE     Assembly and isolation of intermediate steps of transcription
            complexes formed on the human 5S rRNA gene
  JOURNAL   Nucleic Acids Res 31 (9), 2408-2416 (2003)
   PUBMED   12711686
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Fridell,R.A., Fischer,U., Luhrmann,R., Meyer,B.E., Meinkoth,J.L.,
            Malim,M.H. and Cullen,B.R.
  TITLE     Amphibian transcription factor IIIA proteins contain a sequence
            element functionally equivalent to the nuclear export signal of
            human immunodeficiency virus type 1 Rev
  JOURNAL   Proc Natl Acad Sci U S A 93 (7), 2936-2940 (1996)
   PUBMED   8610146
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Drew,P.D., Nagle,J.W., Canning,R.D., Ozato,K., Biddison,W.E. and
            Becker,K.G.
  TITLE     Cloning and expression analysis of a human cDNA homologous to
            Xenopus TFIIIA
  JOURNAL   Gene 159 (2), 215-218 (1995)
   PUBMED   7622052
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Arakawa,H., Nagase,H., Hayashi,N., Ogawa,M., Nagata,M.,
            Fujiwara,T., Takahashi,E., Shin,S. and Nakamura,Y.
  TITLE     Molecular cloning, characterization, and chromosomal mapping of a
            novel human gene (GTF3A) that is highly homologous to Xenopus
            transcription factor IIIA
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 235-238 (1995)
   PUBMED   7789179
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Moorefield,B. and Roeder,R.G.
  TITLE     Purification and characterization of human transcription factor
            IIIA
  JOURNAL   J Biol Chem 269 (33), 20857-20865 (1994)
   PUBMED   8063702
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Seifart,K.H., Wang,L., Waldschmidt,R., Jahn,D. and Wingender,E.
  TITLE     Purification of human transcription factor IIIA and its interaction
            with a chemically synthesized gene encoding human 5 S rRNA
  JOURNAL   J Biol Chem 264 (3), 1702-1709 (1989)
   PUBMED   2912980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D32257.1, BP254755.1, U20272.1,
            AW627732.1 and AL137059.20.
            
            On Nov 23, 2018 this sequence version replaced NM_002097.2.
            
            Summary: The product of this gene is a zinc finger protein with
            nine Cis[2]-His[2] zinc finger domains. It functions as an RNA
            polymerase III transcription factor to induce transcription of the
            5S rRNA genes. The protein binds to a 50 bp internal promoter in
            the 5S genes called the internal control region (ICR), and
            nucleates formation of a stable preinitiation complex. This complex
            recruits the TFIIIC and TFIIIB transcription factors and RNA
            polymerase III to form the complete transcription complex. The
            protein is thought to be translated using a non-AUG translation
            initiation site in mammals based on sequence analysis, protein
            homology, and the size of the purified protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.289034.1,
                                           SRR3476690.656735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000381140.10/ ENSP00000370532.5
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                D32257.1           76-128
            54-125              BP254755.1         110-181
            126-1298            U20272.1           1-1173
            1299-1329           AW627732.1         2-32                c
            1330-1443           AL137059.20        102072-102185       c
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..1443
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /note="general transcription factor IIIA"
                     /db_xref="GeneID:2971"
                     /db_xref="HGNC:HGNC:4662"
                     /db_xref="MIM:600860"
     exon            1..320
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1217
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="transcription factor IIIA"
                     /protein_id="NP_002088.2"
                     /db_xref="CCDS:CCDS45019.1"
                     /db_xref="GeneID:2971"
                     /db_xref="HGNC:HGNC:4662"
                     /db_xref="MIM:600860"
                     /translation="MDPPAVVAESVSSLTIADAFIAAGESSAPTPPRPALPRRFICSF
                     PDCSANYSKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILTHTGEKPFVC
                     AANGCDQKFNTKSNLKKHFERKHENQQKQYICSFEDCKKTFKKHQQLKIHQCQHTNEP
                     LFKCTQEGCGKHFASPSKLKRHAKAHEGYVCQKGCSFVAKTWTELLKHVRETHKEEIL
                     CEVCRKTFKRKDYLKQHMKTHAPERDVCRCPREGCGRTYTTVFNLQSHILSFHEESRP
                     FVCEHAGCGKTFAMKQSLTRHAVVHDPDKKKMKLKVKKSREKRSLASHLSGYIPPKRK
                     QGQGLSLCQNGESPNCVEDKMLSTVAVLTLG"
     exon            321..421
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            422..518
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            519..607
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            608..681
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            682..762
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            763..992
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1052
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1443
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /note="hexamer: ATTAAA"
     polyA_site      1308
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /note="major polyA site"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
                     /note="hexamer: ATTAAA"
     polyA_site      1443
                     /gene="GTF3A"
                     /gene_synonym="AP2; TFIIIA"
ORIGIN      
        1 aagtgtgccg gcgtcgcgcg aaggttcagc agggagccgt gggccgggcg cgccggttcc
       61 cggcacgtgt ctcggcacgt ggcagcgcgc ctggccctgg gcttggaggc gccggcgccc
      121 tggatccgcc ggccgtggtc gccgagtcgg tgtcgtcctt gaccatcgcc gacgcgttca
      181 ttgcagccgg cgagagctca gctccgaccc cgccgcgccc cgcgcttccc aggaggttca
      241 tctgctcctt ccctgactgc agcgccaatt acagcaaagc ctggaagctt gacgcgcacc
      301 tgtgcaagca cacgggggag agaccatttg tttgtgacta tgaagggtgt ggcaaggcct
      361 tcatcaggga ctaccatctg agccgccaca ttctgactca cacaggagaa aagccgtttg
      421 tttgtgcagc caatggctgt gatcaaaaat tcaacacaaa atcaaacttg aagaaacatt
      481 ttgaacgcaa acatgaaaat caacaaaaac aatatatatg cagttttgaa gactgtaaga
      541 agacctttaa gaaacatcag cagctgaaaa tccatcagtg ccagcatacc aatgaacctc
      601 tattcaagtg tacccaggaa ggatgtggga aacactttgc atcacccagc aagctgaaac
      661 gacatgccaa ggcccacgag ggctatgtat gtcaaaaagg atgttccttt gtggcaaaaa
      721 catggacgga acttctgaaa catgtgagag aaacccataa agaggaaata ctatgtgaag
      781 tatgccggaa aacatttaaa cgcaaagatt accttaagca acacatgaaa actcatgccc
      841 cagaaaggga tgtatgtcgc tgtccaagag aaggctgtgg aagaacctat acaactgtgt
      901 ttaatctcca aagccatatc ctctccttcc atgaggaaag ccgccctttt gtgtgtgaac
      961 atgctggctg tggcaaaaca tttgcaatga aacaaagtct cactaggcat gctgttgtac
     1021 atgatcctga caagaagaaa atgaagctca aagtcaaaaa atctcgtgaa aaacggagtt
     1081 tggcctctca tctcagtgga tatatccctc ccaaaaggaa acaagggcaa ggcttatctt
     1141 tgtgtcaaaa cggagagtca cccaactgtg tggaagacaa gatgctctcg acagttgcag
     1201 tacttaccct tggctaagaa ctgcactgct ttgtttaaag gactgcagac caaggagcga
     1261 gctttctctc agagcatgct tttctttatt aaaattactg atgcagaaca tttgattcct
     1321 tatcatttcc atggtctttg ttcaaagtgt ctctttcctg ggtctcttga gtttctttat
     1381 atgccttctc ctcatttttg ctgaaagcac gaagaacaca cattaaagct tttcctcctt
     1441 gaa
//
