LOCUS       NM_032999               4515 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens general transcription factor IIi (GTF2I), transcript
            variant 1, mRNA.
ACCESSION   NM_032999
VERSION     NM_032999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4515)
  AUTHORS   Adams,J.W., Vinokur,A., de Souza,J.S., Austria,C., Guerra,B.S.,
            Herai,R.H., Wahlin,K.J. and Muotri,A.R.
  TITLE     Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in
            human cellular models of neurodevelopment
  JOURNAL   Cell Rep 43 (3), 113867 (2024)
   PUBMED   38416640
  REMARK    GeneRIF: Loss of GTF2I promotes neuronal apoptosis and synaptic
            reduction in human cellular models of neurodevelopment.
REFERENCE   2  (bases 1 to 4515)
  AUTHORS   Nir Sade,A., Levy,G., Schokoroy Trangle,S., Elad Sfadia,G., Bar,E.,
            Ophir,O., Fischer,I., Rokach,M., Atzmon,A., Parnas,H.,
            Rosenberg,T., Marco,A., Elroy Stein,O. and Barak,B.
  TITLE     Neuronal Gtf2i deletion alters mitochondrial and autophagic
            properties
  JOURNAL   Commun Biol 6 (1), 1269 (2023)
   PUBMED   38097729
  REMARK    GeneRIF: Neuronal Gtf2i deletion alters mitochondrial and
            autophagic properties.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4515)
  AUTHORS   Roy,A.L.
  TITLE     Biochemistry and biology of the inducible multifunctional
            transcription factor TFII-I: 10 years later
  JOURNAL   Gene 492 (1), 32-41 (2012)
   PUBMED   22037610
  REMARK    Review article
REFERENCE   4  (bases 1 to 4515)
  AUTHORS   Makeyev,A.V. and Bayarsaihan,D.
  TITLE     Alternative splicing and promoter use in TFII-I genes
  JOURNAL   Gene 433 (1-2), 16-25 (2009)
   PUBMED   19111598
  REMARK    GeneRIF: analyzed promoter regions of TFII-I genes and described
            their additional exons, as well as tested tissue specificity of
            both previously reported and novel alternatively spliced isoforms
REFERENCE   5  (bases 1 to 4515)
  AUTHORS   Cheriyath,V. and Roy,A.L.
  TITLE     Alternatively spliced isoforms of TFII-I. Complex formation,
            nuclear translocation, and differential gene regulation
  JOURNAL   J Biol Chem 275 (34), 26300-26308 (2000)
   PUBMED   10854432
REFERENCE   6  (bases 1 to 4515)
  AUTHORS   Roy,A.L., Du,H., Gregor,P.D., Novina,C.D., Martinez,E. and
            Roeder,R.G.
  TITLE     Cloning of an inr- and E-box-binding protein, TFII-I, that
            interacts physically and functionally with USF1
  JOURNAL   EMBO J 16 (23), 7091-7104 (1997)
   PUBMED   9384587
REFERENCE   7  (bases 1 to 4515)
  AUTHORS   Grueneberg,D.A., Henry,R.W., Brauer,A., Novina,C.D., Cheriyath,V.,
            Roy,A.L. and Gilman,M.
  TITLE     A multifunctional DNA-binding protein that promotes the formation
            of serum response factor/homeodomain complexes: identity to TFII-I
  JOURNAL   Genes Dev 11 (19), 2482-2493 (1997)
   PUBMED   9334314
REFERENCE   8  (bases 1 to 4515)
  AUTHORS   Yang,W. and Desiderio,S.
  TITLE     BAP-135, a target for Bruton's tyrosine kinase in response to B
            cell receptor engagement
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 604-609 (1997)
   PUBMED   9012831
REFERENCE   9  (bases 1 to 4515)
  AUTHORS   Morris,C.A.
  TITLE     Williams Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301427
REFERENCE   10 (bases 1 to 4515)
  AUTHORS   Roy,A.L., Meisterernst,M., Pognonec,P. and Roeder,R.G.
  TITLE     Cooperative interaction of an initiator-binding transcription
            initiation factor and the helix-loop-helix activator USF
  JOURNAL   Nature 354 (6350), 245-248 (1991)
   PUBMED   1961251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292832.1, AF035737.1,
            AF015553.1, CB118501.1, BC099907.1 and AA641906.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_032999.3.
            
            Summary: This gene encodes a phosphoprotein containing six
            characteristic repeat motifs. The encoded protein binds to the
            initiator element (Inr) and E-box element in promoters and
            functions as a regulator of transcription. This locus, along with
            several other neighboring genes, is deleted in Williams-Beuren
            syndrome. There are many closely related genes and pseudogenes for
            this gene on chromosome 7. This gene also has pseudogenes on
            chromosomes 9, 13, and 21. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed. [provided
            by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            gamma).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.258771.1,
                                           SRR1803615.97837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000573035.6/ ENSP00000460070.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK292832.1         39-78
            41-2038             AF035737.1         1-1998
            2039-2725           AF015553.1         1930-2616
            2726-3070           AF035737.1         2686-3030
            3071-3071           CB118501.1         232-232
            3072-4169           AF035737.1         3032-4129
            4170-4171           BC099907.1         4089-4090
            4172-4515           AA641906.1         13-356              c
FEATURES             Location/Qualifiers
     source          1..4515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..4515
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /note="general transcription factor IIi"
                     /db_xref="GeneID:2969"
                     /db_xref="HGNC:HGNC:4659"
                     /db_xref="MIM:601679"
     exon            1..351
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            352..455
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..3353
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTK-associated protein, 135kD; Bruton tyrosine
                     kinase-associated protein 135; general transcription
                     factor II-I; SRF-Phox1-interacting protein;
                     Williams-Beuren syndrome chromosome region 6"
                     /codon_start=1
                     /product="general transcription factor II-I isoform 1"
                     /protein_id="NP_127492.1"
                     /db_xref="CCDS:CCDS5573.1"
                     /db_xref="GeneID:2969"
                     /db_xref="HGNC:HGNC:4659"
                     /db_xref="MIM:601679"
                     /translation="MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEV
                     ACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRM
                     SVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFK
                     HPENYDLATLKWILENKAGISFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPI
                     KVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLSKPLQGS
                     HHSSEGNEGTEMEVPAEDSTQHVPSETSEDPEVEVTIEDDDYSPPSKRPKANELPQPP
                     VPEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKGPVTIPYPLFQS
                     HVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNSTREDLQLDK
                     PASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLP
                     ENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVKEDWNV
                     RITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWF
                     GIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKVP
                     EIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENL
                     FNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNK
                     AKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTASGVEDLNIIQVTIPDDDN
                     ERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVS
                     FKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQSESEGPVIQESAEPSQ
                     LEVPATEEIKETDGSSQIKQEPDPTW"
     exon            456..594
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..729
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            730..913
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..942
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            943..997
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1041
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1119
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1179
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1236
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1299
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1410
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1476
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1660
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1719
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1791
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1975
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2034
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2106
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2290
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2349
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2424
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2526
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2592
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2776
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2832
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2913
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..2997
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3181
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3210
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3252
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3294
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3370
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..4515
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagaag ctgggagagc agagaaaagg ggccaccggt cgcccccccg cttccccgca
       61 cgcgctctcc agccgcggcc gcccgcctgc cgcggtcacc ccggcctctg cctctgtccc
      121 ccagtgatcg gatcaaggcg ctgagcgagg ccctgcctgc ggggcggcca tgcggcggtg
      181 acaggagcgc gaccgacacg cacgggcccc tcgccccctc tcgcctcccg tccgctcgcc
      241 agctcccctc agccgaggct gctccgcggc ggccgcagcc cgcgcgcggc ccacactcgc
      301 ctcccctcgg cacccccggc cccggagctg cctggaggcg gccgcactcg gggatcatgg
      361 cccaagttgc aatgtccacc ctccccgttg aagatgagga gtcctcggag agcaggatgg
      421 tggtgacatt cctcatgtca gctctcgagt ccatgtgtaa agaactggcc aagtccaaag
      481 ccgaagtggc ctgcattgca gtgtatgaaa cagacgtgtt tgtcgtcgga actgaaagag
      541 gacgtgcttt tgtcaatacc agaaaggatt ttcaaaaaga ttttgtaaaa tattgtgttg
      601 aagaagaaga aaaagctgca gagatgcata aaatgaaatc tacaacccag gcaaatcgga
      661 tgagtgtaga tgctgtagaa attgaaacac tcagaaaaac agttgaggac tatttctgct
      721 tttgctatgg gaaagcttta ggcaaatcca cagtggtacc tgtaccatat gagaagatgc
      781 tgcgagacca gtcggctgtg gtagtgcagg ggcttccgga aggtgttgcc tttaaacacc
      841 ccgagaacta tgatcttgca accctgaaat ggattttgga gaacaaagca gggatttcat
      901 tcatcattaa gagacctttt ttagagccaa agaagcatgt aggtggtcgt gtgatggtaa
      961 cagatgctga caggtcaata ctatctccag gtggaagttg tggccccatc aaagtgaaaa
     1021 ctgaacccac agaagattct ggcatttccc tggaaatggc agctgtgaca gtaaaggaag
     1081 aatcagaaga tcctgattat tatcaatata acattcaagc aggcccttct gaaactgatg
     1141 atgttgatga aaaacagccc ctatcgaagc ctttgcaagg aagccaccat tcttcagagg
     1201 gcaatgaagg cacagaaatg gaagtaccag cagaagattc tactcaacat gtcccttcag
     1261 aaacaagtga ggaccctgaa gttgaggtga ctattgaaga tgatgattat tctccaccgt
     1321 ctaagagacc aaaggccaat gagctaccgc agccaccagt cccggaaccc gccaatgctg
     1381 ggaagcggaa agtgagggag ttcaacttcg agaaatggaa tgctcgcatc actgatctac
     1441 gtaaacaagt tgaagaattg tttgaaagga aatatgctca agccataaaa gccaaaggtc
     1501 cggtgacgat cccgtaccct cttttccagt ctcatgttga agatctttat gtagaaggac
     1561 ttcctgaagg aattcctttt agaaggccat ctacttacgg aattcctcgc ctggagagga
     1621 tattacttgc aaaggaaagg attcgttttg tgattaagaa acatgagctt ctgaattcaa
     1681 cacgtgaaga tttacagctt gataagccag cttcaggagt aaaggaagaa tggtatgcca
     1741 gaatcactaa attaagaaag atggtggatc agcttttctg caaaaaattt gcggaagcct
     1801 tggggagcac tgaagccaag gctgtaccgt accaaaaatt tgaggcacac ccgaatgatc
     1861 tgtacgtgga aggactgcca gaaaacattc ctttccgaag tccctcatgg tatggaatcc
     1921 caaggctgga aaaaatcatt caagtgggca atcgaattaa atttgttatt aaaagaccag
     1981 aacttctgac tcacagtacc actgaagtta ctcagccaag aacgaataca ccagtcaaag
     2041 aagattggaa tgtcagaatt accaagctac ggaagcaagt ggaagagatt tttaatttga
     2101 aatttgctca agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat
     2161 caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta
     2221 cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg
     2281 ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa
     2341 acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc
     2401 ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc
     2461 gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt
     2521 cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca
     2581 atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat
     2641 ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa
     2701 gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta
     2761 agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta
     2821 agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg
     2881 aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag
     2941 ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg
     3001 aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg
     3061 gctgtgtggt agttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg
     3121 aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta
     3181 gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc
     3241 ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa
     3301 aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt
     3361 ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca
     3421 agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt tttctacttt
     3481 tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg
     3541 tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa
     3601 tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt
     3661 gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca
     3721 tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt
     3781 tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga
     3841 acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat
     3901 gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta
     3961 tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt
     4021 ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc
     4081 gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg
     4141 ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg
     4201 taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc
     4261 tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga
     4321 gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct
     4381 ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat
     4441 gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa tccatccatg
     4501 cctttcacac actaa
//
