LOCUS       NM_001368300            4784 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens GTF2I repeat domain containing 2 (GTF2IRD2),
            transcript variant 3, mRNA.
ACCESSION   NM_001368300
VERSION     NM_001368300.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4784)
  AUTHORS   Serrano-Juarez,C.A., Venegas-Vega,C.A., Yanez-Tellez,M.G.,
            Rodriguez-Camacho,M., Silva-Pereyra,J., Salgado-Ceballos,H. and
            Prieto-Corona,B.
  TITLE     Cognitive, Behavioral, and Adaptive Profiles in Williams Syndrome
            With and Without Loss of GTF2IRD2
  JOURNAL   J Int Neuropsychol Soc 24 (9), 896-904 (2018)
   PUBMED   30375319
  REMARK    GeneRIF: atypical Williams Syndrome patients with GTF2IRD2 deletion
            had more impaired visuospatial abilities and more significant
            behavioral problems, mainly related to the construct of social
            cognition
REFERENCE   2  (bases 1 to 4784)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   3  (bases 1 to 4784)
  AUTHORS   Gunbin,K.V. and Ruvinsky,A.
  TITLE     Evolution of general transcription factors
  JOURNAL   J Mol Evol 76 (1-2), 28-47 (2013)
   PUBMED   23229069
REFERENCE   4  (bases 1 to 4784)
  AUTHORS   Palmer,S.J., Taylor,K.M., Santucci,N., Widagdo,J., Chan,Y.K.,
            Yeo,J.L., Adams,M., Gunning,P.W. and Hardeman,E.C.
  TITLE     GTF2IRD2 from the Williams-Beuren critical region encodes a
            mobile-element-derived fusion protein that antagonizes the action
            of its related family members
  JOURNAL   J Cell Sci 125 (Pt 21), 5040-5050 (2012)
   PUBMED   22899722
REFERENCE   5  (bases 1 to 4784)
  AUTHORS   Porter,M.A., Dobson-Stone,C., Kwok,J.B., Schofield,P.R., Beckett,W.
            and Tassabehji,M.
  TITLE     A role for transcription factor GTF2IRD2 in executive function in
            Williams-Beuren syndrome
  JOURNAL   PLoS One 7 (10), e47457 (2012)
   PUBMED   23118870
  REMARK    GeneRIF: We provide the first evidence for a role for GTF2IRD2 in
            higher-level (executive functioning) abilities and highlight the
            importance of integrating detailed molecular characterisation of
            patients with comprehensive neuropsychological profiling
REFERENCE   6  (bases 1 to 4784)
  AUTHORS   Edelmann,L., Prosnitz,A., Pardo,S., Bhatt,J., Cohen,N., Lauriat,T.,
            Ouchanov,L., Gonzalez,P.J., Manghi,E.R., Bondy,P., Esquivel,M.,
            Monge,S., Delgado,M.F., Splendore,A., Francke,U., Burton,B.K. and
            McInnes,L.A.
  TITLE     An atypical deletion of the Williams-Beuren syndrome interval
            implicates genes associated with defective visuospatial processing
            and autism
  JOURNAL   J Med Genet 44 (2), 136-143 (2007)
   PUBMED   16971481
REFERENCE   7  (bases 1 to 4784)
  AUTHORS   Del Campo,M., Antonell,A., Magano,L.F., Munoz,F.J., Flores,R.,
            Bayes,M. and Perez Jurado,L.A.
  TITLE     Hemizygosity at the NCF1 gene in patients with Williams-Beuren
            syndrome decreases their risk of hypertension
  JOURNAL   Am J Hum Genet 78 (4), 533-542 (2006)
   PUBMED   16532385
REFERENCE   8  (bases 1 to 4784)
  AUTHORS   Hinsley,T.A., Cunliffe,P., Tipney,H.J., Brass,A. and Tassabehji,M.
  TITLE     Comparison of TFII-I gene family members deleted in Williams-Beuren
            syndrome
  JOURNAL   Protein Sci 13 (10), 2588-2599 (2004)
   PUBMED   15388857
  REMARK    GeneRIF: There is high indentity between CTF2IRD2 and CTF2I, which
            suggests that heterodimers as well as homodimers are possible, and
            indicates overlapping functions between their respective short
            isoforms.
REFERENCE   9  (bases 1 to 4784)
  AUTHORS   Makeyev,A.V., Erdenechimeg,L., Mungunsukh,O., Roth,J.J.,
            Enkhmandakh,B., Ruddle,F.H. and Bayarsaihan,D.
  TITLE     GTF2IRD2 is located in the Williams-Beuren syndrome critical region
            7q11.23 and encodes a protein with two TFII-I-like helix-loop-helix
            repeats
  JOURNAL   Proc Natl Acad Sci U S A 101 (30), 11052-11057 (2004)
   PUBMED   15243160
  REMARK    GeneRIF: GTF2IRD2 genes in mice and humans allows refinement of the
            centromeric breakpoint position of the primate-specific inversion
            within the Williams-Beuren syndrome critical region.
REFERENCE   10 (bases 1 to 4784)
  AUTHORS   Tipney,H.J., Hinsley,T.A., Brass,A., Metcalfe,K., Donnai,D. and
            Tassabehji,M.
  TITLE     Isolation and characterisation of GTF2IRD2, a novel fusion gene and
            member of the TFII-I family of transcription factors, deleted in
            Williams-Beuren syndrome
  JOURNAL   Eur J Hum Genet 12 (7), 551-560 (2004)
   PUBMED   15100712
  REMARK    GeneRIF: Williams-Beuren syndrome patients are hemizygous for the
            GTF2IRD2 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC211424.4 and AC211433.4.
            
            On Oct 19, 2020 this sequence version replaced NM_001368300.1.
            
            Summary: This gene is one of several closely related genes on
            chromosome 7 encoding proteins containing helix-loop-helix motifs.
            These proteins may function as regulators of transcription. The
            encoded protein is unique in that its C-terminus is derived from
            CHARLIE8 transposable element sequence. This gene is located in a
            region of chromosome 7 that is deleted in Williams-Beuren syndrome,
            and loss of this locus may contribute to the cognitive phenotypes
            observed in this disease. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1514795.1,
                                           SRR14372079.432082.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC211424.4         105864-106102       c
            240-1418            AC211424.4         103609-104787       c
            1419-1522           AC211424.4         90777-90880         c
            1523-1661           AC211424.4         87302-87440         c
            1662-1781           AC211424.4         79430-79549         c
            1782-1965           AC211424.4         77121-77304         c
            1966-1994           AC211424.4         76924-76952         c
            1995-2049           AC211424.4         74466-74520         c
            2050-2093           AC211424.4         74051-74094         c
            2094-2171           AC211424.4         67236-67313         c
            2172-2228           AC211424.4         65393-65449         c
            2229-2294           AC211424.4         63605-63670         c
            2295-2372           AC211424.4         61431-61508         c
            2373-2456           AC211424.4         59274-59357         c
            2457-2640           AC211424.4         57795-57978         c
            2641-2669           AC211424.4         56482-56510         c
            2670-4087           AC211424.4         51345-52762         c
            4088-4784           AC211433.4         232916-233612       c
FEATURES             Location/Qualifiers
     source          1..4784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..4784
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /note="GTF2I repeat domain containing 2"
                     /db_xref="GeneID:84163"
                     /db_xref="HGNC:HGNC:30775"
                     /db_xref="MIM:608899"
     exon            1..239
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            240..1418
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             938..4273
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /note="isoform 3 is encoded by transcript variant 3;
                     general transcription factor II-I repeat domain-containing
                     protein 2A; general transcription factor II i repeat
                     domain 2 alpha; transcription factor GTF2IRD2-alpha; GTF2I
                     repeat domain-containing protein 2A; GTF2I repeat
                     domain-containing protein 2, alpha"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 2A isoform 3"
                     /protein_id="NP_001355229.1"
                     /db_xref="CCDS:CCDS94122.1"
                     /db_xref="GeneID:84163"
                     /db_xref="HGNC:HGNC:30775"
                     /db_xref="MIM:608899"
                     /translation="MAPKHKSSDAGNLDRPKRSRKVLPLSEKVKVLDLIRKDKKSYAE
                     VAKIYGKNESSIREIVKKEKEIRASFAVSPPTAKVTATVRDKCLVKMEQALHLWVEEM
                     NRKRVPIDSNMLRQKALSLYQDFCKGCSETDTKPFTASKGWLHRFRHRFSHHYKKKKK
                     GIMAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFV
                     VGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDY
                     FCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENK
                     AGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAE
                     AVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVK
                     IEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGE
                     AIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTV
                     IRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNL
                     RRHYQTNHSKHYDQYMERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQK
                     SPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSE
                     ELLDTVPMTGTKSGNEIFSRVEKSLKNFCIDWSKLVSVASTGTPAMVDANNGLVTKLK
                     SRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTL
                     LYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRD
                     LAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLK
                     LASRNESDGLNYIPKIAELQTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQME
                     VIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMK
                     LSKTKYCSQLKDSQWDSVLHIAT"
     exon            1419..1522
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1661
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1781
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1965
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..1994
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2049
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2093
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2171
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2228
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2294
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2372
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2456
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2640
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2669
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..4784
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4765..4770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /note="hexamer: ATTAAA"
     polyA_site      4784
                     /gene="GTF2IRD2"
                     /gene_synonym="FP630; GTF2IRD2 alpha; GTF2IRD2A"
                     /note="major polyA site"
ORIGIN      
        1 acacgagtcg aggctgcctt ccaggaagca aacaaaaaaa ggggggaaaa gggggggaaa
       61 gaaagaaaga gaaaaaggag ggcgagtggc gagcaggggc ttcggccgcc acccacacgc
      121 cccgaagcgt gctcgtcccc cgcgcggggc tctcggccgc cgccctcggc catcggctgc
      181 tccccggtgg cccaggcctc ggactccgcg gccggcccgg cgcggcccag cgccctcagg
      241 tgtataccaa ggactggaat tgatgggcca agctttgtgt tttaaggaaa aaaaaatcat
      301 gttttagttt cgtgctggta atttgaagta agcagatgtc tagatataag cttggaaact
      361 ggccagttgg agattgctca cggctgcaat tgaagactcc agcagcctct tctcctcttt
      421 gcttccattt ggagaggaag gcgtcatagg ctgtgtgact tccgtggacg cggggcttgg
      481 caccggcttg cagttgggat caatcttcag tggcggtttg gagtgggtca cggttcttcc
      541 tgcttgcctt ccagtttagt ccctgacgtc tgctccccag ggccctggct cttcccccac
      601 gccttcagcc tgcacagtcc cttctctcat tctcaggctg cagaacctgg aagtacagtt
      661 gtcccccctt acccgctgtt tcagttacct gaggtcaacc gtggtctgaa aatactacat
      721 ggaaaattcc ggaaataaac aattcgtaag ttttaaattg cacgctgtga tgaaatctcg
      781 cgctgtgcag cctgggcagt gaatcgtccc ctttgttcag cgtccccacg ctgtggacgc
      841 tccacaccca tagtcactta gtagctggct cggttatcag atcgaccgtc acagtgtccc
      901 agtgtatgtg ttcaagtcac ccttattttc cgtcataatg gccccaaagc acaagagtag
      961 tgatgctggg aatttggata ggccaaagag aagccgtaaa gtgcttcctc taagtgaaaa
     1021 ggtgaaagtt ctcgacttaa tcaggaaaga caaaaaatcc tatgctgagg ttgctaagat
     1081 ctacgggaag aatgaatctt ccatccgtga aattgtgaag aaggaaaaag aaattcgtgc
     1141 tagttttgct gtctcacctc caactgctaa agtgacggcc acagtgcgtg ataagtgctt
     1201 agttaagatg gaacaggcac tgcatttgtg ggtggaagag atgaacagaa aacgtgttcc
     1261 cattgacagc aacatgttgc gccagaaagc tttgagccta taccaagact tctgcaaggg
     1321 atgctctgaa actgacacca agccatttac tgcgagtaag ggatggttac acagattcag
     1381 gcatagattc tcacatcatt acaagaagaa gaagaagggg atcatggccc aggtagcagt
     1441 gtccaccctg cctgttgaag aagagtcctc ctcagagacc aggatggtgg tgacattcct
     1501 cgtgtctgcc ctcgaatcca tgtgtaaaga actggccaag tccaaggcag aagtggcctg
     1561 catcgcagtg tacgaaacag acgtgtttgt cgtcggaacc gagagaggat gcgcttttgt
     1621 taatgccagg acggattttc agaaagattt tgcaaaatac tgcgttgcag agggactgtg
     1681 tgaggtgaaa cctccctgcc ctgtgaacgg gatgcaggtc cactcaggcg aaacggaaat
     1741 actcaggaag gcagtggagg actatttctg cttttgttat ggtaaagcct tagggacaac
     1801 agtgatggtg cctgttccct atgagaagat gctgcgagac cagtcggctg tggtagtgca
     1861 ggggcttccg gaaggcgttg cctttcaaca ccctgagaat tacgaccttg caaccctgaa
     1921 atggattttg gagaacaaag cagggatttc attcatcata aatagaccct tcctaggacc
     1981 agagagtcag ctgggtggcc ctgggatggt aacagatgcg gagagatcca tagtatcacc
     2041 aagtgaaagc tgcggcccca tcaatgtgaa aactgaaccc atggaagatt ctggcatttc
     2101 actgaaagca gaagctgtct cagtcaagaa agaatcagaa gatcctaatt actatcaata
     2161 taatatgcaa ggaagccacc cttcttccac aagcaatgaa gtaatagaaa tggaattacc
     2221 aatggaagat tccactccgc tggtcccttc agaagaacca aatgaggacc ctgaagccga
     2281 ggtgaaaatc gaaggaaaca caaattcatc cagtgttaca aattctgcag caggtgttga
     2341 agatcttaac atcgttcaag tgactgttcc agataatgag aaggaaagat tatcaagcat
     2401 tgaaaagatt aaacagctaa gagaacaagt taatgacctc tttagccgaa aatttggtga
     2461 agcaattggc gtggatttcc ctgtgaaagt tccctacagg aagatcacat tcaaccctgg
     2521 ctgtgtggtg attgatggca tgcccccggg ggtggtattc aaggcccccg gctatctgga
     2581 aatcagttcc atgaggagga tcttggaggc agctgagttt atcaaattca cagtcatcag
     2641 gccgcttcca gggcttgagc tcagtaatgt gggaaaacgc aagatagacc aggagggccg
     2701 tgtgtttcaa gaaaagtggg agagagcgta tttcttcgtg gaagtacaga atattccaac
     2761 atgtctcata tgcaaacaaa gcatgtctgt gtccaaagaa tataacctaa gacgccacta
     2821 tcaaaccaat cacagcaagc attatgacca gtatatggaa agaatgcgtg acgagaagct
     2881 tcacgagctg aaaaaagggc tcaggaagta tctcttaggc tcatcagaca ccgagtgtcc
     2941 cgagcaaaaa caagtgtttg caaacccaag tccaacccag aaatcccccg tgcagcctgt
     3001 agaggaccta gctgggaact tatgggagaa gttacgtgaa aaaatcaggt cttttgtggc
     3061 atattctatc gcaatcgatg agatcacgga tataaataat accacccagt tggccatatt
     3121 catccgtggt gtcgatgaga atttcgatgt gtccgaagaa cttctggaca cggtgcccat
     3181 gacgggtaca aaatctggca acgagatctt ttcgcgtgtt gagaaaagcc tgaaaaactt
     3241 ctgtatcgac tggtcgaaat tagtaagcgt ggcctccact ggcaccccag cgatggtgga
     3301 tgccaataac gggcttgtca caaaactgaa gtccagggtg gcgacgttct gcaagggtgc
     3361 ggaactgaag tccatctgtt gtataattca tccggaatca ctctgtgctc agaagttgaa
     3421 gatggaccac gtcatggacg tggtagtgaa gtccgtgaac tggatatgct cccggggact
     3481 gaaccacagt gagttcacaa ccttgctcta tgagctggac agccagtatg gtagcctcct
     3541 gtactacacg gagattaagt ggctcagtcg cgggctcgtg ctaaagagat ttttcgaatc
     3601 cttggaagaa atcgactcct tcatgtcatc cagagggaaa cccctgcctc aactgagctc
     3661 catagattgg atccgagacc tggccttctt ggttgacatg acgatgcatc tgaacgcttt
     3721 gaacatctct ctccaaggac actcccaaat cgtcacgcag atgtatgacc tgatccgggc
     3781 gttcctagca aaactgtgcc tctgggagac tcatttgacg aggaataatc tggcccactt
     3841 tcccaccctg aaattggctt ccagaaatga aagcgatggc ctgaactaca ttcccaaaat
     3901 cgcggaactc cagaccgaat tccagaaaag gctgtctgat ttcaaactct acgaaagcga
     3961 actgactctg ttcagctccc cgttctccac gaagatcgac agtgtgcacg aggagctcca
     4021 gatggaggtt atcgacctgc aatgcaacac ggtcctgaag acgaaatacg acaaggtggg
     4081 aataccagaa ttctacaagt acctctgggg tagctacccg aaatacaagc accattgcgc
     4141 aaagattctt tccatgttcg ggagcaccta catctgcgaa cagctgttct ccattatgaa
     4201 actgagcaaa acaaaatact gctcccagtt aaaggattcc cagtgggatt ctgtactcca
     4261 catcgcaacg tgatggagag aaaactcctg gcagggccct atggtgggaa aggctggagt
     4321 cttctagtcc caagggattg ggagatgaca aaatgaattt ttttttcttt tttgagatgg
     4381 agtcttgctc tgtcgcccag gttggagtgc agtggcgtga tctcggctta ctgcaacttc
     4441 cagctcctgg gttcgaacga ttctcctgcc tcagcctccc gagcagctgg gactacaggc
     4501 gtgcgccacc atgcctggct aatttttgta ttagtagaga tgaggtttca ccatgttggc
     4561 caggctggtc tccaactcct gacctcaggt gatccacctg cctcgacctc acaaagtgct
     4621 gggattacag gcatgaacca ctgtgcccag ctgacaaaat gagttcttaa actttttttt
     4681 ttttcagttt tttttccact ttgaatcaga aatataatct gcagtatcat acttgtttat
     4741 attacattgt atgcctcact attcattaaa aatcaagaaa gttt
//
