LOCUS       NM_005685               3284 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens GTF2I repeat domain containing 1 (GTF2IRD1),
            transcript variant 2, mRNA.
ACCESSION   NM_005685
VERSION     NM_005685.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3284)
  AUTHORS   Zhuang,H., Zhang,C. and Hou,B.
  TITLE     GTF2IRD1 overexpression promotes tumor progression and correlates
            with less CD8+ T cells infiltration in pancreatic cancer
  JOURNAL   Biosci Rep 40 (9) (2020)
   PUBMED   32936232
  REMARK    GeneRIF: GTF2IRD1 overexpression promotes tumor progression and
            correlates with less CD8+ T cells infiltration in pancreatic
            cancer.
REFERENCE   2  (bases 1 to 3284)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3284)
  AUTHORS   Nambara,S., Masuda,T., Kobayashi,Y., Sato,K., Tobo,T., Koike,K.,
            Noda,M., Ogawa,Y., Kuroda,Y., Ito,S., Eguchi,H., Sugimachi,K. and
            Mimori,K.
  TITLE     GTF2IRD1 on chromosome 7 is a novel oncogene regulating the
            tumor-suppressor gene TGFbetaR2 in colorectal cancer
  JOURNAL   Cancer Sci 111 (2), 343-355 (2020)
   PUBMED   31758608
  REMARK    GeneRIF: Study showed that GTF2IRD1 was overexpressed due to copy
            number amplification at Ch.7q in colorectal cancer (CRC). The
            expression of GTF2IRD1 was positively associated with the malignant
            pathological phenotype. Furthermore, high expression of GTF2IRD1
            was an independent poor prognostic factor in CRC. Mechanistically,
            GTF2IRD1 promoted cell cycle progression by downregulation of
            TGFbetaR2 in CRC.
REFERENCE   4  (bases 1 to 3284)
  AUTHORS   Fan,C.C., Schork,A.J., Brown,T.T., Spencer,B.E., Akshoomoff,N.,
            Chen,C.H., Kuperman,J.M., Hagler,D.J. Jr., Steen,V.M., Le
            Hellard,S., Haberg,A.K., Espeseth,T., Andreassen,O.A., Dale,A.M.,
            Jernigan,T.L. and Halgren,E.
  CONSRTM   Pediatric Imaging, Neurocognition and Genetics Study, Alzheimer's
            Disease Neuroimaging Initiative
  TITLE     Williams Syndrome neuroanatomical score associates with GTF2IRD1 in
            large-scale magnetic resonance imaging cohorts: a proof of concept
            for multivariate endophenotypes
  JOURNAL   Transl Psychiatry 8 (1), 114 (2018)
   PUBMED   29884845
  REMARK    GeneRIF: Among 110 SNPs within the 7q11.23 William's Syndrome (WS)
            chromosomal region, we found one associated locus located at
            GTF2IRD1, which has been implicated in animal models of WS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3284)
  AUTHORS   Huo,Y., Su,T., Cai,Q. and Macara,I.G.
  TITLE     An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren
            Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter
  JOURNAL   Cell Rep 15 (10), 2089-2096 (2016)
   PUBMED   27239038
  REMARK    GeneRIF: The mis-regulation of genes downstream of GTF2IRD1,
            including TbetaR2 and BMPR1b, also individually promoted mammary
            cancer development, and silencing of TbetaR2 suppressed
            GTF2IRD1-driven tumor promotion.
REFERENCE   6  (bases 1 to 3284)
  AUTHORS   Tassabehji,M., Carette,M., Wilmot,C., Donnai,D., Read,A.P. and
            Metcalfe,K.
  TITLE     A transcription factor involved in skeletal muscle gene expression
            is deleted in patients with Williams syndrome
  JOURNAL   Eur J Hum Genet 7 (7), 737-747 (1999)
   PUBMED   10573005
REFERENCE   7  (bases 1 to 3284)
  AUTHORS   Osborne,L.R., Campbell,T., Daradich,A., Scherer,S.W. and Tsui,L.C.
  TITLE     Identification of a putative transcription factor gene (WBSCR11)
            that is commonly deleted in Williams-Beuren syndrome
  JOURNAL   Genomics 57 (2), 279-284 (1999)
   PUBMED   10198167
REFERENCE   8  (bases 1 to 3284)
  AUTHORS   Franke,Y., Peoples,R.J. and Francke,U.
  TITLE     Identification of GTF2IRD1, a putative transcription factor within
            the Williams-Beuren syndrome deletion at 7q11.23
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 296-304 (1999)
   PUBMED   10575229
REFERENCE   9  (bases 1 to 3284)
  AUTHORS   O'Mahoney,J.V., Guven,K.L., Lin,J., Joya,J.E., Robinson,C.S.,
            Wade,R.P. and Hardeman,E.C.
  TITLE     Identification of a novel slow-muscle-fiber enhancer binding
            protein, MusTRD1
  JOURNAL   Mol Cell Biol 18 (11), 6641-6652 (1998)
   PUBMED   9774679
  REMARK    Erratum:[Mol Cell Biol 2000 Jul;20(14):5361]
REFERENCE   10 (bases 1 to 3284)
  AUTHORS   Morris,C.A.
  TITLE     Williams Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301427
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF151354.1, AF156489.1,
            AF118270.2 and AY648295.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_005685.3.
            
            Summary: The protein encoded by this gene contains five GTF2I-like
            repeats and each repeat possesses a potential helix-loop-helix
            (HLH) motif. It may have the ability to interact with other
            HLH-proteins and function as a transcription factor or as a
            positive transcriptional regulator under the control of
            Retinoblastoma protein. This gene plays a role in craniofacial and
            cognitive development and mutations have been associated with
            Williams-Beuren syndrome, a multisystem developmental disorder
            caused by deletion of multiple genes at 7q11.23. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, compared to variant 3. The encoded isoform
            (2) is shorter compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.124542.1, AF118270.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424337.7/ ENSP00000408477.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AF151354.1         117-317
            202-2230            AF156489.1         21-2049
            2231-3269           AF118270.2         2002-3040
            3270-3284           AY648295.1         3302-3316
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3284
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /note="GTF2I repeat domain containing 1"
                     /db_xref="GeneID:9569"
                     /db_xref="HGNC:HGNC:4661"
                     /db_xref="MIM:604318"
     exon            1..271
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            272..400
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..3112
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Williams-Beuren syndrome chromosome region 11; binding
                     factor for early enhancer; general transcription factor 3;
                     muscle TFII-I repeat domain-containing protein 1 alpha 1;
                     general transcription factor II-I repeat domain-containing
                     protein 1; USE B1-binding protein; general transcription
                     factor III; slow-muscle-fiber enhancer-binding protein;
                     williams-Beuren syndrome chromosomal region 12 protein"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 1 isoform 2"
                     /protein_id="NP_005676.3"
                     /db_xref="CCDS:CCDS47613.1"
                     /db_xref="GeneID:9569"
                     /db_xref="HGNC:HGNC:4661"
                     /db_xref="MIM:604318"
                     /translation="MALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSA
                     LSKLNAEVACVAVHDESAFVVGTEKGRMFLNARKELQSDFLRFCRGPPWKDPEAEHPK
                     KVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLRE
                     PGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELN
                     GVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIRELKQEAPS
                     CPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDK
                     SEKWDAFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGI
                     PDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPP
                     EDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTV
                     PDPSPTSEEMTDSMPGHLPSEDSGYGMEMLTDKGLSEDARPEERPVEDSHGDVIRPLR
                     KQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLR
                     KILEASNSIQFVIKRPELLTEGVKEPIMDSQERDSGDPLVDESLKRQGFQENYDARLS
                     RIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKP
                     CTFGSQNLERILAVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEK
                     YGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVR
                     MVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEGNSVSSSSSSSSSSSSNPDSVA
                     SANQISLVQWPMYMVDYAGLNVQLPGPLNY"
     exon            401..542
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            543..698
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            699..882
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1193
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1283
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1367
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1551
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1577
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1686
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1724
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1805
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1895
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1943
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2009
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2193
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2243
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2300
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2384
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2568
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2597
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2675
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2868
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2906
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3043
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3284
                     /gene="GTF2IRD1"
                     /gene_synonym="BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1;
                     RBAP2; WBS; WBSCR11; WBSCR12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcctctcc ccgcgccgcc ccgccctccg ccgcagcccg cgccgggggt gggggccgcc
       61 gagcgccagc cccccggccg gccgattccc cccccgcgcc ccctccccgc gcctccctcc
      121 ccgccctcgc cgcgccgccg tcctcgcctc cctctgcctc tccttccccc attctcccgg
      181 attaattaag gaggcagcgg caggaggctg agtcctggcc gcgggccggg gccggggcgc
      241 cgctggcagg agcgcttggg gatcctccaa ggcgaccatg gccttgctgg gtaagcgctg
      301 tgacgtcccc accaacggct gcggacccga ccgctggaac tccgcgttca cccgcaaaga
      361 cgagatcatc accagcctcg tgtctgcctt agactccatg tgctcagcgc tgtccaaact
      421 gaacgccgag gtggcctgtg tcgccgtgca cgatgagagc gcctttgtgg tgggcacaga
      481 gaaggggaga atgttcctga atgcccggaa ggagctacag tcagacttcc tcaggttctg
      541 ccgagggccc ccgtggaagg atccggaggc agagcacccc aagaaggtgc agcggggcga
      601 gggtggaggc cgtagcctcc ctcggtcctc cctggaacat ggctcagatg tgtaccttct
      661 gcggaagatg gtagaggagg tgtttgatgt tctttatagc gaggccctgg gaagggccag
      721 tgtggtgcca ctgccctatg agaggctgct cagggagcca gggctgctgg ccgtgcaggg
      781 gctgcccgaa ggcctggcct tccgaaggcc agccgagtat gaccccaagg ccctcatggc
      841 catcctggaa cacagccacc gcatccgctt caagctcaag aggccacttg aggatggcgg
      901 gcgggactcg aaggccctgg tggagctgaa cggtgtctcc ctgattccca aggggtcacg
      961 ggactgtggc ctgcatggcc aggcccccaa ggtgccaccc caggacctgc ccccaaccgc
     1021 cacctcctcc tccatggcca gcttcctgta cagcacggcg ctccccaacc acgccatccg
     1081 agagctcaag caggaagcac cttcctgccc ccttgccccc agcgacctgg gcctgagtcg
     1141 gcccatgcca gagcccaagg ccaccggtgc ccaagacttc tccgactgtt gtggacagaa
     1201 gcccactggg cctggtgggc ctctcatcca gaacgtccat gcctccaagc gcattctctt
     1261 ctccatcgtc catgacaagt cagagaagtg ggacgccttc ataaaggaaa ccgaggacat
     1321 caacacgctc cgggagtgtg tgcagatcct gtttaacagc agatatgcgg aagccctggg
     1381 cctggaccac atggtccccg tgccctaccg gaagattgcc tgtgacccgg aggctgtgga
     1441 gatcgtgggc atcccggaca agatcccctt caagcgcccc tgcacttatg gagtccccaa
     1501 gctgaagcgg atcctggagg agcgccatag tatccacttc atcattaaga ggatgtttga
     1561 tgagcgaatt ttcacaggga acaagtttac caaagacacc acgaagctgg agccagccag
     1621 cccgccagag gacacctctg cagaggtctc tagggccacc gtccttgacc ttgctgggaa
     1681 tgctcggtca gacaagggca gcatgtctga agactgtggg ccaggaacct ccggggagct
     1741 gggcgggctg aggccgatca aaattgagcc agaggatctg gacatcattc aggtcaccgt
     1801 cccagacccc tcgccaacct ctgaggaaat gacagactcg atgcctgggc acctgccatc
     1861 ggaggattct ggttatggga tggagatgct gacagacaaa ggtctgagtg aggacgcgcg
     1921 gcccgaggag aggcccgtgg aggacagcca cggtgacgtg atccggcccc tgcggaagca
     1981 ggtggagctg ctcttcaaca cacgatacgc caaggccatt ggcatctcgg agcccgtcaa
     2041 ggtgccgtac tccaagtttc tgatgcaccc ggaggagctg tttgtggtgg gactgcctga
     2101 aggcatctcc ctccgcaggc ccaactgctt cgggatcgcc aagctccgga agattctgga
     2161 ggccagcaac agcatccagt ttgtcatcaa gaggcccgag ctgctcactg agggagtcaa
     2221 agagcccatc atggatagtc aagagaggga ttccggggac cctctggtgg acgagagcct
     2281 gaagagacag ggctttcaag aaaattatga cgcgaggctc tcacggatcg acatcgccaa
     2341 cacactaagg gagcaggtcc aggacctttt caataagaaa tacggggaag ccttgggcat
     2401 caagtacccg gtccaggtcc cctacaagcg gatcaagagt aaccccggct ccgtgatcat
     2461 cgaggggctg cccccaggaa tcccgttccg aaagccctgt accttcggct cccagaacct
     2521 ggagaggatt cttgctgtgg ctgacaagat caagttcaca gtcaccaggc ctttccaagg
     2581 actcatccca aagcctgatg aagatgacgc caacagactc ggggagaagg tgatcctgcg
     2641 ggagcaggtg aaggaactct tcaacgagaa atacggtgag gccctgggcc tgaaccggcc
     2701 ggtgctggtc ccttataaac taatccggga cagcccagac gccgtggagg tcacgggtct
     2761 gcctgatgac atccccttcc ggaaccccaa cacgtacgac atccaccggc tggagaagat
     2821 cctgaaggcc cgagagcatg tccgcatggt catcattaac cagctccaac cctttgcaga
     2881 aatctgcaat gatgccaagg tgccagccaa agacagcagc attcccaagc gcaagagaaa
     2941 gcgggtctcg gaaggaaatt ccgtctcctc ttcctcctcg tcttcctctt cctcgtcctc
     3001 taacccggat tcagtggcat cggccaacca gatctcactc gtgcaatggc caatgtacat
     3061 ggtggactat gccggcctga acgtgcagct cccgggacct cttaattact agacctcagt
     3121 actgaatcag gacctcactc agaaagacta aaggaaatgt aatttatgta caaaatgtat
     3181 attcggatat gtatcgatgc cttttagttt ttccaatgat ttttacacta tattcctgcc
     3241 accaaggcct ttttaaataa gtaaaaaaag aaaaaaaaaa aaaa
//
